Mokhoa oa ho sebelisa Lorista N bakeng sa lefu la tsoekere

Lorista ® N - sethethefatsi se kopaneng, se na le khatello ea maikutlo.

Losartan. Seleng angiotensin II receptor antagonist (mofuta oa AT 1) bakeng sa tsamaiso ea molomo, tlhaho e se nang protheine. Ho vivo le in vitro losartan le eona e sebetsang ea carboxy metabolite (EXP-3174) e thibela litla-morao tsohle tsa 'mele tse bohlokoa tsa angiotensin II ho li-receptor tsa 1 1.

Losartan e sa sebetse e baka ts'ebetso ea li-receptor tsa AT 2 ka ho eketsa boemo ba angiotensin II.

Losartan ha e thibele mosebetsi oa kininase II, enzyme e kenyellelitsoeng ho metabolism ea bradykinin.

E fokotsa OPSS, khatello e "potoloho" e nyane ea ho potoloha ha mali, e fokotsa khatello ea mali ka morao, e nang le phello ea diuretic.

E kena-kenana le nts'etsopele ea hypertrophy ea myocardial, e eketsa mamello ho bakuli ba nang le lefu la pelo le sa foleng. Ho nka losartan hang ka letsatsi ho lebisa ho fokotseheng ho hoholo hoa lipalo ho SBP le DBP. Ka ho tšoanang, Losartan e laola khatello letsatsi lohle, athe phello ea antihypertensive e tsamaisana le morethetho oa tlhaho oa potoloho. Ho fokotseha ha khatello ea mali qetellong ea tekanyetso ea moriana ho ne ho batla ho le 70-80% ea phello ea tlhako ea lithethefatsi, lihora tse 5-6 kamora ts'ebetso. Withdawal syndrome ha e bonoe, 'me losartan ha e na phello e kholo litekanyetsong tsa pelo.

Losartan e sebetsa hantle ho banna le basali, hammoho le ho batho ba tsofetseng (ba ka holimo ho lilemo tse 65) le bakuli ba banyenyane (ba ka tlase ho lilemo tse 65).

Hydrochlorothiazide. A thiazide diuretic, phello ea diuretic e amanang le ho ts'oaroa ha sesepa sa sodium, chlorine, potasiamo, magnesium, ion ea metsi ka har'a nephron ea distal, e liehisa tlhahiso ea calcium ion, uric acid. E na le thepa ea antihypertensive. Hoo e batlang e se phello ea khatello e tloaelehileng ea mali.

Kameho ea diuretic e etsahala kamora lihora tse 1-2, e fihla hofihlella kamora lihora tse 4 mme e nka lihora tse 6-12.

Mofumahali

The pharmacokinetics of losartan le hydrochlorothiazide ha e nkuoa ka nako e tšoanang ha e fapana le eo ha e tsamaisoa ka thoko.

Losartan. E monya hantle ho tsoa mohopolong oa tšilo ea lijo. E na le metabolism ea bohlokoa nakong ea "karolo ea pele" ka har'a sebete, e etsa metabolite e sebetsang (EXP-3174) e nang le carboxylic acid le metabolites tse ling tse sa sebetseng. Bioavailability ke hoo e ka bang 33%. Ho nka sethethefatsi sena ka lijo ha ho na phello e matla mokokotlong oa melemo ea sona ea serum. T max - hora e le 1 ka mor'a taolo ea molomo, le metabolite ea eona e sebetsang (EXP-3174) - lihora tse 3-4.

Ho feta 99% ea losartan le EXP-3174 li tlama liprotheine tsa plasma, haholoholo le albin. Bophahamo ba kabo ea losartan ke lilitha tse 34. E kenella hampe haholo ka BBB.

Losartan e tšelisoa ka ho thehoa ha metabolite e sebetsang (EXP-3174) le 14% mme e sa sebetse, ho kenyelletsa metabolites e meholo e 2 e thehiloeng ke hydroxylation ea sehlopha sa butyl sa ketane, le metabolite e sa bohlokoa haholo - N-2-tetrazole glucuronide.

Hlakollo ea plasma ea losartan le metabolite ea eona e sebetsang e batla e le 10 ml / s (600 ml / min) le 0,83 ml / s (50 ml / min), ka ho latellana. Tlhahiso ea renal ea losartan le metabolite ea eona e sebetsang e ka ba 1,23 ml / s (74 ml / min) le 0.43 ml / s (26 ml / min). T 1/2 ea losartan le metabolite e sebetsang ke lihora tse 2 le lihora tse 2, ka ho latellana. E chekoa haholo ka bile - 58%, liphio - 35%.

Hydrochlorothiazide. Kamora ho tsamaisoa ka molomo, ho monya ha hydrochlorothiazide ke 60-80%. C max hydrochlorothiazide maling e fihlella lihora tse 1-5 kamora ho kenella.

Ho tlama ho protheine ea plasma ea hydrochlorothiazide ke 64%.

Hydrochlorothiazide ha e tšeloe 'mele' me e qepha ka potlako liphio. T 1/2 ke lihora tse 5-15.

Maemo a ikhethileng

• 1 tab losartan potasiamo 100 mg hydrochlorothiazide 25 mg Excipients: pregelatinized starch - 69.84 mg, cellcrystalline cellulose - 175,4 mg, lactose monohydrate - 126.26 mg, magnesium stearate - 3.5 mg. Sebopeho sa membrane ea filimi: hypromellose - 10 mg, macrogol 4000 - 1 mg, dae quinoline yellow (E104) - 0,11 mg, titanium dioxide (E171) - 2.89 mg, talc - 1 mg. losartan potasiamo 100 mg hydrochlorothiazide 12.5 mg Baeti: pregelatinized starch, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Sebopeho sa Shell: hypromellose, macrogol 4000, quinoline e dae (E104), titanium dioxide (E171), talc. losartan potasiamo 100 mg hydrochlorothiazide 25 mg Excipients: pregelatinized starch, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Sebopeho sa Shell: hypromellose, macrogol 4000, quinoline e dae (E104), titanium dioxide (E171), talc. potasium losartan 50 mg hydrochlorothiazide 12.5 mg Excipients: pregelatinized starch, microcrystalline cellulose, lactose monohydrate, magnesium stearate Shell composition: hypromellose, macrogol 4000, quinoline yellow dae (E104), titanium dioxide (E171), tal. losartan potasiamo 50 mg hydrochlorothiazide 12.5 mg Baeti: pregelatinized starch, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Sebopeho sa Shell: hypromellose, macrogol 4000, quinoline e dae (E104), titanium dioxide (E171), talc.

