Glidiab: lefu la tsoekere, ho loantšana le maikutlo a fapaneng

Phello ea kalafo e fumanoeng ha Glidiab e nkuoa e bakoa ke ts'ebetso ea glycoslide e kenyellelitsoeng ho sebopeho sa eona, e leng karolo ea bobeli ea moloko oa sulfonylurea. Ho fapana le lithethefatsi tsa molala oa pele, e tšoauoa ka katleho e kholo le chefo e tlase, mme phello ea eona ea ho theola tsoekere e khethoa ke 'nete ea hore tlasa ts'usumetso ea gliclazide:

• Ho na le keketseho ea seculin ea insulin ka lisele tsa beta ka har'a sethala sa manyeme oa batho, tseo ka ho sebelisa liprotheine tse sebetsang, li tsamaisang tsoekere liseleng tsa 'mele, ho khothaletsa ts'ebetso ea synthetics ea glycogen ka har'a sebete, mesifa le ho thibela gluconeogeneis,
• Ho thehoa ha tsoekere ho tsoa lithong tsa adipose ka har'a sebete hoa thibeloa.
• Ketso ea ho potoloha ha insulin maling e ea matlafatsoa,
• Ts'ebeliso ea tsoekere e matlafalitsoeng ke mesifa ea marapo le sebete
• Ts'ebetso ea ho phatloha ha hydrolytic ea mafura (lipolysis) liseleng tsa adipose ha ea thibeloa.

Tlhahlobo ea Glidiab, e hlophisitsoeng ke lingaka le bakuli, e bonts'a hore ha o ntse o nka moriana, kutloisiso ea methapo ea methapo ho ea ho insulin, ts'ebetso ea li-enzymes tse kenang (ho kenyeletsoa le glycogen synthetase e teng linthong tsa mesifa) e ea hlasimoloha, 'me nako ea nako lipakeng tsa lijo e fokotsehile haholo. qaleho ea secretion ke litšoelesa tsa secretion ea kahare ea insulin (ka mantsoe a mang, ka keketseho ea insulin). Hape, ho fapana le lithethefatsi tse ling tse tsoang ho sulfonylurea derivatives (ho kenyelletsa glibenclamide le chlorpropamide) mme li na le phello khafetsa mohatong oa bobeli oa ho eketsoa, ​​Glidiab e thusa ho khutlisa tlhoro ea pele ea insulin le ho fokotsa maemo a phahameng a tsoekere maling serum.

Ntle le ho ama metabolism ea carbohydrate, moriana o ntlafatsa li-microcirculation tsa mali, o fokotsa khokahanyo ea liplatelete le ho kopana, ha o ntse o fokotsa tsoelo-pele ea parietal thrombi.

Ntle le moo, ho latela litaelo, Glidiab:

• E fokotsa mats'oao a ho kula ha methapo ea methapo ea methapo,
• E thibela nts'etsopele ea microthrombosis,
• E fokotsa kutloisiso ea methapo ho adrenaline,
• E boetse e tsamaisa mokhoa oa ho sebetsa oa 'mele oa parietal fibrinolysis (ho felisoa ha makatse le ho phatloha ha mali),
• E fokotsa ts'oarelo ea cholesterol e felletseng maling, ka hona e liehisa nts'etsopele ea atherosulinosis le ho tsosa khatello ea eona (ke hore, e na le phello ea anti-atherogenic),
• E thibela ts'ebetso ea tsoekere ea lefu la tsoekere sethaleng se sa feteleng pele.

Tlhahlobo ea Glidiab e tiisa 'nete ea hore tšebeliso ea eona ea nako e telele ho diabetes nephropathy e ka fokotsa haholo dikahare tsa protheine ha ho hlahlojoa moroto.

Lithethefatsi ha li hlahise keketseho ea boima ba 'mele, hobane li ama tlhako ea pele ea tlhahiso ea insulin ke litšoelesa tsa endocrine mme ha e lebise ho hyperinsulinemia. Ho fapana le hoo, bakuli ba nang le botenya ba Glidiab, ha ba e-ja lijo tse khethehileng ba ka tlosa liponto tse eketsehileng.

