Litaelo tsa Thioctacid - BV (Thioctacid - HR) bakeng sa tšebeliso

Thioctacid BV: litaelo tsa tšebeliso le litlhahlobo

Lebitso la Latin: Thioctacid

Khoutu ea ATX: A16AX01

Motsoako o sebetsang: thioctic acid (thioctic acid)

Mohlahisi: GmbH MEDA Production (Jeremane)

Nchafatso ea litlhaloso le foto: 10.24.2018

Litheko makaleng a meriana: ho tloha ho li-ruble tse 1605.

Thioctacid BV ke lithethefatsi tsa metabolic tse nang le litlamorao tsa antioxidant.

Sokolla foromo le sebopeho

Thioctacid BV e fumaneha ka mokhoa oa matlapa a koahetsoeng ka koae ea filimi: botala bo botala-mosehla, li-oblong biconvex (li-pcs tse 30, 60 kapa 100. Ka libotlolong tsa khalase tse lefifi, botlolo e le 'ngoe ka lebokoseng la karete.

Letlapa le le leng le na le:

• ntho e sebetsang: thioctic (alpha-lipoic) acid - 0,6 g,
• likarolo tse thusang: magnesium stearate, hyprolose, hyprolose e nkiloeng ka tlase,
• sebopeho sa koaelo ea filimi: titanium dioxide, macrogol 6000, hypromellose, varnish ea aluminium e thehiloeng ho indigo carmine le dae quinoline e ntšo, talc.

Pharadodynamics

Thioctacid BV ke lithethefatsi tsa metabolic tse ntlafatsang li-trophic neurons, li na le hepatoprotective, hypocholesterolemic, hypoglycemic, le lipid-lowering liphello.

Sesebelisoa se sebetsang sa lithethefatsi ke thioctic acid, e leng 'meleng oa motho ebile ke antioxidant ea endo native. Ha e le coenzyme, e nka karolo phosphorylation ea oxidative ea pyruvic acid le alpha-keto acid. Mochine oa ts'ebetso oa thioctic acid o haufi le phello ea biochemical ea livithamini tsa B. E thusa ho sireletsa liseleng ho tsoa litlamong tse chefo tsa radicals tse sa fetoheng tse etsahalang lits'ebetsong tsa metabolic, 'me li sitisa metsoako ea chefo e tsoang' meleng. Ho eketsa boemo ba glutathione ea endo native antioxidant, ho baka ho fokotseha ho teba ha matšoao a polyneuropathy.

Matla a synergistic a thioctic acid le insulin ke keketseho ea ts'ebeliso ea tsoekere.

Mofumahali

Ho amoheloa ha thioctic acid ho tsoa lipakeng tsa gastrointestinal (GIT) ha e tsamaisoa ka molomo e etsahala kapele le ka botlalo. Ho nka sethethefatsi ka lijo ho ka fokotsa ho monya ha eona. C_max (mahloriso a mangata) plasma ea mali kamora ho nka tekanyetso e le 'ngoe e fumanoa kamora metsotso e 30 mme ke 0.004 mg / ml. Tekanyo e felletseng ea Thioctacid BV ke 20%.

Pele o kenella ho potoloha ha tsamaiso ea mali, thioctic acid e feta phello ea karolo ea pele e kenang ka har'a sebete. Mekhoa e kholo ea metabolism ea eona ke oxidation le conjugation.

T_1/2 (halofo ea bophelo) ke metsotso e 25.

Tlhahiso ea ntho e sebetsang ea Thioctacid BV le metabolites li etsoa ka liphio. Ka moroto, 80-90% ea lithethefatsi e hlobolisitsoe.

Litaelo tsa ho sebelisa Thioctacid BV: mokhoa le litekanyetso

Ho ea ka litaelo, Thioctacid BV 600 mg e nooa ka mpeng e se nang letho kahare, lihora tse 0.5 pele ho lijo tsa hoseng, e metsa e felletseng mme e nooa metsi a mangata.

Tekanyetso e khothalelitsoeng: 1 pc. Hang ka letsatsi.

Ha ho fanoa ka ts'ebeliso ea bongaka, bakeng sa kalafo ea mefuta e matla ea polyneuropathy, ts'ebetso ea pele ea tharollo ea thioctic acid bakeng sa tsamaiso ea methapo (Thioctacid 600 T) e khonahala ka nako ea matsatsi a 14 ho isa ho a 28, e lateloe ke phetisetso ea mokuli ho ea ts'ebelisong ea letsatsi le letsatsi ea lithethefatsi (Thioctacid BV).

