Li-analog tse tummeng le tse theko e tlaase tsa Roxer
Lipalo-palo tsa sejoale-joale ke karolo ea bohlokoa ea kalafo ea mantlha kapa e kopanyang ea methapo e kotsi - hypercholesterolemia, i.e., maemo a phahameng a cholesterol maling, a ke keng a khalemeloa ka mekhoa e sa sebeliseng lithethefatsi ka nako e telele.
E 'ngoe ea lithethefatsi tsena ke Roxer: e nkoa ke lingaka tse ngata tsa pelo e le karolelano e ntlafalitsoeng ea katleho le polokeho. Haeba mokuli a se na monyetla oa ho e reka, o ka reka lithethefatsi tse haufi haholo kamoo ho ka khonehang ka ho hlophisoa kapa ho ama 'mele - li-analogues.
Tlhahisoleseling ka kakaretso mabapi le lithethefatsi le litaelo tsa ho li sebelisa
Roxera (Roxera) - moriana o thehiloeng ho rosuvastatin (IV moloko oa li-statins) ho tsoa k'hamphaning ea Europe Europe KPKA (KRKA), Slovenia.
Matšoao a sebelisoang a kenyelletsa mefuta e fapaneng ea dyslipidemia le hypercholesterolemia, hammoho le atherosulinosis le li-pathologies tse ling tsa pelo.
Ketso ea li-statins e thehiloe ho thibelo ea enzyme, e ikarabellang bakeng sa tlhahiso ea k'holeseterole ke sebete (mohloli oa hoo e ka bang 80% ea ntho).
Phello e theolang lipid e bonahala phetohong ea "mpe" (LDL, LDL) le "good" (VLDL, HDL) plasma lipoproteins. Ts'ebetso ea pharmacological e fumaneha sebakeng sa sebete, moo rosuvastatin e thibelang HMG-KoA-Reductase, enzyme e thusang ho hlophisoa ha cholesterol (Chol, XC).
Ntle le moo, Roxer o imolla ho ruruha ho sa feleng ha tlhaho, e leng le leng la mabaka a mantlha a ho thehoa ha cholesterol plaque, mme e boetse e khothaletsa tlhahiso ea nitric oxide, e thusang ho phomotsa methapo ea mali, e bakang phello e eketsehileng ea antiatherosselotic.
Fomu ea tokollo - matlapa a pota-potileng (a pota-potileng kapa a oval) a nang le 5, 10, 15, 20, 30 kapa 40 mg ea rosuvastatin, e koahetsoeng ka membrane ea filimi e tšoeu.
Setlhare se nooa ka molomo nako efe kapa efe ea letsatsi. Tekanyetso ea pele ea 5 mg ka letsatsi, ha ho se na matla a matla, e nyolohela ho 1040 mg.
Phello ea phello e bonahala ka mor'a matsatsi a 7-9 ho nka Roxer, empa ho nka libeke tse 4-6 ho fumana sephetho se phahameng. Ka karolelano, boemo ba cholesterol e felletseng e fokotseha ka 47-55%, lipoprotein tse tlaase-ka tekanyo ea 42-65%, mme litaba tsa lipoprotein tse phahameng haholo li eketseha ka 8-14%.
Li-analogues tse tummeng ka ho fetisisa le tse nkang sebaka sa Roxers
Li-analogs tse tobileng le tse nkang sebaka sa Roxers li bitsoa "li-synonyms" kapa "li-generics" - lithethefatsi tse fetohang tšebetsong ea tsona li thehiloe nthong e le 'ngoe e sebetsang. Li fapana le nts'etsopele ea pele ka theknoloji ea tlhahiso, lebitso la khoebo le palo ea likarolo tse ling.
Kaha katleho ea lithethefatsi tse joalo, joalo ka molao, ha e tlase ho ea mantlha, mokuli o na le tokelo ea ho ikhethela generic e amohelehang, a shebana le ho se mamellane ho feta tekano, tekanyetso kapa lithahasello tse ling tsa motho. Ntho ea bohlokoa ke ho boloka litekanyetso li behiloeng ke ngaka le mofuta oa moriana.
Mertenil (Mertenil) - e 'ngoe ea litšoantšiso tse ntle ka ho fetisisa tsa Roxers. E khetholloa ke tekanyo e phahameng ka ho fetisisa ea tlhoekiso ea karolo e sebetsang, e netefatsang mamello ea eona e ntle esita le ts'ebeliso ea nako e telele. Tabeng ena, hangata Mertenil o sebelisetsoa ho phekola bakuli ba tsofetseng le ba banyenyane.
Meetso ea sebopehoE tšoana nthong e 'ngoe le e' ngoe ho tloha qalong, ntle le dae.
Khampani, naha eo a tsoang ho eona: Gedeon Richter, Hungary.
Litsenyehelo tse lekantsoeng: ho tloha 487 RUB / 30 li-pcs 5 mg ho isa ho 1436 li-ruble / 30 li-pcs. 40 mg
Rosuvastatin-SZ
Rosuvastatin-C3 (Rosuvastatin-SZ) ke analogue e theko e tlase ea li-roxers tse entsoeng ka lapeng. E na le palo e lekanang ea rosuvastatin joaloka ea pele, empa e fapana hanyane ka tekanyo ea metsoako e thusang, e e etsang meriana e sa leka-lekanang le e sebetsang kapele.
Meetso ea sebopeho: e na le soya lecithin le varnish ea aluminium ea mefuta e 3.
Khampani, naha eo a tsoang ho eona: FC Northern Star 3AO, Russia
Litsenyehelo tse lekantsoeng: ho tloha 162 p. / 30 likhomphutha. 5 mg ho isa ho 679 p. / 30 likhomphutha. 40 mg
Crestor (Crestor) - sethethefatsi sa pele se thehiloeng ho rosuvastatin, se theko e boima haholo ho feta analogues. E na le metabolism hanyane ka har'a sebete (ka tlase ho 10%), e fokotsang haholo menyetla ea liphetoho tse fapaneng tsa mmele - sena se netefatsoa ke litlhahlobo tse ngata tse ntle tsa bakuli.
Meetso ea sebopeho: formula ea litekanyetso ea litokelo tsa pele.
Khampani, naha eo a tsoang ho eona: Astra Zeneca, Engelane.
Litsenyehelo tse lekantsoeng: ho tloha 1685 ho isa ho 522 li-ruble.
Rosart ke eona e nkang sebaka sa Roxers ka ho fetisisa lefatšeng. Ha ho na moriana o bakang karabelo e mpe ea 'mele, hobane lintho tse sebelisoang le likarolo tse thusang li hloekisitsoe hantle. Ke hore, analogue e na le melemo eohle ea mantlha mme ka nako e ts'oanang e theko e tlase haholo ho feta eona.
Meetso ea sebopeho: sebopeho se lumellana le sa pele, ntle le dae.
Khampani, naha eo a tsoang ho eona: Sehlopha sa Actavis, Iceland.
