Likhatiso tsa matlapa a Rosucard

Likhatiso tsa rosucard ea lithethefatsi, li ka fetolehang ka mokhoa o amang 'mele, ho hlahisoa litokisetso tse nang le ntho e le' ngoe kapa tse ling tse tšoanang. Ha u khetha li-synonyms, u se ke ua nahana feela ka litšenyehelo tsa bona, empa hape le naha ea tlhahiso le botumo ba moetsi.

1. Tlhaloso ea lithethefatsi
2. Lethathamo la li-analogues le litheko
3. Litlhahlobo
4. Litaelo tsa semmuso bakeng sa tšebeliso

Tlhaloso ea lithethefatsi

Rosucard - Sethethefatsi sa hypolipidemic se tsoang sehlopheng sa li-statins. Inhibitor e khethiloeng ea HMG-CoA reductase, enzyme e fetolang HMG-CoA ho mevalonate, moetapele oa k'holeseterole (Ch).

E eketsa palo ea li-receptor tsa LDL holim'a li-hepatocytes, tse lebisang ho ho eketseha le ho ts'oaroa ha LDL, thibelo ea tlhahiso ea VLDL, ho fokotsa kakaretso ea LDL le VLDL. E fokotsa mokokotlo oa LDL-C, HDL cholesterol-non-lipoproteins (HDL-non-HDL), HDL-V, cholesterol e felletseng, TG, TG-VLDL, apolipoprotein B (ApoV), e fokotsa karolelano ea LDL-C / LDL-C, kakaretso HDL-C, Chs-eseng HDL / Cs-HDL, ApoB / apolipoprotein A-1 (ApoA-1), e eketsa khatello ea Cs-HDL le ApoA-1.

Phello ea ho fokotsa lipid e lekana ka kotloloho le tekanyo ea tekanyo e boletsoeng. Phello ea kalafo e hlahella ka hara beke 1 kamora ho qala kalafo, kamora libeke tse peli e fihla ho 90% ea boholo, e fihla hofihlella ka libeke tse 4 ebe e lula e le joalo.

Tafole 1. Phello e itšetlehileng ka tekanyetso ho bakuli ba nang le hypercholesterolemia ea mantlha (mofuta oa IIa le IIb ho latela sehlopha sa Fredrickson) (phetoho e tloaelehileng ea liperesente ha e bapisoa le boleng ba pele)

Dose	Palo ea bakuli	HS-LDL	Kakaretso ea kakaretso	HS-HDL
Sebaka sa sebaka	13	-7	-5	3
10 mg	17	-52	-36	14
20 mg	17	-55	-40	8
40 mg	18	-63	-46	10
Dose	Palo ea bakuli	TG	Xc- e seng HDL	Apo v	Apo AI
Sebaka sa sebaka	13	-3	-7	-3	0
10 mg	17	-10	-48	-42	4
20 mg	17	-23	-51	-46	5
40 mg	18	-28	-60	-54	0

Tafole 2. Phello e itšetlehileng ka tekanyetso ho bakuli ba nang le hypertriglyceridemia (mofuta IIb le IV ho ea ka phapanyetsano ea Fredrickson) (phetoho e tloaelehileng ea liperesente ha e bapisoa le boleng ba pele)

Dose	Palo ea bakuli	TG	HS-LDL	Kakaretso ea kakaretso
Sebaka sa sebaka	26	1	5	1
10 mg	23	-37	-45	-40
20 mg	27	-37	-31	-34
40 mg	25	-43	-43	-40
Dose	Palo ea bakuli	HS-HDL	Xc- e seng HDL	Xc- VLDL	TG- VLDL
Sebaka sa sebaka	26	-3	2	2	6
10 mg	23	8	-49	-48	-39
20 mg	27	22	-43	-49	-40
40 mg	25	17	-51	-56	-48

Ho sebetsa hantle ha kliniki

E sebetsa hantle ho bakuli ba baholo ba nang le hypercholesterolemia e nang le kapa ntle le hypertriglyceridemia, ho sa tsotelehe hore na ke ba morabe ofe, bong kapa lilemo. ho bakuli ba nang le lefu la tsoekere le "hypercholesterolemia" ea lefu la tsoekere. Ho 80% ea bakuli ba nang le mofuta oa IIa le IIb hypercholesterolemia (ho latela sehlopha sa Fredrickson) ba nang le karolelano ea mantlha ea LDL-C e ka bang 4,8 mmol / L, ha ba ntse ba sebelisa lithethefatsi ka tekanyetso ea 10 mg, khatello ea LDL-C e fihla tlase ho 3 mmol / L.

Ho bakuli ba nang le heterozygous Familyal hypercholesterolemia ba fumanang rosuvastatin ka tekanyo ea 20-80 mg / ka letsatsi, ho ile ha bonoa tšusumetso e ntle ea profid ea lipid. Kamora ho kenella litekong tsa letsatsi le letsatsi tsa 40 mg (libeke tse 12 tsa kalafo), ho fokotseha hoa khatello ea LDL-C ke 53% ho hlokometsoe. Ho bakuli ba mashome a mararo a metso e meraro (33%) ea bakuli, lenane la LDL-C le ka tlase ho 3 mmol / L le fihletsoe.

Ho bakuli ba nang le homozygous Familyal hypercholesterolemia ba fumanang rosuvastatin ka lethal dose ea 20 mg le 40 mg, ho fokotseha ho hoholo ha khatello ea LDL-C ho ne ho le 22%.

