Mokhoa oa ho sebelisa lithethefatsi Gluconorm?

Lebitso la machabeng - gluconorm

Sebopeho le mofuta oa tokollo

Matlapa a koahetsoeng ka filimi tšoeu, pota, biconvex. Letlapa le le leng le na le glibenclamide 2,5 mg, metformin hydrochloride 400 mg.

Bahlomphehi: "microcrystalline cellulose" - 100 mg, starch ea poone - 20 mg, colloidal silicon dioxide - 20 mg, gelatin - 10 mg, glycerol - 10 mg, magnesium stearate - 7 mg, phofo ea talcum e hloekisitsoeng - 15 mg, sodium ea carboxymethyl. - 18,3 mg, cellacephate - 2 mg, diethyl phthalate - 0,2 mg.

Li-pcs tse 10 - lithutsoana (1, 2, 3, 4) - liphutheloana tsa karete.
20 likhomphutha. - lithutsoana (1, 2, 3, 4) - liphutheloana tsa karete.
Li-pcs tse 30 - lithutsoana (1, 2, 3, 4) - liphutheloana tsa karete.

Sehlopha sa tliliniki le meriana

Setlhare sa molomo sa hypoglycemic.

Sehlopha sa Pharmacotherapeutic

Moemeli oa Hypoglycemic bakeng sa tsamaiso ea molomo (sulfonylurea ea moloko oa II + biguanide).

Ketso ea pharmacological

Gluconorm ke motsoako o tsitsitseng oa li-agents tse peli tsa molomo tsa hypoglycemic tsa lihlopha tse fapaneng tsa pharmacological: metformin le glibenclamide.

Metformin ke ea sehlopha sa Biguanides mme e fokotsa boemo ba tsoekere e serumeng sa mali ka ho eketsa kutloelo-bohloko ea lisele tsa thipa molemong oa ts'ebetso ea insulin le ho ntlafatsa ho ts'oaroa ha tsoekere. E fokotsa ho kenngoa ha lik'habohaedreite ka har'a tšilo ea lijo 'me e thibela gluconeogenesis ka har'a sebete. Motsoako ona o boetse o na le phello e molemo ho profid ea lipid ea mali, e theola boemo ba cholesterol e felletseng. LDL le triglycerides. Ha e bake karabelo ea hypoglycemic.

Glibenclamide ke ea sehlopha sa lihlahisoa tsa sulfonylurea tse tsoang molokong oa bobeli. E hlohlelletsa secretion ka ho theola monyako oa pancreatic β-cell glucose, e eketsa kutloisiso ea insulin le ho tlamahanya le eona liseleng tse lebisitsoeng, e eketsa ho tsoa ha insulin, ho ntlafatsa phello ea insulin metsong le tsoekere ea glucose, hape e thibela lipolysis ho lithane tsa adipose. E sebetsa mohatong oa bobeli oa insulin secretion.

Pharmacokinetics ea Gluconorm

Ha e kenngoa, ho amoheloa ho tsoa ka mpeng ea gastrointestinal ke 48-84%. Nako ea ho fihla C_max - Lihora tse 1-2 V_d - lilithara tse 9-10. Puisano le liprotheine tsa plasma ke 95%.

Hoo e batla e na le metabolism e felletseng ka har'a sebete ka ho etsoa ka li-metabolite tse peli tse sa sebetseng, e 'ngoe e supuoa ke liphio, e' ngoe e le mala. T_1/2 - ho tloha lihora tse 3 ho isa ho 10-16

Kamora ho tsamaisoa ka molomo, e ananeloa ho tsoa pampiring ea mahlaba ka botlalo, 20-30% ea lethal dose e fumanoa ka har'a mantle. Boaoavailability e felletseng e tsoa ho 50 ho isa ho 60%. Ka ho kenella ka nako e tšoanang, ho kenngoa ha metformin hoa fokotseha ebe hoa lieha. E ajoa ka potlako ka har'a lithane, ka mokhoa o ha e tlamele liprotheine tsa plasma.

E tšelisoa ka tekanyo e fokolang haholo 'me e supe ke liphio. T_1/2 hoo e ka bang lihora tse 9-12

Type 2 lefu la tsoekere ho batho ba baholo:

- ka ho se sebetse hantle ha kalafo ea ho ja, ho ikoetlisa le kalafo e fetileng ka metformin kapa glibenclamide,

- ho khutlisa kalafo e fetileng ka lithethefatsi tse peli (metformin le glibenclamide) ho bakuli ba nang le boemo ba tsoekere bo maling bo nang le taolo le hantle.

Mokhoa oa ho fokotsa litekanyetso le mokhoa oa ts'ebeliso ea Gluconorm

Setlhare se sebelisoa ka molomo, le lijo. Tekanyetso ea lithethefatsi e khethoa ke ngaka ka bonngoe ho mokuli ka mong, ho latela boemo ba tsoekere ea mali.

