Letlapa la analogue la Glibenclamide
Hypoglycemia (e khahlanong le regimen ea dosing le lijo tse sa lekaneng), boima ba 'mele, feberu, arthralgia, proteinuria, ho kula (ho ruruha ha letlalo, ho hlohlona), dyspepsia (ho nyekeloa ke pelo, lets'ollo, maikutlo a boima ho epigastrium), mathata a methapo ea kutlo (ho holofala ha methapo ea kutlo) , hemopoiesis (hypoplastic kapa hemolytic anemia, leukopenia, agranulocytosis, pancytopenia, eosinophilia, thrombocytopenia), ts'ebetso ea sebete e sa sebetseng (cholestasis), porphyria ea morao-rao, liphetoho tsa tatso, polyuria, foto ensibilizatsiya, hlooho e opang, mokhathala, ho fokola, ho tsekela.
Sesebelisoa le litekanyetso
Tekanyetso ena e itšetleha ka lilemo, ho teba ha lefu la tsoekere, ho tebela ha glucose ea mali le lihora tse peli ka mor'a ho ja. Tekanyetso e tloaelehileng ea letsatsi le letsatsi e tloha ho 2,5 ho isa ho 15 mg. Khafetsa ea tsamaiso ke makhetlo a 1-3 ka letsatsi bakeng sa metsotso e 20-30 pele ho lijo. Melemo ea lipalo tse fetang 15 mg / ka letsatsi ha e ekehe botebo ba phello ea hypoglycemic. Tekanyetso ea pele ho bakuli ba tsofetseng ke 1 mg / letsatsi.
Ha u nkela lithethefatsi tsa hypoglycemic mofuta o tšoanang, glibenclamide e laetsoe ho latela morero o kaholimo, 'me sethethefatsi se fetileng se hlakotsoe hanghang. Ha o fetoha ho tloha ho biguanides, tekanyetso ea pele ea letsatsi le letsatsi ke 2,5 mg, haeba ho hlokahala, tekanyetso ea letsatsi le letsatsi e eketsoa matsatsi a mang le a tšeletseng a6,5 ka 2,5 mg ho fihlela phello e fumanehang. Ha ho se na matseliso nakong ea libeke tse 4-6, ho a hlokahala hore u nke qeto ka phekolo e kopaneng.
Litaelo tse khethehileng
Hoa hlokahala hore nako le nako u lekole boemo ba tsoekere maling maling ka mpeng e se nang letho le ka mor'a ho ja, khalase ea letsatsi le letsatsi ea litaba tsa tsoekere maling le moriring.
Tabeng ea mehato ea ho buuoa kapa ho bola ha lefu la tsoekere, monyetla oa ho sebelisa litokisetso tsa insulin o lokela ho nahaneloa.
Bakuli ba lokela ho hlokomelisoa ka kotsi e eketsehang ea hypoglycemia maemong a ho ja ka mokhoa oa ethanol (ho kenyelletsa le nts'etsopele ea maikutlo a kang a discriram: bohloko ba ka mpeng, ho nyekeloa ke pelo, ho hlatsa, hlooho e bohloko), li-NSAIDs le tlala.
Nakong ea kalafo, ha ho khothalletsoe hore u lule letsatsing nako e telele.
Phetoho ea tekanyetso ea hlokahala bakeng sa ho fetella hoa mmele le maikutlo, phetoho ea lijo.
Lipontšo tsa kliniki tsa hypoglycemia li ka koaloa ha ho nkuoa li-beta-blockers, clonidine, reserpine, guanethidine.
Nakong ea kalafo, tlhokomelo e lokela ho nkuoa ha ho khannoa likoloi le ho etsa lintho tse ling tse ka bang kotsi tse hlokang ho tsepamisa mohopolo le ho potlakisa karabelo ea psychomotor.
Tšebelisano
Li-inhibitors tsa ACE (Captopril, enalapril), H2-histamine receptor blockers (cimetidine), lithethefatsi tsa antifungal (miconazole, fluconazole), NSAIDs (phenylbutazone, azapropazone, oxyphenbutazone), fibrate (clofibrate, anti-agonamides), anti-agonamides li-anabolic, li-beta-blockers, li-inhibitors tsa MAO, nako e telele li sebetsa sulfonamides, cyclophosphamides, biguanides, chloramphenicol, fenfluramine, acarbose, fluoxetine, guanethidine, pentoxifylline, tetracycline, theophylline, tubule blockers oh, secretion, reserpine, bromocriptine, disopyramide, pyridoxine, ka insulin, allopurinol ntlafatsa phello.