Glidiab Pharmacokinetics

Ka tsamaiso ea molomo ea matlapa a Glidiab, ntho e sebetsang e ka har'a eona e ananeloa hantle ho tsoa pampiring ea mala. Kamora ho ja tekanyetso e le 'ngoe ea 80 mg, khatello e phahameng ea gliclazide maling a mali e bonoa kamora lihora tse ka bang' ne. Ts'ebetso ea biotransfform e etsahala sebeteng, moo metabolite e robeli e thehiloeng ke oxidation, hydroxylation le glucuronidation tse se nang bokhoni ba ho theola maemo a tsoekere, athe e 'ngoe ea li-metabolites tse hlahisang e ama microcirculation.

70% ea metabolites e hloekisoa haholo ke liphio ka moroto, e ngoe 12% - e nang le litaba tsa mala ka nako ea motsamao oa mokokotlo. Ha e sa fetoloe ke liphio, 1% ea gliclazide e qotsitsoe. Ho felisoa ha halofo ea bophelo ho etsa lihora tse 8 ho isa ho tse 11.

Matšoao a ho sebelisoa

Litaelo tsa Glidiab li bonts'a hore lithethefatsi li khothalletsoa ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 lefu le tsitsitseng, le tsamaeang le mefuta ea pele ea lefu la tsoekere la lefu la tsoekere. Ka nako e ts'oanang, ts'ebeliso ea eona e lumelletsoe ka bobeli e le moemeli oa monotherapeutic, hape e le karolo ea kalafo e rarahaneng, e bolelang tšebeliso ea lithethefatsi tse ling tse nang le phello ea hypoglycemic.

Matlapa a Glidiab a ka boela a beoa hammoho le lithethefatsi tse ling tsa hypoglycemic e le prophylactic bakeng sa likhathatso tse fapaneng tsa rheology ea mali.

Contraindication

Moriba o na le mefuta e mengata e fapaneng ea litlolo. Kahoo, ha ho lumelloe ho fana ka taelo ea Glidiab:

• Bakuli ba lefu la tsoekere la 1
• Ka lefu la tsoekere,
• Ka lefu la tsoekere le letlalong,
• Bakuli ba nang le insuloma,
• Batho ba nang le bothata ba ho ruruha bo sa sebetseng hantle bo amanang le phepo e matla,
• Mefuteng e matla ea microangiopathy,
• Bakeng sa mafu a tšoaetsanoang
• Ka likotsi le ts'ebetso e kholo ea ho buoa,
• Batho ba nang le hypersensitivity ho litokollo tsa sulfonylurea le litokisetso tsa sulfonamide,
• Basali nakong ea bokhachane le pelehi.

Tekanyetso le tsamaiso

Bakeng sa mokuli e mong le e mong, tekanyetso e nepahetseng ea letsatsi le letsatsi ea Glidiab e khethoa ke ngaka ka boeona e ipapisitseng le datha ea boemo ba 'mele oa hae, lilemo le mofuta oa lefu lena. Ka ho khetheha, ba ela hloko setšoantšo sa bongaka ba lefu lena le matšoao a glycemia, a bonoang hoseng ka mpeng e se nang letho le lihora tse peli ka mor'a lijo.

Tekanyetso ea pele ea letsatsi le letsatsi ea Glidiab hangata e le 80 mg, karolelano ea litekanyetso tsa letsatsi le letsatsi ke 160 mg, mme boholo ke ba 320 mg. Ho ata ha li-reception ke 2. Matlapa a noang a khothalletsoa hoseng le ka shoalane halofo ea hora pele ho lijo.

Litlamorao

Litlhahlobo mabapi le Glidiab ke bopaki ba hore maemong a mang, ho nwa moriana ho ka tsamaellana le karabelo e mpe.

Bakuli ba bang ba na le lintho tse amanang le ho kula, ho ipolaisa tlala, ho nyekeloa, ho hlatsa, ho utloa bohloko le ho opeloa sebakeng sa epigastric. Supombocytopenia, leukopenia, agranulocytosis kapa anemia ka linako tse ling e ka bonoa (e le molao, liketsahalo tsena kaofela lia fetoha).