Hangata tekanyetso ea pele ke 1 tab. (400 mg / 2.5 mg) / letsatsi. Ka mor'a libeke tse ling le tse ling tse peli kamora ho qala kalafo, tekanyetso ea moriana e lokisoa ho latela boemo ba tsoekere ea mali. Ha u khutlisetsa kalafo ea motsoako e fetileng le metformin le glybeklamide, ho boleloa matlapa a 1-2. Gluconorm ho latela tekanyetso e fetileng ea karolo ka 'ngoe.

Sekhahla se phahameng sa letsatsi le letsatsi ke matlapa a 5.

Litla-morao

Liphetoho le lintho tse ling: ka seoelo - urticaria, erythema, ho hlohlona ha letlalo, feberu, arthralgia, proteinuria.

Ka lehlakoreng la metabolism ea carbohydrate: hypoglycemia ea khonahala.

Ho tsoa ho sheropoietic system: ka seoelo - leukopenia, thrombocytopenia, erythrocytopenia, ka seoelo haholo - agranulocytosis, hemolytic kapa meWIblastic anemia, pancytopenia.

Ho tloha lehlakoreng la tsamaiso ea methapo e bohareng: hlooho e opang, ho tsekela, ho fokola, ho tepella, ka seoelo - li-paresis, mathata a kutloelo-bohloko.

Boitšoaro ba letlalo: ka seoelo - photosensitivity.

Ho tsoa pampiring ea mala le sebete: ka seoelo - ho nyekeloa ke pelo, ho hlatsa, ho opeloa ke mpa, ho felloa ke takatso ea lijo, tatso ea "tšepe" molomong, maemong a mang - jaundice ea cholestatic, ts'ebetso e eketsehileng ea li-enzyme tsa sebete, hepatitis.

Ka lehlakoreng la metabolism: lactic acidosis.

Tse ling: ho hlaseloa ka matla ke ho se mamelle joala ka mor'a ho noa, ho hlahisoang ke mathata a litho tsa mokokotlo le a ho hema (disulfiram-like reaction: ho hlatsa, ho utloa mocheso sefahlehong le 'mele o kaholimo, tachycardia, letsoalo, hlooho).

Contraindication Gluconorm

- mofuta oa 1 lefu la tsoekere

- mafu a tšoaetsanoang, ts'ebetso e kholo ea ts'ebetso ea ho buoa, likotsi, ho chesa haholo le maemo a mang a hlokang kalafo ea insulin,

- lefu la tsoekere ketoacidosis, lefu la tsoekere, lefu la tsoekere,

- maemo a hlobaetsang a ka lebisang phetohong ea ts'ebetso ea liphio (ho omella, ts'oaetso e matla, ho tsitsipana),

- mafu a hlobaetsang kapa a sa foleng a tsamaeang le "hypoxia" ea methapo (pelo kapa ho se khone ho phefumoloha, infarction ea myocardial ea morao-rao, tšabo),

- Sebelisa bonyane lihora tse 48 pele le ka hare ho lihora tse 48 kamora ho etsa lithuto tsa radioisotope kapa X-ray ka ho hlahisoa ha iodine e nang le phapang e mahareng.

- ho latela mokhoa oa ho ja lijo tse nang le khalori e tlase (ka tlase ho likhalori tse ka tlase ho 1000 / letsatsi),

- Ho lemala hampe renal,

- tsamaiso e tšoanang ea miconazole,

- Joala bo sa foleng, ho tahoa ho hoholo,

- lactic acidosis (ho kenyeletsoa le nalane),

- nako ea ho anyesa,

- Hypersensitivity ho metformin, glibenclamide kapa tse ling tse tsoang sulfonylurea, hammoho le lintho tse thusang.

Ha ho khothalletsoe ho sebelisa lithethefatsi ho batho ba lilemo tse fetang 60 ba etsang mosebetsi o boima oa 'mele, o amanang le kotsi e kholo ea ho ba le lactic acidosis ho bona.

Le tlhokomeliso: febrile syndrome, adrenal insuffanele, hypofunction ea anterior pituitary, lefu la qoqotho le nang le ts'ebetso e sa sebetseng.

Bokhachane le pelehi

Nakong ea kemolo, tšebeliso ea gluconorm e hokahane. Ha u rera ho ima, hammoho le ketsahalong ea kemolo nakong ea ho nka Gluconorm, moriana o lokela ho khaotsa mme kalafo ea insulin e lokela ho fanoa.

Gluconorm e kopantsoe le ho anyesa, ha metformin e fetela lebeseng la matsoele. Maemong ana, o tlameha ho fetoha kalafo ea insulin kapa ho emisa ho anyesa.

