Ho ts'oaroa ka ts'ebeliso ea ts'ebeliso ea morao-rao ka mokokotlo oa "prinopathy" ea lefu la tsoekere ka mor'a ho ts'oaroa ke "laser" sengoloa sa sengoloa saenseng se ikhethang - Clinical Pharmacology

Ho bakuli ba 112 (mahlo a 222) ba nang le lefu la tsoekere la mofuta oa 2 o rarahaneng ke prollopathy ea tsoekere ea tsoekere, litaba tsa mokelikeli ka makhetlo a fapaneng ka mor'a ho ts'oaroa ke "cytokine" ea "laptinal", e khothalletsang nts'etsopele ea methapo ea kutlo? Ho ile ha bontšoa hore ho khethoa ha immunocorrection nakong ea ts'ebetso ho lumella ho ntlafatsa lits'ebetso tsa sebopeho sa pono kamora ho ts'oaroa ke laser mme ho baka keketseho e tlase haholo ho dikahare tsa interleukin4 ka mokelikeli oa lacrimal, ka hona, ho fokotsa karabelo ea ho hlekefetsa ho pepeseha hoa mahlahana mme, mohlomong, boteng ba sekhahla sa mali-ophthalmic.

Ho bakuli ba 112 (mahlo a 222), a tšoeroeng ke lefu la tsoekere la bobeli, a thatafalitsoeng ke prollopative diabetesic retinopathy, ho ithutoang e ne e le litaba tsa cytokine tsa interleukin4, tse khothalletsang nts'etsopele ea methapo, ho mokelikeli oa lacrimal ka linako tse fapaneng kamora ho ts'oaroa ke "lasercoagulation". Ho bontšoa ke 'nete ea hore ho tsamaisa khalemelo ea' mele ea ho itšireletsa mafung nakong ea ts'ebetso ho phahamisa litholoana tse sebetsang bakeng sa leihlo ka mor'a lasercoagulation mme ho baka boemo bo tlase haholo ba sekhahla sa phallo ea inflleukin4 mokhoeng oa lacrimal mme, ka lebaka leo, ho fokotsa karabelo ea ho se sebetse hantle phello e cheleng, mme, mohlomong , boteng ba tšitiso ea mali-ocular.

Lingoloa tsa saense e bua ka sehlooho se reng "Postoperative immunocorrection with derinate of prollopathy diabetesic retinopathy after panretinal laser"

UDC 616.379 - 008.64 - 06: 617.735 - 085.849.19: 617.764.1 - 008.8 - 07: 577.175.859

TLHOKOMELISO EA PUSO YA LITLHAKISO TSA PUSO TSE KHOLO TLHALOSO EA METSOALLE EA PUSO TSE KOTSI

Vladimir Borisovich Kuzin, Tatyana Pavlovna Sokolova

Lefapha la Kakaretso le Clinical Pharmacology (Hlooho - Prof. VB Kuzin) Nizhny Novgorod State

Ho bakuli ba 112 (mahlo a 222) ba nang le lefu la tsoekere la mofuta oa 2 o rarahaneng ke prollopathy ea tsoekere ea tsoekere, dikahare tsa metsi a llang ka linako tse fapaneng ka mor'a ho ts'oaroa ke "laser" ea "interleukin-4-cytokine", e khothalletsang kholo ea methapo ea kutlo. Ho ile ha bontšoa hore ho khethoa ha immunocorrection nakong ea ts'ebetso ho ntlafatsa sephetho sa ts'ebetso ea sebopeho sa pono kamora ho ts'oaroa hoa laser mme ho baka keketseho e tlase haholo ho litaba tsa interleukin-4 mokhoeng oa lacrimal, ka hona, ho fokotsa karabelo ea ho hlekefetsoa ha ho chesoa 'me, mohlomong, boteng ba tšitiso ea mali-ophthalmic.

Mantsoe a bohlokoa: "retinopathy" ea lefu la tsoekere, ho ts'oaroa ha laser, leseling, lacleimal, 4le.

Diabetesic retinopathy, ho latela lingoliloeng, ke sesosa se ka sehloohong sa bofofu bo ke keng ba fetoloa ho batho ba lilemo tse 4, 10. Mokhoa oa ho khetha kalafo ho bakuli ba nang le mofuta oa pele oa lefu la tsoekere ke retinal laser coagulation 1, 10. Hajoale, ho thoeng panra e sebelisoa e le mokhoa o ka sehloohong -inal laser coagulation, e lebisang timetsong e kholo ea retina le phetisetso ea lithane tse tlatsitsoeng ka sekhahla se iphetotseng (serese) se sebelisang oksijene ka tekanyo e nyane haholo ea 1, 6, 7, 9, 10. Wie tham mong bang laser eneji, le holim'a retina hlokahala ho fumana e le hantle phekolo, a tsamaea le e ke keng ea qojoa tshenyo ka tsela e feteletseng ho dibopeho tsa lona, ho akarelletsa le neuroepithelium e,e netefalitsoeng ke lithuto tsa bongaka le tsa morphological le tsa electrophysiological. Ho na le litlaleho tsa boithuto ba bokhoni ba "immunological" ba tishu ea mahlo ka mor'a ho fokotseha hoa laser ea retina, ho bonts'a ho ba teng hoa liphetoho mokhoeng oa autoimmune

pa E qetellang e bontša tlhokahalo ea kalafo ea immunomodulating bakeng sa tokiso ea ts'ebetso ea ts'oaetso le e senyang le ea autoimmune kamora ho ts'oenyeha ha laser.