Melemo ea pharmacological

Sesebelisoa sa mantlha sa lithethefatsi ke sa sehlopha sa li-hypoglycemic agents, ketso ea eona e bakoa ke phello liseleng tsa manyeme. Glidiab e fana ka litlamorao tse joalo tsa 'mele' meleng, joalo ka:

1. Lisele tsa pancreatic li susumetsoa ke secretion ea insulin.
2. E eketsa kutloisiso ea mesifa ho insulin, e lumellang ho fihlela litholoana tse ntle kamora ts'ebeliso ea pele ea lithethefatsi.
3. Fokotsa bolelele ba nako ho tloha ha lijo li kena 'meleng ho fihlela manyeme a etsa insulin, a etsa hore ho hloekisoa ho tsoelang pele.
4. E fokotsa khokahano ea liplatelete le khokahano ea methapo, e thusang ho thibela nts'etsopele ea maloetse a pelo le methapo e amanang le ho etsoa ha methapo ea mali.
5. E fokotsa botebo ba li-receptors tsa lebota la vascular ho litlamorao tsa adrenaline.
6. Ho hlohlelletsa ho fokotseha ha proteinuria moo ho nang le nephrotic syndrome e matla.

Monyetla o moholo oa lithethefatsi ke hore ka tšebeliso ea nako e telele, keketseho ea methapo ea 'mele ha e mele, e leng ntho e tloaelehileng ho lefu la tsoekere. Ho latela lijo tse khothalletsoang, Glidiab e thusa ho tsitsisa boima ba 'mele.

Glidiab e shebahala joang?

Nts'etsopele ea retinopathy e liehisoa, e lumellang mokuli ho boloka pono. Khahlano le semelo sa tšebeliso ea nako e telele, ho buuoa ka methapo e mengata haholo, ho thusang ho fokotsa ponaletso ea polyneuropathy. Ka litekanyetso tse nepahetseng tsa lithethefatsi, litla-morao tsa lefu la tsoekere lia fokotsoa.

Kamora ho kenya matlapa kahare, a phatlalatsoa ka pompong ho tsoa mohloling oa tšilo ea lijo. Keketseho ea bongata ba lithethefatsi e etsahala butle butle, e felisang nts'etsopele ea maikutlo a mabe a tsoang tsamaisong ea pelo le mokokotlo (ho nyekeloa pelo, ho tsekela le tse ling).

Ts'oarello e kholo e fihlella lihora tse 6-12 kamora ho nka matlapa. Ho ja ha ho ame ho monya le ho tsamaisoa ha likarolo tse sebetsang tsa moriana.

Bophelo ba halofo ke hoo e ka bang lihora tse 16. Sena se o lumella ho nka moriana ona hang ka letsatsi, mme ts'ebetso ea ona e phahameng e phehella letsatsi lohle.

Motsoako o sebetsang oa lithethefatsi ke gliclazide, eo ho eona ho nang le pilisi e le 'ngoe e nang le 30 mg. Likarolo tse thusang:

• phospholle cellulose,
• hypromellose,
• silika
• magnesium stearate.

Matlapa a na le "cylindrical" e nang le chamfer bohareng. E kenelletse ka har'a lisele tse 10 tsa li-pcs.

Matšoao a ho khethoa

Moriana o laetsoe boteng ba lefu la tsoekere la mofuta oa 2, hammoho le ho felisa lipontšo tse tsamaeang le ona.

• khatello ea kelello ea methapo
• lefu la pelo
• nephrotic syndrome.

Pele u sebelisa lithethefatsi, ho khothalletsoa ho etela setsebi.

Mekhoa ea kopo

Ho na le mefuta e 'meli ea Glidiab: khafetsa le Glidiab MV. Phapang litokisetsong e ka tekanyetso le litekanyetso tsa tsamaiso.

Tekanyetso ea pele ea letsatsi le letsatsi ea lefu la tsoekere la mofuta o tsoelang pele ke 80 mg ka letsatsi. E ka eketsoa hanyane ka hanyane ha ho se na phello ea kalafo. Tekanyetso e phahameng ea letsatsi le letsatsi ea lithethefatsi ke 320 mg. E arotsoe ka litekanyetso tse 'maloa ka linako tse ling, tse u lumellang ho boloka maemo a tsoekere ea mali ka tekanyo e itseng esita le ka mor'a ho nka lik'habohaedreite.

Ho khothalletsoa ho nka Gladiab hang hoba u tsohe lijong tsa hoseng ka metsi a fokolang. Ka boteng ba pathologies ea meno, phetoho ea litekanyetso ha e hlokehe.

Glidiab MV

Moriba o na le tšusumetso ea nako e telele, ka hona, ho nka letlapa le le leng ka letsatsi ka tekanyo ea 30 mg. Ha ho e-na le phello ea kalafo, keketseho ea tekanyo ea ho fihlela ho 120 mg ka letsatsi e lumelletsoe. Mohato o etsoa butle butle, o eketsa halofo ea letlapa ka letsatsi beke le beke.