Sebelisa bakeng sa ts'ebetso ea sebete e sa sebetseng

E amana le ho hloleha ha sebete.

Sebelisa bakeng sa ts'ebetso ea renal e senyehileng

Ts'ebeliso e kopantsoe le ho senyeha ha renal le maemo a hlobaetsang a ka lebisang phetohong ea ts'ebetso ea ho hlaphoheloa ha renal (ho omella, ts'oaetso e matla, ho makala),

Sebelisa ho bakuli ba tsofetseng

Ha ho khothalletsoe ho sebelisa lithethefatsi ho batho ba lilemo tse fetang 60 ba etsang mosebetsi o boima oa 'mele, o amanang le kotsi e kholo ea ho ba le lactic acidosis ho bona.

Litaelo tse khethehileng tsa ho amoheloa

Ho kenella ka matla ho kenelletseng le ho tsoa likotsi, ho cha haholo, mafu a tšoaetsanoang a nang le febrile syndrome ho ka hloka ho khaotsa lithethefatsi le ho khethoa ha kalafo ea insulin.

Hoa hlokahala hore kamehla u lekole boemo ba tsoekere maling maling ka mpeng e se nang letho le ka mor'a ho ja.

Bakuli ba lokela ho lemosoa ka kotsi e eketsehang ea hypoglycemia maemong a ethanol, NSAIDs, le tlala.

Phetoho ea tekanyetso ea hlokahala bakeng sa ho fetella hoa mmele le maikutlo, phetoho ea lijo.

Nakong ea kalafo, ha ho khothalletsoe ho nka joala.

Lihora tse 48 pele ho ts'ebetso ea bongaka kapa iv tsamaiso ea moemeli ea nang le iodineine e nang le iodineine, tsamaiso ea gluconorm e lokela ho emisoa. Phekolo ea gluconorm e khothalletsoa hore e qale hape ka mor'a lihora tse 48.

Tšusumetso ho bokhoni ba ho khanna makoloi le litsamaiso tsa taolo

Nakong ea kalafo, tlhokomelo e lokela ho nkuoa ha ho khannoa likoloi le ho etsa lintho tse ling tse ka bang kotsi tse hlokang ho tsepamisa mohopolo le ho potlakisa karabelo ea maikutlo haholo.

Bongata

Ho fetella kapa ho ba teng ha maemo a kotsi ho ka baka nts'etsopele ea lactic acidosis, joalo ka Metforminum ke karolo ea boitokiso. Ha matšoao a lactic acidosis a hlaha (ho hlatsa, bohloko ba ka mpeng, bofokoli bo akaretsang, mesifa ea mokokotlo), o tlameha ho emisa ho sebelisa moriana. Lactic acidosis ke boemo bo hlokang tlhokomelo ea bongaka ea tšohanyetso, kalafo ea lactic acidosis e lokela ho etsoa sepetlele. Phekolo e sebetsang ka ho fetisisa ke hemodialysis.

Ho fetella le hona ho ka lebisa ho nts'etsopele ea hypoglycemia ka lebaka la boteng ba glibenclamide ha e ntse e hlophisoa. Matšoao a hypoglycemia: tlala, ho ruruha ho feteletseng, bofokoli, ho hlapoloha ka letlalo, ho phahama ha letlalo la molomo, ho thothomela, ho tšoenyeha ka kakaretso, hlooho e opang, ho otsela ha methapo, ho tsitsinyeha ha boroko, ho tšaba, ho hokahanya ho sisinyeha ha motsamao, mathata a nakoana a methapo ea kutlo. Ha tsoelo-pele ea hypoglycemia e ntse e tsoela pele, bakuli ba ka 'na ba lahleheloa ke boitšoaro le ho hloka tsebo.

Ka hypoglycemia e bonolo kapa e leka-lekaneng, dextrose (tsoekere) kapa tharollo ea tsoekere e nkuoa ka molomo. Maemong a hypoglycemia e matla (ho lahleheloa ke kelello), tharollo ea 40% dextrose (glucose) kapa glucagon e kenang kahare, v / m, s / c e tsamaisoa iv. Kamora ho hlaphoheloa kelellong, mokuli o lokela ho fuoa lijo tse nang le lik'habohaedreite ho qoba tsoelopele ea hypoglycemia.

Tšebelisano le Meriana e meng

Barbiturates, corticosteroids, adrenostimulants (epinephrine, clonidine), lithethefatsi antiepileptic (phenytoin), butle-butle calcium Channel blockers, carbonic anhydrase inhibitors (acetazolamide), thiazide diuretics, chlortalidone, furosemide, diazanazide , morphine, ritodrine, salbutamol, terbutaline, tsoekere, rifampicin, lihomone tsa qoqotho tse nang le iodine, letsoai la lithium, litekanyetso tse phahameng - nicotinic acid, chlorpromazine, lithibela-pelehi tsa molomo le estrogens.

