Diabefarm - litaelo tsa semmuso bakeng sa tšebeliso

TLOTLISO
bakeng sa ts'ebeliso ea litlhare tsa bongaka

Nomoro ea ngoliso:

Lebitso la khoebo: Diabefarm ®

Lebitso le sa Tšoaneleheng la Machabeng: gliclazide

Foromo ea litekanyetso: matlapa

Sebopeho:
Letlapa le 1 le na le
Lintho tse sebetsang: gliclazide 80 mg
Baeti: lactose monohydrate (tsoekere ea lebese), povidone, magnesium stearate.

Tlhaloso
Letlapa le lesoeu kapa le lesoeu le bosoeu bo bosehla, le boreleli, 'moho le' mele oa sefapano se kotsi.

Sehlopha sa Pharmacotherapeutic: moemeli oa hypoglycemic bakeng sa tsamaiso ea molomo ea sehlopha sa bobeli sa sulfonylurea

Khoutu ea ATX: A10VB09

Ketso ea pharmacological
Mofumahali
Glyclazide e phahamisa secretion ea insulin ka lisele tsa "pancreatic β", e ntlafatsa sephetho sa "insulin" le "glucose" mme e eketsa kutloisiso ea lisele tsa pherekano ho insulin. E susumetsa ts'ebetso ea li-enzymes tse kenang ka hare - mesifa ea glycogen synthetase. Fokotsa nako ea nako ho tloha motsotso oa ho ja ho isa ho qala ho secretion ea insulin. E khutlisetsa tlhoro ea pele ea insulin secretion (ho fapana le tse ling tse tsoang ho sulfonylurea, tse nang le phello haholo nakong ea mekhahlelo ea bobeli ea secretion). E fokotsa keketseho ea postprandial tsoekere ea mali.
Ntle le ho ama metabolism ea carbohydrate, e ntlafatsa microcirculation: e fokotsa ho khomarela ka liplatelete le ho kopana, ho tiisa boteng ba methapo, ho thibela nts'etsopele ea micothrombosis le atherossteosis, hape e khutlisa ts'ebetso ea phariological parietal fibrinolysis. E fokotsa kutloisiso ea vascular receptor ho adrenaline. E fokotsa nts'etsopele ea lefu la tsoekere la retinopathy sethaleng sa ieproliferative. Ka lefu la tsoekere le lefu la tsoekere le tšebeliso e telele, ho na le phokotseho e kholo botebong ba proteinuria. Ha e lebise keketseho ea boima ba 'mele, hobane e na le tšusumetso e kholo tlhorong ea pele ea insulin secretion mme ha e bake hyperinsulinemia, e thusa ho fokotsa boima ba 'mele ho bakuli ba batenya ka lijo tse nepahetseng. E na le thepa ea anti-atherogenic, e theola khatello ea cholesterol e felletseng maling.
Mofumahali
Kamora ho tsamaisoa ka molomo, e kenella ka potlako maling a ka mpeng. Ho chona ho phahameng. Kamora ho tsamaisoa ka molomo ka 80 mg, khatello e phahameng maling (2.2-8 μg / ml) e fihlella kamora lihora tse ka bang 4, kamora ts'ebetso ea 40 mg, khatello e phahameng maling (2-3 μg / ml) e fihlella kamora lihora tse 2-3. ka liprotheine tsa plasma - 85-97%, bophahamo ba modumo - 0,35 l / kg. Khokahano e lekanang maling e fihlelloa kamora matsatsi a mabeli. E tšelisoa ka har'a sebete, 'me ea theha li-metabolites tse 8.
Palo ea metabolite ea mantlha e fumanoeng maling ke 2-3% ea kakaretso ea lithethefatsi tse nooeng, ha e na phello ea hypoglycemic, empa e ntlafatsa microcirculation. E epolloa ke liphio - 70% ka sebopeho sa metabolites, e ka tlase ho 1% ka sebopeho se sa fetoheng, ho ea ka mala - 12% ka sebopeho sa metabolites.
Bophelo ba halofo ke lihora tse 8 ho isa ho tse 20.

Matšoao a ho sebelisoa
Type 2 lefu la tsoekere ho batho ba baholo hammoho le kalafo ea ho ja le ho ikoetlisa ka tsela e leka-lekaneng ha e sa sebetse.