Barbiturates, corticosteroids, adrenostimulants (epinephrine, clonidine), lithethefatsi tsa antiepileptic (phenytoin), BMKK, anhibidase ea carbonic anhydrase inhibitors (acetazolamide), thiazide diuretics, chlortalidone, furosemide, triamterene isinazinazinazinazinazinazinazinazinazin. salbutamol, terbutaline, glucagon, rifampicin, lihomere tsa qoqotho, Li + letsoai, litekanyetso tse phahameng - nicotinic acid, chlorpromazine, lithibela-pelehi tsa molomo le estrogens.
Ho eketsa lithethefatsi tsa moroto (ammonium chloride, CaCl2, ascorbic acid ka tekanyetso e kholo) ntlafatsa sephetho ka ho fokotsa tekanyo ea ho ikarola le ho eketsa botjha ba glibenclamide.
Lithethefatsi tse thibelang hematopoiesis ea masapo li eketsa kotsi ea myelosuppression.
Setsebi sa lefu la tsoekere: "Ho tsitsisa boemo ba tsoekere ea mali."
Li-analog tsa sethethefatsi Glibenclamide
Analogue e theko e phahameng haholo ho tloha ho li-ruble tse 145.
Moetsi: Pharmstandard (Russia)
Mefuta ea Tsamaiso:
- Tab. 2 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 191
- Tab. 3 mg, li-pcs tse 30.. Theko e tsoang ho li-ruble tse 272
Litaelo tsa ho sebelisoa
Glimepiride ke setlhare sa lapeng ho phekoloa lefu la tsoekere la mofuta oa 2. E fumaneha ka mokhoa oa matlapa a nang le ntho e le 'ngoe e sebetsang ka litekanyetso tsa 2 ho isa ho 4 mg ka pilisi.
Analogue e theko e phahameng haholo ho tsoa ho li-ruble tse 82.
Moetsi: E ntse e hlakisoa
Mefuta ea Tsamaiso:
- Tab. le MV 30 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 128
- Tab. 3 mg, li-pcs tse 30.. Theko e tsoang ho li-ruble tse 272
Litaelo tsa ho sebelisoa
Diabetesalong ke lithethefatsi tsa matlapa bakeng sa kalafo ea mofuta oa 2 mellitus o thehiloeng gliclazide ka bongata ba 30 mg. Moriana o fanoe ka katleho e sa lekanang ea ho ikoetlisa le ho ja. Ho na le li-contraindication le litla-morao.
Analogue e theko e phahameng haholo ho tloha ho li-ruble tse 73.
Moetsi: Akrikhin (Russia)
Mefuta ea Tsamaiso:
- Letlapa 80 mg, li-pcs tse 60., Theko e tsoang ho li-ruble tse 119
- Tab. 3 mg, li-pcs tse 30.. Theko e tsoang ho li-ruble tse 272
Litaelo tsa ho sebelisoa
Glidiab ke e 'ngoe ea li-substitute tse molemo ka ho fetisisa bakeng sa gliclazide. E fumaneha hape ka sebopeho sa letlapa, empa litekanyetso tsa DV li phahame mona, tse lokelang ho tsotelloa pele ho qala kalafo. Ho bontšoa mofuta oa lefu la tsoekere la mofuta oa 2 o nang le lijo tse sa sebetseng le ho ikoetlisa.
Analogue e theko e phahameng haholo ho tsoa ho li-ruble tse 83.
Moetsi: Farmakor (Russia)
Mefuta ea Tsamaiso:
- Letlapa 30 mg, 60 likhomphutha., Theko ho tloha li-ruble tse 129
- Tab. 3 mg, li-pcs tse 30.. Theko e tsoang ho li-ruble tse 272
Litaelo tsa ho sebelisoa
Akrikhin (Russia) Glidiab ke e 'ngoe ea tse molemo ka ho fetisisa tse nkang sebaka sa gliclazide. E fumaneha hape ka sebopeho sa letlapa, empa litekanyetso tsa DV li phahame mona, tse lokelang ho tsotelloa pele ho qala kalafo. Ho bontšoa mofuta oa lefu la tsoekere la mofuta oa 2 o nang le lijo tse sa sebetseng le ho ikoetlisa.