Li-inhibitors tsa ACE (Captopril, enalapril), li-histamine H blockers li ntlafatsa phello ea hypoglycemic ea lithethefatsi₂li-receptors (cimetidine), li-antifungal agents (miconazole, fluconazole), NSAIDs (phenylbutazone, azapropazone, oxyphenbutazone), li-fibrate (clofibrate, bezafibrat), lithethefatsi tse felisang lefuba (ethionamide), salicytates, anticoagulant antagonists MAO, sulfonamides ea nako e telele, cyclophosphamide, chloramphenicol, fenfluramine, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubular secretion blockers, reserpine, bromocriptine, disopyramide, pyridoxine, ba bang lithethefatsi tsa hypoglycemic (acarbose, biguanides, insulin), allopurinol.

Litlhare tsa urine acidifying (ammonium chloride, calcium chloride, ascorbic acid ka tekanyetso e kholo) li matlafatsa sephetho ka ho fokotsa tekanyo ea ho ikarola le ho eketsa botjha ba glibenclamide.

Ethanol e eketsa menyetla ea lactic acidosis.

Metformin e fokotsa C_max le T_1/2 furosemide ka 31% le 42.3%, ka ho latellana.

Furosemide e eketsa C_max metformin ka 22%.

Nifedipine e eketsa ho monya, C_max e liehisa ho felisoa ha metformin.

Lithethefatsi tsa cationic (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamteren le vancomycin) tse fumanehang ka har'a marang-rang li qothisana le litsamaiso tsa tsamaiso ea methapo ebile li ka eketsa C ka kalafo ea nako e telele._max 60% metformin.

Lipehelo tsa Maemo a Phomolo ea meriana

Setlhare ke ngaka.

Lipehelo le maemo a polokelo

Setlhare se lokela ho bolokoa ka se omileng, se sirelelitsoeng ke bobebe, hole le bana ka mocheso o sa feteng 25 ° C. Bophelo ba Shelf ke lilemo tse 3.

Ts'ebeliso ea lithethefatsi Gluconorm feela joalo ka ha u laetsoe ke ngaka, litaelo ke tsa tataiso!

Lokolla liforomo le sebopeho

Setlhare se hlahisoa ka mokhoa oa matlapa. Letlapa le le leng le na le 2,5 mg ea glibenclamide le 400 mg ea metformin hydrochloride e le lintho tse sebetsang. Li pota-potile ka sebopeho. Mmala - ho tloha ho o mosoeu ho isa ho o mosoeu.

Gluconorm ea hlokahala kalafo ho loantša lefu la tsoekere.

Ketso ea pharmacological

Metformin ke ea sehlopha sa lintho tse bitsoang Biguanides. Tekanyo ea tsoekere maling ha e nkoa e ea fokotseha ka lebaka la hore menyetla ea likarolo tsa thipa ea ts'ebetso ea insulin e eketseha. Ho ts'oaroa ha glucose ho sebetsa haholoanyane. Limatlafatsi tsa lik'habohaedreite ha li kenngoe ka potlako tsamaisong ea tšilo ea lijo. Ho thehoa ha tsoekere maling ho ea fokotseha. Khetla ea cholesterol maling e ea fokotseha. Hypoglycemia ha e khone ho baka.

Mabapi le glibenclamide, ho hlokomeloa hore ke ntho e nkiloeng ka sulfonylurea ea moloko oa bobeli. E kenya letsoho tlhahiso ea insulin, ho lokolloa ha eona, e fokotsa ts'ebetso ea lipolysis liseleng tsa adipose.

Tekanyo ea tsoekere ea mali ha u nka Gluconorm e fokotseha ka lebaka la hore kutloisiso ea litho tsa thipa tsa ts'ebetso ea insulin e eketseha.

Mofumahali

Khokahano e phahameng ka ho fetisisa ea glibenclamide maling e tlalehiloe lihora tse 1-2 kamora ho nka pilisi. 95% e kopantsoe le liprotheine tsa mali tsa mali. Ho bola hoo e ka bang 100% ho etsahala ka har'a sebete. Bonyane halofo ea bophelo ke lihora tse 3, boholo bo ka fihla lihora tse 16.

Metformin e fumaneha ka 50-60%. Puisano le liprotheine tsa plasma ea mali ha li nyane, ho ajoa ha lisele li ka hlalosoa e le setsi. Oa senyeha ka mokhoa o fokolang, o pepesitsoeng ka liphio. Bophelo ba halofo ke lihora tse 9-12.

Khokahano e phahameng ka ho fetisisa ea glibenclamide maling e tlalehiloe lihora tse 1-2 kamora ho nka pilisi.