Lithibelo tsa Lorista N

• Hypersensitivity ho losartan, ho lithethefatsi tse nkiloeng ho sulfonamides le likarolo tse ling tsa lithethefatsi, anuria, ho senyeha haholo ha renal (creatinine clearance (CC) ka tlase ho 30 ml / min., Hyperkalemia, dehydration (ho kenyelletsa le litekanyetso tse phahameng tsa diuretics) ho hlobaela ho matla ha sebete, "hypokalemia" e matlafatsang, ho ima, ho lactation, hyperension ea methapo, lilemo tse ka tlase ho lilemo tse 18 (ho sebetsa hantle le polokeho ha li so theoe), khaello ea lactase, galactosemia kapa glucose / gal malabsorption syndrome. Ketso. Ka tlhokomeliso: Phallo ea mali-electrolyte e pharalletseng ea mali (hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), lefu la methapo ea methapo ea methapo kapa lefu la sethoathoa sa methapo e le 'ngoe ea methapo, lefu la tsoekere, hypercalcemia, hyperuricemia le e ntlafalitsoe pele ka lithethefatsi tse ling, ho kenyelletsa le inhibitors ea AP

Litlamorao tsa Lorista N

• Karolong ea mali le tsamaiso ea methapo ea kutlo: hangata: khaello ea mali, Shenlane-Genokha Purpura. Ka lehlakoreng la tsamaiso ea 'mele ea ho itšireletsa mafung: ka seoelo: karabelo ea anaphylactic, angioedema (ho kenyelletsa ho ruruha ha larynx le leleme, ho baka tšitiso ea tsela ea moea le / kapa ho ruruha ha sefahleho, molomo, pharynx). Ho tloha lehlakoreng la tsamaiso ea methapo e bohareng le tsamaiso ea methapo ea methapo: khafetsa: hlooho ea hlooho, tsamaiso ea methapo le eo e seng ea tsamaiso, ho hloka boroko, mokhathala, lefu le sa foleng: migraine. Ho tsoa ho tsamaiso ea pelo: hangata: orthostatic hypotension (e itšetlehileng ka lethal dose), palpitations, tachycardia, ka seoelo: vasculitis. Ho tsoa ts'ebetsong ea ho hema: khafetsa: ho khohlela, tšoaetso ea phepelo ea phepelo e phahameng, pharyngitis, ho ruruha ha mucosa ea nasal. Ho tsoa pampiring ea ka mpeng: khafetsa: lets'ollo, lets'ollo, ho nyekeloa, ho hlatsa, bohloko ba ka mpeng. Ho tsoa ts'ebetsong ea hepatobiliary: ka seoelo: hepatitis, ts'ebetso ea sebete e senyehileng. Ho tloha letlalong le mafura a subcutaneous: hangata: urticaria, ho hlohlona letlalo. Ho tsoa ho sistimi ea musculoskeletal le lisele tse sebetsanang: khafetsa: myalgia, bohloko ba morao, hangata: arthralgia. Tse ling: khafetsa: asthenia, bofokoli, edema ea ho potoloha, bohloko ba sefuba. Matšoao a laboratori: khafetsa: hyperkalemia, palo e eketsehileng ea hemoglobin le hematocrit (eseng ea bohlokoa haholo), hangata: keketseho e leka-lekaneng ea serum urea le creatinine, ka seoelo: mosebetsi o eketsehileng oa sebete le li-enzymes tsa bilirubin.

Maemo a polokelo

• boloka ka mocheso oa kamore 15-25 likhato
• qoba bana

Selemo se seng le se seng, batho ba bangata ba tšoenngoa ke mafu a pelo le pelo. Ho latela lipalo-palo, morao tjena, le bana ba banyenyane ba kile ba tobana le bothata bona. Kajeno, ho na le lithethefatsi tse ngata tse thusang ho loantša khatello ea mali. E 'ngoe ea tse sebetsang ka ho fetisisa ke Lorista N.

Lorista N ke sethethefatsi se kopaneng se nang le ts'usumetso e matla. Lintho tse sebopeho sa tsona li etsa hore khatello ea mali e tloaelehe le ho thusa ho tlosa ho nyekeloa ke pelo. Kameho e ntle ea matlapa e netefatsoa ke motsoako o ka sehloohong o sebetsang -. E baka tšitiso ea li-receptor tsa angiotensin II ka pelong, methapo ea mali le liphio. Ka lebaka la sena, ho fokotseha ha vasoconstriction hoa bonoa.

Ho fapana le Lorista

Lifekthering tsa Russia, lihlahisoa tse 'maloa tse tšoanang li rekisoa hang-hang - Lorista N' me ba bangata ha ba tsebe hore na phapano lipakeng tsa bona ke eng.

Phapang e kholo ke sebopeho sa lithethefatsi. Ho Lorista, losartan le eona ke motsoako o ka sehloohong o sebetsang. Karolo ea likarolo tse ling e etsoa ke: starch ea poone, cellactose, magnesium stearate.