Analogue e theko e phahameng haholo ho tloha li-ruble tse 81.
Moetsi: E ntse e hlakisoa
Mefuta ea Tsamaiso:
- Letlapa 30 mg, 60 likhomphutha., Theko e tsoang ho li-ruble tse 127
- Tab. 3 mg, li-pcs tse 30.. Theko e tsoang ho li-ruble tse 272
Litaelo tsa ho sebelisoa
Gliclazide MV ke litokisetso tsa letlapa bakeng sa kalafo ea mofuta oa tsoekere ea lefu la tsoekere le ipapisitse le karolo e le ngoe e sebetsang litekanyetsong tsa 30 mg. E fuoa mokhoa oa ho ja hantle le ho ikoetlisa. Gliclazide MV e hanyetsanoa ho bakuli ba nang le lefu la tsoekere la mofuta oa 1 (ba itšetlehileng ka insulin).
Analogue e theko e phahameng haholo ho tloha ho li-ruble tse 263.
Moetsi: Sanofi-Aventis S.p.A. (Itali)
Mefuta ea Tsamaiso:
- Tab. 1 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 309
- Tab. 2 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 539
Litaelo tsa ho sebelisoa
Amaryl ke kalafo bakeng sa lefu la tsoekere la mofuta oa 2 ka mofuta oa litafole tse reretsoeng ho sebelisoa kahare. Joaloka ntho e sebetsang, glimepiride e sebelisoa ka tekanyetso ea 1 ho isa ho 4 mg. Ho na le li-contraindication le litla-morao.
Analogue e theko e phahameng haholo ho tsoa ho li-ruble tse 93.
Moetsi: Berlin-Chemie / Menarini Pharma (Jeremane)
Mefuta ea Tsamaiso:
- Matlapa a 5 mg, li-pcs tse 120., Theko e tsoang ho li-ruble tse 139
- Tab. 2 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 539
Litaelo tsa ho sebelisoa
Letlhare la litlhare bakeng sa kalafo ea lefu la tsoekere le thehiloeng ho glibenclamide (ka sebopeho sa micron) ka litekanyetso tsa 1,75 mg. Ho bonts'oa ts'ebeliso ea mofuta oa 2 lefu la tsoekere (ka ho se sebetse hantle ha lijo tse thata).
Analogue e theko e phahameng haholo ho tloha li-ruble tse 140.
Moetsi: Canonfarma (Russia)
Mefuta ea Tsamaiso:
- Tab. 2 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 186
- Tab. 4 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 252
Litaelo tsa ho sebelisoa
Glimepiride Canon ke e 'ngoe ea lithethefatsi tse molemo haholo bakeng sa ho phekola lefu la tsoekere la mofuta oa 2 le thehiloeng ho glimepiride ka tekanyo e ts'oanang. E laetsoe ho se sebetse hantle ha lijo le ho ikoetlisa.
Analogue e theko e phahameng haholo ho tloha ho li-ruble tse 164.
Moetsi: Akrikhin (Russia)
Mefuta ea Tsamaiso:
- Tab. 1 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 210
- Tab. 2 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 319
Litaelo tsa ho sebelisoa
Canonpharma (Russia) Glimepiride Canon ke e 'ngoe ea lithethefatsi tse molemo haholo bakeng sa ho phekoloa lefu la tsoekere la mofuta oa 2 le thehiloeng ho glimepiride ka tekanyo e ts'oanang. E laetsoe ho se sebetse hantle ha lijo le ho ikoetlisa.
Analogue e theko e phahameng haholo ho tsoa ho li-ruble tse 256.
Moetsi: Krka (Slovenia)
Mefuta ea Tsamaiso:
- Matlapa a 60 mg, li-pcs tse 30., Theko ho tloha li-ruble tse 302
- Tab. 2 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 319
Litaelo tsa ho sebelisoa
Litokisetso tsa letlapa la Slovenia bakeng sa kalafo ea lefu la tsoekere la mofuta oa 2. Joalo ka ntho e sebetsang, gliclazide e sebelisoa ho litekanyetso li 30 kapa 60 mg ka ho pepa. Ho na le li-contraindication le litlamorao tse ka bang teng.