Ho hlahisoa ha mekhoa e sa hlaseleng ea ho fumana mafu ke e 'ngoe ea likarolo tsa pele tsa bongaka ba sejoale-joale. Mokhoa o bonolo, o fumanehang ebile o ruta 'nete o u lumellang ho fumana leseli mabapi le methapo ea methapo le ea bohloeki ea leihlo ke tlhahlobo ea methapo ea methapo ea kutlo le 2: 3, 5. Mellano ea methapo ea methapo ea mali le ea biochemical ea metsi le lintho tse ling tse netefalitsoeng e le liteko' me ho bonahala e hlalosoa ke mohloli o tloaelehileng oa phepelo ea mali leihlo. le tšoelesa ea tlhaho. Ho fihla joale, ha ho na datha ho lingoliloeng tse ithutoang ka liphetoho liparamenteng tsa lacrimal fluid nakong ea prolopathy ea lefu la tsoekere ka mor'a ho ts'oaroa ke "laser" le khahlanong le semmuso sa immunocorrection.

Morero oa mosebetsi e ne e le ho ithuta phetoho ea litaba tsa li-interleukin-4 (IL-4) mokelikeli o nang le phepo e nepahetseng ho bakuli ba mofuta oa 2 lefu la mellitus le rarahaneng ka ho fetoloa hoa lefu la tsoekere, ka bobeli kamora ho ts'ebelletsoa hoa ts'ebeliso ea "laser" le ka morao ho tokiso ea ts'ebeliso ea morao-rao ka tšohanyetso ea immunomodulator.

Re bone bakuli ba 112 (mahlo a 222) ba lilemo li 47 ho isa ho tse 74 (lilemo tse pakeng tsa 58) ba nang le lefu la tsoekere la mofuta oa 2 le rarahaneng ke lefu la tsoekere la tsoekere la tsoekere. Nako ea lefu la tsoekere e ne e le karolelano ea lilemo tse 25. Tlhahlobo ea "Ophthalmologic" e kenyeletsa visometry, biomicroscopy

karolo e ka ntle ea leihlo, e sa amanang le ophthalmoscopy.

Mokhahlelo oa pele oa lefu la tsoekere e le sesupo se hlakileng sa ho ts'oaroa hoa marang-rang. Bakuli bohle ba ile ba fumana likarolo tse peli tsa "panretinal laser coagulation" ea laser e nang le wavelength ea 532 nm (Zeiss) nako ea matsatsi a 10. The parameter ea laser coagulation e ne e le ka tsela e latelang: matla - ho tloha ho 100 ho isa ho 220 mW, bophara ba sebaka sa laser - 200 μm, nako ea tlhahiso ea pulse e le 'ngoe - 60 ms, palo ea li-coagulates ka karolo e le' ngoe - 1500. Matla nakong ea laser coagulation e ile ea khethoa ka bonngoe ho fumana coagrate ea tekanyo ea bobeli (2nd) ( ka L'Esperans). Bakuli ba ile ba aroloa ka lihlopha tse peli. Sehlopha sa 1 se ne se kenyelletsa batho ba 56 (mahlo a 111), ba sa kang ba fumana kalafo ea postoperative ka mor'a ho ts'oaroa ke laser. Kamora ho ts'oaroa ha laser, bakuli ba 56 ba sehlopha sa 2 (mahlo a 111) ba ile ba fuoa immunomodulator le li-derinat tsa lehae karolong e ka tlase ea conjunctival arch 1-2 e theoha makhetlo a 3 ka letsatsi bakeng sa khoeli e le ngoe. Derinat ke ea sehlopha sa li-immunomodulators tsa khale 'me ke letsoai la sodium ea letsoalloa le tsoang sebakeng sa tlhaho sa deoxyribonucleic acid (DNA-Na) ka tharollo ea 0,1% ea sodium chloride. Setlhare se tloaela boemo ba mmele ba ho itšireletsa mafung le methating, ke sefutho se matla sa tokiso ea lisele, nchafatso le botsitso ba hematopoiesis. Bakuli bohle ba ile ba fumana mokelikeli oa metsi ka makhetlo a mararo - pele ho ho ts'oaroa ha laser, matsatsi a 10 le khoeli e le 'ngoe ka mor'a thuto ea pele. Mokelikeli oa likhapha o ile oa bokelloa ka li-micropipette tse se nang litšila tse tsoang karolong e ka tlaase ea konsare ka li-epindorphs ka boholo ba 0.5 di ml mme tsa bolokoa ho lehloa ka -18 ° C bakeng sa likhoeli tse peli. Mohlahisi ea amanang le li-immunosorbent tse kopantsoeng le enzyme (Stat Fax) o ile a sebelisoa ho ithuta lintho tsa tlhaho tse fumanoeng ke enzyme-e kopantsoeng le immunosorbent assay ho tseba litaba tsa cytokine interleukin-4 (IL-4). Liphetho tsohle tsa tlhahlobo li ile tsa kenngoa ts'ebetsong ea lipalo ka khomphutha ea hau e sebelisa sephutheloana sa software ea Exel.

Ho ea ka datha ea rona, ho bakuli ba sehlopha sa 2, maemo a tloaelehileng a IL-4 mokelikeng oa meokho pele ho marang-rang a laser e ne e le 135 ± 36.07 pg / ml, sehlopheng sa 1 - 132.12 ± 37.61 pg / ml.Matsatsi a 10 kamora ho ruruha hoa laser, litaba tsa IL-4 mokelikeli o tsoang ho bakuli ba sehlopha sa 1 li eketsehile ka karolelano ho 356.7 ± 45.01 pg / ml, ka la bobeli - ho 224.91 ± 5.21 pg / ml , kamora khoeli e le 'ngoe e fokotsehile, ka tatellano, ho 209.53 ± 30.61 le ho 120.43 43 31.23 pg / ml.

Kahoo, ka lihlopha tsena ka bobeli, ho ts'oenyeha ka "laser" ea patretinal laser ho lebisitse keketseho e kholo ea lipalo tsa IL-4 mokhoeng oa lacrimal ka mor'a matsatsi a 10 - makhetlo a 2,7 sehlopheng sa 1 (p 0.05). Matla a khoheli a IL-4 ho bakuli ba sehlopha sa 2 a hlahisoa ho setšoantšo sa 1.

pele o buuoa matsatsi a 10 ka khoeli e le 'ngoe

ka mor'a ho buuoa ka mor'a ho buuoa _ _ ■ ntle le kalafo ea postoperative

- khahlano le bokapele ba ts'ebeliso ea Derinat

Sa feiga. 1. Matla a litaba tsa IL-4 mokelikeling oa batho ba nang le lefu la tsoekere la mofuta oa 2 a rarahaneng ke lefu la tsoekere la tsoekere ka linako tse fapaneng ka mor'a ho ba le laser.