Contraindication
Hypersensitivity ho lithethefatsi, mofuta oa 1 lefu la tsoekere, lefu la tsoekere, "lefu la tsoekere," lefu la tsoekere, hyperosmolar coma, "hepatic" e matla le / kapa ho se sebetse, ts'ebetso e kholo ea ts'ebetso, ho chesoa haholo, likotsi le maemo a mang a hlokang kalafo ea insulin. mala, maemo a tsamaeang le malabsorption ea lijo, nts'etsopele ea hypoglycemia (mafu a tšoaetsanoang), leukopenia, ho ima, ho anyesa, bana ozrast ho lilemo tse 18.

Ka tlhokomelo (tlhoko ea ho shebella le ho khetha litekanyetso ka hloko) e laeloa ho lefu la febrile, lino tse tahang le lefu la qoqotho.

Sebelisa nakong ea bokhachane le pelehi
Setlhare se kopantsoe nakong ea bokhachane le nakong ea ho fepa.
Ha ho ima ho etsahala, moriana o lokela ho emisoa hang-hang.

Tekanyetso le tsamaiso
Tekanyo ea lithethefatsi e beoa ka bonngoe, ho latela lilemo tsa mokuli, lipontšo tsa kliniki ea lefu lena le boemo ba ho pepeseha glucose ea mali le lihora tse peli kamora ho ja. Tekanyetso ea pele ea letsatsi le letsatsi ke 80 mg, karolelano ea letsatsi le letsatsi ke 160 mg, mme lethal dose le leholo la letsatsi le letsatsi ke 320 mg. Diabefarm e nooa ka molomo makhetlo a 2 ka letsatsi (hoseng le mantsiboea) metsotso e 30-60 pele ho lijo.

Litla-morao
Hypoglycemia (boemong ba tlolo ea moriana oa litekanyetso le lijo tse sa lekaneng): hlooho ea hlooho, ho ikutloa o khathetse, tlala, ho fufuleloa, bofokoli bo matla, ho ba mabifi, ho tšoenyeha, ho teneha, ho fokotseha ho teba le ho lieha ho arabela, khatello ea maikutlo, ho senyeha ha pono, aphasia, ho thothomela, ho ferekana ha maikutlo, ho tsekela tahlehelo ea boitšoaro, ho ferekana kelellong, ho akheha, khatello ea maikutlo, ho se tsebe, ho hema ka thata, bradycardia.
Litla-morao: ho hlohlona, ​​urticaria, lekhopho la maculopapular.
Ho tsoa lithong tsa hemopoietic: phokolo ea mali, thrombocytopenia, leukopenia.
Ho tsoa ts'ebetsong ea tšilo ea lijo: dyspepsia (ho nyekeloa ke pelo, lets'ollo, ho imeloa kelellong ho epigastrium), anorexia - boima ba eona bo fokotseha ha ho nkuoa ka lijo, ho se sebetse hantle ha ts'ebetso ea sebete (cholestatic jaundice, ts'ebetso e eketsehang ea transaminase ea "sebete").

Bongata
Matšoao: hypoglycemia e ka etsahala, hofihlela kholo ea kholo ea hypoglycemic coma.
Phekolo: haeba mokuli a le hlokolosi, nka lik'habohaedreite tse bonolo tse tsoekere (tsoekere) ka hare, a e-na le bothata ba ho se tsebe, tharollo ea 40% dextrose (glucose) e fanoa kahare, 1-2 mg ea glucagon intramuscularly. Kamora ho hlaphoheloa kelellong, mokuli o lokela ho fuoa lijo tse nang le lik'habohaedreite tse ngata tse jang habonolo (molemong oa ho qoba ntlafatso ea hypoglycemia) hape. Ka boko edema, mannitol le dexamethasone.

