Licrofloxacin 250 le lipilisi tsa 500 mg

Tlhaloso e amanang le 20.08.2015

• Lebitso la Latin: Ciprofloxacinum
• Khoutu ea ATX: S03AA07
• Lintho tse sebetsang: Koprofloxacin (Ciprofloxacinum)
• Moetsi: PJSC "Farmak", PJSC "Technologist", OJSC "Kyivmedpreparat" (Ukraine), LLC "Ozon", OJSC "Veropharm", OJSC "Synthesis" (Russia), C.O. Khamphani ea Rompharm S.R.L. (Romania)

Tsebe le leihlo le theoha ciprofloxacin na ciprofloxacin hydrochloride moketjaneng oa 3 mg / ml (ho latela sesebelisoa se sa tsoakoang), Trilon B, benzalkonium chloride, chloride ea sodium, metsi a hloekisitsoeng.

Ka oli ea leihlo, ntho e sebetsang e boetse e na le pokello ea 3 mg / ml.

Matlapa a Ciprofloxacin.

Tharollo ea infusion e na le ntho e mafolofolo motsoakong oa 2 mg / ml. Ba tlisoang ke eona: sodium chloride, edetate disodium, lactic acid e hlapolotsoeng hydrochloric asitimetsi d / le.

Mofumahali

Mochine oa ts'ebetso ea lithethefatsi o bakoa ke bokhoni ba ho thibela li-gyrase tsa DNA (enzyme ea lisele tsa libaktheria) ka motsoako o kotsi oa DNA, karohano le kholo ea likokoana-hloko.

Wikipedia e bonts'a hore, khahlano le nalane ea ts'ebeliso ea lithethefatsi, ho hanana le li-inhibitors tse ling tse seng tsa gyrase ha ho hlahisoe, lithibela-mafu. Sena se etsa hore profrofloxacin e sebetse haholo khahlano le libaktheria tse hanyetsang ketso. penicillin, lijana tsa mollo, hellollis, cephalosporins le ba bang ba bangata lithibela-mafu.

Tse sebetsang ka ho fetisisa khahlanong le Gram (-) le Gram (+) aerobes: H. influenzae, N. gonorrhoeae, Salmonella spp., P. aeruginosa, N. meningitidis, E. coli, Shigella spp.

E sebetsang ho tsoaetso e bakoang ke: marang-rang staphylococcus (ho kenyeletsoa le tse hlahisang penicillinase), likatse ka bomong enterococcus, legionella, campylobacter, chlamydia, mycoplasma, mycobacteria.

E sebetsa khahlanong le microflora e hlahisang beta-lactamase.

Anaerobes e na le teka-tekano ka tsela e leka-lekaneng kapa e hanyetsanang le lithethefatsi. Ka hona, bakuli ba tsoakiloeng ts'oaetso ea anaerobic le aerobic kalafo ea ciprofloxacin e lokela ho tlatselletsoa ka lengolo la ngaka lincosamides kapa Metronidazole.

Ho hanela lithibela-mafu ke: Ureaplasma urealyticum, Streptococcus faecium, Treponema pallidum, Nocardia asteroides.

Ho hanyetsa ha likokoana-hloko sejong ho thehoa butle butle.

Mofumahali

Kamora ho sebelisa pilisi, moriana o potlaka ebile o kenella ka botlalo mokhoeng oa ho silila.

Matšoao a mantlha a pharmacokinetic:

• bioavailability - 70%,
• TCmax ho plasma ea mali - lihora tse 1-2 kamora ts'ebetso,
• T½ - lihora tse 4

Pakeng tsa 20 le 40% ea ntho e tlama liprotheine tsa plasma. Ciprofloxacin e tsamaisoa hantle metsing a tlhaho le liseleng tsa 'mele,' me ho kenella ha eona liseleng le maro ho ka feta plasma haholo.

E feta ka har'a placenta ho kenella mokelikeli oa "cerebrospinal fluid", e tšeloa ka lebese la matsoele, 'me mohopolo o phahameng o behiloe ka hara bile. Ho fihla ho 40% ea tekanyetso e nkuoeng e felisoa ka nako ea lihora tse 24 e sa fetoloe ke liphio, karolo ea lethal dose e pepesitsoe ka har'a bile.

Moriana oa mofuta oa marotholi a mahlo / tsebe ke ofe?

Ho ophthalmology e sebelisoa bakeng sa likokoana-hloko tse fetang tsa mahlo tsa leihlo (leihlo) le lihlahisoa tsa eona, hammoho le ulcerative keratitis.

Matšoao a sebelisang ciprofloxacin ho otology: bakteria ea otitis externa le a hlobaetsang le bacterial otitis media ea tsebe e bohareng ho bakuli ba nang tympanostomy tube.

