Phapang ke efe pakeng tsa atorvastatin le rosuvastatin?

K'holeseterole e phahameng ke eona e bakang mafu a mangata a pelo, bokong, likepe tse potang. Atherossteosis (ho kenngoa ha cholesterol leboteng la methapo ea methapo) ke sesosa se etelletseng pele sa lefu lefatšeng le linaheng tsa Soviet Union ea mehleng. Statins ke lithethefatsi tse ka thibelang, 'me ka tšebeliso ea nako e telele, emisa nts'etsopele ea atherosclerosis. Papiso ea Atorvastatin le Rosuvastatin, e le baemeli ba babeli ba molemo ka ho fetisisa sehlopheng sena, e tla u lumella ho khetha moriana bakeng sa motho ka mong.

Atorvastatin le rosuvastatin li na le metsoako e tšoanang.

Mokhoa oa ketso

Lithethefatsi ka bobeli ke baemeli ba sehlopha se le seng sa meriana, ka hona ts'ebetso ea bona ea ts'ebetso e tšoana. Phapang lipakeng tsa tsona e matleng a ketso: ho fumana litlamorao tse tšoanang tsa kliniki, lethalinyana la Rosuvastatin e kanna ea ba halofo ea Atorvastatin.

Mochine oa ts'ebetso ea lithethefatsi ke ho hatella enzyme e kenyang karolo ea ho thehoa ha cholesterol. Ka lebaka leo, boemo ba cholesterol e felletseng le lipoprotein tse tlaase le tse tlase haholo (LDL, VLDL), triglycerides lia fokotseha. Ke tsona lisosa tsa ho thehoa hoa lipampiri methapong ea mali, ho nyekeloa ke pelo, stroke, jj.

Lithethefatsi ka bobeli li lokela ho sebelisoa maemong a latelang:

  • K'holeseterole ea mali e phahamisitsoeng
  • Methati e phahamisitsoeng ea LDL, VLDL, triglycerides,
  • Lefu la pelo (ho nyekeloa ke mali le sa lekaneng mesifa ea pelo) le liponahatso tsohle tsa lona (ho nyekeloa ke pelo, angina pectoris),
  • Atherosclerosis ea aorta, likepe tsa lipalo tse tlase, bokong, methapo ea kutlo,
  • Ka khatello e phahameng ea mali - ho thibela nts'etsopele ea atherosclerosis.

Contraindication

Atorvastatin e ke ke ea sebelisoa bakeng sa:

  • Ho se mamelle lithethefatsi,
  • Lefu la sebete le matla,
  • Ts'ebetso ea sebete e sa sebetseng,
  • Bokhachane le pelehi.

  • Ho se mamelle lithethefatsi,
  • Lefu la sebete le matla,
  • Ts'ebetso ea sebete e sa sebetseng,
  • Bofokoli bo matla ba kutlo
  • Tsamaiso ea masapo a marapo,
  • Ho nka cyclosporine,
  • Bokhachane le pelehi
  • Lilemo ho isa ho lilemo tse 18.

Litlamorao

Atorvastatin e ka baka:

  • Ho opeloa ke hlooho
  • Bofokoli
  • Ho hloka boroko
  • Bohloko ba sefuba
  • Ts'ebetso ea sebete e sa sebetseng,
  • Tšoaetso ea litho tsa ENT,
  • E ja sekhopi,
  • Mesifa le bohloko ba kopaneng
  • Ho ruruha
  • Litla-morao.

Litla-morao tsa rosuvastatin:

  • Nts'etsopele ea lefu la tsoekere mellitus (carbohydrate metabolism disorder),
  • Ho opeloa ke hlooho
  • E ja sekhopi,
  • Ts'ebetso ea sebete e sa sebetseng,
  • Bohloko ba mesifa
  • Bofokoli.