Ho sebelisana le lithethefatsi tse ling
Angiotensin-converting enzyme inhibitors (Captopril, enalapril), H2-histamine receptor blockers (cimetidine), lithethefatsi tsa antifungal (miconazole, fluconazole), lithethefatsi tse seng khahlanong le ts'oaetso tsa ts'oaetso (phenylbutazoflubrate, indigo), li thibela phello ea hypoglycemicma ea Diabeferrma. (ethionamide), salicylates, coumarin anticoagulants, anabolic steroids, beta-blockers, cyclophosphamide, chloramphenicol, monoamine oxidase inhibitors, su fanilamidy nako e telele bohato, fenfluramine, fluoxetine, pentoxifylline, guanethidine, theophylline, lithethefatsi tse thibela tubular secretion, reserpine, bromocriptine, disopyramide, pyridoxine, allopurinol, ethanol 'me etanolsoderzhaschie litokisetso, hammoho le lithethefatsi tse ling tse hypoglycemic (acarbose, biguanides, ka insulin).
Re utloile phello ea hypoglycemic ea Diabefarma barbiturates, glucocorticosteroids, sympathomimetics (epinephrine, clonidine, ritodrine, salbutamol, terbutaline), phenytoin, butle-butle calcium calcium blockers, carbonic anhydrase inhibitors, thiazide azoleflendate diateaneatetseatetsetsetsetsetsetsetsetsetsetsetsebebebebebehane, thiazide, lezolezum diazole. , diazoxide, isoniazid, morphine, glucagon, rifampicin, lihomone tsa qoqotho, letsoai la lithium, litekanyetso tse phahameng - nicotinic acid, chlorpromazine, estrogens le lithibela-pelehi tsa molomo tse nang le tsona.
Ha o sebelisana le ethanol, karabelo e kang ea discriram e ka etsahala.
Diabefarm e eketsa kotsi ea "extrasystole ea" ventricular extrasystole ha e ntse e nka pelo le pelo.
Beta-blockers, clonidine, reserpine, guanethidine e ka pata lipontšo tsa kliniki tsa hypoglycemia.
Meriana e thibelang hematopoiesis ea masapo e eketsa kotsi ea myelosuppression.

Litaelo tse khethehileng
Kalafo ea Diabefarm e etsoa hammoho le lijo tse nang le khalori e tlase e tlaase. Hoa hlokahala hore nako le nako u lekole litaba tsa tsoekere maling maling ka mpeng e se nang letho le ka mor'a ho ja.
Maemong a ts'ebetso ea ts'ebetso ea bongaka kapa ho bolaoa ha lefu la tsoekere, hoa hlokahala ho nahana ka monyetla oa ho sebelisa litokisetso tsa insulin.
Hoa hlokahala ho lemosa bakuli ka kotsi e eketsehang ea hypoglycemia maemong a ho nka lithethefatsi tsa ethanol, tse seng tsa steroidal tse thibelang mafu, ho bolaoa ke tlala. Tabeng ea ethanol, ho boetse ho khonahala ho ba le discriram-syndrome (bohloko ba ka mpeng, ho nyekeloa ke pelo, ho hlatsa, hlooho).
Hoa hlokahala ho fetola tekanyetso ea lithethefatsi ka mokhoa o feteletseng oa 'mele kapa oa maikutlo, phetoho ea lijo
Haholo-holo a amehang ka ketso ea lithethefatsi tsa hypoglycemic ke batho ba tsofetseng, bakuli ba sa fumaneng lijo tse nang le phepo e nepahetseng, bakuli ba fokolang, bakuli ba nang le bothata ba ho hloka pituitary-adrenal.
Qalong ea kalafo, nakong ea khetho ea lethal dose, bakuli ba tloaetseng ho nts'etsopele ea hypoglycemia ha ba khothaletsoe ho etsa lintho tse hlokang tlhokomelo e potlakileng le lebelo la karabelo ea psychomotor.

Fomu ea tokollo
Matlapa a 80 mg
Ho matlapa a 10 a moqomo o tlotsitsoeng o tsoang filiming ea polyvinyl chloride le foil e hatisitsoeng ea aluminium e hatisitsoeng.
Marang-rang a 3 kapa a 6 a nang le litaelo tsa tšebeliso a behiloe ka har'a pakete ea karete.

Maemo a polokelo
Lenane B. Sebakeng se omileng se lefifi ka mocheso o sa feteng 25 ° C.
Qoba hole le bana.

Letsatsi la ho felloa ke nako
Lilemo tse 2
Se ke oa sebelisa kamora letsatsi la ho felloa ke nako.

Lipehelo tsa Khefu ea Litlama
Ka lengolo la ngaka.

Likopo li lokela ho lebisoa ho moetsi:
FARMAKOR PRODUCTION LLC, Russia
Aterese ea Tlhahiso:
198216, St. Petersburg, Leninsky Prospect, d.140, lit. F
Aterese ea molao:
194021, St. Petersburg, Lenaneo la Bobeli la Murinsky, 41, mat. A