Contraindication

Phekolo ka sethethefatsi e ke ke ea etsoa ha mokuli a e-na le maemo a latelang:

• hypoglycemia,
• li-pathologies tse amanang le hypoxia ea tishu: infraction ea myocardial, lefu la pelo le mathata a ho hema, ho ts'oha,
• lefu la tsoekere ketoacidosis,
• mofuta oa 1 lefu la tsoekere
• lactic acidosis le porphyria,
• ho chesa haholo kapa mekhoa ea ts'oaetso e hlokang kalafo ea insulin e potlakileng,
• eketseha habonolo ho lisebelisoa tse ka sehloohong tse sebetsang tsa moriana.

Phekolo ka sethethefatsi e ke ke ea etsoa ha mokuli a e-na le menyetla ea ho sebelisa metsoako ea mantlha ea moriana.
Phekolo ka sethethefatsi e ke ke ea etsoa ha mokuli a e-na le lefu la tsoekere la mofuta oa 1.
Phekolo ka moriana o joalo e ke ke ea etsoa ha mokuli a e-na le lefu le itseng la pelo.

Le lefu la tsoekere

Pele o nka lipilisi, mokuli ka mong o lokela ho ithuta litaelo e le hore a se ke a lematsa. Litekanyetso li lokela ho fuoa ke ngaka e laelang moriana. O etsa qeto ea tekanyetso e nepahetseng e ipapisitseng le boemo bofe ba tsoekere maling bo tlalehiloeng ho mokuli ka nako e boletsoeng. Hangata, lijo li nahaneloa.

Tekanyetso e phahameng ka ho fetisisa ka letsatsi e ke ke ea feta matlapa a 5. Ha e le hantle, ke Letlapa le le leng ka letsatsi (400 mg / 2,5 mg). Ho tloha qalong ea kalafo, ka mor'a libeke tse ling le tse ling tse peli tsa kalafo ho ka ba le khalemelo, ha ngaka e ntse e hlahloba litekanyetso tsa tsoekere ea mali. Haeba e oela, ka hona, ka ho loketseng, tekanyetso e lokela ho fokotsoa.

Litekanyetso li lokela ho fuoa ke ngaka e laelang moriana.

Hematopoietic litho tsa ka hare

Ha e le karabelo e sa tloaelehang e tsoang ho hematopoietic system, nts'etsopele ea leukopenia, thrombocytopenia e etsahala. Hangata, ho fokotseha hoa palo ea leukocytes, anemia ea megaloblastic e hlaha.

Ha e le karabelo e sa tloaelehang ho tsoa ho hematopoietic system, nts'etsopele ea leukopenia e etsahala.

Tšusumetso ho bokhoni ba taolo ea methapo

Ka lebaka la matšoao a tsamaiso ea methapo e kholo, ho molemo ho hana ho laola methapo ea methapo.

Ka lebaka la matšoao a tsamaiso ea methapo e kholo, ho molemo ho hana ho laola methapo ea methapo.

Sebelisa nakong ea bokhachane le pelehi

Moriana ha oa lokela ho nooa nakong ea letsoalo. Haeba ho na le tlhokahalo ea lefu la tsoekere, sena se lokela ho etsoa ka kalafo ea insulin.

Metformin e bokelloa ka lebese la matsoele. Sena se bolela hore nakong ea kalafo, o lokela ho emisa kalafo ka moriana kapa o tlohele ho anyesa mme o fetise ngoana ho ya maiketsetso.

Gluconorm overdose

Haeba tekanyetso e khothalletsoang ke ngaka e feta haholo, mokuli a ka kopana le lactacide, kalafo eo e lokelang ho etsoa maemong a ho ema ka hemodialysis. Hypoglycemia e ka hlaha, e tla iponahatsa ka ponahalo ea tlala, ho thothomela, mathata a ho robala ka nakoana le mathata a methapo ea kutlo.

Litšoaneleho tsa pharmacological

Gluconorm ke setlhare se kopaneng se kopantseng lithethefatsi tsa lihlopha tse fapaneng tsa pharmacological ho ea ka mochini oa ts'ebetso.

Karolo ea pele ea foromo ke metformin, moemeli oa li-biguanides, e emisang likhahla tsa glycemic ka ho ntlafatsa ho hanyetsa ha lisele ho insulin ea tsona le ho potlakisa ts'ebeliso ea tsoekere ke lisele. Ntle le moo, biguanide e thibela ho kenngoa ha lik'habohaedreite hape e thibela tlhahiso ea tsoekere maling. E ntlafatsa metformin le tekanyo ea mafura, ho boloka khokahano e nepahetseng ea mefuta eohle ea cholesterol le triglycerol.