Lokolla liforomo le theko

Theko ea matlapa a Atorvastatin e fapana haholo ho latela moetsi:

  • 10 mg, li-pcs tse 30. - 130 - 260 leq.
  • 10 mg, 60 likhomphutha. - 300 r
  • 10 mg, li-pcs tse 90. - 550 - 710 r,
  • 20 mg, li-pcs tse 30. - 165 - 420 r,
  • 20 mg, li-pcs tse 90. - 780 - 1030 r,
  • 40 mg, li-pcs tse 30. - 295 - 630 leq.

Litsenyehelo tsa litafole tsa rosuvastatin le tsona li fapana haholo:

  • 5 mg, 28 likhomphutha. - 1970 leq
  • 5 mg, li-pcs tse 30. - 190 - 530 r,
  • 5 mg, li-pcs tse 90. - 775 - 1020 r,
  • 5 mg, li-pcs tse 98. - 5620 r,
  • 10 mg, 28 likhomphutha. - 420 - 1550 r,
  • 10 mg, li-pcs tse 30. - 310 - 650 p,
  • 10 mg, 60 likhomphutha. - 620 r
  • 10 mg, li-pcs tse 90. - 790 - 1480 r,
  • 10 mg, li-pcs tse 98. - 4400 r,
  • 10 mg, 126 li-pcs. - 5360 r,
  • 15 mg, li-pcs tse 30. - 600 r
  • 15 mg, li-pcs tse 90. - 1320 r,
  • 20 mg, 28 likhomphutha. - 505 - 4050 r,
  • 20 mg, li-pcs tse 30. - 400 - 920 p,
  • 20 mg, 60 likhomphutha. - 270 - 740 r,
  • 20 mg, li-pcs tse 90. - 910 - 2170 r,
  • 40 mg, 28 likhomphutha. - 5880 r,
  • 40 mg, li-pcs tse 30. - 745 - 1670 r,
  • 40 mg, li-pcs tse 90. - 2410 - 2880 leq.

Rosuvastatin kapa Atorvastatin - e leng betere?

Haeba u khetha hore na ho na le lithethefatsi life tse ntle ho feta pono ea bongaka, ka hona e tla ba Rosuvastatin. Kaha e ka nooa ka tekanyetso e tlase, palo le litla-morao tsa litlamorao tsa eona li tlase haholo ho feta Atorvastatin. Leha ho le joalo, e theko e boima haholo, haholo e hlahisoang ke khampani Teva kapa Astrazenek (Krestor). Tšoara moriana khoeli le khoeli, o tla nka palo e joalo e khahlisang ho bakuli ba bang. Tabeng ena, atorvastatin e lula e le "statin" e sebelisoang ka ho fetisisa.

Ke efe e betere: atorvastatin kapa rosuvastatin? Litlhahlobo

  • Ke na le k'holeseterole e phahameng haholo, ntate oa ka o bolailoe ke lefu la pelo hoo e ka bang lilemo tse 40. Ke se ke qetile nako e telele ke e-noa Atorvastatin, 'me ke batla ke le 40,' me ha ke sa tlo shoa, le likepe li se li se hantle haholo, empa li khona ho mamella
  • Ha ke khone ho noa sethethefatsi sena - hang-hang sebete se qala ho koata, bofokoli bo hlaha,
  • Setlhare se makatsang haholo. Litlamorao tsa eona ha li utluoe, empa lingaka tsohle li mo qobella ho nka. Empa liteko li hantle kamora hae.

  • Ha ke khone ho sebelisa chelete e joalo khoeli le khoeli, leha ke e rata. Ha ke khone ho ema Atorvastatin,
  • Phetoho e ntle bakeng sa atorvastatin: litekanyetso tse tlase, mamello e molemo,
  • Ha ke utloisise hore na ke hobaneng ha o lefa chelete e joalo ea bohlanya haeba o ka noa li-analogues tse theko e tlaase.

Li-statins ke eng?

Statins e kenyelletsa sehlopha se seholo sa lithethefatsi se sebelisetsoang ho theola khatello ea mali ea LDL le VLDL maling.