Glidiab MV e nkile khato ea nako e telele

Ho khothalletsoa ho nooa lipilisi hoseng ka mor'a lijo tsa hoseng kapa nakong ea lijo. Mabakeng a ho hloka ts'ebetso, ho bohlokoa ho buisana le ngaka mabapi le monyetla oa phetoho ea litekanyetso.

Monyetla o ka sehloohong oa lithethefatsi ke hore e ka sebelisoa hammoho le li-agents tse ling tsa hypoglycemic, tse sa ntšeng bophelo bo botle.

Bongata

Tabeng ea tekanyetso e kholo ea lithethefatsi, ho na le maemo a mabeli a bohlokoa: hypoglycemia le pancytopenia. Tabeng ea pele, tsoekere ea mali e theohela tlaase haholo. Maemong a bobeli, motsoako oa masapo a lisele tsa mali o ea fokotseha, e leng se sitisang lits'ebetso tsohle tsa metabolic. Ka bobeli, sena se ka qholotsa nts'etsopele ea lefu la tsoekere, hammoho le sephetho se bolaeang.

Haeba mokuli a hlokomela, a fuoa lijo tse nang le tsoekere e le hore a eketse tsoekere maling. Boemo bo sa tsebeng letho bo hloka ho ts'oaroa ha glucose le ho lekola kamehla litekanyetso tsa mali a biochemical.

Ho sebelisana le lithethefatsi tse ling

Glibiad MV e kopantsoe hantle le lithethefatsi tse ling tse nang le thepa ea hypoglycemic, empa ka kalafo e rarahaneng ho bohlokoa ho nahanela palo eohle ea lithethefatsi e le hore li se ke tsa baka tsoelo-pele ea tsoekere e tlase ea mali.

Ka ts'ebeliso e le 'ngoe ea lithethefatsi ka lithethefatsi tsa NSAID, ho na le hyperemia ea letlalo, pallor le matšoao a mang a phokolo ea mali, ho kenyelletsa ho tsekela le ho hloka takatso ea lijo.

Sulfanilamides hammoho le Glibiad ba tsosa tsoekere e maling ea mali, e leng se eketsang likotsi tsa ho ba le komello ea hypoglycemic.

Ka tšebeliso e tšoanang ka li-fibrate, thepa ea hypoglycemic ea lithethefatsi e eketseha makhetlo a 'maloa.

Ka tlhokomeliso e fetelletseng, sethethefatsi sena se kopantsoe le glucocorticosteroids, hobane ea morao e ka baka tsoelo-pele ea lefu la tsoekere la steroid.

Lithethefatsi tsa Hormonal tse laetsoeng ho lokisa boemo ba mafu a endocrine li khethoa ka lipositi tse tlase, hobane ha ho sebelisana le Glidiab, ts'ebetso ea ho phekola ea morao e fokotseha makhetlo a 'maloa.

Theophylline le salicylic acid e tsoang ho makhetlo a 'maloa e ntlafatsa katleho ea moriana, o ka bakang kholo ea hypoglycemia.

Ho thibetsoe ka thata ho kopanya Miconazole le lithethefatsi tse ling tsa antifungal le Glidiab

Ho thibetsoe ka thata ho kopanya Miconazole le lithethefatsi tse ling tsa antifungal le Glidiab, tse kenyelletsang nts'etsopele ea lefu la tsoekere le phello e bolaeang ka tšohanyetso.

Hape, u se ke ua sebelisa lithethefatsi le litlatsetso tsa joala, hobane limolek'hule tsa ethanol li baka tlolo ea thepa ea 'mele e khothalletsang mathata, e amang manyeme hampe.

Bareki ba Adrenergic ba kopaneng le Glidiab ba khona ho pata matšoao a hypoglycemia, e eketsang kotsi ea ho ba le maemo a tšohanyetso.

Barbiturates hoo e batlang e thibela ka botlalo ts'ebetso ea lithethefatsi Glidiab MV, ka hona, ha e sebelisoe hammoho ka lebaka la khaello ea matla a kalafo.

Ho latela litlhahiso tsohle tsa setsebi, matlapa a Glidiab a ka thusa ho fokotsa litheko tse phahameng tsa tsoekere ea mali, hammoho le ho fokotsa lipontšo tsa lefu la tsoekere. Mokhoa oa boithatelo o lokela ho qheleloa ka thoko, kaha ho na le kotsi e kholo ea ho ba le karabelo e mpe.