Interleukin-4 ke sehlahisoa sa mantlha sa bathusi ba sehlopha sa 2 T, e hlohlelletsa phapang ea bona, e khothaletsa nts'etsopele ea maikutlo le lintho tse sa thabiseng, 'me e na le phello ea antitumor. Keketseho ea letšoao lena kamora nako ea ts'ebetso e ka ba sesupo sa karabelo ea ho haba le phello ea ho chesoa ke borashe ba laser. Lits'ebetso tse tlase tsa letšoao lena tse khahlanong le semelo sa tšebeliso ea li-derading li ka hlalosoa ka phello e nchafalitsoeng ea lithethefatsi sena le keketseho e nyane haholo ea boteng ba tšitiso ea mali le bokong ba mali ha bo bapisoa le ba sehlopha sa bakuli ba sa kang ba fumana kalafo ea ts'ebetso ea postoperative.

Sena se boetse se tiisoa ke litholoana tsa boithuto ba li-visual acuity ka lihlopha tsena ka bobeli. Ho bakuli ba sehlopha sa 1, maikutlo a tloaelehileng a acuity pele ho kopane ea laser e ne e le 0.54 ± 0.029, 'me khoeli e le' ngoe ka mor'a ho ts'oaroa ke laser, 0.48 ± 0.028, sehlopheng sa 2, ka tatellano, 0.58 ± 0.023 le 0.66 ± 0.024. Kahoo, sehlopheng sa bakuli ba sa kang ba amoheloa, mokokotlo oa laser o boetse o bakile ho fokotseha hoa ts'ebetso ea pono khoeli ka mor'a ho buuoa ka karolelano ea 11% (p. Ha ke fumane seo u se hlokang? Leka ts'ebeletso ea khetho ea lingoliloeng.

4. Khyshiktuev B.S., Maksimenya M.V., Kozlov S.A. Boleng ba ho khetholla lithuto tsa maro a marang-rang ho lefu la tsoekere la retinopathy // Klin. lab. ts'oaetso - 2006. - Che. 3. - P.34 - 36.

5. Bloomgarden, Z.T. Diabetes retinopathy // Tlhokomelo ea lefu la tsoekere. - 2008 .-- Moq. 31, No. 5. - P.1080 - 1083.

6. Hietala K., Forsblom C., Summanen P. et al. Heritability ea proliferative lefu la tsoekere retinopathy // Lefu la tsoekere. - 2008 .-- Moq. 57, Che. 8. - P.2176 - 2180.

7. Imai M, Iijima H. Liphello tsa ho ts'oasa limela kareteng ea 'mele ho li-photopic ERG ka mahlo a tloaelehileng a mmutla // Jpn. Y. Ophthalmol. - 1995. - Moq. 39, Che. 2. - R. 120 - 123.

8. Bopaki ba Immunohistochemical of macrophages in laser Photocoagulation lesion in the retina / X. Yi, K. Takahashi, N. Ogata, M. Uyama // Jpn. J .. Oththalmol. - 1998. - Moq. 40, No. 2. - P. 192 - 201.

9. Linss W., Loffler J., Dietze U, Deufrains A. Licht und electronenmikroskopische Befunde ke pigmentepithel und an der Bruchscher Membran des Kaninchenaugen ke Fotokoagulation // Fol. Ophthalmol. - 1985. - B.10, Che.5 - S.311 - 317.

10. Takahashi A, Nagaoka T, Sato E, Yoshida A. Tšusumetso ea ho ts'oaroa hoa potretinal ho potoloha ha potoloho ea mafu a mocheso ho bakuli ba nang le lefu la tsoekere le tebileng la retinopathy // Br. J. Ophthalmol. - 2008 .-- Moq. 92, Che.10 - P.1369 - 1373.

TLHOKOMELISO EA PUSO EA LITLHAKISO TSA PUSO EA LITLHAKISO TSA PUSO TSE KOTSI

V.B. Kuzin, T.P. Sokolova

Ho bakuli ba 112 (mahlo a 222), ba nang le lefu la tsoekere la bobeli, ba thatafalloang ke lefu la tsoekere la prollopathy, ba ithutile e ne e le litaba tsa interleukin-4 - cytokine, e khothalletsang nts'etsopele ea methapo, ho mokelikeli oa lacrimal ka linako tse fapaneng kamora ho ba le ponzi e kholo. lasercoagulation. Ho bontšoa ke 'nete ea hore ho tsamaisa khalemelo ea' mele ea ho itšireletsa mafung nakong ea ts'ebetso ho phahamisa litholoana tse sebetsang bakeng sa leihlo ka mor'a lasercoagulation 'me ho baka boemo bo tlase haholo ba sekhahla sa "inflleukin-4" ka har'a mokelikeli oa lacrimal mme, ka lebaka leo, ho fokotsa karabelo ea ho se sebetse hantle phello e cheleng, mme mohlomong, boteng ba tšitiso ea mali-ocular.

Mantsoe a bohlokoa: "retinopathy" ea lefu la tsoekere, lasercoagulation ea panretinal, mokelikeli oa lacrimal, interleukin-4.