Ho bakuli ba nang le hypertriglyceridemia ba nang le khatello ea mantlha ea TG ho tloha ho 273 mg / dL ho isa ho 817 mg / dL, ba amohelang rosuvastatin ka tekanyetso ea 5 mg ho isa ho 40 mg 1 nako / letsatsi bakeng sa libeke tse 6, khatello ea TG maling a mali e fokotsehile haholo (bona tafole 2 )

Phello ea tlatsetso e bonoa hammoho le fenofibrate ha e bapisoa le khatello ea kelello ea TG le nicotinic acid ho lipid tse fokotsang litekanyetso (tse fetang 1 g / letsatsi) mabapi le khatello ea HDL-C.

Phuputsong ea METEOR, kalafo ea rosuvastatin e fokotsitse sekhahla sa tsoelo-pele ea boholo bo boholo ba "intima-media complex" (TCIM) bakeng sa likarolo tse 12 tsa mokokotlo oa carotid ha o bapisoa le placebo. Ha ho bapisoa le litekanyetso tsa motheo sehlopheng sa rosuvastatin, ho fokotseha ha TCIM e phahameng ka 0.0014 mm / selemo ho ile ha bonoa ha ho bapisoa le keketseho ea letšoao lena ka 0.0131 mm / selemo sehlopheng sa placebo. Ho fihla joale, kamano e tobileng pakeng tsa ho fokotseha ha TCIM le ho fokotseha ha menyetla ea liketsahalo tsa pelo ha e so bontšoe.

Liphetho tsa boithuto ba JUPITER li bonts'itse hore rosuvastatin e fokotse haholo kotsi ea ho ba le mathata a pelo le phokotseho ea kotsi ea 44%. Ho sebetsa hantle ha kalafo ho ile ha bonoa kamora likhoeli tse 6 tsa pele tsa ho sebelisa moriana. Ho bile le ho fokotseha ho hoholo ha lipalo ho 48% ho ntlha e kopaneng, ho kenyelletsa le lefu le bakoang ke pelo, ho fokotseha hoa lefu la 54% ha motho a bolaoa kapa a sa bolaee motho ka boeena, le 48% ea lefu le bolaeang kapa le sa bolaeang. Ho shoa ha batho ka kakaretso ho fokotsehile ka 20% sehlopheng sa rosuvastatin. Boemo ba polokeho ho bakuli ba nkang rosuvastatin ea 20 mg hangata bo ne bo tšoana hantle le boemo ba polokeho sehlopheng sa placebo.

Likhakanyo tsa lithethefatsi Rosucard

Analogue e theko e tlase ho li-ruble tse 529.

Moetsi: Biocom (Russia)
Mefuta ea Tsamaiso:

• Letlapa 10 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 110
• Letlapa 20 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 186

Litheko tsa Atorvastatin lifekthering tsa marang-rang
Litaelo tsa ho sebelisoa

Atorvastatin ke litokisetso tse lokiselitsoeng bakeng sa ho phekola le ho thibela mafu a pelo. Contraindred nakong ea bokhachane, lactation le ho bana ba ka tlase ho lilemo tse 18.

Analogue e theko e tlaase ho tloha li-ruble tse 161.

Moetsi: Pharmstandard (Russia)
Mefuta ea Tsamaiso:

• Letlapa 10 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 478
• Letlapa 20 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 790

Litheko tsa Acorta ka litlhare tsa marang-rang
Litaelo tsa ho sebelisoa

Akorta ke lithethefatsi tse entsoeng ka Serussia tse fumanehang ka mokhoa oa matlapa 'me li reretsoe kalafo ea mafu a methapo ea pelo. E kopantsoe le ho ima le ho nyeka. Ho na le litla-morao.

Analogue e theko e tlaase ho tloha li-ruble tse 176.

Moetsi: AstraZeneca (UK)
Mefuta ea Tsamaiso:

• Letlapa 10 mg, 7 li-pcs., Theko ho tloha 463 li-ruble
• Letlapa 20 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 790

Litheko bakeng sa Crestor ho litlhare tsa marang-rang
Litaelo tsa ho sebelisoa

Krestor ke lithethefatsi bakeng sa ho phekola maloetse a methapo ea pelo. E le ntho e sebetsang, rosuvastatin ka bongata ba 5 mg e sebelisoa. bakeng sa Letlapa le le leng. Ho na le li-contraindication le litla-morao.

Analogue e theko e tlaase ho tloha li-ruble tse 180.

Moetsi: Jonathan Richter (Hungary)
Mefuta ea Tsamaiso:

• Matlapa a 5 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 459
• Letlapa 20 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 790

Litheko tsa Mertenil ka litlhare tsa marang-rang
Litaelo tsa ho sebelisoa

Mertenil ke sethethefatsi se fokotsang lipid sa Hungary se thehiloeng ho rosuvastatin. E rekisitsoe ka mabokoseng a matlapa a 30. Matšoao a mantlha a kopano: hypercholesterolemia, hypertriglyceridemia (mofuta oa IV ho ea ka Fredrickson), le thibelo ea mantlha ea mathata a maholo a pelo (lefu la pelo, ho nyekeloa ke pelo, ho hlaseloa ha methapo ea kutlo).

Analogue e theko e tlaase ho tloha li-ruble tse 223.

Moetsi: Krka (Slovenia)
Mefuta ea Tsamaiso:

• Tab. p / obol. 5 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 416
• Letlapa 20 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 790

Litheko tsa Roxer lihoebi tsa marang-rang
Litaelo tsa ho sebelisoa

Roxera ke lithethefatsi tse theolelang ka tlase ho lipid. E fumaneha ka mokhoa oa matlapa a nang le rosuvastatin ka tekanyo ea 5 ho isa ho 20 mg. E sebelisetsoa ho fokotsa cholesterol e phahameng ea mali.

Analogue e theko e tlaase ho tloha li-ruble tse 371.