Contraindication

Contraindication bakeng sa ts'ebeliso ea kemiso:

• hypersensitivity
• boimana
• lebone
• phatlalatso dysfunction ea liphio / sebete,
• matšoao a nalane ea teninitis e bakoang ke ts'ebeliso ea li-quinolones.

Marotholi a mahlo le litsebe a kopantsoe tšoaetso ea fungal le vaerase ea mahlo / litsebe, le ho hloka mamello ho ciprofloxacin (kapa li-quinolones tse ling), nakong ea kemero le ho nyekeloa.

Bakeng sa bana, matlapa le tharollo ea tsamaiso ea iv e ka laeloa ho tloha ho lilemo tse 12, mahlo le tsebe li theoha ho tloha ho lilemo tse 15.

Litlamorao

Setlhare se mamelletsoe hantle. Litlamorao tse atileng haholo ka ho qala / ho kenella:

• ho tsekela
• mokhathala
• hlooho e bohloko
• thothomela
• tsosa.

Bukeng ea Vidal, ho tlaleha hore maemong a ikhethileng, bakuli ba tlalehiloeng:

• mofufutso
• mathata a Gait
• litšitiso tsa ho potoloha ha maikutlo,
• maqhubu,
• intracranial khatello ea mali,
• khatello ea maikutlo,
• boikutlo ba ho tshoha
• ho sitisoa hoa pono
• botlaela,
• bohloko ba ka mpeng
• ts'oaroa,
• nausea / Ho hlatsa
• lets'ollo,
• hepatitis,
• hepatocyte necrosis,
• tachycardia,
• khatello ea kelello ea methapo(ka seoelo)
• letlalo la letlalo le boreleli
• ponahalo ea lekhopho letlalong.

Litlamorao tse sa tloaelehang haholo: bronchospasm, anaphylactic makala, Edema ea Quincke, arthralgia, petechiae, hampe erythema, vasculitis, Lefu la Lyell, leukemia le thrombocytopenia, eosinophilia, phokolo ea mali, hemolytic anemia, thrombotic kapa leukocytosis, ho eketseha ha likhahla tsa plasma tsa LDH, bilirubin, alkaline phosphatase, sebete transaminases, creatinine.

Ts'ebetso ho ophthalmology e tsamaea le:

• khafetsa - maikutlo a ho hloka botsitso le / kapa ho ba teng hoa 'mele osele ka leihlo, ponahalo ea lejoe le lesoeu (hangata ho bakuli ba nang leulcerative keratitis le tšebeliso ea marotholi khafetsa), sebopeho sa likristale / li-flakes, bokaholimo ba khokahano le hyperemia, ho luma le ho chesa,
• maemong a ikhethileng - keratitis/keratopathy, edema ea eyelid, letheba la mokokotlo, ho choachoasela ha moea, ho fokotseha hoa pono, ho fokotseha ha kelello, ho kenella ka hare ho sefahleho.

Litla-morao tse amanang le kapa tsa ts'ebeliso ea lithethefatsi hangata li bobebe, ha li tšose 'me li tsamaea ntle le kalafo.

Ho bakuli ba nang le ulcerative keratitis ponahalo ea koae e tšoeu ha e ame hampe kalafo ea lefu lena le mahlakore a pono mme a nyamela a le mong. Joaloka molao, e hlaha ka nako ea matsatsi a 1-7 ka mor'a ho qaleha ha ts'ebeliso ea lithethefatsi mme e nyamela hanghang kapa ka nako ea matsatsi a 13 kamora ho felisoa.

Mathata a Neophthalmic ha o sebelisa marotholi: ponahalo ea kamora kotlo e sa thabiseng molomong, maemong a sa tloaelehang - ho nyekeloa ke pelo, dermatitis.

Ha li sebelisoa ho otology, ho ka etsahala tse latelang:

• hangata - ho phethola tsebe,
• maemong a mang - tinnitus, hlooho ea hlooho, dermatitis.

Ts'ebeliso ea ampoules

Ciprofloxacin ka ampoules e khothalletsoa hore e tsamaisoe kahare ka mokhoa oa infusion ea drip. Tekanyetso ho motho e moholo ke 200-800 mg / letsatsi. Nako ea thupelo e etsoa ka karolelano ho tloha bekeng e le ngoe ho isa ho matsatsi a 10.

Ho ts'oaetso ea urogenital, tšenyo e kopanenglemasapo kapa Litho tsa ENT mokuli o kenngoa ka makhetlo a 200-400 mg habeli ka letsatsi. Ho tšoaetso ea phepelo ea phefumoloho, ts'oaetso ea intraperitoneal, septicemia, lisele tse bonolo le letlalo Tekanyetso e le 'ngoe e nang le khafetsa ea tšebeliso ke 400 mg.