Lisosa tsa pele tsa lefu la tsoekere la mofuta oa 2

Mofuta oa lefu la tsoekere la mofuta oa 2, o nkoang e le lefu la seoa le sa tšoaeheng la XX - la pele la XXI, ke bothata bo tebileng ba bongaka le sechabeng. Ho latela litsebi tsa WHO, "lefu la tsoekere ke bothata ba lilemo tsohle le lichaba tsohle." Hajoale, ba limilione tse 146.8 (2.1%) ba baahi ba lefatše ba na le lefu la tsoekere la mofuta oa 2. Ho latela likhakanyo tsa Setsi sa Machaba sa Lefu la Ts'oaetso ka 2010, palo ea batho ba nang le lefu lena ba ka fihla ho batho ba fetang limilione tse 200 (Amos A. Et al., 1997), kapa 3% ea baahi ba lefatše (Pratt R., Dzau V., 1999). Ho latela I.I. Dedova (2008), naheng ea Russia batho ba limilione tse 8, kapa 5% ea baahi kaofela, ba na le lefu la tsoekere, bao 90% ea bona e leng lefu la tsoekere la mofuta oa 2. Ho shoa ha bakuli ba nang le lefu la tsoekere la mofuta oa 2 ho phahame haholo ho feta palo ea batho ba shoang. Maemong a 60%, sesosa sa lefu la bakuli ba nang le lefu la tsoekere la 2 ke angiopathy, e leng: lefu la pelo, ho 10% - mathata a methapo ea methapo (Russo, Kaski J. S, 2000). Ho fihlela ho 80% ea bakuli ba nang le lefu la tsoekere ba na le lefu la methapo ea methapo (Alderman M.N. et al., 1991). Sehlopheng sena sa bakuli, menyetla ea ho shoa pele ho nako e eketseha haholo, mme tebello ea bophelo e fokotsehile ka 1/3 (Bonnardeaux A. et al., 1994). Har'a bakuli ba nang le lefu la tsoekere, ho ata ha lefu la pelo ea pelo (CHD) ke makhetlo a 2-4, kotsi ea tšoaetso ea methapo ea pelo (MI) e hlobaetsang ka makhetlo a 6-10 le ho tšoaroa ke lefu la mokokotlo ka makhetlo a 4 ho7 ho feta hara batho ba se nang lefu la tsoekere (Gibbons G., 1997).Ka lebaka la kotsi e kholo ea ho ba le mathata a pelo le methapo e lebisang ho holofala kapele le lefu la pele ho nako, lefu la tsoekere la 2 haufinyane e ka ba bothata bo boholo ba bophelo bo botle ba sechaba linaheng tsohle tsa lefats'e (Lean M.E., 1998). Ho tloha ka lithuto tsa O. Minkowski le J. Von Mering (1889-1892), tse bakileng lefu la tsoekere ho lintja ka ho tlosa makhopho a tsona, ho ile ha fumaneha hore secretion ea insulin ke e 'ngoe ea lintlha tse hlokahalang bakeng sa nts'etsopele ea lefu la tsoekere. Kamora nako, ho ile ha hlaha mesebetsi e lumellang kutloisiso e qaqileng haholoanyane ea etiology ea lefu lena (Alberti K.G.M.M., Zimmet P.Z., 1998). Mofuta oa 2 oa lefu la tsoekere ke lefu le matla, kholiseho ea lona e kenyelletsa liphatsa tsa lefutso (Gale E., 2005) le maemo a tikoloho (Kononenko IV, Smirnova OM, 2005, Kochemasova TV, 2000), hammoho le motsoako oa tsona e amang metabolism ea carbohydrate (Balabolkin MI, 2000). 1. Lisosa tsa ho itšireletsa khahlanong le insulin: litekanyetso tsa mali tse phahameng tsa mafura acid, cytokine: leptin, tumor necrosis factor alpha (TNF-alpha), jj (Volkova AK et al., 2000). 2. Lintho tse amanang le lefu la tsoekere la mofuta oa 2. Ho latela liphuputso tse fapaneng tse etsoang linaheng tse fapaneng, hoa tsebahala hore lefu la tsoekere la mofuta oa 2 le na le mefuta ea mofuta oa mono- le polygenic. 3. Age. Ho qala ka lilemo tse 45, palo ea bakuli ba nang le lefu la tsoekere ea eketseha. Ho tsofala ka boeona ho eketsa kotsi ea ho ba le insulin ea ho hanyetsa le lefu la tsoekere (Anderson EA, Mark A.L., 1993). 4. Boima bo tlase ba tsoalo le eona ke sesosa sa lefu la tsoekere la mofuta oa 2. Bafuputsi ba bang ba hlokomela hore khaello ea phepo e nepahetseng nakong ea kemolo e ka baka pherekano ea metabolism ka popelong e ntseng e hola, eo qetellong e lebisang qalehong ea lefu la tsoekere (Durrencton P.N., 1991). 5.

Ho nona haholo. 85% ea bakuli ba nang le lefu la tsoekere la mofuta oa 2 ba nonne ho feta tekano kapa ba batenya, ho sa tsotelehe hore na boima bo feteletseng ba 'mele bo fuoe kapa bo fumanoe (Oganov R.G., Nebieridze A.V., 2002). Lithane tse ngata tsa adipose li lebisa nts'etsong ea insulin, ho hanyetsa leptin le keketseho ea phetoho ea androgens ho estrogens liseleng tsa lithane tsa adipose. Eseng boteng feela, empa le mofuta oa kabo ea mafura o ama kotsi ea ho ba le lefu la tsoekere la mofuta oa 2 (Kannel W.B., McGee D.L., 1979). Karolo e ikhethileng lits'ebetsong tsena e fuoe mafura a seminal (omental and subcutaneous). 6. Mefuta ea lelapa. 25-25% ea bakuli bohle ba nang le lefu la tsoekere la mofuta oa 2 ba na le baena ba nang le lefu la tsoekere. Ho batho ba nang le mong ka leloko la matsibolo a nang le lefu lena, monyetla oa ho ba le lefu la tsoekere la mofuta oa 2 ke 40%. 7. Moroko. Kotsi ea ho ba le lefu la tsoekere la mofuta oa 2 e atile har'a merabe e buang Sepanish ea baahi ba Amerika le Canada, baahi ba lihlekehleke tsa Pacific le Indian Oceans, baahi ba India le Australia le batho ba Maafrika. 8. Ho ikoetlisa. Boithuto bo mabapi le likarolo tse fapaneng merabeng bo bonts'a hore ho ata ha lefu la tsoekere har'a batho ba phelang bophelo ba ho lula fatše hangata ho phahame makhetlo a 2-3 ho feta hara palo e ts'oanang ea batho ba sebetsang ka mmele (Gogin E.E., 1997). 9. Phepo e nepahetseng. Lijo tse nang le khalori e phahameng tse nang le mafura a mangata a nang le mafura a mangata, se na le mafura a mangata a limela le lijo tse fokotsehileng (ho tloha meroho, litholoana, lijo-thollo) li eketsa menyetla ea ho ba le lefu la tsoekere, ke hore, ts'ehetso e ikemiselitsoeng ka bobeli lethathamong la khalori eohle le sebopeho sa lijo (Prekina V.I. ., Tyuryakhi-na N.A., 1999). Hajoale, motheo oa liphatsa tsa lefutso la tsoekere e sa itšetleheng ka insulin (NIDDM) ha o na lipelaelo (Liberman IS, 1997). Ntle le moo, ho lokela ho hopoloa hore lipalo tsa lefutso tsa NIDDM li bohlokoa le ho feta ho lefu la tsoekere la mofuta oa 1.