Mofuteng o ntlafalitsoeng oa moriana ona o nang le prefix H, lenane le tlatselletsoa ke hydrochlorothiazide. E kenya letsoho ho fokotseha hoa boemo ba karolo ea cortical ea Na + reabsorption. Ha ho na tlhoko ea hore ka bomong u khethe litekanyetso tsa pele bakeng sa bakuli ba lilemo tse holileng.

Phapang e 'ngoe lipakeng tsa lithethefatsi tsena ke litšenyehelo. Theko e tloaelehileng ea Lorista e tlase hanyane mme e bokana ho li-ruble tse 100-130. Ha e le mochine oa ts'ebetso, lithethefatsi ka bobeli li thusa khatello ea mali e tlase.

Sebopeho le litekanyetso tsa theko ea lithethefatsi

Setlhare sena se fumaneha ka mokhoa oa matlapa a nang le 'mala o mosehla. Ka linako tse ling ho na le matlapa a mmala o motala. Li nyane ka boholo le bohare ba sebopeho, e leng se etsang hore kamohelo e be bonolo joalo ka moo ho ka khonehang. Ka lehlakoreng le leng ho na le mola o arolang (Lorista ND, e nang le litaba tse phahameng tsa karolo e sebetsang, ha e eo).

Kamora ho fetisa tlhahlobo le ho buisana le ngaka, mokuli a ka utloisisa se molemong oa hae - N kapa ND. Ha ho na thuso ho fana ka kalafo ka boeona, e le hore e se ke ea lematsa 'mele. Theko e tloaelehileng ke li-ruble tse 230.

Sebopeho, mochini oa ketso le thepa

Letlapa le leng le le leng le kopantsoe le filimi 'me le na le: losartan potasiamo (50 mg), hydrochlorothiazide (12,5 mg), setlolo sa poone sa pregelatinized, MCC, magnesium stearate le lactose monohydrate. Hape, matlapa a fumaneha ka sekhahla se eketsehang sa losartan (100 mg). Ba bitsoa Lorista ND. 25 mg ea hydrochlorodisiad e kenyellelitsoe sebopeho sa bona. Likarolo tse thusang li ile tsa lula li le joalo.

Bakeng sa ho etsa koae ea filimi, baetsi ba sebelisa talc, dae e mosehla, E 171 (titanium dioxide), hypromellose, macrogol 4000.

Mokhoa oa tšebetso ea likarolo tse sebetsang ke ho theola khatello ea mali le ho fokotsa ho lutla ka pelong. Likarolo tsa matlapa li thusa ho eketsa ts'ebetso ea plasma renin, ho fokotseha ha dikahare tsa potasiamo tsa serum le ntlafatso ea secretion ea aldosterone.

Ntho ea bohlokoa ea lithethefatsi e tšoantšoa le ketso ea uricosuric. E thibela litlamorao tsa 'mele tsa angiotensin II. Hammoho le hydrochlorothiazide, ntho ena e fokotsa haholo hyperuricemia. Moriana ona ha o ame maqhubu a methapo ea pelo. Matla a antihypertensive a etsoa ke ho atoloha ha methapo ea methapo. Kamora lihora tse 2-3, ho ba le phello e lumellang letsatsi.

Losartan e anngoe hantle ka kotloloho ho tsoa mpeng ea mpa, boemo ba bioavailability ke 32-33%. Ntho ena e latela liprotheine tsa plasma. Hoo e ka bang 58% ea moriana o qheletsoe ka ntle ho 'mele o na le bile,' me 35% e hloekisoa ke liphio. Kamora ho kenella, hydrochlorothiazide e kopana le liprotheine tsa plasma (e ka bang 65%). Kamora lihora tse 5-10 kantle ho mmele ka moroto.

Matšoao le mefokolo

Setlhare se sebetsa e le e 'ngoe ea likarolo tsa kalafo e rarahaneng ho hlokeng lefu la khatello ea mali le methapo. Matšoao a boetse a kenyelletsa:

1. Fokotsa kotsi ea ho ba le methapo ea methapo le pelo.
2. Ho felisoa ha matšoao a sa thabiseng ka hypertrophy ea 'mele ea morao.

Hypertrophy ea letsoho le letšehali

Lorista N o na le li-contraindication tse 'maloa, tse lokelang ho fuoa tlhokomelo e khethehileng pele o nka:

• ho omella
• ho haella ha lactose 'meleng,
• Anuria
• ho hloleha ha rems
• khatello e tlase ea mali
• boimana
• ho se mamellehe ha motho ka mong kapa hypersensitivity ho likarolo.

Hape, lithethefatsi ha li laetsoe bana ba ka tlase ho lilemo tse 18. Ka lefu la gout, lefu la tsoekere, asthma, mafu a mali, sethethefatsi se lumelloa, empa ka tlasa taolo e tiileng ea ngaka e eang.

Ho ikoetlisa ho ka mpefatsa boemo. Pele o nka moriana, o hloka ho tseba hore na o fuoe khatello efe.

Litaelo tsa ho sebelisoa

Setlhare sena se etselitsoe ho tsamaisoa ka molomo, ho sa tsotelehe ho ja lijo tse ngata. Ho kenella ka mokhoa o rarahaneng le lithethefatsi ho theola khatello ea mali ho lumelloa. Litekanyetso li latela mofuta oa pathology.

Ho latela litaelo tsa tšebeliso, ka khatello ea mali ea methapo ka letsatsi, e lumelloa ho nka letlapa le le leng. Sekhahla se phahameng ke 2 likhomphutha. Tlhokahalo ea keketseho ea lethal dose e khethoa ke ngaka e eang.

Ha u hlahloba hypertrophy ea ventricular ea letsoho le letšehali, tekanyetso ea pele ea letsatsi le letsatsi e boetse e le 50 mg, ke hore, Letlapa le le leng. Hoseng kapa ka shoalane - ha ho hlile ha ho na taba.