Moetsi: Belupo (Kroatia)
Mefuta ea Tsamaiso:

• Matlapa a 10 mg 14 likhomphutha., Theko e tsoang ho li-ruble tse 268
• Letlapa 20 mg, li-pcs tse 30., Theko e tsoang ho li-ruble tse 790

Litheko tsa Rosistark ka litlhare tsa marang-rang
Litaelo tsa ho sebelisoa

Rosistark ke sethethefatsi sa hypolipidemic sa sehlopha sa statins. Ho kenyelletsa molek'hule ea rosuvastatin. Lowers cholesterol le dikarolwana tsa yona, e tlosa ho se sebetse ha endothelial. E na le thepa ea antiproliferative le antioxidant. E fuoe hypercholesterolemia, e eketsa triglycerides maling, e le ho felisa ho ata ha atherosulinosis le ho fokotsa kotsi ea likotsi tsa vascular. Lihlahisoa tsohle tse nang le rosuvastatin li sebelisoa ka nako efe kapa efe ea letsatsi, ho sa tsotelloe lijo tse ngata. Li-contraindication tse felletseng tsa ts'ebeliso ke mafu a tebileng a liphio le sebete, myopathy, basali ba lilemo tsa ho ikatisa ntle le lithibela-pelehi. Litlamorao tsa litla-morao, tse atileng haholo ke ho sokela, ho opeloa ke hlooho le ho opeloa ke mesifa.

Analogue e theko e tlase ho li-ruble tse 305.

Moetsi: Aegis (Hungary)
Mefuta ea Tsamaiso:

• Tab. p / obol. 5 mg, 28 likhomphutha., Theko e tsoang ho li-ruble tse 334
• Tab. p / obol. 10 mg, li-pcs tse 28., Theko e tsoang ho li-ruble tse 450

Litheko tsa Rosulip lifekthering tsa marang-rang
Litaelo tsa ho sebelisoa

Rosulip ke rosuvastatin e 'ngoe ea sehlopha sa statin. E hlahisoa, joalo ka Rosart, hammoho le li-rosuvastatin tsohle tse teng ka mokhoa oa matlapa. Ha e nkuoa, e theola maemo a phahameng a choleopoloteine, lipoprotein tse tlaase le tse tlase haholo (LDL, VLDL), triglycerides, 'me e eketsa lipenshene tse phahameng tsa methapo ea methapo, e sirelletsang' mele oa motho ho tloha liphihlelong tsa pelo le bokong. E ntlafatsa thepa ea mali, e thibela ho etsoa ha li-plaque atherosselotic. Matšoao a sebelisang, litekanyetso le kalafo ea tsamaiso, li-contraindication le litla-morao li tšoana hantle le Rosart le Rosistark, hobane lithethefatsi tsena kaofela li na le rosuvastatin.

Thepa ea lithethefatsi

Ho khetha li-analogues tsa Rosucard, o hloka ho fumana hore na e na le thepa efe. Setlhare se fumaneha ka mokhoa oa litafole tsa 10 mg. Setlhare se fokotsa bongata ba li-lipoprotein tse fokolang kapa "cholesterol" e mpe ebe se eketsa palo ea lipoprotein tse phahameng. Sesebelisoa sa mantlha se sebetsang ke rosuvastatin.

E sebelisoa bakeng sa atherosclerosis, hyperlipidemia, hypercholesterolemia. E ka sebelisoa e le prophylactic khahlano le mafu a pelo le pelo.

Hoa hlokahala ho kopanya ho nka lipilisi le lijo tse fokotsang lipid, ke hore, phepo e nepahetseng, eo ho fokotsoang mafura a mangata.

Tsela ea kalafo ka moriana e lokela ho nka khoeli. Tekanyetso e khethoa ke ngaka ka bonngoe. Phekolo e etsoa ka tlasa taolo e matla ea cholesterol ea mokuli le tsoekere, hobane ho na le kotsi ea ho holisa mofuta oa lefu la tsoekere la 2 kamora ho qeta thupelo.

U ke ke ua nka batho ba nang le mafu a joalo:

• ho hloleha ha sebete le meno,
• myopathy
• hypothyroidism.

Hape, sethethefatsi ha se khothaletsoe nakong ea bokhachane, ho lactation, bana ba ka tlase ho lilemo tse 18, ka ho hloka mamello ea lactose.

Phekolo e ka se kopantsoe le joala le cyclosporin immunosuppressant. Tlhokomeliso e lokela ho fuoa bakuli ba fetang lilemo tse 65 le batho ba mofuta oa Mongoloid.

Nakong ea kalafo, litla-morao tse latelang li ka hlaha:

• ho tsekela
• hlooho e bohloko
• ho nyekeloa
• ho sokela
• asthenia
• karabelo
• ts'ebetso ea menoana e sa sebetseng.

Litsenyehelo tsa moriana o nang le matlapa a 30 ke li-ruble tse 870.

Menahano ea lithethefatsi

Akorta ke generic ea Rosucard, kapa ntho e tšoanang ea Serussia. E na le ntho e tšoanang e sebetsang. E fumaneha matlapeng a 10 le 20 mg. Matšoao, li-contraindication le litla-morao li tšoana le tsa Rosucard. Theko ea lithethefatsi e theko e tlaase - li-ruble tse 653.

Atomax Setlhare sena se hlahisoa hammoho ke Russia le India. Sesebelisoa sa mantlha se sebetsang ke atorvastatin calcium trihydrate. E fumaneha ka foromo ea letlapa.

E sebelisetsoa k'holeseterole e phahameng. E kopantsoe le bana, baimana le baimana. Ho lokela hore ho nkuoe tlhokomeliso bakeng sa tlolo ea ka har'a sebete, khatello e tlase ea mali, mathata a endocrine, joala bo sa foleng, lefu la sethoathoa.