Analog e theko e phahameng haholo ho tsoa ho li-ruble tse 350.
Moetsi: Beringer Ingelheim International GmbH (Jeremane)
Mefuta ea Tsamaiso:
- Tab. 30 mg, li-pcs tse 60., Theko e tsoang ho li-ruble tse 396
- Tab. 2 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 319
Litaelo tsa ho sebelisoa
Glurenorm ke litokisetso tsa letlapa bakeng sa kalafo ea mofuta oa 2 lefu la tsoekere le thehiloeng glycidone ho litekanyetso tsa 30 mg. E na le khokahano ea mofuta oa 1 lefu la tsoekere, ho nyeka, ho ima, lefu la sebete le liphio. Lenane le felletseng la li-contraindication le ka fumanoa litaelong.
Sebopeho, sephutheloana, foromo ea tokollo
Moriana "Glibenclamide" o entsoe ka mofuta ofe? Buka e tlaleha hore sehlahisoa sena se fumaneha ka mokhoa oa matlapa a behiloeng ka lijaneng tsa polasetiki (lisele tsa contour) le mabokoseng a karete.
Sebopeho sa moriana o hlahang se kenyelletsa 5 mg ea glibenclamide, hammoho le metsoako e thusang joalo ka litapole, starch monohydrate, magnesium stearate, croscarmellose sodium, indigo carmine E 132, colloidal silicon dioxide le povidone 25.
Ketso ea lithethefatsi
Moriana "Glibenclamide" ke eng? Litaelo tsa tšebeliso li re ena ke phello ea hypoglycemic ho batho ba phetseng hantle le bakuli ba nang le lefu la tsoekere la mofuta oa 2.
Ho sebetsa ha moriana ona ho bakoa ke bokhoni ba ona ba ho eketsa secretion ea insulin ke lisele tsa beta tsa manyeme ka lebaka la ts'usumetso ea tsona. Ho latela litsebi, phello ena ea lithethefatsi e ntlafatsoa ke tšusumetso ea tsoekere.
Likarolo tsa Kinetic tsa moriana o molomo
Ke lintlha life tsa pharmacokinetic tse khethollang sethethefatsi Glibenclamide? Litaelo tsa tšebeliso li re kamora ho tsamaisoa ha litafole ka molomo, ntho ea tsona e sebetsang e potlakile ebile e batla e anngoe ka ho feteletseng mokhoeng oa ho silila.
Ts'ebeliso e tšoanang ea lijo e lebisa ho fokotseha hoa khatello ea glibenclamide ho plasma ea mali (ha e bapisoa le ho itima lijo). Khokahano ea karolo ena le albin e feta 98%.
Sebeteng sa mokuli, glibenclamide e fetoloa ka metabolites e latelang: 3-cis-hydroxy-glibenclamide le 4-trans-hydroxy-glibenclamide. Li hlahisoa ka mokhoa o tšoanang ka liphio le ka makhopho.
Karolelano ea lithethefatsi halofo ea bophelo ke lihora tse 2-3,3. Ho batho ba nang le ts'ebetso ea sebete e sa sebetseng, letšoao lena le fokotsehile haholo.
Melao ea ho sebelisa
Na ho na le li-contraindication bakeng sa Glibenclamide? Litaelo tsa tšebeliso li re sesebelisoa sena ha sea lokela ho fuoa bakuli ba nang le:
- ho chesa haholo
- hypersensitivity ho motsoako o sebetsang, hammoho le thiazide diuretics kapa sulfonamides,
- ketoacidosis,
- lefu la tsoekere le mofets'e,
- nts'etsopele ea hypoglycemia,
- mehato ea ho buoa le likotsi tse ling,
- paresis ea mala le mala
- boimana
- mofuta oa 1 lefu la tsoekere
- sefuba.
Melemo "Glibenclamide": litaelo tsa tšebeliso
Moriana o buoang o lokela ho fuoa feela ke ngaka e nang le boiphihlelo. Ho nka moriana ona ho lokela ho lula ho kopantsoe le lijo tse thata. Ke maemong ana feela moo e tla sebetsa. Rejimithi ea litekanyetso e ipapisitse le liphetho tsa tlhahlobo ea mokuli (tsoekere ea mali, matšoao a fumanoang ka lebaka la liteko tsa moroto, joalo-joalo).