Litlamorao

• ho tsoa ho ts'ilo ea lijo: hangata - ho nyekeloa pelo, hangata - ho hlatsa, bohloko ka mpeng le mala, lets'ollo, tlolo ea methapo ea maikutlo,
• ho tloha tsamaisong ea methapo: hangata - ho tsekela,
• karohano e bakoang ke ho hlaseloa ke lintho tse sa utloahaleng: ka seoelo - ho hlohlona, ​​lekhopho la letlalo, urticaria, ho ts'oaroa hoa moea,
• ho tsoa 'meleng ka kakaretso: ka seoelo - ho fokotseha ha tsoekere ea mali, ponahalo ea matšoao a hypoglycemia ka hlooho, pherekano, mofufutso o eketsehileng, le ho senyeha hoa mahlo.

Bongata

Matšoao: Khahlano le semelo sa tekanyetso e le 'ngoe ea 10-40 g ea thioctic acid, ho tahoa ho matla ho ka hlaha ka lipontšo tse kang ho ts'oaroa ka mokhoa o phollatsi, hypoglycemic coma, likhathatso tse matla tsa tekano ea acid-base, lactic acidosis, mathata a tsoang mali a mangata (ho kenyeletsa le lefu).

Phekolo: haeba ho belaelloa tekanyetso e fetang ea Thioctacid BV (tekanyetso e le 'ngoe bakeng sa batho ba baholo ho feta matlapa a 10, ngoana o feta 50 mg ka kilo e le' ngoe ea boima ba hae ba mmele), mokuli o hloka ho kenella sepetlele hanghang ka ho beoa kalafo ea matšoao. Haeba ho hlokahala, kalafo ea anticonvulsant e sebelisoa, mehato ea tšohanyetso e reretsoeng ho boloka mesebetsi ea litho tsa bohlokoa.

Litaelo tse khethehileng

Kaha ethanol ke sesosa sa kotsi bakeng sa nts'etsopele ea polyneuropathy mme e baka ho fokotseha hoa katleho ea kalafo ea Thioctacid BV, tšebeliso ea joala e hanyetsoa ka thata ho bakuli.

Phekolo ea lefu la tsoekere la polyneuropathy, mokuli o lokela ho theha maemo a netefatsang hore ho ba le tsoekere e ngata maling.

Fomati ea ho lokolloa, ho paka le sebopeho Thioctacid ® BV

Matlapa, filimi e koahetsoeng ka 'mala o mosehla-botala, oblong, biconvex.

Bahlomphehi: hyprolose e nkang sebaka se tlase - 157 mg, hyprolose - 20 mg, magnesium stearate - 24 mg.

Sebopeho sa seaparo sa filimi: hypromellose - 15,8 mg, macrogol 6000 - 4.7 mg, titanium dioxide - 4 mg, talc - 2.02 mg, alarnum varnish e thehiloeng ho dae quinoline e sootho - 1,32 mg, alarnum varnish e thehiloeng ho indigo carmine - 0,16 mg.

Li-pcs tse 30 - libotlolo tsa khalase tse lefifi (1) - lipakete tsa karete.
Likhomphutha tse 60. - libotlolo tsa khalase tse lefifi (1) - lipakete tsa karete.
Li-pcs tse 100 - libotlolo tsa khalase tse lefifi (1) - lipakete tsa karete.

Ho sebelisana le lithethefatsi

Ka tšebeliso e tšoanang ea Thioctacid BV:

• Cisplatin - e fokotsa matla a eona a ho phekola,
• insulin, li-agents tsa hypoglycemic tsa molomo - li ka ntlafatsa ts'ebetso ea tsona, ka hona, ho hlahlojoa khafetsa maemo a tsoekere ea mali ho hlokahala, haholo-holo qalong ea phekolo ea motsoako, haeba ho hlokahala, phokotso ea tekanyetso ea lithethefatsi tsa hypoglycemic,
• ethanol le metabolites tsa eona - li baka ho fokola ha moriana.

Hoa hlokahala ho ela hloko thepa ea thioctic acid ho tlamisa tšepe ha e kopantsoe le lithethefatsi tse nang le tšepe, magnesium le tšepe tse ling. Ho khothalletsoa hore ho amoheloa ha bona ho chechisoe thapama.