Ho netefatsa motheo oa liphatsa tsa lefutso tsa NIDDM ke 'nete hore ka mafahla a tšoanang NIDDM e ntse e hola ka linako tsohle (95-100%) ka bobeli. Ka nako e ts'oanang, sekoli sa liphatsa tsa lefutso se khethollang nts'etsopele ea NIDDM ha se khethoe ka botlalo (Blagoslonnaya Y.V. et al., 1996). Ho latela pono ea kajeno, ho na le likhetho tse peli tse ntseng li hlahlojoa. Ea pele: liphatsa tse peli tse ikemetseng li kentse letsoho ho pathogenesis ea NIDDM, e 'ngoe e ikarabella bakeng sa secretion ea insulin, mme ea bobeli e baka nts'etsopele ea insulin.Re boetse re nahana ka monyetla oa sekoli se tloaelehileng ts'ebetsong ea ts'ebeliso ea tsoekere ke li-P-cell kapa li-tishu tse poteletseng, ka lebaka leo ho nang le phokotseho ea ho tsamaisoa ha tsoekere kapa ho fokotseha ha karabelo ea lisele tse 3 tsa tsoekere. Batho ba kotsing e kholo ea ho ba le lefu la tsoekere la mofuta oa 2 ba kenyelletsa mafahla a tšoanang le a batsoali ba nang le lefu la tsoekere la 2, banab'abo bakuli ba joalo, mme ea belehileng ngoana ea phelang kapa ea shoeleng ea boima bo fetang li-4.5 kg, le merabe e meng e nang le lefu la tsoekere e kholo. (Mohl. Ma-India a Maindia a Amerika a Pima). Batho ba amanang le karolelano ea pele ea kinship ba nang le botenya le ho feta ka mamello e tloaelehileng ea glucose ba phatlalalitse ho hanyetsa insulin. Ma-mawine a monozygotic a nang le lefu la tsoekere le itšetlehileng ka insulin (NIDDM), ho hanyetsa insulin ho boetse ho boleloa haholoanyane ha ho bapisoa le mafahla a se nang lefu la tsoekere. Karolo e fumanoeng ea ho hanyetsa insulin e iponahatsa e se e le nakong ea ponahatso ea lefu la tsoekere. Liphuputso tse 'maloa li bontšitse hore ho ba le insulin ho leka-lekana ho inshorense maemong a pele a kinship ha ho ntse ho boloka mamello e tloaelehileng ea tsoekere ho eketsoa haholo haeba ba e-na le lefu la metabolism la carbohydrate. Lintlha tse tšoanang li fumanoe nakong ea lithuto ho mafahla a monozygotic. Lihokela tsa mantlha tsa pathogenetic tsa mofuta oa 2 lefu la tsoekere ke: ho hanyetsa insulin (IR), secretion ea insulin le mathata a tsoang ho eona, mafu a pancreatic kapa syndromes tse ling tsa endocrine (acromegaly, Itsenko-Cushing's syndrome, pheochromocytoma, jj.) (Curtis J., Wilson C, 2005). Karolelano ea likarolo tsena tsa pathogenesis ea NID e fapane ho batho ka bomong le ho bakuli ba itseng ba palo e le 'ngoe. Ha ho boetse ha ho tsejoe hore na ke liphoso life tse thathamisitsoeng ho sesosa sa ALI. Kahoo, har'a Maindia a Pima, ho hanyetsa insulin ho tla pele ho NIDI.