Litsenyehelo tse lekantsoeng: ho tloha ho 422 rub. / 30 likhomphutha. 5 mg ho isa ho 1318 li-ruble / 30 li-pcs. 40 mg
Suvardio ke setlama se seng sa Slovenia. Naheng ea Russia, e hlahisoa ka assortment e lekantsoeng - ke 10 le 20 mg feela, e etsang hore e be khetho e sa lokelang bakeng sa ho qala kalafo, hobane, ho qoba tekanyetso e sa nepahalang, ha ho kgothaletswe ho arola matlapa ka rosuvastatin likarolo.
Meetso ea sebopeho: e thehiloe holima setofo sa poone.
Khampani, naha eo a tsoang ho eona: Sandoz, Slovenia.
Litsenyehelo tse lekantsoeng: ho tloha ho li-ruble tse 382 ho isa ho tse 649.
Lithethefatsi tse tšoanang li thehiloe nthong e ngoe e sebetsang
Haeba ho hlokahala, ho etsa mohlala, hypersensitivity to rosuvastatin, o ka nkela Roxer le lithethefatsi tse tšoanang hantle, empa o ipapisitse le ntho e 'ngoe e sebetsang - pitavastatin. Phetoho e joalo e ke ke ea etsoa ka bo bona, hobane litlhaloso tsa litekanyetso le litekanyetso li fapane haholo.
Livazo (Livazo) - setlhare sa mantlha se nang le pitavastatin. Moriana ona o mocha o tšoauoa ka bioavailability ea lipalo tse fetang 51% le ho tlama liprotheine tsa plasma tsa mali tse fetang 99%, ke ka lebaka leo e nang le phello e boletsoeng esita le ka litekanyetso tse nyane mme e sa ame boemo ba liphio le sebete.
Meetso ea sebopehoE na le lactose, joalo ka li-statins tse ling tse ngata.
Khampani, naha eo a tsoang ho eona: Recordati, Ireland
Litsenyehelo tse lekantsoeng: ho tloha 584 RUB / 28 likhomphutha 1 mg ho 1244 li-ruble / 28 li-pcs. 4 mg
Tafole ea Kakaretso ea Lipapiso
Ho bapisa theko ea lithethefatsi ka nepo, lenane le hlophisitsoeng le kenyelletsa lingoloa tsa litekanyetso tsa haufi-ufi tsa Roxer ka tekanyo e lekaneng ho etsa thupelo e fokolang (matsatsi a 28-30) - ka nako ena, joalo ka molao, e lekane ho tseba matla a karabelo ea kalafo.
CompsetjhabaphetisoeonaleiRoxerska kakaretsotoimoSTI(tafoleng):
| Lebitso le litekanyetso tsa meriana | Palo ea matlapa | Theko ka pakete, rub. |
| Rosuvastatin - 10 mg | ||
| Roxera | 30 | 438–465 |
| Mertenil (Mertenil) | 30 | 539–663 |
| Rosuvastatin-C3 (Rosuvastatin-SZ) | 30 | 347–411 |
| Crestor | 28 | 1845–2401 |
| Rosart | 30 | 527–596 |
| Suvardio | 28 | 539–663 |
| Pitavastatin - 1 mg | ||
| Livazo | 28 | 612–684 |
Analogue e theko e boima ka ho fetisisa ea Roxer ke Russia Rosuvastatin-C3, e fumanehang ho bareki ba ka bang teng ka bongata. Leha ho le joalo, ha u khetha lithethefatsi, ha hoa lokela ho nahana feela ka litšenyehelo tsa tsona, empa hape le naha ea moetso (haholo-holo Europe), hammoho le botumo ba k'hamphani ea meriana.
Atoris kapa Roxer: ke eng e betere?
Atoris (Atoris) ke generic ea atorvastatin, eo e leng ea moloko oa III oa sehlopha sa li-statins.
Mabapi le ts'ebetso, e batla e lekana le moriana oa Roxer, empa ea bobeli e sebetsa ka bonolo, e na le litla-morao tse fokolang mme ka kakaretso mmele o nolofalloa ho e tloaela.
Ntle le moo, matlapa a Roxer ha a thibele ts'ebetso ea sebete joalo ka meloko e fetileng, empa tšebeliso ea eona ea nako e telele e ka mpefatsa boemo ba liphio, haholoholo haeba mokuli a se a ntse a e-na le mathata ka tsamaiso ea mokokotlo. Ka hona, ka linako tse ling ngaka e ntse e khetha Atoris.
Re ka reka barekisi ba Roxer kae?
O ka reka sethethefatsi sa Roxer kapa se seng sebakeng sa sona ho latela:
- https://apteka.ru - Roxera No. 30 bakeng sa li-ruble tse 10 mg 436., Rosuvastatin-C3 No. 30 bakeng sa li-ruble tse 10 mg 315., Atoris No. 30 bakeng sa li-ruble tse 10 mg 312., Livazo No. 28 bakeng sa li-ruble tse 1 mg 519.
- https://piluli.ru - Roxer No. 30 bakeng sa li-ruble tse 10 mg 498, Rosuvastatin-C3 No. 30 bakeng sa li-ruble tse 10 mg 352, Atoris No. 30 bakeng sa li-ruble tse 10 mg 349, Livazo No. 28 bakeng sa li-ruble tse 1 mg 642.
Motse-moholo, li-analog tsa Roxerra li rekisoa makaleng a mangata a meriana a haufi:
- Puisano, st. 6 Kozhukhovskaya, d. 13 ho tloha ka 08:00 ho isa ho 23:00 bosiu. +7 (495) 108–17–25,
- Rigla, st. B. Polyanka, d. 4-10 ho tloha ka 08:00 ho isa ho 22:00 tere. +7 (495) 231-16-1697.
St. Petersburg
St. Petersburg, lithethefatsi li boetse li fumaneha litsing tsa meriana tse tsamaeang butle:
- ZdravCity, st. Zvezdnaya, d. 16 ho tloha ka 9:00 ho isa 21:00 bosiu. +7 (981) 800–41–32,
- Ozerki, st. Michurinskaya, d. 21 ho tloha ka 08:00 ho isa 22:00 bosiu. +7 (812) 603-00-00.
Qetellong, ho bohlokoa ho hlokomela hore kalafo e nang le li-statins leha e le life, ho kenyelletsa le matlapa a Roxer, e etsoa feela khahlano le semelo sa pholiso e felletseng ea 'mele: lijo tsa k'holeseterole, boikoetliso khafetsa, ho robala hantle' me, haeba ho khonahala, ho qoba maemo a likhohlano le khatello ea maikutlo.
Rosucard kapa roxer e betere ke eng?
Motsoako oa Rosucard ke pheko e sebetsang khahlanong le ntoa khahlanong le k'holeseterole e phahameng, e ka amang ts'ebetso ea pelo hampe. Rosucard e fumaneha ka mokhoa oa litafole tsa tsamaiso ea molomo. Sesebelisoa sa eona se sebetsang ke rosuvastatin. Moriana o fuoa bakuli ba nang le bothata ba:
- mefuta e fapaneng ya hypertriglyceridemia,
- atherosmithosis,
- hypercholesterolemia.
Ka lebaka la ho sebelisa lithethefatsi, ts'ebetso ea thibelo e ka fumanoa:
- pelo ischemia
- myocardial infarction
- mathata a mang a pelo.