Bakuli ba thahasella hore na ba noe moriana oo bophelo bohle kapa che. E le hore khatello ea ho fokotseha le matšoao a lefu leo ​​a fokotsehe, ho bohlokoa ho feta tlhahlobo e felletseng (matsatsi a ka bang 30). Kamora moo, ngaka e eang e tla etsa tlhahlobo e 'ngoe ebe e tlaleha liketso tse ling. Ka litlhaselo tse pheta-phetoang, o ka hloka ho nka thupelo hape.

Ho bohlokoa ho ela hloko tšebelisano ea lithethefatsi:

Litla-morao le ho sebelisa overdose haholo

Haeba moriana o nooa ka tsela e sa lokelang, ho ka hlaha litlamorao tse sa rateheng (Tafole ea 2).

Hape, litla-morao li ka hlaha ka mokhoa oa methapo ea tlhaho ho letlalong, e tsamaeang le ho hlohlona. Haeba ho na le lithethefatsi tse ngata tse feteletseng, mokuli o na le:

• makhetlo a bradycardia / tachycardia,
• ho fokotseha ho hoholo ha khatello ea mali,
• hyponatremia,
• hypochloremia

Haeba matšoao a pele a overdose a hlaha, ho hlokahala hore o botse setsebi. Thuso ea pele maemong a joalo ke lavage ea ka mpeng. Ho feta moo, mokuli o tla hloka kalafo ea matšoao.

Bakeng sa kalafo ea methapo ea pelo, hammoho le khatello e phahameng ea mali, ho boetse ho sebelisoa li-Lorista N.. Maemong a mangata, tlhoko ena e hlaha mabapi le ho se mamellane ha likarolo tse ling.

Ntle le moo, lingoloa tse ling li theko e tlaase haholo Lorista N. Lenane la meriana le nang le ts'ebetso e ts'oanang e kenyelletsa:

1. Co-Centor (50 mg). Litsenyehelo ke li-ruble tse 130.
2. (Che. 30). Khemisi e ka rekoa li-ruble tse 100-110.
3. Lozap 100 Plus (li-ruble tse 250).
4. Simartan-N.

Pele o fetola lithethefatsi tse fanoeng ke ngaka, ho hlokahala hore a buisane le eena e le hore a se ke a qholotsa ho hlaha ha mathata.

Sebopeho le sebopeho sa moriana

Matlapa a koahetsoeng ka filimi ho tloha mosehla ho isa ho o mosehla o nang le "tint" e putsoa, ​​oval, biconvex hanyane, mme o na le kotsi ka lehlakoreng le le leng.

Bahlahisi: setlama sa pregelatinized - 34,92 mg, cellcrystalline cellulose - 87,7 mg, lactose monohydrate - 63.13 mg, magnesium stearate - 1,75 mg.

Sebopeho sa khetla ea filimi: hypromellose - 5 mg, macrogol 4000 - 0.5 mg, dae quinoline e mosehla (E104) - 0,11 mg, titanium dioxide (E171) - 1,39 mg, talc - 0.5 mg.

Li-pcs tse 10 - lithutsoana (3) - lipakete tsa karete.
Li-pcs tse 10 - lithutsoana (6) - lipakete tsa karete.
Li-pcs tse 10 - marangrang (9) - lipakete tsa karete.

Ketso ea pharmacological

Ketso ea pharmacological - hypotensive .

Pharadodynamics

Lorista ® N - sethethefatsi se kopaneng, se na le khatello ea maikutlo.

Losartan. Seleng angiotensin II receptor antagonist (mofuta oa AT 1) bakeng sa tsamaiso ea molomo, tlhaho e se nang protheine. Ho vivo le in vitro losartan le eona e sebetsang ea carboxy metabolite (EXP-3174) e thibela litla-morao tsohle tsa 'mele tse bohlokoa tsa angiotensin II ho li-receptor tsa 1 1.

Losartan e sa sebetse e baka ts'ebetso ea li-receptor tsa AT 2 ka ho eketsa boemo ba angiotensin II.

Losartan ha e thibele mosebetsi oa kininase II, enzyme e kenyellelitsoeng ho metabolism ea bradykinin.

E fokotsa OPSS, khatello e "potoloho" e nyane ea ho potoloha ha mali, e fokotsa khatello ea mali ka morao, e nang le phello ea diuretic.

E kena-kenana le nts'etsopele ea hypertrophy ea myocardial, e eketsa mamello ho bakuli ba nang le lefu la pelo le sa foleng. Ho nka losartan hang ka letsatsi ho lebisa ho fokotseheng ho hoholo hoa lipalo ho SBP le DBP. Ka ho tšoanang, Losartan e laola khatello letsatsi lohle, athe phello ea antihypertensive e tsamaisana le morethetho oa tlhaho oa potoloho. Ho fokotseha ha khatello ea mali qetellong ea tekanyetso ea moriana ho ne ho batla ho le 70-80% ea phello ea tlhako ea lithethefatsi, lihora tse 5-6 kamora ts'ebetso. Withdawal syndrome ha e bonoe, 'me losartan ha e na phello e kholo litekanyetsong tsa pelo.

Losartan e sebetsa hantle ho banna le basali, hammoho le ho batho ba tsofetseng (ba ka holimo ho lilemo tse 65) le bakuli ba banyenyane (ba ka tlase ho lilemo tse 65).

Hydrochlorothiazide. A thiazide diuretic, phello ea diuretic e amanang le ho ts'oaroa ha sesepa sa sodium, chlorine, potasiamo, magnesium, ion ea metsi ka har'a nephron ea distal, e liehisa tlhahiso ea calcium ion, uric acid. E na le thepa ea antihypertensive. Hoo e batlang e se phello ea khatello e tloaelehileng ea mali.

Kameho ea diuretic e etsahala kamora lihora tse 1-2, e fihla hofihlella kamora lihora tse 4 mme e nka lihora tse 6-12.