Moriana o ka baka litlamorao tse joalo.

• asthenia
• ho hloka boroko
• hlooho e bohloko
• ho lla litsebeng
• mofufutso
• feberu.

Nako ea kalafo ke libeke tse 2-4. Theko ea lithethefatsi ke li-ruble tse 323.

Lipitor - lipilisi tse nang le k'holeseterole e tlase, tlhahiso ea Jeremane. Ntho e sebetsang ke atorvastatin. Theko ke li-ruble tse 630.

Pravastatin ke analogue ea tlhahiso e kopaneng ea Russia le Slovenia. Ntho e sebetsang ke pravastatin sodium. Ka k'holeseterole e phahameng, sethethefatsi se na le phello e sithabetsang ho sona. Hape e fokotsa palo ea li-triglycerin, lipoprotein tse fokolang.

E sebelisoa bakeng sa ho thibela ho hlaseloa khafetsa ha pelo, lefu la pelo, angina pectoris. E sebelisoa e le adjunct ho ja ho fokotsa lipid.

Lithethefatsi li loants'oa mafu a sebete, ho ima le ho nyekeloa.

Nako ea kalafo e tsoa matsatsing a 7 ho isa ho a 28. E etsoa ka ho lekola khafetsa maemo a lipid.

Theko ea lithethefatsi ke li-ruble tse 650 bakeng sa matlapa a 10.

U ka kenya Rosucard ka matlapa a entsoeng ka Seromania - Simvastol. Ntho e sebetsang ea lithethefatsi ke simvastatin. E theola cholesterol ea mali. Nako ea kalafo ke likhoeli tse 1-1,5.

E bontšoa bakeng sa cholesterol e phahameng le lefu la pelo.

Phekolo le moriana o kopantsoe le mafu a joalo:

• lefu la sethoathoa
• lefu la sebete
• hypotension
• likotsi tsa morao tjena le ts'ebetso.

E ka baka litla-morao tse joalo:

• botlaela
• ho nyekeloa
• ho tsekela
• phokolo ea mali
• Keketseho ea ESR
• fokotseha potency.

Matlapa a lokela ho nooa bosiu, a noe metsi hantle. Ha e khothalletsoe ho kopanya le meriana e joalo:

• antifungal agents
• nicotinic acid
• cytostatics
• anticoagulants.

Hape ho lokela ho hopoloa hore tšebeliso ea lero la morara e ntlafatsa matla a sethethefatsi.

Theko ea lithethefatsi ke li-ruble tse 211.

Ariescor ke molekane oa Russia. Sebopeho sa matlapa a kenyelletsa:

• simvastatin
• asiti ea ascorbic
• citric acid
• lactose.

Theko ea analogue ea Russia ke li-ruble tse 430.

Zokor - setlhare se thehiloeng ho simvastatin. E sebelisetsoa k'holeseterole e phahameng. Naha e hlahisang sehlahisoa ke Netherlands. Matšoao le li-contraindication lia tšoana. Theko ke li-ruble tse 572.

Pele o nka lipilisi tse nang le cholesterol e tlase, o lokela ho buisana le ngaka kamehla.

Litulo tsa Serussia le tsa kantle ho Rosucard

Analogue e theko e tlase ho li-ruble tse 529.

Atorvastatin ke sethethefatsi sa hypocholesterolemic, karolo ea mantlha eo e leng enhibitor e 'ngoe ea HMG-CoA reductase: atorvastatin. Tsena ke li-capsules tsa 10, 15 le 20 mg. Ho bontšoa bakeng sa hypercholesterolemia ea tšimoloho efe kapa efe, mafu a lefutso - dysbetalipoproteinemia, hypertriglyceridemia, mefuta e meng ea hyperlipidemia, mafu a tsamaiso ea methapo ea pelo. Motsoako ha oa itšetleha ka morabe ebile o tloha ho 10 ho isa ho 80 mg ea moriana ka letsatsi. E amana le ho se sebetse ha sebete, ho se mamellane ha likarolo tsa moriana, nakong ea kemaro le ho lactation, le ka tlasa lilemo tse 18. E hanana le lithethefatsi tse ngata.

Rosistark (matlapa) Tekanyetso: 40 Holimo

Analogue e theko e tlaase ho tloha li-ruble tse 371.

Rosistark ke analogue ea Rosucard, e fumanehang matlapeng a 10, 20 le 40 mg. E laetsoe mafu a tšoanang le a lithethefatsi tse ling, ntho e sebetsang eo e leng rosuvastatin, ka lipontšo le li-contraindication le eona ha e fapana le tsona. Ha e na tšusumetso ho maikutlo a psychomotor, ka hona e ka sebelisoa ke bakhanni ba likoloi le batho ba laolang lisebelisoa tse ling.

Analogue e theko e tlase ho li-ruble tse 305.

Rosulip e fumaneha matlapeng. Ntho e sebetsang: rosuvastatin. Tekanyetso: 5 mg, 10 mg, 20 mg, 40 mg. Ho ba inhibitor ea HMG-CoA reductase, rosuvastatin e theola cholesterol ea mali le triglycerides mme e laeloa ho lefu la pelo, hypercholesterolemia e bakoang ke lisosa tsa lefutso le lilemo, hypertriglyceridemia. Biooavailability ea ntho ena e phahame ho batho ba morabe oa Mongoloid, ka hona, lithethefatsi tse thehiloeng ho eona li laetsoe ka hloko. Litekanyetso tsa letsatsi le letsatsi, ho latela lefu le boima ba lona, ​​li tloha ho 10 ho isa ho 40 mg.