Rosucard e nkoa e le analogue ea Roxer, leha e na le likarolo tse ikhethang. Litaelo tsa ho sebelisoa ha Rosucard li netefatsa ho fokotseha ha cholesterol 'meleng ka matsatsi a 5 ho tloha nakong ea tsamaiso. Matlapa a Roxer a bontša phello e joalo feela ka letsatsi la 10.
Matlapa a hlalositsoeng a ka baka litlamorao ka tsela ea lefu la tsoekere. Ho itokisa ha Roxer ka boeona ha ho fane ka setšoantšo se joalo sa kliniki. Rosucard ha e lebise ponahalong ea protheine maro a ka hare a 'mele, ho fapana le mohanyetsi oa eona.
Moetsi oa Rosucard o khothaletsa ho nka pheko ena ka lilemo tse 15 tlasa taolo ea ngaka e phekolang. Roxer e lokela ho sebelisoa ke batho ba lilemo tse 18, kaha lipilisi tsena li na le phello mosebetsing oa sebete. Theko ea Roxer libakeng tsa meriana ke li-ruble tse 1676, 'me litheko tsa Rosucard ha li feta li-ruble tse 600.
Ke eng e fetang Roxer kapa Crestor?
Krestor ke eona ntho e tšoanang bakeng sa Roxer. Thepa ea eona e fokotsang lipid e ka fokotsa palo ea cholesterol ho feta e loketseng 'mele. Sesebelisoa se ka sehloohong se sebetsang ke rosuvastatin. Litlamorao tsa kalafo e hlalositsoeng li hlaha kamora ho ja beke le beke, mme molemo o moholo - kamora khoeli ea almanaka.
Analogue ena ea Roxer e tsoa 'meleng ho tsoa mantle. Matšoao bakeng sa ts'ebeliso ea ona:
- tsoelo-pele ea atherosclerosis,
- kontane Fredrickson hypercholesterolemia,
- hypertriglyceridemia,
- Hypsygous hypercholesterolemia ea lelapa.
Ka ts'ebeliso e tšoanang ea Krestor ka meriana e meng, mokuli o fuoa lijo tse thata tse fokotsang lipid. Contraindication ho Crestor ke:
- boemo bo eketsehileng ba maikutlo a mmele,
- enteuterine ho silila,
- nako ea kemolo
- lefu la liphio
- litlhaselo tsa myopathy.
O ka nwa matlapa a hlalositsoeng ka nako efe kapa efe ea letsatsi, ho sa tsotelehe lijo. Krestor o khona ho qholotsa nts'etsopele ea lefu la tsoekere ka mofuta oa bobeli, e seng tšobotsi ea matlapa a Roxer. Lifekthering, analog e hlalositsoeng ea Roxer e rekisoa ho li-ruble tse 720 ka pakete. Litlhahlobo tse ngata tsa bakuli li paka katleho ea meriana ena ka bobeli, kahoo khetho e emelang e 'ngoe le e' ngoe ea tsona e lokela ho etsoa ka khothalletso ea ngaka.
E netefalitsoe
Matlapa a Atorvastatin a kenyelelitsoe karolong ea li-analog tsa Roxer tse theko e tlaase. Li thehiloe ho limolek'hule tsa "atorvastatin-calcium" "fethydrate" tse nang le motsoako o rarahaneng oa likhomphutha tse thusang. Moriana ona o khethiloe e le hypolipidemic statin. Hape, analogue e hlalositsoeng e ama boemo ba atheroma le methapo ea mali. Litho tsa eona tse tloaelehileng, ha li nkuoa khafetsa, li bonts'a thepa ea antiproliferative le antioxidant, e ntlafatsa litšobotsi tsa rheological tsa mali.
Thanks ho Atorvastatin, palo ea cholesterol e fokotsehile ho bakuli ba sehlopha "homozygous Familia hypercholesterolemia", se ke keng sa fihlella ka lithethefatsi tse ling tsa hypolipidemic. Matšoao a sebeliso:
- hypoiser hypertriglyceridemia,
- hypercholesterolemia ea mantlha,
- hyperlipidemia e kopaneng "e kopaneng"
Matlapa a Atorvastatin a nooa ka molomo ka tekanyetso e le 'ngoe, hammoho le lijo tse khethehileng. Tšusumetso e ntle ea kalafo e joalo e phethahala ka letsatsi la leshome le metso e mehlano ho tloha nakong ea kamohelo. Ha ho kgothaletswe ho nwa analogue e bonts'itsoeng ho batho ba nang le:
- mafu a leka-lekaneng le a matla a hepatic,
- hypersensitivity to atorvastatin,
- bana ba ka tlase ho lilemo tse 18
- basali baimana
- sethaleng sa ho nyeka,
- e seng mokhoa oa ho thibela pelehi o ka tšeptjoang lilemong tsa ho beleha.
Batho ba nang le ho haelloa ke hepatic ba khothalletsoa hore ba noe Atorvastatin ka tlhokomelo e kholo, ba lekola matšoao a loketseng. Haeba lefu la kelello le qala ho tsoela pele, joale kalafo ka moriana e lokela ho tloheloa. Ts'ebeliso e tšoanang ea li-inhibitors, analogue e hlalositsoeng le joala bo kotsi ho bophelo bo botle!
Boitšoaro bo bobe mokhoeng ona ke:
- mesifa ea mesifa
- myositis
- hypoglycemia,
- hyperglycemia
- pancreatitis
- hepatitis
- ho hloka matla.
Litsenyehelo tse tloaelehileng tsa matlapa ke li-ruble tse 112.
Ho latela lintlha tse kaholimo, ho ka phethoa ka melemo ea ho nka matlapa a Atorvastatin le Roxer.
Atoris ke e 'ngoe ea li-counterparter tse theko e tlaase haholo. Lifekthering, theko ea Roxer ke bonyane li-ruble tse 1650, le Atoris - li-ruble tse 350.
Karolo e ka sehloohong ea sethethefatsi ke limolek'hule tsa rosuvastatin. Motsoako ke letlapa le koahetsoeng ka koae e pepeneneng.
Tšusumetso e ntle ea lithethefatsi e bonoa qetellong ea beke ea 2 ea kalafo ka analog. Ka nako e ts'oanang, tšekamelo ea ho shebahala ea mathata a ischemic e fokotsehile haholo.
Ho fapana le lithethefatsi Roxer, Atoris e fuoe batho ba nang le bothata ba:
- Hyperlipidemia:
- hypercholesterolemia ea mantlha,
- Hyperlipidemia e kopaneng (e tsoakaneng)
- dysbetalipoproteinemia,
- hypertriglyceridemia ea lelapa.
Atoris e ka sebelisoa e le sethethefatsi sa prophylactic bakeng sa li-pathologies tse itseng tsa pelo. Bakeng sa ho qoba kotsi ea ho ba le maikutlo a mabe, analogue ena ha ea lokela ho tahoa ka tsoelo-pele ea 'mele:
- hepatic cirrhosis,
- hypersensitivity mabapi le sebopeho sa sehlahisoa,
- mafu a sebete a sebetsang
- ho hloleha ha sebete
- maloetse a mesifa a marapo.
