Thiogammacene, fumana, reka

Khoebo lebitso la lithethefatsi: Thiogamma

Lebitso le sa Tšoaneleheng Kantle ho Naha: Thioctic asiti

Foromo ea boholo: matlapa, tharollo bakeng sa tsamaiso ea infusion, tsepamisa mohopolo ho lokiseng tharollo ea infusion

Lintho tse sebetsang: thioctic asiti

Sehlopha sa Pharmacotherapeutic:

lipid le metabolism ea carbohydrate

Sebopeho sa pharmacological:

Ntho e sebetsang ea Thiogamma (Thiogamm-Turbo) ke acid e bitsoang thioctic (alpha-lipoic). Thioctic acid e thehoa 'meleng' me e sebetsa e le coenzyme bakeng sa metabolism ea matla a alpha-keto acid ka oxidative decarboxylation. Thioctic acid e lebisa ho fokotseha ha tsoekere e ngata serumeng ea mali, e thusa ho bokella glycogen ho hepatocytes. Mathata a Metabolic kapa ho haella ha thioctic acid ho bonoa ka ho bokellana ho feteletseng hoa metabolites e itseng 'meleng (mohlala,' mele oa ketone), hammoho le ts'ebeliso ea tahi. Sena se lebisa ho tsitsinyehong ho ketane ea aerobic glycolysis. Thioctic acid e teng 'meleng ka sebopeho sa mefuta e' meli: e fokotsehile ebile e na le oxidized. Mefuta eo ka bobeli e sebetsa 'meleng, e fana ka litlamorao tsa antioxidant le anti-toxic.

Thioctic acid e laola metabolism ea lik'habohaedreite le mafura, e ama hantle metabolism ea cholesterol, e na le phello ea hepatoprotective, e ntlafatsa ts'ebetso ea sebete. Tšusumetso e ntle lits'ebetsong tse iphetisang ho tishu le litho. Melemo ea meriana ea thioctic acid e tšoana le litlamorao tsa livithamine tsa B. Ka mokhoa oa ho fumaneha hoa lithethefatsi, ho fokotseha hoa bohlokoa hoa motho ka mong hoa hlokomeleha.

Ha e sebelisoa kahare, e potlakile ebile e batla e amohuoa ka botlalo ho tsoa mohloling oa tšilo ea lijo. Metabolism e tsoela pele le oxidation ea lehlakore la lehlakore la thioctic acid le conjugation ea eona. Nako ea ho felisoa ha halofo ea bophelo ba Tiogamma (Tiogamm-Turbo) e tsoa metsotso e 10 ho isa ho e 20. Ho felisoa ka moroto, ka metabolites ea thioctic acid e ka pele.

Matšoao a sebeliso:

Diabetesic polyneuropathy, joala ba joala ba polyneuropathy.

Contraindication:

Boimana, ho lactation (ho anyesa), bana ba ka tlase ho lilemo tse 18, hypersensitivity ho thioctic acid kapa likarolo tse ling tsa lithethefatsi.

Tekanyetso le tsamaiso:

Thiogamma bakeng sa tsamaiso ea batsoali.

Thiogamm e etselitsoe tsamaiso ea batsoali ka ho kenella ka hare ho marang-rang. Bakeng sa batho ba baholo, lethal dose ea 600 mg (litaba tsa 1 vial kapa 1 ampoule) e sebelisoa hang ka letsatsi. Ho kenella ho etsoa butle, bakeng sa metsotso e 20-30. Nako ea phekolo e nka libeke tse peli ho isa ho tse 'ne. Nakong e tlang, ho khothalletsoa ts'ebeliso ea kahare ea Tiogamma matlapeng. Tsamaiso ea botsoali Thiogamm bakeng sa infusion e laeloa mafu a tebileng a maikutlo a amanang le lefu la tsoekere.

Likahare tsa botlolo e le 'ngoe ea Thiogamma-Turbo kapa 1 ampoule ea Thiogamma (600 mg ea lithethefatsi) li qhibilihile ka 50-250 ml ea tharollo ea chloride ea 0,9%. Tekanyo ea infravenous infusion - eseng ho feta 50 mg ea thioctic acid ka motsotso o le mong - sena se lekana le 1,7 ml ea tharollo ea Tiogamma. Litokisetso tse hlapolotsoeng li lokela ho sebelisoa hang ka mor'a ho kopanya le solvent. Nakong ea infusion, tharollo e lokela ho sireletsoa leseli ke thepa e khethehileng e sireletsang leseli.

Matlapa a etselitsoe ho sebelisoa kahare. Ho khothalletsoa ho fana ka 600 mg ea moriana o 1 ka letsatsi. Letlapa le lokela ho metsoa le felle, ho sa natsoe lijo, le hlatsuoe ka metsi a lekaneng. Nako ea kalafo ea pilisi e tsoa ho likhoeli tse 1 ho isa ho tse 'ne.

Litla-morao:

Tsamaiso ea methapo e bohareng: maemong a sa tloaelehang, hang hang ka mor'a tšebeliso ea lithethefatsi ka mokhoa oa ho kenella, ho ka khoneha hore ho be le mesifa e sisinyehang ea mesifa.

Litho tsa kutlo: tlolo ea maikutlo a tatso, diplopia.

Sisteme ea Hematopoietic: purpura (hemorrhagic rash), thrombophlebitis.

Boitšoaro ba Hypersensitivity: Boits'oaro bo hlophisehileng bo ka baka ho ts'oaroa ha anaphylactic, eczema kapa urticaria sebakeng sa ente.

Sistimi ea digestive (bakeng sa matlapa a Tiogamma): lipontšo tsa dyspeptic.

Ba bang: haeba Tiogamm-Turbo (kapa Tiogamm bakeng sa tsamaiso ea batsoali) e tsamaisoa ka potlako, khatello ea maikutlo le moea oa ho thatafala sebakeng sa hlooho li ka khonahala - lits'oants'o tsena li emisa kamora ho fokotseha ha sekhahla sa infusion. Hape ho khoneha: hypoglycemia, ho chesa ho chesang, ho tsekela, ho fufuleloa, pelo, ho fokotseha tsoekere ea mali, ho nyekeloa, pono e ferekanyang, hlooho e bohloko, ho hlatsa, tachycardia.

Ho sebelisana le lithethefatsi tse ling:

Thioctic acid e fokotsa katleho ea cosplatin ha u ntse u e nka, hape e kopana le lithethefatsi tse nang le tšepe, tse kang iron, magnesium.

Thioctic acid e kopana le limolek'hule tsa tsoekere, e etsa li-solarle tse bonolo tse qhibilihang ka mohlala, ka tharollo ea levulose (fructose).

Thioctic asiti e ntlafatsa phello ea anti-inflammatory ea corticosteroids.

Ka tšebeliso e tšoanang ea thioctic acid le lithethefatsi tsa insulin kapa tsa molomo, phello ea bona e ka ntlafatsoa.

Ethanol le metabolites ea eona e fokolisa phello ea thioctic acid.

Thioctic acid infusion tharollo ha e lumellane le tharollo ea dextrose, tharollo ea Ringer, le tharollo e arabelang ka lihlopha tsa disulfide le SH.

Letsatsi la ho felloa ke nako: Lilemo tse 5

Lipehelo tsa Maemo a Phomolo ea meriana: ka ngollano

Moetsi:

Werwag Pharma GmbH & Co KG (Worwag Pharma GmbH & Co KG), Beblingen, Jeremane.