Teko ea tsoekere ea mali

Ka lefu la tsoekere la mofuta oa 2, ho na le tlolo ea ts'ebetso ea heestatic. Mefuta e phahameng ea tsoekere e baka glycosylation le ho bokella lihlahisoa tsa glycosylation tsa ho qetela, e leng nako ea mantlha ea ho qala ketsahalo e lebisang liketsahalong tsa liketsahalo tse latellanang leboteng la likepe tse khethang liphetoho tse latelang tsa morphological le sebopeho (Shostak N.A., Anichkov D.A., 2002). Lihlahisoa tsa glycosylation ea ho qetela (tlatsetso ea tsoekere ho amine - sehlopha sa NH2 sa lysine ea protheine efe kapa efe) li tlama ka mokhoa o sa fetoheng liprotheine, mme li fetole thepa le litšoaneleho tsa protheine tse tsamaellanang. Liprotheine tse phetseng nako e telele (collagen, jj.) Li ikarabella bakeng sa thepa e mengata ea karolo ea kamore e ka tlase, ho kenyelletsa le methapo ea methapo ea lebota, ho suna, joalo-joalo. , immunoglobulins, 'me, ka hona, li-immune complex (Klebanova E.M., Balabolkin M.I., Kreminskaya V.M. et al., 2006). Mefuta e joalo e fetoha "osele" 'meleng, e kenyelletsang lisele tse sa sebetseng tsa' mele (Pickup J.C., Crook M.A., 1998). Liprotheine tse nang le lihlahisoa tsa glycosylation ea hoqetela li kopana le li-receptor tsa macrophage, tseo ka lebaka la sena li kopanang le ho boloka lethathamo la li-cytokines (tumor necrosis factor, IL-1, joalo-joalo), tseo le tsona li tlatsetsang katololong ea lisele le boteng ba lesapo la mokokotlo (Bak JF, Schmitz O., Niels SS, Pedersen O., 1989). Lihlahisoa tse tšoanang, ha li sebelisana le li-receptor tsa lisele tsa endothelial, li kenya letsoho ho eketseng motsoako oa li-cellular BAS ho tsona joalo ka mohlala, endothelium-1, e leng ntlha e matla ea vaso-constrictor e lebisang ho thrombosis ea lehae (Juhan-Vague I et al., 1993). Ka nako e ts'oanang, motsoako oa cyclin e bonolo liseleng tsa endothelial oa fokotseha (Williamson JR, Tilton RG, Chang K., 1998).Hammoho le sena, tlasa tšusumetso ea ho bokella lihlahisoa tsa ho qetela tsa glycosylation liphatlalatsong tsa masapo a marang-rang, tšibollo ea thromboxane ea eketseha. Karolelano ea li-prostacyclin le li-thromboxanes li fetoha ka lehlakoreng la keketseho ea morao, eo hape e le lebaka le eketsehileng la ts'ebetso e fokolang ea methapo, ho eketseha ha thrombosis (Celermager D.S. 1994). Ka lebaka leo, seo ho thoeng ke diffuse intravascular coagulation syndrome (DIC) sea nts'etsopele (Klimont A.L. et al., 2004).

Pharmacotherapy ea mathata ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 le monyetla oa ho sebelisa li-proinat immunomodulator .. Melao-motheo ea sejoale-joale ea kalafo ea bakuli ba nang le mathata a lefu la tsoekere e ipapisitse le mehopolo mabapi le pathogenesis ea kholo ea bona (Van Staa et al., 1997). Lihokela tse latelang tsa pathogenesis ea lefu lena li arohantsoe (Shestakova M.V., Chugunova L.A., Shamkhalova M. Sh., 2002, Savelyev BC, Koshkin V.M., Nosenko E.M., Dadova L.V. et al. ., 2003), e ka susumetsoang ke mokhoa oa pharmacotherapeutic: 1) sebopeho sa lihlahisoa tsa ho qetela tsa glycation, 2) li-microcirculation tse senyehileng, 3) keketseho ea ho etsoa ha li-radicals tsa mahala, 4) ho fokotseha ha ts'ebetso ea li-antioxidant le lits'ireletso tsa ts'ireletso. Phekolo e rarahaneng ea angiopathies e kenyelletsa, ho kenyelletsa ho tloaelehileng le taolo e hlokolosi ea metabolism ea carbohydrate, likarolo tse fapa-fapaneng tse fapaneng, joalo ka ts'ebeliso ea lithethefatsi tse tsoang lihlopheng tse fapaneng tsa pharmacological - li-painkillers, antispasmodics, lithethefatsi tse ntlafatsang mesifa ea trophic nerve, microcirculation le rheological thepa ea mali, lipid-lowing, antioxidant le tse ling. (Weidmann PR, 1991). E 'ngoe ea lithethefatsi tse ts'episang tsa sehlopha sa immunomodulator tse sebelisoang tleliniking ea endocrinology ke Derinat, e leng letsoai la sodium ea tlhaho ea DNA' me e na le phello e matla e sa tobang ea tlhaho ea tlhaho. Ho tloha ka 1994, boitokisetso ba Derinat bo amohetsoe bakeng sa ts'ebeliso e pharalletseng ea bongaka ke Komiti ea Pharmacological ea Russian Federation. Ka 1997, Russian Biographical Institute e ile ea amohela sethethefatsi sena e le sethethefatsi se hantle ka ho fetisisa sehlopheng sa immunomodulator. Derinat e kopana le litlhoko tsa bohlokoahali bakeng sa lithethefatsi tsa mofuta ona (Gorodkov B.G., 2002). Lithethefatsi li na le motsoako oa thepa ea bohlokoa ka ho fetisisa ea meriana: 1. Chefo e tlase (Sharygin AS, 2002). 2. Botebo bo pharaletseng ba ketso ea kalafo ho tloha 0,1 mg (lerotholi le le leng la tharollo ea 0,25%) ho isa ho 75 mg (tekanyetso e le 'ngoe ea ente) (Kaplina EN, 2004). 3. Tšusumetso ea lithethefatsi e latela boemo ba mokuli le sethala sa hae sa lefu. Motsoako ona ha o na tšusumetso ho motho ea phetseng hantle, 'me maemong a pheliso e na le tšusumetso e matla le e susumetsang (Filonenko SB, Lipatov V.A., 2001). 4. Ha ho na lithibelo mabapi le ho tsamaellana le lithethefatsi tse ling tse tsejoang (Chernov VN, 2008). 5.

Synergistic, i.e. ketso e sa lebelloang le lithethefatsi tsa bohlokoa ka ho fetisisa (li-interleukin-2, lithibela-mafu) (Dubynina V.P., 2000). 6. Setlhare se ntlafatsa sepheo sa ho hlola khanyetso e hlahang ea lithethefatsi ka ts'ebetso e khahlanong le ts'oaetso (lithibela-mafu - doxorubicin, li-interferons) (Chernov VN, Sharkovskaya TE, 2007). 7. Derinat ha e hatelle mohopolo oa kahare oa karabelo ho likarolo tse mpe tsa setho ka boeona. Kahoo, moriana o na le tšusumetso e matla e khahlanong le ho ruruha haeba ho ka thoe ho na le ts'oaetso e feteletseng, mme ka mokhoa o fapaneng, maemong a ts'ebetso a sa tsitsang a ka mpefatsa ho ruruha mme a thusa ho potlakisa phetheho ea lefu lena (Andrievsky A.E., 2004). 8. Ho tla fihlela joale, ha ho na li-contraindication tse sebelisoang bakeng sa ts'ebeliso ea Derinat, ntle le mamello ea motho ka mong (Karaulov A.V., 2002). Ho latela lingoliloeng, ts'ebetsong ea ho hlophisoa ha Derinat 'meleng, ho na le libaka tse' maloa tse bohlokoa bakeng sa kalafo e rarahaneng ea lefu la tsoekere.