Analogue e theko e tlaase ho tloha li-ruble tse 223.

Roxera e lumellana ka botlalo ho latela lipontšo le mefuta e meng ea Rosucard e nang le rosuvastatin, e tla ka mokhoa oa matlapa a nang le litekanyetso tsa 5, 10, 15 kapa 20 mg. Lenane le tiileng la li-contraindication le litlamorao tse ka bang teng li ka bonoa ka holimo, hammoho le matšoao a ts'ebeliso. Ha e sebelisoe hammoho le cyclosporine le lithethefatsi tse ling.

Melemo ea pharmacological

Karolo e sebetsang ea lithethefatsi Rosucard rosuvastatin, e na le thepa ea ho thibela ts'ebetso ea reductase, le ho fokotsa ho hlophisoa ha limolek'hule tsa mevalonate, tse ikarabellang ka ho hlophisoa ha cholesterol mehatong ea pele liseleng tsa sebete.

Motsoako ona o na le phello e matlafatsang ea ho phekola lipoprotein, o fokotsa metsoako ea tsona ka lisele tsa sebete, tse fokotsang haholo li-lipoprotein tsa boima ba limolek'hule le ho eketsa bongata ba lipoprotein tse phahameng tsa limolek'hule.

Pharmacokinetics ea sethethefatsi Rosucard:

• Khokahano e phahameng ka ho fetisisa ea likarolo tse sebetsang motsoakong oa plasma ea mali, kamora ho nka matlapa, e etsahala kamora lihora tse 5,
• The bioavailability ea lithethefatsi ke 20.0%,
• Ho pepesetsoa ha Rosucard tsamaisong ho itšetleha ka tekanyetso e ntseng e eketseha,
• 90.0% ea meriana ea Rosucard e tlama liprotheine tsa plasma, hangata, ke protheine ea albin,
• Motsoako oa lithethefatsi tse liseleng tsa sebete nakong ea pele ke hoo e ka bang 10,0%,
• Bakeng sa cytochrome isoenzyme No. P450, motsoako o sebetsang oa rosuvastatin ke substrate,
• Lithethefatsi li hlahisoa ke 90.0% ka makhopho, 'me lisele tsa mala li ikarabella bakeng sa ona,
• 10.0 e qhekelloa ho sebelisa lisele tsa liphio ka moroto,
• The pharmacokinetics ea lithethefatsi Rosucard ha ea itšetleha ka sehlopha sa bakuli, le hore na bong ke bofe. Moriana o sebetsa ka tsela e tšoanang, 'meleng oa motho e monyane le ho motho ea tsofetseng, botsofaling feela ho lokela ho ba le tekanyetso e fokolang ea kalafo ea index ea cholesterol e ngata maling.

Litlamorao tsa kalafo ea lithethefatsi tsa sehlopha sa Rosacard tsa li-statins li ka utluoa kamora ho nka moriana matsatsi a 7. Phello e phahameng ea phekolo e ka bonoa kamora ho nka pilisi matsatsi a 14.

Boemo ba mantlha ba ho sebelisa meriana ena ke ho ithuta ka ho hlaka polelo le ho lumellana le litlhahiso tsohle tsa ngaka, ebe litlamorao tsa kalafo li tla ba ngata.

Litsenyehelo tsa moriana oa Rosucard li itšetlehile ka moetsi oa sethethefatsi, e leng naha eo moriana o entsoeng ho eona. Lingoloa tsa Russia tsa lithethefatsi li theko e tlaase, empa phello ea lithethefatsi ha e ea itšetleha ka theko ea sethethefatsi.

Analogue ea Russia ea Rosucard, ka tsela e atlehileng e fokotsa index ho cholesterol ea mali, le meriana ea kantle ho naha.

Theko ea Rosucard ea lithethefatsi ho la Russian Federation:

• Theko ea rosucard 10,0 mg (matlapa a 30) Li-ruble tse 550.00,
• Motsoako Rosucard 10,0 mg (li-pcs tse 90.) Li-ruble tse 1540,00,
• Motsoako oa mantlha Rosucard 20,0 mg. (Tab ya 30.) 860.00 li-ruble.

Bophelo ba sehatsetsing le tšebeliso ea matlapa a Rosucard ke selemo se le seng ho tloha mohla ba lokolloang. Kamora letsatsi la ho felloa ke matla, ho molemo ho se sebelise sethethefatsi.

Matšoao a ho sebelisoa

Pele o sebelisa kalafo ea lithethefatsi ho fokotsa index e phahameng ka har'a cholesterol ea mali, hoa hlokahala ho sebelisa mekhoa e seng ea lithethefatsi ea tšusumetso ho motsoako oa lipoprotein 'meleng:

• Ho ikoetlisa le ho ikoetlisa,
• Ho felisoa hoa mabaka ohle a lematsang (joala le tahi ea nicotine),
• Nka lijo tse loantšang cholesterol ho theola lipids tsa mali le ho chesa liponto tse eketsehileng.

Haeba mekhoa eohle e seng ea lithethefatsi ea cholesterol e seng lithethefatsi e sa hlahise litholoana, ngaka e etsa qeto ea tumellano ea meriana ea sehlopha sa statin.

Ho ea ka lingaka tse ngata, li-statin li lokela ho nkuoa hammoho le lijo tsa k'holeseterole, tse tla thusa ho fokotsa lenane la cholesterol ka nako e khuts'oane.

Khafetsa, ha ke lokisa khatello ea cholesterol maling, ke sebelisa lithethefatsi tse nang le motsoako o sebetsang oa rosuvastatin.