Tlhahlobo ho Thioctacide BV

Tlhahlobo ea Thioctacide BV hangata e ntle. Bakuli ba nang le lefu la tsoekere ba bontša ho fokotseha ha tsoekere ea mali le cholesterol, bophelo bo botle khahlano le semelo sa tšebeliso ea lithethefatsi ka nako e telele. Karolo ea lithethefatsi ke tokollo e potlakileng ea thioctic acid, e thusang ho potlakisa lits'ebetso tsa metabolic le ho tlosoa hoa mafura a tsoang 'meleng, phetoho ea lik'habohaedreite matla.

Tšusumetso e ntle ea kalafo e hlokomeleha ha u sebelisa moriana bakeng sa kalafo ea sebete, mafu a methapo le botenya. Ha ho bapisoa le li-analogues, bakuli ba bonts'a boemo bo tlase ba litlamorao tse sa batleheng.

Ho bakuli ba bang, ho sebelisa moriana ona ho ne ho se na phello e lebelletsoeng ea ho theola cholesterol kapa ho tlatsetsa ho nts'etsopele ea urticaria.

Ketso ea pharmacological

Lithethefatsi tsa Metabolic. Thioctic (α-lipoic) asiti e fumanoa 'meleng oa motho, moo e sebetsang e le coenzyme phosphorylation ea oxidative ea pyruvic acid le alpha-keto acid. Thioctic acid ke antioxidant ea mehleng; ho ea ka ts'ebetso ea biochemical ea ts'ebetso, e haufi le livithamini tsa B.

Thioctic acid e thusa ho sireletsa lisele ho litlamorao tsa chefo ea radicals e fumanehang lits'ebetsong tsa metabolic, e boetse e kenyelletsa metsoako ea chefo e tsoang ka hare ho mmele. Thioctic asiti e eketsa khatello ea "glutathione" ea endo native antioxidant glutathione, e lebisang ho fokotseheng le ho teba ha matšoao a polyneuropathy.

Lithethefatsi li na le hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect, e ntlafatsa li-neurons tsa trophic. Ketso ea synergistic ea thioctic acid le insulin e hlahisa ts'ebeliso e matla ea tsoekere.

Sebopeho, litlhaloso, sebopeho le phepelo ea moriana

U ka reka meriana ka mefuta e 'meli e fapaneng:

• Litokisetso tsa molomo "Thioctacid BV" (matlapa). Taelo ea tšebeliso e re e na le sebopeho sa khanyetsano, joalo ka khetla e mosehla kapa e nang le botala bo botala. Ha li rekisoa, matlapa a joalo a tla ka libotlolo tsa likotoana tse 30. Sesebelisoa se sebetsang sa sesebelisoa sena ke thioctic acid. Moriana ona o boetse o kenyelletsa lintho tse eketsehileng ka sebopeho sa hydroxypropyl cellulose e sa nkeloang sebaka se phahameng, magnesium stearate, hydroxypropyl cellulose, hypromellose, macrogol 6000, quinoline yellow aluminium letsoai, titanium dioxide, talc le indigo carmine aluminium salts.
• Tharollo "Thioctacid BV" 600. Litaelo tsa ts'ebeliso li tlaleha hore mofuta ona oa lithethefatsi o etselitsoe ente ea methapo. Tharollo e hlakile ke 'mala o mosehla,' me ea fumaneha ka metsing a mafifi a khalase. Karolo ea eona e sebetsang e boetse e le thioctic acid. Joaloka lintho tse ling, ho sebelisoa metsi a hloekisitsoeng le trometamol.

Thutela-litso

'Meleng oa motho, acid ea thioctic e bapala karolo ea coenzyme, e amehang molemong oa ho fetoha hoa oksijene ea phosphorylation ea alpha-keto acid, hammoho le acid ea pyruvic. Ntle le moo, ke antioxidant ea mehleng. Ka molao-motheo oa ts'ebetso (biochemical), motsoako ona o haufi haholo le livithamini tsa B.

Ho latela litsebi, thioctic acid e sireletsa lisele ho litlamorao tsa chefo ea li-radicals tsa mahala tse thehiloeng nakong ea metabolism. E boetse e thusa ho kenyelletsa metsoako ea chefo e tsoang ka hare ho 'mele oa motho.