Mokhoa oa ho fumana tlhahlobo ea HCT

Boikemisetso ba k'holeseterole e serum ea motho e entsoe ka ho sebelisa tekete bakeng sa boikemisetso bo bongata ba k'holeseterole e felletseng (e pakiloeng le e sa ngolisoang) serumeng sa motho ho tsoa k'hamphaning "Deacon DDS", Russia-Jeremane. Serum e senang motho e ne e sebelisoa mosebetsing. Seramu ea mali e ile ea aroloa le lisele tsa mali pele ho hora e le 'ngoe ka mor'a ho tšeloa mali. Molao-motheo oa mokhoa ona. Nakong ea hydrolysis ea cholesterol esters e nang le cholesterol esterase, k'holeseterole ea mahala e thehoa.Cholesterol e thehiloe ka lebaka la hydrolysis mme e teng sampole e hlahisoa ke oksijene ea sepakapaka tlasa ts'ebetso ea cholesterol oxidase ho etsa palo e lekanang ea hydrogen peroxide. Tlas'a ketso ea peroxidase, haedrojene hydrogen peridates e chromogenic substrates ka sebopeho sa setsi sa mebala, botebo ba mmala bo lekanang ka kotloloho le pokellong ea cholesterol sampole mme e lekantsoe ka mokhoa oa setšoantšo ka mokhoa oa wavelength oa 500 (480-520) nm. Mefuta e tloaelehileng ea serum kapa plasma cholesterol ke 4,4 ± 1.1 mmol / L. Boikemisetso ba dikahare tsa cholesterol tsa lipoprotein tse phahameng le tse tlase li ile tsa etsoa ka mokhoa oa ho kenngoa serum ea mali ho sebelisa kit bakeng sa boikemisetso bo bongata ba k'holeseterole ea density lipoproteins (HDL) e phahameng ka serum ea motho. Molao-motheo oa mokhoa ona. Phosphovungstic asiti le ion ea magnesium e tlama li-chylomicrons, lipoprotein tse tlaase haholo le lipoprotein tse tlaase tsa serum. The precipitate e thehiloeng e khatholloa ke centrifugation. Karolo e phahameng ea methapo ea methapo ea methapo ea methapo ea methapo ea methapo e lula e le khanya e pepeneneng, eo ho eona litaba tsa k'holeseterole ea HDL li khetholloang ka mokhoa oa enzymatic Photometric ho wavelength ea 500 (480-520) nm. Lisampole tse hlahlobiloeng ke serum ea mali e sa hemeleng. Seramu ea mali e ile ea aroloa le lisele tsa mali pele ho hora e le 'ngoe ka mor'a ho tšeloa mali.

3 ml ea mali a heparinised e ile ea kenngoa ka har'a tube ea centrifuge, 1 ml ea tharollo ea B e ile ea eketsoa, ea tsoakoa ka bonolo, 'me tube ea kenngoa ka therong ea 37C bakeng sa 20 min (erythrocyte sedimentation). The supernatant e tlositsoe ka tube e hloekileng ea centrifuge, tharollo A ho fihlela ho 10 ml e kentsoe moo, centrifuged bakeng sa 10 min ka 1000 rpm. The supernatant e ne e reriloe, tharollo A ho fihlela ho 10 ml e ile ea eketsoa ho li-precipitate, centrifuged tlasa maemo a ts'oanang. The supernatant was drained, bophahamo ba ho emisoa ha sele bo ile ba fetoloa hore e be 1 ml ka tharollo A. Bakeng sa thuto e 'ngoe le e' ngoe, ho behiloe mehlala e 'meli: ka latex - "O" mme ntle le latex - "K". 50 μl ea ho emisoa ka seleng, 50 μl ea latex, 50 μl ea tharollo ea C e kentsoe selibeng sa "O" sa poleiti. 50 solutionl ea tharollo ea A e ile ea etsoa selibeng sa "K" ho fapana le latex. Litharollo tsohle li ne li kopantsoe hantle pele ho ts'ebeliso. Ka mor'a moo, 50 μl ea motsoako e nkuoe lilibeng, e fetisetsoa ho li-slide tse khabisitsoeng hantle tsa khalase ebe e kenngoa mochesong o 37C ka metsotso e 30 ka phapusing e mongobo (sejana sa Petri se nang le pampiri ea pampiri e kolobisitsoeng). Li-Slide li ne li beoa ka kotloloho ho tšela motsoako o fetelletseng le ho fihlela e omme ka botlalo. Khalase e ne e entsoe ka joala la ethyl metsotso e 30. Ho pheha nko, likhalase li ile tsa tšoaroa ka azure-eosin ho latela Romanovsky bakeng sa metsotso e 3 Khalase e ne e hlatsoa ka metsi a kolobisitsoeng.