Contraindication

Hypersensitivity ho losartan, ho lihlahisoa tse nkiloeng ho sulfonamides le likarolo tse ling tsa lithethefatsi, anuria, ho senyeha ho matla ha renal (Cl creatinine ea lilemo li 65) le bakuli ba banyenyane (

Mofumahali

Maemo a ikhethileng

• 1 tab losartan potasiamo 100 mg hydrochlorothiazide 25 mg Excipients: pregelatinized starch - 69.84 mg, cellcrystalline cellulose - 175,4 mg, lactose monohydrate - 126.26 mg, magnesium stearate - 3.5 mg. Sebopeho sa membrane ea filimi: hypromellose - 10 mg, macrogol 4000 - 1 mg, dae quinoline yellow (E104) - 0,11 mg, titanium dioxide (E171) - 2.89 mg, talc - 1 mg. losartan potasiamo 100 mg hydrochlorothiazide 12.5 mg Baeti: pregelatinized starch, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Sebopeho sa Shell: hypromellose, macrogol 4000, quinoline e dae (E104), titanium dioxide (E171), talc. losartan potasiamo 100 mg hydrochlorothiazide 25 mg Excipients: pregelatinized starch, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Sebopeho sa Shell: hypromellose, macrogol 4000, quinoline e dae (E104), titanium dioxide (E171), talc. potasium losartan 50 mg hydrochlorothiazide 12.5 mg Excipients: pregelatinized starch, microcrystalline cellulose, lactose monohydrate, magnesium stearate Shell composition: hypromellose, macrogol 4000, quinoline yellow dae (E104), titanium dioxide (E171), tal. losartan potasiamo 50 mg hydrochlorothiazide 12.5 mg Baeti: pregelatinized starch, microcrystalline cellulose, lactose monohydrate, magnesium stearate. Sebopeho sa Shell: hypromellose, macrogol 4000, quinoline e dae (E104), titanium dioxide (E171), talc.

Lintlha tsa Lorista N

• * Arterial hypertension (ho bakuli ba bontšitsoeng kalafo ea ho kopanya). * Ho fokotsa kotsi ea ho fokolloa ke pelo le lefu ho bakuli ba nang le khatello ea mali le khatello ea methapo ea pelo.

Lithibelo tsa Lorista N

• Hypersensitivity ho losartan, ho lithethefatsi tse nkiloeng ho sulfonamides le likarolo tse ling tsa lithethefatsi, anuria, ho senyeha haholo ha renal (creatinine clearance (CC) ka tlase ho 30 ml / min., Hyperkalemia, dehydration (ho kenyelletsa le litekanyetso tse phahameng tsa diuretics) ho hlobaela ho matla ha sebete, "hypokalemia" e matlafatsang, ho ima, ho lactation, hyperension ea methapo, lilemo tse ka tlase ho lilemo tse 18 (ho sebetsa hantle le polokeho ha li so theoe), khaello ea lactase, galactosemia kapa glucose / gal malabsorption syndrome. Ketso. Ka tlhokomeliso: Phallo ea mali-electrolyte e pharalletseng ea mali (hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia), lefu la methapo ea methapo ea methapo kapa lefu la sethoathoa sa methapo e le 'ngoe ea methapo, lefu la tsoekere, hypercalcemia, hyperuricemia le e ntlafalitsoe pele ka lithethefatsi tse ling, ho kenyelletsa le inhibitors ea AP

Litekanyetso tsa Lorista H

• 100 mg + 25 mg 12.5 mg + 100 mg 12,5 mg + 50 mg 25 mg + 100 mg 25 mg + 100 mg 50 mg + 12,5 mg

Litlamorao tsa Lorista N

• Karolong ea mali le tsamaiso ea methapo ea kutlo: hangata: khaello ea mali, Shenlane-Genokha Purpura. Ka lehlakoreng la tsamaiso ea 'mele ea ho itšireletsa mafung: ka seoelo: karabelo ea anaphylactic, angioedema (ho kenyelletsa ho ruruha ha larynx le leleme, ho baka tšitiso ea tsela ea moea le / kapa ho ruruha ha sefahleho, molomo, pharynx). Ho tloha lehlakoreng la tsamaiso ea methapo e bohareng le tsamaiso ea methapo ea methapo: khafetsa: hlooho ea hlooho, tsamaiso ea methapo le eo e seng ea tsamaiso, ho hloka boroko, mokhathala, lefu le sa foleng: migraine. Ho tsoa ho tsamaiso ea pelo: hangata: orthostatic hypotension (e itšetlehileng ka lethal dose), palpitations, tachycardia, ka seoelo: vasculitis. Ho tsoa ts'ebetsong ea ho hema: khafetsa: ho khohlela, tšoaetso ea phepelo ea phepelo e phahameng, pharyngitis, ho ruruha ha mucosa ea nasal. Ho tsoa pampiring ea ka mpeng: khafetsa: lets'ollo, lets'ollo, ho nyekeloa, ho hlatsa, bohloko ba ka mpeng. Ho tsoa ts'ebetsong ea hepatobiliary: ka seoelo: hepatitis, ts'ebetso ea sebete e senyehileng. Ho tloha letlalong le mafura a subcutaneous: hangata: urticaria, ho hlohlona letlalo. Ho tsoa ho sistimi ea musculoskeletal le lisele tse sebetsanang: khafetsa: myalgia, bohloko ba morao, hangata: arthralgia. Tse ling: khafetsa: asthenia, bofokoli, edema ea ho potoloha, bohloko ba sefuba. Matšoao a laboratori: khafetsa: hyperkalemia, palo e eketsehileng ea hemoglobin le hematocrit (eseng ea bohlokoa haholo), hangata: keketseho e leka-lekaneng ea serum urea le creatinine, ka seoelo: mosebetsi o eketsehileng oa sebete le li-enzymes tsa bilirubin.