Thepa ea lithethefatsi

Mpa ea lithethefatsi "Thioctacid BV 600 ke eng? Litaelo tsa tšebeliso li tlaleha hore acid ea thioctic e khona ho eketsa bongata ba li-antioxidant tse joalo joalo ka glutathione. Phello e ts'oanang e lebisa phokotsong e kholo ea ho teba ha matšoao a polyneuropathy.

Ha ho khonehe hore re se ke ra re sethethefatsi seo ho buuoang ka sona se na le hypoglycemic, hepatoprotective, hypocholesterolemic and hypolipidemic effect. Hape o khona ho ntlafatsa li-neurons tsa trophic.

Liphello tsa synergistic tsa thioctic acid le insulin li eketsa ts'ebeliso ea tsoekere.

Contraindication

Ka lebaka la ho haelloa ke boiphihlelo bo lekaneng ka tšebeliso ea sesebelisoa sena le lithuto tsa bongaka, ha ho khothalletsoe haholo ho e khetha ho bo-mme le basali baimana.

Na hoa khoneha ho fa ngoana sethethefatsi "Thioctacid 600BV"? Tšebeliso ea moriana ona ho bana le lilemong tsa bocha ha hoa lumelloa. Hape, ha ea lokela ho sebelisoa haeba ho e-na le karabelo e itseng ho e 'ngoe ea likarolo.

Boikutlo bo fapaneng

Ka tsamaiso ea kahare ea lithethefatsi, mokuli a ka ba le litlamorao tse sa rateheng:

• karabelo ea ho kulisa ka mokhoa oa lekhopho le ho hlohlona letlalong, hammoho le urticaria,
• litla-morao tse tsoang ho tšilo ea lijo (lets'ollo, ho nyekeloa le pelo, bohloko le ho hlatsa).

Ha e le foromo e enteloang, hangata e baka:

• lekhopho la letlalo, ho thothomela ha anaphylactic le ho hlohlona,
• ho hema ka thata le ho eketseha ka sekhahla ha khatello (intracranial),
• ho tsoa mali, makhopho, mathata a pono le ho hema hanyane.

Litaba tsa ho sebelisa lithethefatsi tse ngata

Haeba litekanyetso tsa moriana tse khothalelitsoeng li ka feta, mokuli a ka ba le matšoao a kang ho tsitsipana, lactic acidosis, mathata a ho tsoa mali le mokokotlo oa hypoglycemic.

Ha u bona karabelo e joalo, u lokela ho ea ngakeng, 'me hape u hlatse ho hlaseloa, mo fe li-enterosorbents le ho hlatsoa mpa ea hau. Mokuli le eona e lokela ho tšehetsoa ho fihlela ambulense e fihla.

Foromo ea litekanyetso

Matlapa a koahetsoeng ka filimi ea 600 mg

Letlapa le leng le na le

ntho e sebetsang - thioctic acid (alpha lipoic) 600 mg,

Baeti: hydroxypropyl cellulose, hydroxypropyl selulose, magnesium stearate,

hypromellose, macrogol 6000, titanium dioxide (E 171), talc, quinoline eu (E 104), indigo carmine (E 132).

Matlapa, a koahetsoeng ka 'mala oa lamunu-botala, a lutseng ka sebopeho le biconvex.

Li-analog le litšenyehelo

Pheta sethethefatsi se kang Thioctacid BV ka lithethefatsi tse latelang: Berlition, Alpha Lipon, Dialipon, Tiogamm.

Ha e le theko, e ka fapana bakeng sa mefuta e fapaneng le ea baetsi. Litšenyehelo tsa sebopeho sa letlapa la "Thioctacid BV" (600 mg) li ka bang li-ruble tse 1700 ka likotoana tse 30. Motsoana o ka tharollo o ka rekoa li-ruble tse 1,500 (bakeng sa likotoana tse 5).

Litlhahlobo mabapi le lithethefatsi

Joalokaha u tseba, lithethefatsi "Thioctacid BV" e etselitsoe batho ba nang le mathata a tebileng a metabolic. Litlhahlobo tsa bakuli mabapi le sebopeho sa letlapa lia ferekanya. Ho latela litlaleho tsa bona, sesebelisoa sena se sebetsa haholo. Empa ka bomalimabe, hangata litafole li baka karabelo e mpe, e iponahatsang ka lebaka la ho nyekelwa ke pelo, urticaria, mme ka linako tse ling e le ka mokhoa o benyang o fetisang le ho fetoha hoa bophelo ba mokuli le maikutlo.