Ho latela litaelo tsa tšebeliso, tse fanoeng ke moetsi oa meriana, moriana oa Rosucard o laetsoe li-pathologies tsa 'mele:

• Heterozygous hypercholesterolemia,
• Hypercholesterolemia e tsoakiloeng
• Psychology ea hypercholesterolemia,
• Hypertriglycerinemia,
• Pathology ea methapo ea mali ea methapo.

Tšebeliso ea lithethefatsi Rosucard maemong a thibelo ea mafu a joalo:

• Mehato ea thibelo bakeng sa tlhaselo ea pelo
• Ka bokamoso ba 'mele ho fihlela nts'etsopele ea angina pectoris,
• Thibelo ea ho bolaoa ke lefu la sethoa "
• Ho thibela nts'etsopele ea methapo ea methapo ea methapo ea methapo,
• Bakeng sa thibelo ea index ea khatello e phahameng ea mali ho khatello ea mali,
• Kamora ho buuoa methapong ea mali.

Khafetsa, ha ke lokisa khatello ea cholesterol maling, ke sebelisa lithethefatsi tse nang le motsoako o sebetsang oa rosuvastatin.

Contraindication

E ke ke ea sebelisoa ho theola index ea cholesterol maling a bakuli ba nang le mathata a joalo a mmele le li-pathologies tsa 'mele:

• Boikutlo bo phahameng ba 'mele ho lintho tse karolo ea moriana oa Rosucard,
• Cirrhosis e sebetsang ea sebete
• Ho hloleha ha sebete le liphio
• Ha re utloisoa bohloko haholo ke lefu la masapo,
• Ka lenane la transaminase le ntseng le eketseha,
• Ka lefu la kahare, myopathy,
• Nakong ea bokhachane ho basali,
• Nakong ea ho fepa ngoana ka lebese la matsoele.

Hape, Rosucard ha e fuoe basali ba lilemo tsa ho ba le bana ba sa sebeliseng lithibela-pelehi.

Ho na le khanyetsano ea ho khethoa ha moriana Rosucard, le litekanyetso tse ngata ka har'a letlapa le le leng la karolo e sebetsang ea rosuvastatin ho 40.0 milligram:

• Ka joala bo sa foleng, setlhare sa Rosucard ha se laeloe,
• Ho senyeha ho matla ha ho leka-lekana ha ts'ebetso ea setho sa renal,
• Ka likotsi tsa ho ba le Psychology, myopathy,
• Pathology hypothyroidism, ka sebopeho se boletsoeng,
• Phekolo ea k'holeseterole e phahameng le lithethefatsi tsa sehlopha sa fibrate,
• Sepsis maling
• Bakuli ba Hypotension
• Kamora ho buuoa 'mele.
• Nts'etsopele ea ho ts'oaroa 'meleng le methapo ea mesifa ea mesifa,
• Pathology ea lefu la sethoathoa,
• Ho senya mekhoa ea metabolic 'meleng, e etsahalang ka mokhoa o matla.

Se ke oa nka meriana bakeng sa basali nakong ea kemolo

U ka nka rosucard joang?

Rosucard ea lithethefatsi e lokela ho nooa ka molomo ka metsi a lekaneng. Ho hlafuna letlapa ha lea lumelloa, hobane le koahetsoe ka membrane e qhibilihang mala.

Pele o qala thupelo ea kalafo ka kalafo ea Rosucard, mokuli o tlameha ho latela mokhoa oa ho ja oa anticholesterol, 'me lijo li tlameha ho tsamaea le kalafo kaofela ka li-statins, li ipapisitse le karolo e sebetsang ea rosuvastatin.

Ngaka ka boeona e khetha moriana ho mokuli ka mong, ho latela liphetho tsa liteko tsa laboratori, hammoho le mamello ea 'mele oa motho ka mong.

Ke ngaka feela, haeba ho hlokahala, e tsebang ho kenya matlapa a Rosucard. Phetoho ea moriana le motsoako oa moriana o mong le motsoala o mong ha e fihle ho feta libeke tse peli ho tloha nakong ea tsamaiso.

Litekanyetso tsa pele tsa moriana oa Rosucard ha lia lokela ho ba holimo ho li-milligram tse 10,0 hang ka letsatsi.

Butle-butle, nakong ea phekolo, haeba ho hlokahala, nakong ea matsatsi a 30, ngaka e etsa qeto ea ho eketsa tekanyetso.

Bakeng sa ho eketsa tekanyetso ea letsatsi le letsatsi ea moriana oa Rosucard, ho hlokahala mabaka a latelang:

• Mofuta o matla oa hypercholesterolemia, e hlokang litekanyetso tse phahameng tsa li-milligram tsa 40.0,
• Haeba ho litekanyetso li-milligram tse 10,0, lipilone e bontšitse ho fokotseha ha cholesterol. Ngaka e eketsa litekanyetso tsa li-milligram tse 20,0, kapa hang-hang lethal dose.
• Ka mathata a tebileng a ho hloleha ha pelo,
• Ka mohato o tsoetseng pele oa pathology, atherosclerosis.

Bakuli ba bang, pele ba eketsa tekanyetso, ba hloka maemo a ikhethang:

• Haeba tlhekefetso ea lisele tsa sebete e tsamaisana le palo ea bana ea P0 ea 7,0, joale ho eketsa tekanyetso ea Rosucard ha ho kgothaletswe,
• Maemong a ho hloleha ha menoana, o ka qala sehlopha sa lithethefatsi ka matlapa a 0.5 ka letsatsi, 'me ka mor'a moo o ka eketsa litekanyetso ho li-milligram tse 20,0, kapa esita le ho tekanyetso e phahameng.
• Ho hloleha ho matla ha a-renal, "statins" ha e lumelloe,
• Botebo bo leka-lekaneng ba ho se sebetse hantle ha renal. Tekanyo e phahameng ea moriana oa Rosucard ha e laeloe ke lingaka,
• Haeba ho na le kotsi ea lefu la tsoekere, myopathy le eona e hloka ho qala ka matlapa a 0.5 mme lethal dose ea 40.0 milligrams le thibetsoe.