Glibenclamide, motsoako oa bobeli o sebetsang oa ngakeng, e le moemeli oa sehlopha sa bobeli sa sulfonylurea, o ntlafatsa tlhahiso ea insulin ka thuso ea cells-cell ea li-pancreas tse ikarabellang ts'ebetsong ena. E e sireletsa ho tsoa ho glucose e mabifi, e ntlafatsa ho hanyetsa ha insulin le boleng ba ligaments tse nang le lisele. Ho tsoa insulin ho ama ka matla ho kenngoa ha glucose ke sebete le mesifa, ka hona, setoko sa eona ha se thehe karolong ea mafura. Ntho ena e sebetsa mohato oa bobeli oa tlhahiso ea insulin.

Litšobotsi tsa pharmacokinetics

Kamora ho kena ka mpeng, glibenclamide e kenngoa ke 84%. Cmax (tlhoro ea boemo ba hae) o fihla ka mor'a lihora tse 1-2. Ho ajoa ka boholo (Vd) ke lilithara tse 9-10. Ntho ena e tlama liprotheine tsa mali ka 95%.

Karolo e leng ka har'a sebete e fetoloa ka ho lokisoa ha metabolites e 'meli. E 'ngoe ea tsona e tlosa mala, ea bobeli - liphio. Bophelo ba halofo ea T1 / 2 bo kahare ho lihora tse 3-16.

Kamora ho kenella ts'ebetsong ea tšilo ea lijo, metformin e kenella ka mafolofolo, ha ho feta 30% ea lethal dose e setseng setulong. The bioavailability ea biguanide ha e fetang 60%. Ka mokhoa o tšoanang oa limatlafatsi, ho amoheloa ha moriana ho ea butle. E ajoa ka potlako, ha e kene puisanong le liprotheine tsa plasma.

Sebopeho sa litekanyetso tsa Gluconorm le sebopeho

Gluconorm, e leng foto ea eona e ka bonoang karolong ena, e kena marang-rang a meriana ka mokhoa oa matlapa a potolohileng a nang le khetla e tšoeu. Ha le robeha, moriti oa moriana o putsoa. Letlapeng le leng ho na le metsoako e 'meli ea mantlha ka litekanyetso tse latelang: metformin - 400 mg, glibenclamide - 2,5 g. Tlatsetsa foromo ka li-fillers: talc, cellulose, starch, glycerol, cellacephate, gelatin, stearate ea magnesium, croscarmellose sodium, sodium carboxymethyl starch, silicon diodium diethyl phthalate.

Setlhare sena se kenngoe ka likhomphutha tse 10 kapa 20. ka lisele tse entsoeng ka foil ea aluminium. Ka ho paka ka karete e ka ba ho tloha lipapaling tse peli ho isa ho tse 'ne. Bakeng sa Gluconorm, theko e na le litekanyetso haholo: ho tloha li-ruble tse 230, ba lokolla moriana o fanoang. Bophelo ba lishelefo tsa matlapa ke lilemo tse 3. Setlhare ha se hloke maemo a ikhethang bakeng sa polokelo.

Mokhoa oa ho sebelisa Gluconorm

Bakeng sa Gluconorm, litaelo tsa tšebeliso li fana ka ho nka litafole kahare ka lijo. Ngaka e bala tekanyetso ka bonngoe, e ela hloko litšobotsi tsa nako ea lefu lena, li-pathologies tse amanang, lilemo le boemo ba lefu la tsoekere, le karabelo ea 'mele ea moriana. E le molao, qala ka 1 letlapa / letsatsi. Kamora beke kapa tse peli, o ka lekola sephetho, 'me ka ho se sebetse hantle, lokisa maemo.

Haeba Gluconorm ha se moriana oa ho qala, ha u nka mofuta oa kalafo e fetileng, matlapa a 1-2 a beoa ho latela tloaelo e fetileng ea lithethefatsi. Palo e kholo ka ho fetisisa ea matlapa a ka noang ka letsatsi ke likotoana tse 5.

Thuso ka overdose

Ho ba teng ha metformin ka sebopeho hangata ho halefisa mathata a mala, mme ka linako tse ling lactic acidosis. Ka matšoao a mathata (mesifa ea mokokotlo, bofokoli, bohloko sebakeng sa epigastric, ho hlatsa), lithethefatsi li emisitsoe. Ka lactic acidosis, motho ea hlokahalitsoeng o hloka ho kena sepetlele ka potlako. E khutlisetse ka hemodialysis.

Ho ba teng ha glibenclamide ka foromo ha ho khelle nts'etsopele ea hypoglycemia. Ho a khonahala ho lemoha boemo bo kotsi ka takatso e sa laoleheng, ho fufuleloa ho eketsehileng, tachycardia, ho thothomela, letlalo le pherese, isomnia, paresthesia, kizungu le hlooho, ho tšoenyeha. Ka mofuta o bobebe oa hypoclycemia, haeba motho ea hlokahalitsoeng a sa tsebe letho, ba fuoa tsoekere kapa tsoekere. Ka ho akheha, tsoekere, dextrose, glucagon (40% rd) e kentsoe iv, em kapa ka tlasa letlalo. Kamora hore mokuli a hlaphoheloe, o feptjoa lihlahisoa tse nang le lik'habohaedreite tse potlakileng, kaha ho khutlela mokhoeng ona hangata ho etsahala.