Ho ho se sebetse ha meno tekanyetso ea ho qala ke 200 mg, ka mor'a moo e fetoloa ho nahanela Clcr.

Tabeng ea ts'ebeliso ea li-ampoules ka tekanyetso ea 200 mg, nako ea ho kenngoa ke metsotso e 30, ka tlhahiso ea moriana ka tekanyo ea 400 mg - 1 hora.

Liente tsa Ciprofloxacin ha li fuoe.

Boikhethelo

Ha ho na phapang ea mantlha ea hore na u ka nka lithethefatsi joang ho tsoa ho baetsi ba fapaneng: litaelo tsa tšebeliso Ciprofloxacin-AKOS tšoanang le litaelo tsa Ciprofloxacin-FPO, Koprofloxacin-E holisitsoe, Vero-Ciprofloxacinkapa Ciprofloxacin-teva.

Bakeng sa bana le bacha ba ka tlase ho lilemo tse 18, moriana o khothalletsoa hore o laetsoe feela haeba pathogen e hanana le baemeli ba bang ba chemotherapeutic.

Bongata

Ha ho na matšoao a itseng a nang le overdose ea ciprofloxacin. Mokuli o bontšoa lesapo la mokokotlo, a sebelisa lithethefatsi tsa emetic, a etsa karabelo ea moroto oa acid le ho hlahisa mokelikeli o moholo oa metsi. Mesebetsi eohle e lokela ho etsoa ha ho ntse ho bolokoa tšebetso ea litsamaiso le litho tse bohlokoa.

Peritoneal dialysis le hemodialysis kenya letsoho ho felisoeng ha 10% ea lethal dose le nkuoeng.

Setlhare ha se na litlhare tse tobileng.

Tšebelisano

Sebelisa hammoho le Theophylline e kenya letsoho keketseho ea mahloriso a plasma le keketseho ea T1 / 2 ea morao.

Li-antacid tse nang le al / Mg li thusa ho fokotsa ho kenngoa ha ciprofloxacin 'me ka tsela eo e fokotsa ho teba ha moroto le mali. Pakeng tsa tekanyetso ea lithethefatsi tsena e lokela ho bolokoa nako le nako ea bonyane lihora tse 4.

Ciprofloxacin e ntlafatsa phello coumarin anticoagulants.

Ho sebelisana ha ciprofloxacin bakeng sa ts'ebeliso ea li-otology le ophthalmology le lithethefatsi tse ling ha hoa ithutoa.

Litaelo tse khethehileng

Ka lebaka la monyetla oa litlamorao ho tsoa ho tsamaiso ea methapo e kholo ho bakuli ba nang le nalane ea lefu lena la lithethefatsi, lithethefatsi li ka sebelisoa feela ka mabaka a bophelo bo botle.

Ciprofloxacin e khethoa ka hloko ha e theola monyako oa ho ikemisetsa ho ts'oaroa, lefu la sethoathoa, tšenyo ea kelello, lefu le matla la ho nyehla le ho ferekanya kelello (eketsa menyetla ea phepelo e mpe ea mali le stroke), ho ts'ebetso e matla ea sefuba / liphiobotsofaling.

Nakong ea phekolo, ho khothalletsoa ho qoba mahlaseli a letsatsi le mahlaseli a letsatsi le ho eketsa mesebetsi ea mmele, ho laola acidity ea moroto le mofuta oa ho noha.

Ho bakuli ba nang le karabelo ea alkaline ea moroto, linyeoe li tlalehiloe krystalluria. Bakeng sa ho qoba nts'etsopele ea eona, ha ho amohelehe ho feta tekanyetso ea kalafo. Ntle le moo, mokuli o hloka seno se sengata le ho boloka motsoako oa moroto o nang le asiti.

Tendon bohloko le lipontšo tenosynovitis ke sesupo sa ho emisa kalafo, hobane monyetla oa ho ruruha / ho phatloha ha tendon ha o qheleloe ka thoko.

Ciprofloxacin e ka thibela lebelo la karabelo ea psychomotor (haholo-holo khahlano le semelo sa joala), e lokelang ho hopoloa ke bakuli ba sebetsang le lisebelisoa tse ka bang kotsi.

Ka nts'etsopele letšollo le matlae lokela ho qheleloa ka thokopseudomembranous colitishobane lefu lena ke bokhopo ba tšebeliso ea lithethefatsi.

Haeba ho hlokahala, ts'ebetso e ts'oanang ea iv ea barbiturates e lokela ho lekola ts'ebetso ea CCC: haholo, ECG, sekhahla sa pelo, khatello ea mali.

Foromo ea mahlo ea mahlo ea litlhare ha e reretsoe ente ea intraocular.