Ho sebelisana le lithethefatsi

Bongata

Maemo a polokelo

• boloka ka mocheso oa kamore 15-25 likhato
• qoba bana

Selemo se seng le se seng, batho ba bangata ba tšoenngoa ke mafu a pelo le pelo. Ho latela lipalo-palo, morao tjena, le bana ba banyenyane ba kile ba tobana le bothata bona. Kajeno, ho na le lithethefatsi tse ngata tse thusang ho loantša khatello ea mali. E 'ngoe ea tse sebetsang ka ho fetisisa ke Lorista N.

Lorista N ke sethethefatsi se kopaneng se nang le ts'usumetso e matla. Lintho tse sebopeho sa tsona li etsa hore khatello ea mali e tloaelehe le ho thusa ho tlosa ho nyekeloa ke pelo. Kameho e ntle ea matlapa e netefatsoa ke motsoako o ka sehloohong o sebetsang -. E baka tšitiso ea li-receptor tsa angiotensin II ka pelong, methapo ea mali le liphio. Ka lebaka la sena, ho fokotseha ha vasoconstriction hoa bonoa.

Ho fapana le Lorista

Lifekthering tsa Russia, lihlahisoa tse 'maloa tse tšoanang li rekisoa hang-hang - Lorista N' me ba bangata ha ba tsebe hore na phapano lipakeng tsa bona ke eng.

Phapang e kholo ke sebopeho sa lithethefatsi. Ho Lorista, losartan le eona ke motsoako o ka sehloohong o sebetsang. Karolo ea likarolo tse ling e etsoa ke: starch ea poone, cellactose, magnesium stearate.

Mofuteng o ntlafalitsoeng oa moriana ona o nang le prefix H, lenane le tlatselletsoa ke hydrochlorothiazide. E kenya letsoho ho fokotseha hoa boemo ba karolo ea cortical ea Na + reabsorption. Ha ho na tlhoko ea hore ka bomong u khethe litekanyetso tsa pele bakeng sa bakuli ba lilemo tse holileng.

Phapang e 'ngoe lipakeng tsa lithethefatsi tsena ke litšenyehelo. Theko e tloaelehileng ea Lorista e tlase hanyane mme e bokana ho li-ruble tse 100-130. Ha e le mochine oa ts'ebetso, lithethefatsi ka bobeli li thusa khatello ea mali e tlase.

Sebopeho le litekanyetso tsa theko ea lithethefatsi

Setlhare sena se fumaneha ka mokhoa oa matlapa a nang le 'mala o mosehla. Ka linako tse ling ho na le matlapa a mmala o motala. Li nyane ka boholo le bohare ba sebopeho, e leng se etsang hore kamohelo e be bonolo joalo ka moo ho ka khonehang. Ka lehlakoreng le leng ho na le mola o arolang (Lorista ND, e nang le litaba tse phahameng tsa karolo e sebetsang, ha e eo).

Kamora ho fetisa tlhahlobo le ho buisana le ngaka, mokuli a ka utloisisa se molemong oa hae - N kapa ND. Ha ho na thuso ho fana ka kalafo ka boeona, e le hore e se ke ea lematsa 'mele. Theko e tloaelehileng ke li-ruble tse 230.

Sebopeho, mochini oa ketso le thepa

Letlapa le leng le le leng le kopantsoe le filimi 'me le na le: losartan potasiamo (50 mg), hydrochlorothiazide (12,5 mg), setlolo sa poone sa pregelatinized, MCC, magnesium stearate le lactose monohydrate. Hape, matlapa a fumaneha ka sekhahla se eketsehang sa losartan (100 mg). Ba bitsoa Lorista ND. 25 mg ea hydrochlorodisiad e kenyellelitsoe sebopeho sa bona. Likarolo tse thusang li ile tsa lula li le joalo.

Bakeng sa ho etsa koae ea filimi, baetsi ba sebelisa talc, dae e mosehla, E 171 (titanium dioxide), hypromellose, macrogol 4000.

Mokhoa oa tšebetso ea likarolo tse sebetsang ke ho theola khatello ea mali le ho fokotsa ho lutla ka pelong. Likarolo tsa matlapa li thusa ho eketsa ts'ebetso ea plasma renin, ho fokotseha ha dikahare tsa potasiamo tsa serum le ntlafatso ea secretion ea aldosterone.

Ntho ea bohlokoa ea lithethefatsi e tšoantšoa le ketso ea uricosuric. E thibela litlamorao tsa 'mele tsa angiotensin II. Hammoho le hydrochlorothiazide, ntho ena e fokotsa haholo hyperuricemia. Moriana ona ha o ame maqhubu a methapo ea pelo. Matla a antihypertensive a etsoa ke ho atoloha ha methapo ea methapo. Kamora lihora tse 2-3, ho ba le phello e lumellang letsatsi.

Losartan e anngoe hantle ka kotloloho ho tsoa mpeng ea mpa, boemo ba bioavailability ke 32-33%. Ntho ena e latela liprotheine tsa plasma. Hoo e ka bang 58% ea moriana o qheletsoe ka ntle ho 'mele o na le bile,' me 35% e hloekisoa ke liphio. Kamora ho kenella, hydrochlorothiazide e kopana le liprotheine tsa plasma (e ka bang 65%). Kamora lihora tse 5-10 kantle ho mmele ka moroto.

Matšoao le mefokolo

Setlhare se sebetsa e le e 'ngoe ea likarolo tsa kalafo e rarahaneng ho hlokeng lefu la khatello ea mali le methapo. Matšoao a boetse a kenyelletsa:

1. Fokotsa kotsi ea ho ba le methapo ea methapo le pelo.
2. Ho felisoa ha matšoao a sa thabiseng ka hypertrophy ea 'mele ea morao.