Joale u lokela ho nka sethethefatsi "Glibenclamide" joang? Phekolo ea sesebelisoa sena e qala ka tekanyetso e fokolang. Sena ke 'nete haholo ho batho ba nang le tšekamelo ea hypoglycemia le boima ba' mele ka tlase ho 50 kg.
Ka tloaelo, litekanyetso tsa pele tsa moriana ke tafole ea 0.5-1 ka letsatsi. Sena se tsamaisana le 2,5-5 mg ea ntho e sebetsang. Ka phello e sa sebetseng ea lithethefatsi, palo e bonts'itsoeng e ka eketsoa butle-butle hore e be matlapa a mararo ka letsatsi, a tsamaellanang le 15 mg ea motsoako o sebetsang. Sena se lokela ho etsoa nako le nako ka matsatsi a 'maloa ho fihlela beke e le ngoe ho fihlela sephetho se lakatsehang se fihlelle.
U ka fetisetsa mokuli joang ho tsoa ho sethethefatsi se seng ho ea moriana oa Glibenclamide? Ts'ebeliso ea meriana ho sena e lokela ho etsoa ka hloko haholo. Taba ea mantlha, mokuli o fuoa matlapa a 0.5 ka letsatsi, 'me butle-butle tekanyetso e eketsoa hore e sebetse hantle.
Bakeng sa batho ba baholo, hammoho le bakuli ba holofetseng kapa bakuli ba nang le phepo e sa lekanang le ts'ebetso ea sefuba kapa ea liphio, ho bohlokoa hore ba fokotse tlhokomelo kapa litekanyetso tsa pele tsa moriana haholo kamoo ho ka khonehang ka lebaka la nts'etsopele ea hypoglycemia. Hape, potso ea ho fetola tekanyetso ea lithethefatsi e lokela ho arajoa ka ho fokotseha ha boima ba 'mele oa mokuli kapa ka phetoho ea bophelo ba hae bo tloaelehileng.
Mokhoa oa ho nka matlapa a hypoglycemic
Glibenclamide e sebelisoa joang? Litaelo tsa tšebeliso (foto ea lithethefatsi e hlahisoa sehloohong sena) e re matlapa a boletsoeng a tlameha ho nkuoa pele ho lijo, a hlatsuoe ka khalase ea metsi a ts'elitsoeng hore a se ke a hlafuna.
Ka litekanyetso tsa letsatsi le letsatsi tsa matlapa a 2, moriana o khothalletsoa ho aroloa ka litekanyetso tse peli (hoseng le mantsiboea) ka karolelano ea 2: 1.
Ho bohlokoa ho sebelisa moriana ona ka nako e le 'ngoe. Haeba u tlosoa ka moriana o sebelisang lithethefatsi, letlapa leo ha lea lokela ho nkuoa le le latelang.
Nako ea kalafo ka moriana ona e ipapisitse le lefu leo. Nakong eohle ea kalafo, ho hlahlojoa kamehla boemo ba metabolic ba mokuli hoa hlokahala.
Litlamorao
Lithethefatsi "Glibenclamide", li-analogues tsa tsona tse thathamisitsoeng ka tlase, li ka baka nts'etsopele ea maikutlo a mabe a amang methapo ea kutlo, endocrine, tsamaiso ea methapo le methapo ea lijo, hammoho le hematopoietic. Mabapi le sena, mokuli a ka ba le litla-morao tse kang ho nyekeloa ke pelo, hypoglycemia ea ho fapana ho matla, ho se sebetse hantle ha sebete, lets'ollo, hlooho ea hlooho, cholestasis, bofokoli, ho tsekela le ho tepella.
Hape ho lokela ho hlokomeloe hore ho latela semelo sa ho sebelisa lithethefatsi tsena, ponahalo ea maikutlo le mathata a ho kula ha e hlalosoe ka ntle le tšenyo ea letlalo.
Hypoglycemic overdose
Ho na le matšoao afe ha u sebelisa litekanyetso tse phahameng tsa moriana "Glibenclamide"? Litaelo li re ka ho sebelisa tekanyetso e fetang tekano, mokuli a ka ba le hypoglycemia, mohlomong e tsamaisana le bofokoli, tlala, hlooho, ho tšoha, ho fufuleloa ho feteletseng, ho tsekela, ho thothomela ha mesifa, ho phahloha, lefu la mokokotlo, bothata ba pono le puo.