Ntlafatsa litekanyetso nakong ea kalafo

Bongata

Tekanyetso e feteletseng ea moriana oa Rosucard ha e ame li-pharmacokinetics tsa moriana. Liphetoho tse tsoang ho overdose ha li etsahale. Ha ho na mekhoa e ikhethang e entsoeng ho rarolla lithethefatsi tsa Rosucard tse ngata.

Hoa hlokahala ho phekola matšoao a li-statin tse ngata haholo. Hoa hlokahala ho lula ho lekola matšoao a ts'ebetso ea sele ea sebete mme, haeba ho hlokahala, nka mehato.

Tšebeliso ea hemodialysis, e nang le overinose ea statin, ha e na phello e ntle 'meleng.

Ho sebelisana le lithethefatsi tse ling

Dinaheng tse ngata, thekiso ea meriana e etsoa feela joalo ka ha ho laetsoe ke ngaka, re na le lithethefatsi tse ngata ho potoloha mahala, tse khothaletsang bakuli ba bangata ho etsa liteko tsa bophelo ba bona le ho sebelisa lithethefatsi e le litlhare.

Sena se tletse ka litlamorao tse boima bakeng sa 'mele, hobane bakuli ha ba nahane ka mathata ohle a litlamorao tsa lithethefatsi' meleng. Hape, ha se batho ba bangata ba tsebang hore na meriana e sebelisana joang ha e ntse e e-noa.

Tafole e bonts'a liphetho tsa ho leka Rosucard ea lithethefatsi ha li sebelisana le meriana e meng:

Mofuta oa lithethefatsi le litekanyetso tsa lona tsa letsatsi le letsatsi	lethal dose ea letsatsi le letsatsi ea rosucard	Liphetoho kalafong ea litlhare tsa AUC Rosucard
drug Atazanavir 300.0 mg le meriana Ritonavir 100.0 mg hang / /., ka matsatsi a 8.	10,0 mg hang.	Makhetlo a 3.1 a eketseha.
Cyclosporine e tsoang ho 75.0 mg habeli ka letsatsi. ho fihla ho 200.0 mg habeli ka letsatsi. halofo ea selemo	10,0 mg	e phahameng ho 7.1 p.
meriana Lopinavir 400.0 mg / drug Ritonavir 100.0 mg habeli / ka letsatsi.	20,0 mg	keketseho ea 2.1 p.
Matlapa a Simeprivir 150.0 mg 1 nako / letsatsi.	10,0 mg	2.80 leq
Eltrombopak 75.0 mg hang / ka letsatsi.	10,0 mg	e phahameng ho 1,6 p.
drug gemfibrozil 600.0 mg habeli / ka letsatsi.	80.0 mg	keketseho ea 1.90 p.
Tipranavir 500.0 mg le Ritonavir 200.0 mg	10,0 mg	keketseho ea 1.40 p.
meriana Darunavir 600.0 mg le moriana Ritonavir 100.0 mg habeli	10,0 mg	ka holimo ho 1.50 leq.
meriana Itraconazole 200.0 mg hang	10,0 mg	keketseho ea 1,4 p.
Dronedarone 400.0 mg habeli ka letsatsi	ha ho na data	keketseho ea 1,2 p.
meriana Fozamprenavir 700.0 mg le meriana Ritonavir 100.0 mg habeli	10,0 mg	1.4 leq
meriana Aleglitazar 0,30 mg	40.0 mg	se jele paate
Ezetimibe 10,0 mg hang	10,0 mg	se jele paate
Fenofibrate 67.0 mg makhetlo a mararo	10,0 mg	se jele paate
Silymarin 140.0 mg makhetlo a mararo	10,0 mg	ha ho na phetoho
Ketoconazole 200.0 mg habeli	80.0 mg	ha ho na phetoho
Rifampicin 450.0 mg hang	20,0 mg	ha ho na phetoho
meriana erythromycin 500.0 mg makhetlo a mane	80.0 mg	20,0% e fokotsehile
Fluconazole 200.0 mg ka nako e le ngoe	80.0 mg	se jele paate
matlapa a Baikalin 50.0 mg makhetlo a mararo	20,0 mg	47.0% e tlase

Ts'ebeliso e ts'oanang ea Rosucard le antacids, e nang le luminium le magnesium, e fokotsa khatello ea "statin" makhetlo a 2. Haeba u sebelisa lithethefatsi tsena ka karohano ea lihora tse peli ho isa ho tse tharo, joale tshusumetso e mpe e ea fokotseha.

Ha o kopanya ho kenella ha matlapa a rosucard le lithethefatsi le li-inhibitors tsa protein, joale AUC0-24 e eketseha haholo.

Bakeng sa batho ba tšoaelitsoeng, HIV e tšoaetsoe 'me e na le litlamorao tse boima.

Litlamorao

Haeba u sebelisa lithethefatsi ka nepo, 'me u latela litlhahiso tsohle tsa ngaka mabapi le ho nka Rosucard, le phepo e nepahetseng, litlamorao tse matla tsa moriana li ka qojoa.