Hypertrophy ea letsoho le letšehali

Lorista N o na le li-contraindication tse 'maloa, tse lokelang ho fuoa tlhokomelo e khethehileng pele o nka:

• ho omella
• ho haella ha lactose 'meleng,
• Anuria
• ho hloleha ha rems
• khatello e tlase ea mali
• boimana
• ho se mamellehe ha motho ka mong kapa hypersensitivity ho likarolo.

Hape, lithethefatsi ha li laetsoe bana ba ka tlase ho lilemo tse 18. Ka lefu la gout, lefu la tsoekere, asthma, mafu a mali, sethethefatsi se lumelloa, empa ka tlasa taolo e tiileng ea ngaka e eang.

Ho ikoetlisa ho ka mpefatsa boemo. Pele o nka moriana, o hloka ho tseba hore na o fuoe khatello efe.

Litaelo tsa ho sebelisoa

Setlhare sena se etselitsoe ho tsamaisoa ka molomo, ho sa tsotelehe ho ja lijo tse ngata. Ho kenella ka mokhoa o rarahaneng le lithethefatsi ho theola khatello ea mali ho lumelloa. Litekanyetso li latela mofuta oa pathology.

Ho latela litaelo tsa tšebeliso, ka khatello ea mali ea methapo ka letsatsi, e lumelloa ho nka letlapa le le leng. Sekhahla se phahameng ke 2 likhomphutha. Tlhokahalo ea keketseho ea lethal dose e khethoa ke ngaka e eang.

Ha u hlahloba hypertrophy ea ventricular ea letsoho le letšehali, tekanyetso ea pele ea letsatsi le letsatsi e boetse e le 50 mg, ke hore, Letlapa le le leng. Hoseng kapa ka shoalane - ha ho hlile ha ho na taba.

Bakuli ba thahasella hore na ba noe moriana oo bophelo bohle kapa che. E le hore khatello ea ho fokotseha le matšoao a lefu leo ​​a fokotsehe, ho bohlokoa ho feta tlhahlobo e felletseng (matsatsi a ka bang 30). Kamora moo, ngaka e eang e tla etsa tlhahlobo e 'ngoe ebe e tlaleha liketso tse ling. Ka litlhaselo tse pheta-phetoang, o ka hloka ho nka thupelo hape.

Ho bohlokoa ho ela hloko tšebelisano ea lithethefatsi:

Litla-morao le ho sebelisa overdose haholo

Haeba moriana o nooa ka tsela e sa lokelang, ho ka hlaha litlamorao tse sa rateheng (Tafole ea 2).

Hape, litla-morao li ka hlaha ka mokhoa oa methapo ea tlhaho ho letlalong, e tsamaeang le ho hlohlona. Haeba ho na le lithethefatsi tse ngata tse feteletseng, mokuli o na le:

• makhetlo a bradycardia / tachycardia,
• ho fokotseha ho hoholo ha khatello ea mali,
• hyponatremia,
• hypochloremia

Haeba matšoao a pele a overdose a hlaha, ho hlokahala hore o botse setsebi. Thuso ea pele maemong a joalo ke lavage ea ka mpeng. Ho feta moo, mokuli o tla hloka kalafo ea matšoao.

Bakeng sa kalafo ea methapo ea pelo, hammoho le khatello e phahameng ea mali, ho boetse ho sebelisoa li-Lorista N.. Maemong a mangata, tlhoko ena e hlaha mabapi le ho se mamellane ha likarolo tse ling.

Ntle le moo, lingoloa tse ling li theko e tlaase haholo Lorista N. Lenane la meriana le nang le ts'ebetso e ts'oanang e kenyelletsa:

1. Co-Centor (50 mg). Litsenyehelo ke li-ruble tse 130.
2. (Che. 30). Khemisi e ka rekoa li-ruble tse 100-110.
3. Lozap 100 Plus (li-ruble tse 250).
4. Simartan-N.

Pele o fetola lithethefatsi tse fanoeng ke ngaka, ho hlokahala hore a buisane le eena e le hore a se ke a qholotsa ho hlaha ha mathata.

Sebopeho le sebopeho sa moriana

Matlapa a koahetsoeng ka filimi ho tloha mosehla ho isa ho o mosehla o nang le "tint" e putsoa, ​​oval, biconvex hanyane, mme o na le kotsi ka lehlakoreng le le leng.

Bahlahisi: setlama sa pregelatinized - 34,92 mg, cellcrystalline cellulose - 87,7 mg, lactose monohydrate - 63.13 mg, magnesium stearate - 1,75 mg.

Sebopeho sa khetla ea filimi: hypromellose - 5 mg, macrogol 4000 - 0.5 mg, dae quinoline e mosehla (E104) - 0,11 mg, titanium dioxide (E171) - 1,39 mg, talc - 0.5 mg.

Li-pcs tse 10 - lithutsoana (3) - lipakete tsa karete.
Li-pcs tse 10 - lithutsoana (6) - lipakete tsa karete.
Li-pcs tse 10 - marangrang (9) - lipakete tsa karete.

Ketso ea pharmacological

Moemeli ea kopaneng oa antihypertgency. Losartan le hydrochlorothiazide li na le phello e tlatsetsang ea antihypertensive, li theola khatello ea mali ka tekanyo e kholo ho feta karolo ka 'ngoe e arohaneng.

Losartan ke mohanyetsi ea khethang li-receptors tsa angiotensin II (mofuta oa 1) bakeng sa tsamaiso ea molomo. Ho vivo le vitro, losartan le metabolite ea eona e sebetsang ea pharmacologic E-3174 e thibela litlamorao tsohle tsa bohlokoa tsa angiotensin II ho li-receptor tsa AT 1, ho sa tsotelehe tsela eo e iqapetsoeng ka eona: e lebisa keketseho ea ketsahalo ea ho hlatsoa mali le ho fokotseha hoa khatello ea aldosterone ho plasma ea mali. Losartan e sa sebetse e baka ts'ebetso ea li-receptor tsa AT 2 ka ho eketsa khatello ea angiotensin II.Ha e thibele mosebetsi oa kininase II, enzyme e kenyellelitsoeng ho metabolism ea bradykinin. E fokotsa OPSS, khatello ea ho potoloha ha methapo ea mali, e fokotsa khatello ea mali ka myocardium, e nang le phello ea diuretic. E kena-kenana le nts'etsopele ea hypertrophy ea myocardial, e eketsa mamello ho bakuli ba nang le lefu la pelo le sa foleng (CHF). Ho nka losartan 1 nako / letsatsi ho lebisa ho fokotseheng hoa lipalo ho khatello ea mali ea systolic le diastolic.