Mesebetsing ea bongaka ea sejoale-joale, li-statin li ke ke tsa abjoa bakeng sa thibelo le kalafo ea atherosclerosis, hypercholisterinemia (e tsoakiloeng kapa homozygous), hammoho le mafu a pelo.

Ka kakaretso, lithethefatsi tsa sehlopha sena li na le phello e tšoanang ea kalafo, i.e. maemo a tlase a LDL le VLDL. Leha ho le joalo, ka lebaka la likarolo tse fapaneng tsa tšebetso le tse thusang, ho na le liphapang tse tlamehang ho elloa hloko ho qoba ho hlaha hampe.

Statins hangata e arotsoe ka I (Cardiostatin, Lovastatin), II (Pravastatin, Fluvastatin), III (Atorvastatin, Cerivastatin) le IV moloko (Pitavastatin, Rosuvastatin).

Statins e ka ba tsa tlhaho le tsa maiketsetso. Ho setsebi, khetho ea lihlahisoa tse tlase, tse mahareng kapa tse phahameng bakeng sa mokuli ke ntlha ea bohlokoa.

Rosuvastatin le Atorvastatin hangata li sebelisoa ho theola cholesterol. E 'ngoe le e' ngoe ea lithethefatsi e na le likarolo:

Rosuvastatin e bua ka li-statins tsa moloko oa bone. Moemeli ea fokotsang lipid o entsoe ka botlalo ka litekanyetso tse tloaelehileng tsa motsoako o sebetsang. E hlahisoa tlas'a matšoao a fapaneng a khoebo, mohlala, Krestor, Mertenil, Rosucard, Rosart, jj.

Atorvastatin ke ea litloholo tsa III tsa moloko. Joalo ka analogue ea eona, e na le tšimoloho ea maiketsetso, empa e na le tekanyetso e phahameng ea ntho e sebetsang.

Ho na le liemahale tse tšoanang le lithethefatsi tse kang Atoris, Liprimar, Toovacard, Vazator, jj.

Sebopeho sa lik'hemik'hale tsa lithethefatsi

Lithethefatsi ka bobeli lia fumaneha ka sebopeho sa letlapa. Rosuvastatin e hlahisoa ka litekanyetso tse 'maloa - 5, 10 le 20 mg ea karolo e le' ngoe e sebetsang. Atorvastatin e lokolloa ka tekanyetso ea 10,20,40 le 80 mg ea motsoako o sebetsang. Ka tlase ke tafole e bapisang likarolo tse thusang tsa baemeli ba babeli ba tsebahalang ba li-statin.

RosuvastatinAtorvastatin (Atorvastatin)
Hypromellose, starch, titanium dioxide, crospovidone, cellcose ea microcrystalline, triacetin, magnesium stearate, silicon dioxide, daemane ea titanium, dae ea carmine.Lactose monohydrate, sodium croscarmellose, titanium diode, hypromellose 2910, hypromellose 2910, talc, calcium stearate, polysorbate 80, cellulose ea microcrystalline,

Phapang e kholo pakeng tsa Rosuvastatin le Atorvastatin ke thepa ea bona ea fisiks. Monyetla oa rosuvastatin ke hore e robeha habonolo plasma ea mali le maro a mang, i.e. ke hydrophilic. Atorvastatin e na le tšobotsi e 'ngoe: e qhibilihisoa ka mafura, i.e. ke lipophilic.

Ho ipapisitsoe le likarolo tsena, phello ea Rosuvastatin e lebisoa haholo ho lisele tsa "parenchyma" ea sebete, le Atorvastatin - ho sebopeho sa boko.