Liphetoho tsa ho sebelisana le lithethefatsi

Motsoako o nang le li-inhibitors tsa ACE, li-NSAIDs, meriana ea antifungal, fibrate, salicitates, meriana e thibelang lefuba, li-blockers tsa β-adrenergic, guanethidine, MAO inhibitors, sulfonamides, chloramphenicol, tetracycopyridinum, tetracycodiaminophenide, tetracycetaminin extensettanisis le manane a manonyeletso a fetisang. .

Ts'ebetso ea hypoglycemic ea Gluconorm e fokotsehile ho tsoa litlamorao tsa adrenostimulant barbiturates, corticosteroids, lithethefatsi tse khahlanong le lefu la sethoathoa, diuretics (lithethefatsi tsa thiazide), furosemide, chlortalidone, triamteren, morphine, ritodrin, glucagon, lihomone tsa qoqotho, joalo-joalo.

Litlhare tse matlafatsang Urine acid li sebetsa e le sesupo sa ho sebetsa hantle ka ho fokotsa ho ikarola le ho ntlafatsa ho sutumetsoa ha gluconorm. Ethanol e eketsa menyetla ea lactic acidosis. Metformin e ama hampe pharmacokinetics ea furosemide.

Liphetho tse sa rateheng

Metformin ke e 'ngoe ea lithethefatsi tse sireletsehileng ka ho fetisisa tsa hypoglycemic, empa joalo ka moriana o mong le o mong oa maiketsetso o na le litlamorao. Har'a tse atileng haholo ke mafu a dyspeptic, a nyamelang ho batho ba bangata ba lefu la tsoekere ka mor'a hore nako ea ho ikamahanya le maemo e be bona. Glibenclamide le eona ke motsoako o lekiloeng nako le nako o nang le bopaki bo bongata ba ts'ebetso le polokeho. Maemo a thathamisitsoeng tafoleng a fumaneha seoelo, empa litaelo li tlameha ho ithutoa pele ho qala kalafo.

Ke mang ea bontsitsoeng le contraindified Gluconorm

Matlapa a ngolloa batho ba lefu la tsoekere ka mofuta oa 2 oa lefu lena, haeba phetoho ea bophelo le kalafo e fetileng e sa fane ka taolo ea 100% glycemic. Haeba tšebeliso ea lithethefatsi tse peli tse arohaneng (Metformin le Glibenclamide) e lumella matšeliso a tsoekere a tsoekere, ho boetse ho bohlokoa hore u qobelle tse thata ka sethethefatsi se le seng - Glucanorm.

Se ke oa sebelisa Gluconorm ka:

• Type 1 lefu la tsoekere
• Hypoglycemia,
• Lefu la tsoekere la ketoacidosis, komello le lefu la ho bola,
• Mathata a renang le maemo a ho teneha,
• Mathata a sebete
• Maemo a hlohlelletsoang ke tlala ea oksijene ea li-tishu (tse nang le lefu la pelo, methapo ea pelo, tšabo, ho se khonehe phefumoloho),
• Porphyria
• Tšebeliso e tšoanang ea miconazole,
• Maemo a fanang ka tlhahiso ea phetoho ea nakoana ho insulin (nakong ea ts'ebetso, likotsi, tšoaetso, litlhahlobo tse ling li sebelisa matšoao a ipapisitse le iodine),
• Tšebeliso e mpe ea tahi
• Lactic acidosis, ho kenyelletsa nalane ea bongaka,
• Bokhachane le pelehi
• Hypocaloric (ho fihlela ho 1000 kcal) phepo e nepahetseng,
• Hypersensitivity ho likarolo tsa formula.

Ts'ebeliso ea Gluconorm ke Baimana ba baimana le baoki

Leha sethaleng sa ngoana se hlophisoa, Gluconorm e lokela ho nkeloa sebaka ke insulin, kaha sethethefatsi sena se kopantsoe le sena. Ha lebese la matsoele le feptjoa, lithibelo li lula li tletse, kaha sethethefatsi se kenella eseng feela ka placenta ea lesea, empa hape le ka lebese la matsoele. Khetho pakeng tsa insulin le ho fetisetsa ngoana ho lijo tsa maiketsetso ho lokela ho nka tekanyo ea kotsi ho mme le kotsi e ka bang teng ho lesea.

Litaelo tse khethehileng

Ho tsoa likotsi tse mpe le ts'ebetso e tebileng, mafu a tšoaetsanoang a tsamaeang le feberu, a fana ka maikutlo a phetisetso ea nakoana ea mokuli ho insulin.