E le ho thibela nts'etsopele ea maikutlo le litlamorao tse sa rateheng, Atoris ha ea lokela ho nkuoa nakong ea ho emara le nakong ea ho anyesa. Bakeng sa ho senya lisele tse nyane tsa sebete, analog ha ea lokela ho fuoa bana ba ka tlase ho lilemo tse 18.
Matlapa a koahetsoeng ka filimi a beoa lelemeng ebe aa hlatsoa ka metsi a manyane. U ka etsa sena pele u e ja kapa ka mor'a eona.
Rosuvastatin
Litšenyehelo tse tloaelehileng tsa Rosuvastatin ke li-ruble tse 138. Letlapa le leng le le leng le na le calcium rosuvastatin, khatello e phahameng ka ho fetisisa. Bakeng sa ho thibela keketseho ea litaba tsa plasma ea likarolo tse fapaneng, moriana o hlalositsoeng o lokela ho nooa le:
- Family homozygous hypercholesterolemia,
- hypercholesterolemia (mofuta IIa).
E amana le bakuli ba nang le bothata ba ho phekoloa ka methapo.Rosuvastatin ha ea lokela ho tahoa ke:
- hypersensitivity ea 'mele ho sebopeho sa ona,
- mafu a sebete
- myopathies
- sefuba
- boimana ba trimester efe kapa efe,
- ha e fihle lilemong tsa 18.
Rosuvastatin ha ea lokela ho isoa ho basali ba lilemo tsa ho beleha ba sebelisa mekhoa e tšepahalang ea thibelo ea bokhachane. Khafetsa ea tsamaiso le litekanyetso li beoa ke ngaka bakeng sa mokuli e mong le e mong kapa e khothaletsa ho hlokomela lipehelo tsa litaelo tse kentsoeng.
Setlhare sena se ka fumaneha ka theko ka li-ruble tse 420. ka pakete e 'ngoe. Ntho e sebetsang ea lithethefatsi ke limolek'hule tsa calcium rosuvastatin. E hlahisoa ka matlapa a Slovenia.
Suvardio e theola cholesterol le lintho tse e kopanyang maling. E tsoa ka ntle ho mmele ke sebete, 'me ka meriana ea eona, meriana e lokela ho nooa ka hloko e kholo. E kenelletse ho:
- hypersensitivity reaction
- boimana
- lebone.
E kanna ea lebisa kholong ea lefu la tsoekere la mofuta oa 2 'meleng. Ka hona, batho ba tloaetseng ho tšoaroa ke lefu le joalo ha baa lokela ho sebelisa Suvardio ho theola cholesterol ea mali.
Rosucard e etselitsoe:
- hypercholesterolemia ea mantlha,
- heterozygous hereditary hypercholesterolemia,
- tlatsetso ea phepo
- hepatri helena hypercholesterolemia,
- tsoelo-pele ea atherosclerosis.
E ka sebelisoa e le prophylactic khahlano le mathata a maholo a pelo:
- arterial revascularization,
- lefu la pelo
- stroke
- lefu la pelo (coronary lefu la pelo).
E tšoaelitsoe batho ba nang le bothata ba ho:
- hypersensitivity to rosuvastatin,
- tsoelo-pele ea lefu la sebete
- ho hloleha ha sebete
- lefutso la lefutso,
- ho hloleha ha rems
- myopathy.
U ke ke ua nka Rosucard ka lebaka la tlhaelo ea phumano, basali baimana le bana ba ka tlase ho lilemo tse 18. Bo-'mè baoki ba boetse ba lokela ho hana ho sebelisa meriana ena, hobane ha ho na tlhahisoleseling e tšepahalang mabapi le phello ea likarolo tsa lithethefatsi ho bana ka lebese la matsoele. Tlhahlobo e kotsi - ho ima ho supa ho tlosoa hoa moriana.
E ama bokhoni ba ho khanna makoloi. Ka hona, nakong ea tsamaiso ea eona, ho bohlokoa ho khanna likoloi ka hloko e ngata le ho etsa lintho tse hlokang ho tsepamisa mohopolo kapele ka karabelo e potlakileng ea psychomotor. Theko e tloaelehileng ea lithethefatsi ke li-ruble tse 400.
Karolo e ka sehloohong ea Rosart ke karolo e fapaneng ea khalsiamo ea rosuvastatin:
Moriana o fuoa batho ba lilemo tse fetang 18 hore a phekole mafu a latelang.
- hypercholesterolemia ea mefuta e fapaneng,
- thibelo ea ho nyekeloa ke pelo le pelo,
- atherosulinosis.
Contraindication bakeng sa ts'ebeliso ke:
- Ho amoheloa ha li-fibrate ka nako e le 'ngoe,
- ho eketseha ha kutloisiso bakeng sa sebopeho,
- oa Mongols,
- lefu la sebete
- ho hloleha ha meno
- litlhaselo tsa myopathic
- mafu a lefu la mesifa.
Litsenyehelo tse tloaelehileng tsa lithethefatsi ke li-ruble tse 411.
Katleho ea matlapa a Roxer e netefalitsoe ke litlhahlobo tse ngata tse ntle tse tsoang ho bakuli le lingaka. Haeba ho hlokahala, nka meriana ena ka analogue ea eona, o lokela ho buisana le ngaka ea hau pele.
Mehala e ka bang teng bakeng sa matlapa a Roxer
Analogue e theko e tlase ho li-ruble tse 306.
Ntho e 'ngoe ea sehlopha sa statin, atorvastatin, e hlahisoa tlasa mabitso Atoris, Torvakard, restator, Amvastan. Matlapa ha a na lactose, ka hona a loketse batho ba nang le khaello ea lactase. Atorvastatin ha e theko e tlase - ho tloha li-ruble tse 120 ka sephutheloana.
Analogue e theko e tlaase ho tloha li-ruble tse 217.
Ntho e sebetsang ea Vasilip ke simvastatin. Vasilip e lumelloa ho kopantsoe le meriana e meng (cholestyramine, colestipol, barati ba mabili) ho ntlafatsa phello ea ho theola cholesterol. Maemong a mang, kalafo e hloka tekanyo e kholo ea simvastatin (ho fihlela ho 80 mg / ka letsatsi).
Rosistark (matlapa) Tekanyetso: 31 Holimo
Analogue e theko e tlase ho li-ruble tse 148.
Rosuvastatin, e etsoang ke Belupo naheng ea Croatia, e bitsoa Rosistark. Ho na le lipakete tse nyane tsa matlapa a 14. Setlhare sena se sebetsa se tšoanang le sa Roxer, 'me se rekisoa ka theko e ts'oanang.
Analogue e theko e tlase ho li-ruble tse 82.
Sebaka se seng sa Roxery, Rosulip, se etsoa ke k'hamphani ea meriana ea Hungary e bitsoang Egis. Bakeng sa batho ba baholo ba fetang 65, lethal dose la pele le khothalletsoa ho fokotsoa ho tloha ho 10 ho isa ho 5 mg ka letsatsi. Moetsi o ntse a etsa lipatlisiso ka tšebeliso ea Rosulip ho fihlela a le lilemo li 18, empa ho fihlela joale setheba ha se lumelloe ho bana.