Ka mokhoa o tšoanang, Losartan e laola khatello ea mali nakong ea mots'eare, athe matla a antihypertensive a tsamaisana le morethetho oa tlhaho oa potoloho. Ho fokotseha ha khatello ea mali qetellong ea tekanyetso ea moriana ho ne ho batla ho le 70-80% ea phello e phahameng ea losartan, lihora tse 5-6 kamora ho kenella. Ha ho na lefu la ho ntša chelete.

Losartan ha e na phello e kholo litabeng tsa sekhahla sa pelo, e na le phello e leka-lekaneng le e fokolisang ea uricosuric.

Hydrochlorothiazide- le thiazide diuretic, phello ea diuretic e amanang le tlolo ea ts'ebetso ea sabsorption ea sodium, chlorine, potasiamo, magnesium, ion ea metsi ho distal nephron, e liehisa tlhahiso ea calcium ions, uric acid. E na le phello ea antihypertensive, ketso ea eona e hlaha ka lebaka la kholo ea li-arterioles. Hoo e batlang e se phello ea khatello e tloaelehileng ea mali. Kameho ea diuretic e etsahala kamora lihora tse 1-2, e fihla hofihlella kamora lihora tse 4 mme e nka lihora tse 6-12. Phello e phahameng ea antihypertensive e etsahala kamora matsatsi a 3-4, empa ho ka nka libeke tse 3-4 ho fihlela phello e nepahetseng ea kalafo.

Ka lebaka la diuretic effect, hydrochlorothiazide e eketsa ts'ebetso ea plasma ea renin, e tsosa secretion ea aldosterone, e eketsa khatello ea angiotensin II hape e fokotsa khatello ea potasiamo ka plasma ea mali. Ho amohela li-losartan ho thibela litlamorao tsohle tsa 'mele tsa angiotensin II mme, ka lebaka la khatello ea litla-morao tsa aldosterone, ho ka thusa ho fokotsa tahlehelo ea potasiamo e amanang le ho nka diuretic. Hydrochlorothiazide e baka keketseho e nyane khubung ea uric acid maling, motsoako oa losartan le hydrochlorothiazide o thusa ho fokotsa botebo ba hyperuricemia e bakoang ke diuretic.

Mofumahali

Li-pharmacokinetics tsa losartan le hydrochlorothiazide tse sebelisoang ka nako e le 'ngoe ha li fapane le ts'ebeliso ea tsona ka monotherapy.

Kamora ho tsamaisoa ka molomo, losartan e ananeloa hantle ho tsoa ho tšilo ea lijo. E na le metabolism ea bohlokoa nakong ea "karolo ea pele" ka sebete, e theha carboxylated metabolite metabolite (E-3174) le metabolites e sa sebetseng. Bioavailability ke hoo e ka bang 33%. Ka kakaretso C max ea losartan le metabolite ea eona e sebetsang li fihlelloa kamora hora ea 1 le kamora lihora tse 3-4, ka ho latellana. Losartan le metabolite ea eona e sebetsang e tlama liprotheine tsa plasma (haholo-holo c) ke tse fetang 99%. V d ea losartan ke lilithara tse 34. E kenella hampe haholo ka BBB.

Losartan e entsoe ka matla hore e thehe metabolite e sebetsang (E-3174) metabolite (14%) ebile e sa sebetse, ho kenyelletsa metabolites e 'meli ea mantlha e thehiloeng ke hydroxylation ea sehlopha sa butyl sa ketane le metabolite e sa bohlokoahaleng, N-2-tetrazolglucuronide. Tlhahiso ea plasma ea losartan le metabolite ea eona e sebetsang e batla e le 10 ml / sec (600 ml / min) le 0.83 ml / sec (50 ml / min), ka ho latellana. Tlhahiso ea renal ea losartan le metabolite ea eona e sebetsang e ka ba 1,23 ml / sec (74 ml / min) le 0.43 ml / sec (26 ml / min). T 1/2 ea losartan le metabolite e sebetsang ke lihora tse 2 le lihora tse 6-9, ho latela. E pepisoa haholo ka bile ka matumbo - 58%, liphio - 35%. Ha e balehe.

Ha e nooa ka molomo ho tekanyetso ho fihlela ho 200 mg, losartan le metabolite ea eona e sebetsang e na le li-pharmacokinetics tse mola.

Kamora ho tsamaisoa ka molomo, ho monya ha hydrochlorothiazide ke 60-80%. C max ho plasma ea mali e fihlella lihora tse 1-5 kamora ho kenella. Ho kopanya liprotheine tsa plasma ea mali - 64%. E kenella ka har'a sethopo sa placental. E ts'oeroe ka lebese la matsoele. Hydrochlorothiazide ha e tšeloe 'mele' me e pepesetsoa kapele ke liphio. T 1/2 ke lihora tse 5-15. Bonyane 61% ea lethal dose e nkuoeng ka molomo ha e fetoloe ka nako ea lihora tse 24.

Khatello ea mali ea methapo (ho bakuli ba bontšitsoeng kalafo e kopantsoeng), kotsi e fokolisitsoeng ea ho fokola hoa pelo le lefu ho bakuli ba nang le khatello ea mali le methapo ea methapo ea methapo.

Contraindication

Anuria, ho hloleha ho matla ha methapo (CC