Pharmacokinetics le pharmacodynamics - phapang

Hona joale sethaleng sa ho nka litafole, ho na le liphapang tsa ho monya ha tsona. Kahoo, ts'ebeliso ea rosuvastatin ha e ea itšetleha ka nako ea letsatsi kapa ea lijo. Atorvastatin ha ea lokela ho jelloa ka nako e le ngoe le lijo, joalo ka sena se ama hampe ho amoheloa ha karolo e sebetsang. Litaba tse kholo tsa Atorvastatin li fumaneha ka mor'a lihora tse 1-2, le Rosuvastatin - kamora lihora tse 5.

Phapang e 'ngoe lipakeng tsa li-statins ke metabolism ea tsona. Mmeleng oa motho, Atorvastatin e fetoloa sebopeho se sa sebetseng se sebelisa li-enzyme tsa sebete. Kahoo, ts'ebetso ea moriana e amana ka kotloloho le ts'ebetso ea sebete.

E boetse e susumetsoa ke lithethefatsi tse sebelisoang ka nako e le ngoe le Atorvastatin. Analogue ea eona, ka lehlakoreng le leng, ka lebaka la tekanyetso e tlase, ha e sebetse ka litlhare tse ling. Le ha hona ha ho mo pholohe hore a se ke a ba le karabelo e mpe.

Atorvastatin e pepesitsoe haholo ke bile.

Ho fapana le li-statins tse ngata, Rosuvastatin e batla e sa sebelisoe ka har'a sebete: ho feta 90% ea ntho e tlositsoeng e sa fetoloe ke mala mme ke 5-10% feela ke liphio.

Ts'ebetso le Khopolo ea Moreki

Mosebetsi o ka sehloohong oa lithethefatsi tsa statin ke ho fokotsa khatello ea LDL maling le ho eketsa boemo ba HDL.

Ka hona, ho khetha pakeng tsa Atorvastatin le Rosuvastatin, re tlameha ho bapisa hore na ba fokotsa cholesterol hantle hakae.

Phuputso ea saense ea morao-rao e bontšitse hore rosuvastatin ke lithethefatsi tse sebetsang haholoanyane.

Liphetho tsa tleliniking li hlahisoa ka tlase:

  1. Ka litekanyetso tse lekanang tsa lithethefatsi, Rosuvastatin e fokotsa cholesterol ea LDL ka 10% ka katleho ho feta analogue ea eona. Monyetla ona o lumella tšebeliso ea moriana ona ho bakuli ba nang le hypercholesterolemia e matla.
  2. Khafetsa ea nts'etsopele ea mathata a pelo le ho qala ha sephetho se bolaeang e phahame Atorvastatin.
  3. Kotsi ea karabelo e mpe e tšoanang ho lithethefatsi tsena ka bobeli.

Ho bapisoa le katleho ea ho fokotsa khatello ea "cholesterol" e mpe "ho paka 'nete ea hore Rosuvastatin ke lithethefatsi tse sebetsang haholoanyane. Leha ho le joalo, motho ha aa lokela ho lebala ka lintho tse kang ho ba teng ha li-contraindication, litla-morao le theko. Ho bapisoa le litheko tsa meriana ena e 'meli ho hlahisoa ka har'a tafole.

Tekanyetso, palo ea matlapaRosuvastatinAtorvastatin
5mg No. 30335 rub
10mg No. 30Li-ruble tse 360125 rub
20mg No. 30485 rub150 rub
40mg No. 30245 rub
80mg No. 30490 rub

Kahoo, atorvastatin ke analog ea theko e tlaase eo batho ba lefuoang ka tlase ba ka e khonang.

Ke seo bakuli ba nahanang ka lithethefatsi - Rosuvastatin e mamelloa hantle ebile ha e na mathata. Ha e nkoa, k'holeseterole e mpe e ea fokotseha

Papiso ea lithethefatsi e thusa ho fihlela qeto ea hore hona joale molemong oa ntlafatso ea bongaka, maemo a pele har'a matlapa a cholesterol a matle a nkuoa ke li-statins tsa moloko oa bone. Rosuvastatin.

Mabapi le lithethefatsi Rosuvastatin le analogues ea eona li hlalositsoe videong ena.

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