Phekolo ea maemo a joalo e kenyelletsa ts'ebetso e potlakileng ea lihlahisoa tse nang le tsoekere habonolo. Mohlala, lero la litholoana, tsoekere, sirapo ea poone, tee e chesang e tsoekere kapa mahe a linotsi.
Maemong a matla haholo, mokuli o kenngoa ka tharollo ea glucose ea 50%, Dextrose, Glucagon kapa Diazoxide. Ho laoloa ka mokhoa o ikhethileng oa glycemia, creatinine, nitrogen ea urea, li-electrolyte le boikemisetso ba pH.
Tlhahisoleseling e ikhethang
Moemeli oa hypoglycemic tlas'a tlhokomelo e lokela ho sebelisoa ka mokhoa o hlokolosi ho bakuli ba nang le bothata ba ho hlaphoheloa kelellong le hepatic, hammoho le ts'ebetsong ea methapo ea methapo ea qoqotho le ea adrenal, maemo a febrile le joala bo sa foleng.
Bakeng sa kalafo e tloaelehileng ho hlokahala hore ho hlahlojoe khafetsa boemo ba tsoekere maling a mokuli, hammoho le boemo ba hae bo pepenene.
Haeba mokuli a e-ba le hypoglycemia ha a ntse a e-noa moriana, tsoekere e beoa kahare (haeba motho a elelloa). Maemong a ho lahleheloa ke kelello, tsoekere e fanoa ka methapo, le glucagon - ka mokhoa o ikhethileng, intramuscularly kapa intravenous. Kamora hore mokuli a fole, o mo fa lijo tse nang le lik'habohaedreite hangata ho qoba tsoelopele ea hypoglycemia.
Litšenyehelo le li-analogues (li-synonyms) tsa lichelete
Khetha li-analogues tsa moriana ona e lokela feela ho ba setsebi se nang le boiphihlelo. Lingaka li bua ka meriana e latelang: "Maninil", "Manin", "Maniglide", "Betanaz" le "Antibet".
Hape ho lokela ho hopoloa hore libakeng tsa meriana, hangata ba rekisa li-synonyms tsa sethethefatsi sena. Hangata li sebelisoa e le: Glidanil, Glibex, Glibamide, Gilemal, Glibomet, Glibenclamide. Tekanyetso ea lichelete tsena e khethoa ka bonngoe.
Ha e le theko ea lithethefatsi "Glibenclamide", e fapana pakeng tsa li-ruble tse 280-360.
Tlhahlobo ea lithethefatsi
Joale ua tseba hore na "moriana oa" Glibenclamide "ke eng. Litaelo tsa tšebeliso, li-analogues le mofuta oa tokollo ea moemeli enoa li hlalositsoe ka holimo.
Bareki ba reng ka lithethefatsi tse? Ha e le molao, litlaleho tsohle ka eona li theohela puisanong ea mefuta e meng ea kalafo e khothalletsoang batho ba nang le lefu la tsoekere.
Bareki ba bolela hore hangata ba sebelisa Glibenclamide e le monotherapy. Leha ho na le bakuli ba abetsoeng moriana ona hammoho le lithethefatsi tse ling tsa hypoglycemic.
Ho ea ka lingaka, ho khethoa ha meriana eo ho buuoang ka eona ho hloka mokhoa oa motho ka mong. Maemong ana, setsebi se lokela ho tloaelana le liphetho tsohle tsa bohlahlobo le lithuto tse ling. Ho nka "Glibenclamide" ho bakuli ho ea ka maikutlo a bona ho kotsi haholo bakeng sa bophelo bo botle le bophelo.
Ts'ebetso ea pharmacological ea glibenclamide
Glibenclamide e na le phello ea hypocholesterolemic le hypoglycemic 'meleng oa motho.
Sesebelisoa se sebetsang ke glibenclamide. Lisebelisoa tse thusang ke lactose monohydrate, litapole kapa starch ea poone, sodium ea croscarmellose, povidone 25, magnesium stearate, indigo carmine le aerosil.