Litsebi tsa lefu la tsoekere li lokela ho lemosoa ka kotsi ea ho ba le hypoglycemia ka tšebeliso ea li-NSAIDs, joala, lithethefatsi tse nang le ethanol, le khaello ea phepo e nepahetseng khafetsa.

Ka phetoho ea mokhoa oa bophelo, lijo, ho sithabela ha maikutlo le 'meleng, phetoho ea litekanyetso tsa moriana e ea hlokahala.

Haeba mokuli a lokela ho hlahlojoa a sebelisa matšoao a nang le iodineine, gluconorm e hlakotsoe ka matsatsi a mabeli, ebe e nka insulin. O ka khutlela kalafong ea kalafo e fetileng pejana ho feta lihora tse 48 kamora thuto.

Ts'ebetso ea Gluconorm e tla fokotsoa haholo haeba mokuli a sa latele lijo tse tlase tsa carb, a phela bophelo ba ho lula fatše, a sa laole tsoekere ea hae letsatsi le letsatsi.

Gluconorm - analogues

Ho latela khoutu ea ATX ea 4th, ba hokahana le Gluconorm:

Khetho le ho khutlisetsa lithethefatsi ka mokhoa o ikhethileng ke bokhoni ba setsebi. Ho itlhahloba le ho iphekola ntle le ho nahana ka litšobotsi tsohle tsa setho se itseng ho ka fetoha litlamorao tse bohloko.

Litlhahlobo tsa lefu la tsoekere

Mabapi le litlhahlobo tsa lefu la tsoekere la Gluconorm hangata li baka likhang. Ba bang ba pheha khang ea hore moriana ha o na thuso, ho na le menyetla e mengata e mebe, e kenyeletsang ho nona. Ba bang ba re bothata bo boholo ba ho phekola le lithethefatsi e ne e le ho khethoeng ha litekanyetso, ebe tsoekere e khutlela ho tloaelehileng. Mabapi le tee ea limela "Altai 11 Gluconorm e nang le li-blueberries" litlhahlobo tse ntle: e thusa ho boloka pono, ho ntlafatsa bophelo bo botle.

Gluconorm ke lithethefatsi tse fumanehang habonolo ka lipatlisiso tse netefalitsoeng le lithuto tsa mantlha tsa kliniki. Li-derivatives tsa Biguanides le sulfanilurea li sebelisitsoe bakeng sa kalafo ea lefu la tsoekere la mofuta oa 2 bakeng sa nako e fetang halofo ea lekholo, mme mefuta e mecha ea lithethefatsi tsa antidiabetes ha e so ka e batla bolaoli ba eona.

Ho sebelisana le lithethefatsi tse ling

Ha e khothalletsoe tšebeliso e le 'ngoe le lithethefatsi fenfluramine, cyclophosphamide, li-inhibitors tsa ACE, lithethefatsi tsa antifungal, kaha li matlafatsa phello ea lithethefatsi.

Li-diuretics tsa Thiazide dihormone tse nang le iodine ea iodine li ka fokolisa tšebetso ea eona.

Ha e khothalletsoe tšebeliso e kopaneng le fenfluramine.

Litlhahlobo tsa gluconorm

Lingaka le bakuli ba kileng ba phekoloa ka litlhare ba tlohela tlhahlobo e ntle.

D.E. Tikhonov, GP, Ryazan: "Lithethefatsi li hlahisa litholoana tse ntle haholo kalafong ea lefu la tsoekere la mofuta oa 2. Bakuli ba ikutloa ba le betere. ”

O.D. Ivanova, setsebi sa endocrinologist, Moscow: "Ke nka lithethefatsi e le tsona tse molemohali bakeng sa kalafo ea lefu la tsoekere la mofuta oa 2, kaha e thusa ka potlako le ka kotloloho ha e hlahise ponahalo ea maikutlo a mabe. Ke tla mo khetha khafetsa. ”

Mofuta oa 1 oa lefu la tsoekere la Gluconorm

Alina ea lilemo li 29, Bryansk o re: “Ke ile ka tlameha ho phekoloa bokuli bo tebileng joalo ka lefu la tsoekere. Phekolo e ne e le telele, empa boemo bo ile ba ntlafala haholo. Ka hona, nka buella moriana ona. ”

Ivan, ea lilemo li 49, Ufa: “Ke ile ka alafshoa sepetlele. Ke ne ke khotsofetse ke tsohle, ho kenyelletsa tlhokomelo ea lingaka le mosebetsi oa tsona. Ba ile ba ntlhahlobisisa, 'me ba ipapisitse le liphetho, ba fumana moriana oa meriana. Nka bitsa lithethefatsi ena hore li sebetsa 'me ke li khothalletsa ho bakuli bohle ba nang le lefu la tsoekere. ”