Analogue e theko e tlase ho li-ruble tse 41.
Matlapa a Suvardio, a rekisoang Slovenia ke Sandoz, a na le ntho e le 'ngoe e sebetsang. Setlhare se rekisoa ka litekanyetso tsa 10 le 20 mg. Suvardio ea lithethefatsi ha e theko e tlaase, sephutheloana se le seng se ja li-ruble tse 350.
Rustor (matlapa) Tekanyetso: 20 holimo
Analogue e theko e tlase ho li-ruble tse 41.
Rustor ea lithethefatsi tsa lapeng e fumaneha ka tekanyetso ea 10 mg. Ho tloha ka 2014, sethethefatsi sena se hlahisitsoe ke khoebo ea meriana ea Obolensk sebakeng sa Moscow. Leha ho na le tlhahiso ea Serussia, Rustor ha e theko e tlase ho lithethefatsi tsa kantle tse nang le sebopeho se tšoanang.
Analogue e theko e phahameng haholo ho tloha ho li-ruble tse 62.
Sesebelisoa se seng sa Russia, rosuvastatin, Akorta, se hlahisoa ke k'hamphani e kholo ka ho fetisisa ea lapeng e bitsoang Pharmstandard. Setlhare se tla jella moreki theko e phahameng - li-ruble tse 550 bakeng sa matlapa a 30. Har'a litla-morao tsa Acorta o ile a hlokomela asthma ea bronchial, bronchitis, pneumonia.
Matšoao a sebelisang sesebelisoa sena le lipapatso tsa sona
Joalokaha ho se ho boletsoe, ntho ea mantlha e kenyang letsoho ka matla ho rarolla mathata a bophelo bo botle ke rosuvastatin. Ntle le motsoako o sebetsang o hlahisitsoeng, sebopeho sa moriana se kenyelletsa ba tlatsitsoeng ba bang:
magnesium stearate,- crospovidone
- lactose.
magnesium stearate,Motsoako ona o ne o ke ke oa sebetsa ntle le cellcose ea microcrystalline.
Hape, joalo ka Roxer, li-analogue li sebetsa ka ho khetheha ka har'a sebete, kaha setho sena ke synthesizer ea cholesterol maling le linthong tse ling tsa litho tse ling tsa 'mele. Litafole li sebetsa hantle 'me ka potlako li eketsa palo ea li-receptor tsa sebete. Ka lebaka la sena, boemo ba cholesterol le lipoprotein tse ling bo fokotseha haholo litabeng tsa matsatsi.
Meriana e joalo e laetsoe bakeng sa lipatlisiso tse ngata. Ha e le molao, moriana ona le li-analogues tsa ona hangata li laeloa mefuta e fapaneng ea hypercholesterolemia:
Ha ho utloe bohloko ho nka chelete maemong a boima haholo.
Khafetsa, li-analogues li laeloa hore li atherosulinosis. Ntho ena e sebetsa hantle ho bakuli bohle ba nang le lefu la pelo. Lingaka li khothaletsa tšebeliso ea Roxer kamora ho amohela litlamorao tse mpe tsa mafu a tebileng methapong ea mali.
Ke analogue efe e nkoang e sebetsa ka ho fetisisa?
Ebile, Roxer e nkuoa e le sehlahisoa sa boleng, empa ha e ea lokela bakuli bohle ba tletletsang ka cholesterol le mafu a amanang le ntho ena e kotsi. Maemong ana, litsebi li eletsoa ho khetha pheko ea lapeng.
Bo-ramahlale ba nang le boiphihlelo ba khonne ho qapa meriana e mengata e ka nkang lithethefatsi. E 'ngoe ea li-cholesterol tse tummeng ka ho fetisisa le tse batloang ke li-analog tsa Roxer tse kang Atoris le Krestor. Molao-motheo oa ho pepesetsoa litlhare tsena o batla o tšoana. Hangata sephetho ha se sa le nako e telele ea ho tla; ka mor'a matsatsi a seng makae ka mor'a ts'ebetso, mokuli o ikutloa a ntlafala bophelong ka kakaretso. Phapang e kholo lipakeng tsa lithethefatsi tsena ke sebopeho sa eona.
Ntho ea mantlha ho phekolo ea Krestor le Roxer ke rosuvastatin. Re ka re meriana ena e tšoana hantle. Phapang feela pakeng tsa lithethefatsi tsena ke moetsi ka boeena. Haeba Roxeru e ntlafalitsoe ke setsebi sa meriana sa Russia, joale Krestor ke litholoana tsa mosebetsi o behang litholoana oa litsebi tsa kantle ho naha, mme sesebelisoa ha se theko e tlase haholo.
Bakuli ba bangata ba re ho ntse ho na le phapang lipakeng tsa lithethefatsi tsena. Ho ea ka bona, Krestor e ama 'mele hangata hangata, ha Roxer ea nang le cholesterol e qala ho sebetsa feela kamora ho amoheloa ka makhetlo a' maloa. Leha ho le joalo, lebelo le boetse le itšetlehile ka lintlha tse ling: litšobotsi tsa 'mele, ho rarahana ha mmele, le ho se tsotelle ha lefu lena.
Analogue ea bobeli, e batloang haholo 'marakeng bakeng sa meriana e joalo, e na le atorvastatin. Ke karolo ena e bohlokoa kahare ho sesebelisoa. Litšenyehelo tsa Atoris ha li hlile ha li tšoane le moriana o fetileng. Ka cholesterol, ho khothalletsoa ho e sebelisa e le prophylactic. Cholesterol le eona e tla fela methating ea pele ea lefu lena. Hangata, ho fanoa ka moriana haeba mokuli a fumanoa a sa mamelle Roxer.
Ehlile, ho sa na le lithethefatsi tse ngata tse tšoanang tse thusang batho ho hlasela mafu a mang. Har'a bona, motho a ka khetholla Rosucard, Rosistark, Tevastor, Emstat, Rosulip le ba bang. Ke efe e ka bitsoang e sebetsang ka ho fetisisa, ho ke ke ha khoneha ho bua ka 'nete, kaha ho latela motho le' mele oa hae. Maemong ana, mokuli e mong le e mong o hloka tsela ea hae.
Haeba cholesterol e u thibela ho phela bophelo bo felletseng, qala ho nka moriana oa Roxer kapa li-analogues tsa hae, empa feela ka mor'a ho buisana le litsebi tse tšepahalang.
Likhakanyo tsa lithethefatsi Roxer
Analogue e theko e tlase ho li-ruble tse 306.
Moetsi: Biocom (Russia)
Mefuta ea Tsamaiso:
- Letlapa 10 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 110
- Letlapa 20 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 186
Litaelo tsa ho sebelisoa
Atorvastatin ke litokisetso tse lokiselitsoeng bakeng sa ho phekola le ho thibela mafu a pelo. Contraindred nakong ea bokhachane, lactation le ho bana ba ka tlase ho lilemo tse 18.
Analogue e theko e phahameng haholo ho tloha ho li-ruble tse 62.