Ho latela litaelo, Glibenclamide e na le tšusumetso e khethehileng liseleng tsa beta tsa sesebelisoa sa islet, 'me e ama secoretion ea "insulin" ea pancreatic. Mosebetsi oa lithethefatsi o bonahala ha o ntse o boloka tšebetso ea insulin ea manyeme. Sesebelisoa se thusa ho khutlisetsa kutloisiso ea 'mele ea lisele tsa beta ho senyeha ha glycemic.
Lithethefatsi li ka baka phello ea insulin ea kantle le ea endo native ka ho eketsa palo ea li-insulin receptors, e tsosa ntlafatso ea tšebelisano ea insulin-receptor le tsosoloso ea phetisetso ea pontso ea post-receptor.
Keketseho ea plasma ea khatello ea insulin le ho fokotseha ha tsoekere ha e etsahale hanghang, empa butle butle. Tsela e joalo ea lits'ebetso e fokotsa haholo menyetla ea maemo a hypoglycemic.
Ts'ebeliso ea glibenclamide e na le phello e ntle ho eketseng kutloisiso ea li-insulin receptors ho insulin ho lithane tsa pherekano, e tsosang litlamorao tse eketsehileng. Hape, ka lebaka la likarolo tse fumanehang ho lokiso, ts'ebeliso ea tsoekere meroeng le sebete e ea eketseha, ho etsoa ha glycogen ho hlohlelletsa ho bona (tlhahiso ea tsoekere e tsoang ho sebete e fokotsehile). Moriana ona o na le hypolipidemic le antidiuretic effect, o thusa ho fokotsa likarolo tsa mali tsa thrombogenic, o thibela ho hlaha ha arrhythmias.
Matla a sethethefatsi a hlaha ka mor'a lihora tse peli kamora ts'ebetso, se fihla sehlohlolong sa kamora lihora tse 8, mme phello ea sona e nka lihora tse leshome le metso e 'meli.
Glibenclamide e kenella ka potlako le ka botlalo ho tsoa ts'ebetsong ea gastrointestinal. Kamora ho kenella, e fetoloa likarolo tse peli tse sa sebetseng tsa metabolite, e 'ngoe ea tsona e hloekisoe ka har'a moroto, ebe ea bobeli e na le bile e tsoang maling.
Mekhoa ea ts'ebeliso Glibenclamide le litekanyetso
Glibenclamide e nooa ka molomo kamora ho ja hang kapa habeli ka letsatsi. Litekanyetso tsa moriana li hlalosoa ke ngaka ka bo eona, ho latela boteng ba lefu lena. Qala kalafo ka 2,5 - 5.0 - 10,0 mg ka letsatsi. Kamora hore boemo ba glucose maling bo tloaelehe, tekanyo ea tlhokomelo e ka lekana le 5.0 - 7.5 mg ka letsatsi.
Haeba ka nako ea libeke tse 6 lethalano la letsatsi le letsatsi la 20 mg le sa fane ka phello ea meriana, lithethefatsi ha li na katleho e lekaneng bakeng sa mokuli enoa. Tabeng ena, Glibenclamide e ka kopanngoa le li-analogues tsa eona kapa li-biguanides. Haeba motsoako ona o sa thusa, ho bohlokoa ho fana ka ts'ebeliso ea insulin.
Haeba phetoho e etsoa ho tsoa ho sethethefatsi se seng se theolelang tsoekere ea mali, ho nooa tekanyetso ea letsatsi le letsatsi ea 2,5 mg. Haeba ho hlokahala, e nyoloha ka matsatsi a mang le a mang a 5 mg ho fihlela matšeliso a fumaneha. Tekanyo e phahameng ke 20 mg.
Ho khethoa ha Glibenclamide ka nako e le ngoe le butadione, li-inhibitors tsa MAO, le li-coumarin derivatives ha li khothaletsoe. Ho lokela hore ho sebelisoe tlhokomeliso nakong ea tsamaiso ea sethethefatsi sena hammoho le li-anabolic steroids, li-blockers tsa H3-histamine receptor le chloramphenicol.
Contraindication
Ho ea ka litaelo, Glibenclamide ha ea lokela ho nkoa ka lebaka la ho akheha le ho lahleheloa ke kelello, ketoacidosis, ho senyeha ha lesapo la mokokotlo le hepatic, leukopenia, palo ea liplatelete, hammoho le bongoaneng le bohlankaneng.
Ts'ebeliso ea lithethefatsi bakeng sa basali nakong ea kemaro le lactation ha e khothalletsoe.