Joale o tseba seo moriana oa "Thioctacid BV 600" o fanang ka litaelo, theko ea meriana ena e hlalositsoe kaholimo.

Maikutlo mabapi le pheko e boletsoeng ha a tlohele feela bakuli ba nkile mofuta oa eona oa matlapa, empa le ba ba fuoeng tharollo ea ente.

Ho ea ka litlaleho tsa batho ba joalo, litla-morao tsa ts'ebetso ea methapo ea methapo e atileng haholo. Ho feta moo, ha li phatlalatsoe joalo ka ha ho nooa lipilisi.

Kahoo, ho ka hlokomeloa ka polokeho hore "Thioctacid BV" ke sesebelisoa se sebetsang haholo se etselitsoeng ho loants'a matšoao a polyneuropathy a ileng a hlaha kamora ho nka nako e telele ea lino tse tahang kapa khahlanong le semelo sa lefu la tsoekere.

Melemo ea pharmacological

Mofumahali

Ka tsamaiso ea molomo, ho kenngoa ka potlako acid ea thioctic (alpha-lipoic) 'meleng. Ka lebaka la kabo e potlakileng holim'a lithaelese, halofo ea bophelo ba thioctic (alpha-lipoic) acid e plasma ea mali e ka ba metsotso e 25. Khatiso e phahameng ka ho fetisisa ea plasma ea 4 μg / ml e ne e lekantsoe lihora tse 0.5 kamora ho tsamaisoa ha molomo ka 600 mg ea alpha lipoic acid. Ho tlosoa hoa moriana ho hlaha haholo ka liphio, 80-90% - ka mokhoa oa metabolites.

Pharadodynamics

Thioctic (alpha-lipoic) asiti ke antioxidant ea mahareng mme e sebetsa e le coenzyme ho decidboxylation ea oxidative ea alpha-keto acid. Hyperglycemia e bakoang ke lefu la tsoekere e lebisa ho bokelleng ha glucose ho liprotheine tsa methapo ea methapo ea mali le ho etsoa ha seo ho thoeng ke "lihlahisoa tsa ho fela ha glycation e feteletseng." Ts'ebetso ena e lebisa ho fokotseha ha phallo ea mali a endoneural le hyponeia-ischemia, e kopantsoeng le tlhahiso e eketsehang ea li-radicals tsa mahala tsa oksijene, tse lebisang tšenyehong ea methapo ea kutlo le ho theoha ha li-antioxidants tse kang glutathione.

Tekanyetso le tsamaiso

Nka pilisi e le 'ngoe ea Thioctacid 600BV hang ka letsatsi ka tekanyetso e le' ngoe, metsotso e 30 pele ho lijo tsa pele.

Jella ka mpeng e se nang letho, ntle le ho hlafuna le ho noa metsi a mangata. Ho kopantsoe le takatso ea lijo ho ka fokotsa ho monya ha alpha lipoic acid.

Nako ea kalafo e khethoa ke ngaka e eang ka bonngoe.

Ho sebelisana le lithethefatsi

Ho bile le phokotseho ts'ebetsong ea cisplatin ha e fanoa ka nako e ts'oanang le thioctacid. Setlhare ha sea lokela ho laeloa ka nako e le ngoe le tšepe, magnesium, potasiamo, nako ea nako lipakeng tsa tekanyetso ea lithethefatsi tsena e lokela ho ba bonyane lihora tse 5. Kaha tšusumetso ea ho fokotsa tsoekere ea insulin kapa li-antidiabetesic agents e ka ntlafatsoa, ​​ho khothaletsoa ho lekola tsoekere ea mali hangata, haholoholo qalong ea kalafo le Thioctacid 600BV. Bakeng sa ho qoba matšoao a hypoglycemia, ho hlokahala ho hlahloba ka hloko boemo ba tsoekere maling.

Setifikeiti sa ho ingolisa

MEDA Pharma GmbH & Co KG, Jeremane

Aterese ea mokhatlo e amohelang likopo ho tsoa ho bareki ka boleng ba lihlahisoa Rephaboliking ea Kazakhstan Moemeli oa MEDA Pharmaceuticals Switzerland GmbH Rephabliking ea Kazakhstan: Almaty, 7 Al-Farabi Ave., PFC "Nurly Tau", moaho oa 4 A, ofisi 31, tel. 311-04-30, 311-52-49, tel / fekse 277-7732