Moetsi: Pharmstandard (Russia)
Mefuta ea Tsamaiso:
- Letlapa 10 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 478
- Letlapa 20 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 790
Litaelo tsa ho sebelisoa
Akorta ke lithethefatsi tse entsoeng ka Serussia tse fumanehang ka mokhoa oa matlapa 'me li reretsoe kalafo ea mafu a methapo ea pelo. E kopantsoe le ho ima le ho nyeka. Ho na le litla-morao.
Analogue e theko e tlase ho li-ruble tse 41.
Moetsi: Lek dd (Slovenia)
Mefuta ea Tsamaiso:
- Matlapa a 10 mg 28 likhomphutha., Theko ho tloha 375 li-ruble
- Letlapa 20 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 790
Litaelo tsa ho sebelisoa
Suvardio ke lithethefatsi tsa Seslovenia tse thehiloeng ho rosuvastatin ka litekanyetso tsa 5 mg. Matšoao a ka sehloohong a sebelisoang: hypercholesterolemia ea mantlha ho latela sehlopha sa Fredrickson, homozygous hypercholesterolemia, hypertriglyceridemia, thibelo ea mantlha ea mathata a maholo a pelo. Suvardio ha e laetsoe pele ho lilemo tse 18, nakong ea kemaro le ho nyeka. Lenane le felletseng la li-contraindication le lithibelo le ka fumanoa litaelong tsa ts'ebeliso.
Analogue e theko e tlaase ho tloha li-ruble tse 217.
Moetsi: Krka (Slovenia)
Mefuta ea Tsamaiso:
- Letlapa 20 mg, 14 likhomphutha., Theko ho tloha li-ruble tse 199
- Letlapa 10 mg, 28 likhomphutha., Theko ho tloha 289 li-ruble
Litaelo tsa ho sebelisoa
Sebopeho se atlehang haholoanyane sa Seslovenia ka mokhoa o ts'oanang oa tokollo le sete sa lintho tse sebetsang. Matšoao a ka sehloohong a sebelisoang: hypercholesterolemia ea mantlha kapa dyslipidemia, ho fokotseha hoa lefu la pelo le moriana ho bakuli ba nang le lipontšo tsa kliniki ea lefu la pelo le lefu la pelo kapa lefu la tsoekere. Ho na le li-contraindication.
Analogue e theko e tlase ho li-ruble tse 148.
Moetsi: Belupo (Kroatia)
Mefuta ea Tsamaiso:
- Matlapa a 10 mg 14 likhomphutha., Theko e tsoang ho li-ruble tse 268
- Letlapa 10 mg, 28 likhomphutha., Theko ho tloha 289 li-ruble
Litaelo tsa ho sebelisoa
Rosistark ke sethethefatsi sa hypolipidemic sa sehlopha sa statins. Ho kenyelletsa molek'hule ea rosuvastatin. Lowers cholesterol le dikarolwana tsa yona, e tlosa ho se sebetse ha endothelial. E na le thepa ea antiproliferative le antioxidant. E etselitsoe hypercholesterolemia, triglycerides e maling, e le ho felisa ho ata ha atherosulinosis le ho fokotsa kotsi ea likotsi tsa vascular. Lihlahisoa tsohle tse nang le rosuvastatin li sebelisoa ka nako efe kapa efe ea letsatsi, ho sa tsotelloe lijo tse ngata. Li-contraindication tse felletseng tsa ts'ebeliso ke mafu a tebileng a liphio le sebete, myopathy, basali ba lilemo tsa ho ikatisa ntle le lithibela-pelehi. Litlamorao tsa litla-morao, tse atileng haholo ke ho sokela, ho opeloa ke hlooho le ho opeloa ke mesifa.
Analogue e theko e tlase ho li-ruble tse 82.
Moetsi: Aegis (Hungary)
Mefuta ea Tsamaiso:
- Tab. p / obol. 5 mg, 28 likhomphutha., Theko e tsoang ho li-ruble tse 334
- Tab. p / obol. 10 mg, li-pcs tse 28., Theko e tsoang ho li-ruble tse 450
Litaelo tsa ho sebelisoa
Rosulip ke rosuvastatin e 'ngoe ea sehlopha sa statin. E hlahisoa, joalo ka Rosart, hammoho le li-rosuvastatin tsohle tse teng ka mokhoa oa matlapa. Ha e nkuoa, e theola maemo a phahameng a choleopoloteine, lipoprotein tse tlaase le tse tlase haholo (LDL, VLDL), triglycerides, 'me e eketsa lipenshene tse phahameng tsa methapo ea methapo, e sirelletsang' mele oa motho ho tloha liphihlelong tsa pelo le bokong. E ntlafatsa thepa ea mali, e thibela ho etsoa ha li-plaque atherosselotic. Matšoao a sebelisang, litekanyetso le kalafo ea tsamaiso, li-contraindication le litla-morao li tšoana hantle le Rosart le Rosistark, hobane lithethefatsi tsena kaofela li na le rosuvastatin.
Analogue e theko e tlase ho li-ruble tse 41.
Moetsi: E ntse e hlakisoa
Mefuta ea Tsamaiso:
- Tab. p / obol. 10 mg, li-pcs tse 28., Theko e tsoang ho li-ruble tse 375
- Tab. p / obol. 10 mg, li-pcs tse 28., Theko e tsoang ho li-ruble tse 450
Litaelo tsa ho sebelisoa
Rustor ea lithethefatsi tsa lapeng e fumaneha ka tekanyetso ea 10 mg. Ho tloha ka 2014, sethethefatsi sena se hlahisitsoe ke khoebo ea meriana ea Obolensk sebakeng sa Moscow. Leha ho na le tlhahiso ea Serussia, Rustor ha e theko e tlase ho lithethefatsi tsa kantle tse nang le sebopeho se tšoanang.