Empa moetsi o ntse a tlaleha mefuta e meng e fapaneng ea 'mele e sebelisang lipilisi:

tsamaiso ea 'mele le litho tsa eona	khafetsa	eseng hangata haholo	nako le nako	linyeoe tse ikhethileng	khafetsa ha e tsejoe
phallo ea mali	pathology ea heestatic system - thrombocytopenia
endocrine patology	hyperglycemia - lefu la tsoekere
litsi tsa tsamaiso ea methapo	Bohloko hloohong,	ho fokotseha ha mohopolo	Mathata a ho robala,
· Dizziness,	Pathology ea polyneuropathy.
khokahano e senyehileng ea motsamao.
mathata a kelello	Boemo ba khatello ea maikutlo
Boikutlo ba ho tšoha
Ho hloka kutloelo-bohloko.
tšilo ea lijo	Bohloko ka mpeng,
Letšollo
ho sokela
pancreatic pathology - pancreatitis.
tsamaiso ea ho phefumoloha	Khohlela e omeletseng
Ho hema hanyane
· Ho thata ho hema.
hepatic organ	index ea transaminase liseleng tsa hepatic organ e phahama	ho ruruha liseleng tsa sebete - hepatitis
letlalo le hlakileng	Matlalo a letlalo	Johnson-Stevenson syndrome
Masihla a maqhubu,
Ho hlohlona habohloko.
skeleton le mesifa ea mesifa	pathology myalgia	Maloetse a myopathy	pathology arthralgia	Tendon rupture,
Myopathy ea tlhaho ea necrotic.
tikoloho	gynecological litho tsa ka hare
tsamaiso ea methapo	urethral pathology - hematuria
tlholeho e akaretsang ya tlolo	asthenia pathology	ho ruruha sefahlehong le matsoho.

Khafetsa lipontšo tsa litlamorao tse mpe 'meleng li ipapisitse le lintlha tse ngata:

• Keketseho ea tsoekere e maling maling (ka mpeng e se nang letho ea 5.6 mmol ka litha e le ngoe le kaholimo),
• BMI e phahame ho feta li-kilos tse 30 ka mita,
• Lenane le phahameng la mali le bitsoang triglyceride,
• Phaello ea mali.

Litokisetso, tseo rosuvastatin e sebetsang e le karolo e sebetsang, li hlahisoa haholo. E hlahisoa linaheng tse ngata, ho kenyeletsoa le baetsi ba Russia.

Litšoantšo tsa kahare tsa moriana oa Rosucard li theko e tlase haholo ho feta li-analogu tsa kantle ho naha.

Lithethefatsi tse entsoeng ka theko e tlaase tsa Russia le tsona lia sebetsa ho theoleng index ea cholesterol, hammoho le lithethefatsi tse tsoang kantle ho naha, tse leng sehlopheng sa theko e phahameng haholo.

Ke ngaka feela e ka khethang analogue bakeng sa kalafo. Analogues ea lithethefatsi Rosucard, hammoho le lihlahisoa tsa eona:

• Lithethefatsi ke Torvacard,
• Mertenil,
• Statin Rosuvastatin,
• Lithethefatsi Krestor,
• Motsoako oa Roxer
• Generic Atorek,
• Zokor,
• Lithethefatsi Rosuvakard.

Qeto

Moriana oa Rosucard o ka sebelisoa kalafo ea k'holeseterole e phahameng maling, o kopantsoe feela le phepo e nepahetseng ea anticholesterol.

Ho sitoa ho latela lijo ho tla liehisa ts'ebetso ea ho folisa le ho mpefatsa litlamorao tse mpe tsa sethethefatsi 'meleng.

Rosucard ea lithethefatsi e ke ke ea sebelisoa e le mokhoa oa ho iphekola, 'me ha ho fanoa ka taelo, ha hoa lumelloa ho fetola litekanyetso tsa matlapa, hammoho le ho fetola mofuta oa kalafo.

Yuri ea lilemo li 50, Kaliningrad: li-statins li theole cholesterol ea ka ho tloaelehileng ka libeke tse tharo. Empa kamora moo, index e ile ea phahama hape, mme ke ile ka tlameha ho nka tsela ea kalafo ka lipilisi tsa statin hape.

Ke feela ha ngaka e fetolela moriana oa ka oa pele ho Rosucard, ke ileng ka hlokomela hore lipilisi tsena li ka se khutlisetse cholesterol ea ka ho tloaelehileng, empa hape li sa e eketse haholo kamora ts'ebetso ea kalafo.

Natalia, ea lilemo tse 57, Ekaterinburg: k'holeseterole e ile ea qala ho phahama nakong ea ho khaotsa ho ilela khoeli, mme phepo e sa khone ho e theola. Ke se ke qetile lilemo tse peli ke sebelisa lithethefatsi tse thehiloeng rosuvastatin. Likhoeling tse 3 tse fetileng, ngaka e ile ea nkela sethethefatsi sa ka sa pele le matlapa a Rosucard.

Ke ile ka utloa phello ea eona hang hang ka ikutloa ke le betere mme ke maketse hore ebe ke khona ho theola li-kilos tse 4 tsa boima bo feteletseng.

Nesterenko N.A., ngaka ea pelo, Novosibirsk Ke fana ka li-statin ho bakuli ba ka ha feela mekhoa eohle ea ho fokotsa cholesterol e se e lekile mme ho na le kotsi e kholo ea ho nts'etsapele lefu la cardio, hammoho le atherosclerosis.

Statins e na le litla-morao tse ngata 'meleng, tse amang boleng ba bophelo ba bakuli.

Empa ka ho sebelisa moriana oa Rosucard ts'ebetsong ea ka, ke hlokometse hore bakuli ba emisitse ho tletleba ka litlamorao tse mpe tsa li-statins. Ho lumellana le litlhahiso tsohle bakeng sa tšebeliso ho tla fa mokuli tekanyo e fokolang ea ho fetoha ha 'mele.