Li-analog mabapi le sebopeho le pontšo ea ts'ebeliso
| Sehlooho | Theko ho la Russia | Theko Ukraine |
|---|---|---|
| Crestor rosuvastatin | 29 rub | 60 UAH |
| Mertenil rosuvastatin | 179 rub | 77 UAH |
| Klivas rosuvastatin | -- | 2 UAH |
| Rovix rosuvastatin | -- | 143 UAH |
| Rosart Rosuvastatin | 47 rub | 29 UAH |
| Rosator Rosuvastatin | -- | 79 UAH |
| Rosuvastatin Krka rosuvastatin | -- | -- |
| Rosuvastatin Sandoz Rosuvastatin | -- | 76 UAH |
| Rosuvastatin-Teva Rosuvastatin | -- | 30 UAH |
| Rosucard Rosuvastatin | 20 rub | 54 UAH |
| Rosulip Rosuvastatin | 13 rub | 42 UAH |
| Rosusta Rosuvastatin | -- | 137 UAH |
| Romazik rosuvastatin | -- | 93 UAH |
| Romestine rosuvastatin | -- | 89 UAH |
| Rosucor rosuvastatin | -- | -- |
| Fastrong rosuvastatin | -- | -- |
| Calcium ea Acorta Rosuvastatin | 249 rub | 480 UAH |
| Tevastor-Teva | 383 rub | -- |
| Rosistark rosuvastatin | 13 rub | -- |
| Suvardio rosuvastatin | 19 rub | -- |
| Redistatin Rosuvastatin | -- | 88 UAH |
| Rustor rosuvastatin | -- | -- |
Lethathamo le ka holimo la li-analogues tsa lithethefatsi, tse bontshang Roxer, e loketse haholo hobane e na le sebopeho se tšoanang sa lintho tse sebetsang ebile e lumellana ho latela sesupo sa tšebeliso
Li-analoggs ka pontšo le mokhoa oa ts'ebeliso
| Sehlooho | Theko ho la Russia | Theko Ukraine |
|---|---|---|
| Vabadin 10 mg simvastatin | -- | -- |
| Vabadin 20 mg simvastatin | -- | -- |
| Vabadin 40 mg simvastatin | -- | -- |
| Vasilip simvastatin | 31 rub | 32 UAH |
| Zokor simvastatin | 106 rub | 4 UAH |
| Zokor Forte simvastatin | 206 rub | 15 UAH |
| Simvatin simvastatin | -- | 73 UAH |
| Vabadin | -- | 30 UAH |
| Simvastatin | 7 rub | 35 UAH |
| Vasostat-Health simvastatin | -- | 17 UAH |
| Vasta simvastatin | -- | -- |
| Kardak simvastatin | -- | 77 UAH |
| Simvakor-Darnitsa simvastatin | -- | -- |
| Simvastatin-zentiva simvastatin | 229 rub | 84 UAH |
| Simstat simvastatin | -- | -- |
| Alleste | -- | 38 UAH |
| Zosta | -- | -- |
| Lovastatin lovastatin | 52 rub | 33 UAH |
| Litokelo tsa botho pravastatin | -- | -- |
| Leskol | 2586 rub | 400 UAH |
| Leskol Forte | 2673 rub | 2144 UAH |
| Leskol XL fluvastatin | -- | 400 UAH |
| Amvastan | -- | 56 UAH |
| Atorvacor | -- | 31 UAH |
| Atoris | 34 rub | 7 UAH |
| Vasocline | -- | 57 UAH |
| Livostor atorvastatin | -- | 26 UAH |
| Liprimar atorvastatin | 54 rub | 57 UAH |
| Thorvacard | 26 rub | 45 UAH |
| Tulip Atorvastatin | 21 rub | 119 UAH |
| Atorvastatin | 12 rub | 21 UAH |
| Limistin Atorvastatin | -- | 82 UAH |
| Lipodemin Atorvastatin | -- | 76 UAH |
| Litorva atorvastatin | -- | -- |
| Pleostin atorvastatin | -- | -- |
| Tolevas atorvastatin | -- | 106 UAH |
| Torvazin Atorvastatin | -- | -- |
| Torzax atorvastatin | -- | 60 UAH |
| Etset atorvastatin | -- | 61 UAH |
| Aztor | -- | -- |
| Astin Atorvastatin | 89 rub | 89 UAH |
| Atocor | -- | 43 UAH |
| Atorvasterol | -- | 55 UAH |
| Atotex | -- | 128 UAH |
| Novostat | 222 rub | -- |
| Atorvastatin-Teva Atorvastatin | 15 rub | 24 UAH |
| Atorvastatin Alsi Atorvastatin | -- | -- |
| Lipromak-LF atorvastatin | -- | -- |
| Vazator atorvastatin | 23 rub | -- |
| Atorem atorvastatin | -- | 61 UAH |
| Vasoclin-Darnitsa atorvastatin | -- | 56 UAH |
| Livazo pitavastatin | 173 rub | 34 UAH |
Moetso o fapaneng o kanna oa lumellana ho bonts'a mokhoa le mokhoa oa ts'ebeliso
| Sehlooho | Theko ho la Russia | Theko Ukraine |
|---|---|---|
| Lopid Gemfibrozil | -- | 780 UAH |
| Lipofen cf fenofibrate | -- | 129 UAH |
| Tricor 145 mg fenofibrate | 942 rub | -- |
| Trilipix Fenofibrate | -- | -- |
| Pms-cholestyramine e tloaelehileng e natsoang colestyramine | -- | 674 UAH |
| Mokopu oa Mone oa Pumpkin | 109 rub | 14 UAH |
| Ravisol Periwinkle e nyane, Hawthorn, Clover mehend, chestnut ea Horse, Moffletoe e khubelu, Sofora ea Japane, Horsetail | -- | 29 UAH |
| Litlhapi tsa tlhapi tsa Sicode | -- | -- |
| Motsoako oa Vitrum Cardio oa lintho tse ngata tse sebetsang | 1137 rub | 74 UAH |
| Motsoako oa Omacor oa lintho tse ngata tse sebetsang | 1320 rub | 528 UAH |
| Litlhapi tsa oli ea tlhapi | 25 rub | 4 UAH |
| Motsoako oa Epadol-Neo oa lintho tse ngata tse sebetsang | -- | 125 UAH |
| Ezetrol ezetimibe | 1208 rub | 1250 UAH |
| Repata Evolokumab | 14 500 rub | UAH 26381 |
| Alirocoumab ea bohlokoa | -- | 28415 UAH |
U ka fumana analogue e theko e tlaase ea moriana o theko e phahameng?
Ho fumana analogue e theko e phahameng ea moriana, mofuta o tšoanang kapa oa mantsoe, pele ho tsohle re khothaletsa ho ela hloko sebopeho, e leng lintho le lipontšo tse tšoanang tse sebetsang. Metsoako e tšoanang ea lithethefatsi e tla bonts'a hore lithethefatsi li tsamaisana le lithethefatsi, li ka lekana meriana kapa li ka etsa meriana. Leha ho le joalo, u se ke oa lebala ka likarolo tse sa sebetseng tsa lithethefatsi tse tšoanang, tse ka amang polokeho le ts'ebetso. Se ke la lebala ka litaelo tsa lingaka, ho itlama ho ka lematsa bophelo ba hau, ka hona, etela ngaka ea hau kamehla pele u sebelisa meriana leha e le efe.
Taeo ea Roxer
TLOTLISO
mabapi le tšebeliso ea chelete
ROXER
Sebopeho
Matlapa a koahetsoeng ka filimi 1 tab.
Ntho ea bohlokoa
Motsoako o sebetsang: calcium ea "rosuvastatin" 5.21 mg, 10.42 mg, 15.62 mg, 20.83 mg, 31.25 mg, 41.66 mg.
(e lekanang le 5, 10, 15, 20 mg ea rosuvastatin, ka ho latellana)
Baeti: MCC, lactose, crospovidone, colloidal silicon dioxide, magnesium stearate
Filimi sheath: butyl methacrylate, dimethylaminoethyl methacrylate le methyl methacrylate kopolymer (1: 2: 1), macrogol 6000, titanium dioxide, lactose monohydrate
Tlhaloso ea foromo ea litekanyetso
Letlapa, 5 mg: pota, biconvex, e koahetsoeng ka koae e tšoeu ea filimi, e nang le bevel, e tšoaeang "5" ka lehlakoreng le leng, e tiisitsoe *.
Letlapa, 10 mg: pota, biconvex, e koahetsoeng ka koae e tšoeu ea filimi, e nang le bevel, e tšoaeang "10", e tiisitsoe ka lehlakoreng le le leng *.
Matlapa a 15 mg: pota, biconvex, e koahetsoeng ka koae e tšoeu ea filimi, e nang le bevel, e tšoaeang "15", e tiisitsoe ka lehlakoreng le le leng *.
Letlapa, 20 mg: pota, biconvex, e koahetsoeng ka koae e tšoeu ea filimi, e nang le bevel *.
* Likarolo tse peli li bonahala karolong ea sefapano, konokono e tšoeu.
Ketso ea pharmacological
Ts'ebetso ea pharmacological - lipid-lowing, inhibiting red HaseGM-CoA.
Pharadodynamics
Mokhoa oa ketso
Rosuvastatin ke inhibitor e ikhethileng ea tlholisano ea HMG-CoA, enzyme e fetolang methylglutaryl coenzyme A ho mevalonic acid, selelekela sa Xc. Morero o ka sehloohong oa ketso ea rosuvastatin ke sebete, moo ho nang le motsoako oa cholesterol (Ch) le LDL catabolism.
Rosuvastatin e eketsa palo ea li-receptor tsa hepatic LDL ka seleng, e eketsa ho ts'oaroa le ho ts'oaroa ha LDL, e leng se tla lebisa ho thibelo ea motsoako oa VLDL, ka ho etsa joalo e theole kakaretso ea LDL le VLDL.
Pharadodynamics
Rosuvastatin e fokotsa mohopolo o phahameng oa plasma ea LDL cholesterol (HDL-C), cholesterol e felletseng, triglycerides (TG), e eketsa choleum ea polyum-C (HDL-C), hape e fokotsa leqhubu la apolipoprotein B (ApoV), HDL-C, LDL-C, TG-VLDLP mme e eketsa bongata ba apolipoprotein AI (ApoA-I) (bona matlapa a 1 le a 2). Fokotsa tekanyo ea Xs-LDL / Xs-HDL, li-Xs / Xs-HDL ka kakaretso le Xs-eo e seng HDL / Xs-HDL, le ratio ApoV / ApoA-I.
Matla a kalafo a hlaha ka hare ho beke kamora ho qala kalafo, kamora libeke tse peli tsa kalafo li fihla ho 90% ea phello e kholo e ka bang teng. Phello e phahameng ea kalafo hangata e fihlelloa ke beke ea 4 ea kalafo mme e bolokoa ka tšebeliso ea kamehla ea lithethefatsi.
Lethathamo 1
Phello e itšetlehileng ka tekanyetso ho bakuli ba nang le hypercholesterolemia ea mantlha (mofuta oa Friedrichson IIa le IIb) (e bolela phetoho e lekantsoeng ea liperesente ha e bapisoa le motheo)
Dose, mg Palo ea bakuli Chs-LDL Kakaretso ea Chs-HDL TG Xs-e se nang HDL Apo B At A-I
Placebo 13 -7 -5 3 -3 -7 -3 0
5 mg 17 -45 -33 13 -35 -44 -38 4
10 mg 17 -52 -36 14 -10 -48 -42 4
20 mg 17 -55 -40 8 -23 -51 -46 5
40 mg 18 -63 -46 10 -28 -60 -54 0
Lethathamo la 2
Phello e itšetlehileng ka tekanyetso ho bakuli ba nang le mofuta oa IIb le hypertriglyceridemia ho latela Fredrickson) (phetoho e tloaelehileng ea liperesente ho tloha ho basement)
Dose, mg Palo ea bakuli ba nang le TG Xs-LDL Kakaretso ea Xs Xs-HDL Xs-e se nang HDL X-e seng HDL TG-VLDL
Sebaka sa 26 26 1 5 1 -3 2 2 6
5 mg 25 -21 -28 -24 3 -29 -25 -24
10 mg 23 -37 -45 -40 8 -49 -48 -39
20 mg 27 -37 -31 -34 22 -43 -49 -40
40 mg 25 -43 -43 -40 17 -51 -56 -48
Ho sebetsa hantle ha kliniki. Rosuvastatin e sebetsa ho bakuli ba baholo ba nang le hypercholesterolemia e nang le kapa ntle le hypertriglyceridemia, ho sa tsotelehe hore na ke ba morabe ofe, bong kapa lilemo. ho bakuli ba nang le lefu la tsoekere mellitus le hypercholesterolemia ea malapa.
Ho 80% ea bakuli ba nang le mofuta oa IIa le IIb hypercholesterolemia ho latela Fredrickson (karolelano ea serum ea karolelano ea LDL-C e ka ba 4,8 mmol / L) ha ho nooa moriana ka tekanyo ea 10 mg, mahloriso a LDL-C a fihla tlase ho 3 mmol / L.
Bakuli ba nang le heterozygous Familyal hypercholesterolemia ba amohelang rosuvastatin ka tekanyo ea 20-80 mg ba bonts'itse matla a hlakileng matšoao a lipid profil (thuto e amang bakuli ba 435). Kamora ho khetha tekanyetso ho lethal dose ea letsatsi le letsatsi ea 40 mg (libeke tse 12 tsa kalafo), ho fokotseha hoa khatello ea serum ea LDL-C ka 53% ho tsebahala. Ho bakuli ba 33%, serame ea LDL-C e ka tlase ho 3 mmol / L.
Ho bakuli ba nang le homozygous Familyal hypercholesterolemia ba noang rosuvastatin ka tekanyo ea 20 le 40 mg, keketseho e tloaelehileng ea serum mahloriso a LDL-C e ne e le 22%.
Ho bakuli ba nang le hypertriglyceridemia e nang le serum ea TG ea mantlha ea 273 ho 817 mg / dl, ba amohelang rosuvastatin ka tekanyo ea 5 ho isa ho 40 mg hang ka letsatsi bakeng sa libeke tse 6, khatello ea TG maling a mali e fokotsehile haholo (bona tafole ea 2).
Phello ea tlatsetso e bonoa hammoho le fenofibrate mabapi le litaba tsa triglycerides le nicotinic acid ho lipid tse fokotsang litekanyetso ha li bapisoa le khatello ea HDL-C (bona le "Litaelo tse Khethehileng").
Phuputsong ea METEOR ho bakuli ba 984 ba lilemo li 45-70 ba nang le kotsi e tlase ea ho ba le lefu la mokokotlo oa mokokotlo (lilemo tse 10 kotsing ea sekhahla sa Framingham le ka tlase ho 10%), ka kakaretso ea serum ea LDL-C ea 4 mmol / l (154,5 mg / dl) le Subclinical atherosulinosis (e ileng ea hlahlojoa ke botenya ba carotid intima-media complex (TCIM)) e ithutile ka phello ea rosuvastatin ho TCIM. Bakuli ba amohetse rosuvastatin ka tekanyo ea 40 mg / letsatsi kapa placebo ka lilemo tse 2. kalafo ea Rosuvastatin e fokotsitse sekhahla sa tsoelo-pele ea boholo ba TCIM bakeng sa likarolo tse 12 bonono Rhee bapisoa placebo le phapang ea -0,0145 limilimithara / selemo (95% CI -0,0196 ho -0,0093, leq lesedi All hlahisa merero informational le ha le lebaka la ho ho intša meriana kapa Phetolo eang teng