Tlhahlobo ea Boleng ba Bophelo ho tsoa Moforong o Mokhutšoanyane (SF) -36 Potso

Ho lekola kholo ea mali ka bongata, sesebelisoa sa Mini-Maatse-Doppler-K se ile sa sebelisoa, sa ntlafatsoa sa ba sa etsoa ke Minimax LLC (St. Petersburg). Sesebelisoa sa kutlo sa likarolo tse peli tsa sesebelisoa se sebetsa ka makhetlo a 20 MHz. Bophara ba karolo e sebetsang ea sensor ha bo kopana ka ho toba le tishu ke 0,65 limilimithara, 'me mothapo o pharalletseng oa phallo ea mali o nkuoa e le "tšobotsi ea" hemodynamic "ea karolo ena ea tishu. Dopplerography e ntseng e tsoela pele ea wavetrophone ea microdculature e entsoe sebakeng sa mohatla o pikitlang oa monoana oa boraro oa letsoho. Teko ea ischemic e sebelisitsoeng (ho kopanya mokokotlo oa mokokotlo oa brachial ka mor'a moo ho tlose cuff). Boleng ba methapo ea methapo ea methapo ea mali e arohanang le methapo ea mali e ne e lekantsoe le ho bapisoa: systolic maximum flow flow velocity (Vs, cm / s), maximum diastity velocity (Vd, cm / s), lebelo le tloaelehileng bakeng sa potoloho e tloaelehileng ea phallo ea mali (Vm, cm / s), hammoho le nako phallo ea phallo ea mali. Lilemong tsa morao tjena, ho hlahile mekhoa e mecha ea ho lekola katleho ea kalafo e amanang le boleng ba bophelo ba mokuli.Boleng ba bophelo bo hlalosoa e le tšobotsi ea bohlokoa ea mokuli, ts'ebetso ea hae ea kelello, maikutlo le ts'ebelisano le sechaba, e thehiloeng ponong ea hae e ikhethileng. Ho lekola boleng ba bophelo, re sebelisitse lipotso tse khutšoane (SF) -36, tse kenyeletsang sekala se latelang: 1) PhysikalFunctioning (PF) - ts'ebetso ea 'mele, 2) Role-Physikal (RP) - ts'ebetso e sebetsang, 3) Bodili Pain ( BP) - tekanyo ea bohloko, 4) Pelo e akaretsang (GH) - boemo bo akaretsang ba bophelo bo botle, 5) Vitaliti (VT) - bonatla, 6) Ts'ebetso ea Sechaba (SF) - ts'ebetso ea sechaba, 7) Role-Emotional (RE) - boemo ba maikutlo, 8) Pelo ea kelello (MH) - bophelo bo botle ba kelello. Lintlha tse 36 tsa potso ena li arotsoe likarolo tse 8: ts'ebetso ea 'mele, ho bapala karolo, bohloko ba' mele, bophelo bo botle ba 'mele, ts'ebetso ea ts'ebetso ea sechaba, boemo ba maikutlo le bophelo ba kelello. Ts'ebetso ea sekala ka seng e fapana ho tloha ho 0 ho isa ho 100.

Ha boleng ba letšoao bo le holimo, boemo bo tla hloa hanyane ka bongata. Potso e ile ea etsoa tlhahiso ea hore e tlatsoe ke bakuli qalong ea thuto le matsatsi a 21 kamora ho qala kalafo. Ho bapisa sephetho, tlhahlobo ea bophelo e ile ea etsoa ho bakuli ba 20 ntle le lefu la tsoekere la bong bo le bong le lilemo. Liphetho tsa thuto li ile tsa sebetsoa ka lipalo-palo ho sebelisoa sephutheloana sa software "Ms Excel XP" khomphuteng ea IBM-Pentium Ш-500. Bakeng sa disampole tse 'maloa, moelelo oa "arithmetic" le motso o bolelang motso oa liphapang o ile oa baloa. Lintlha tsohle tse ho dissertation li hlahisoa ka mokhoa oa M + m. Ts'ebetso ea lipalo-palo ea liphetho tse fumanoeng tsa lithuto tsa pharmacological e entsoe ka mekhoa ea lipalo tsa phapang, ho ts'epahala ha liphetho ho hlahlojoe ho sebelisoa mokhoa oa "% -square" le tlhahlobo ea t-Student (Belenky M.L., 1963, Sernov L.N., Gatsura V.V., 2000) . Phapang e ile ea nkuoa e le e ka tšeptjoang boemong ba p 0.05. Lisebelisoa tsohle tsa dijithale li entsoe ka mokhoa oa litafole le li-graph li sebelisa sephutheloana sa ts'ebeliso ea Graphic ea Microsoft sehlahisoa sa software sa Microsoft. Lefu la tsoekere le tšoauoa ka bokooa ba pele le lefu le phahameng, e leng bothata bo bohlokoa ho lits'ebeletso tsa bophelo ba naha. Sena ke sona se ileng sa sebeletsa e le motheo oa ho hlophisa mananeo a taolo ea lefu la tsoekere, ts'ebetsong eo kamora moo e ileng ea fumana tšehetso ho Mokhatlo oa Lefatše oa Bophelo, International Diabetes Federation, le European Diabetes Association. Boithuto ba mahlale ba bo-ramahlale ba tsoang linaheng tse ngata tsa lefats'e ba ikemiselitse ho hlakisa mekhoa ea pathogenis ea lefu lena, mathata a lona le nts'etsopele ea lithethefatsi tsa pathogenetic, tšebeliso ea eona e neng e tla thusa ho thibela le ho ntlafatsa tsela ea mathata a seng a hlahile (Melnichenko G.A., 2008). Mathata a methapo a lefu la tsoekere mellitus (DM) ke sesosa se ka sehloohong sa ho holofala le ho shoa kapele.

Karolo e ka sehloohong ho qaleng ha mathata a amehang ho pathogenesis ea mathata a lefu la tsoekere ke a hyperglycemia, ho eketseha ha glucose autoxidation, ho thehoa ka mokhoa o feteletseng oa lihlahisoa tsa qetellong tsa glycosylation, ts'ebetso ea lipid peroxidation le keketseho ea boemo ba methapo ea mahala (Mayorov A.Yu., Surkova E.V., 2008). Lilemong tsa morao tjena, ho entsoe lithuto tsa ho theha lithethefatsi ka hypoglycemic, hypolipidemic le antioxidant le thepa e 'ngoe e amang thibelo le botsitso ba mathata a lefu la tsoekere. Har'a lichelete ka ts'ebetso e bonts'itsoeng, sebaka se itseng se nkuoa ka litokisetso tse fumanoeng motheong oa DNA. Lithethefatsi tse joalo li kenyelletsa Derinat. Liphuputso tse ngata tsa mahlale le liteko li bonts'itse hore Derinat e ntlafatsa syntulin ebile e nts'etsapele ntlafatso ea lisele tse 3 tsa pancreatic (V. Balashov et al., 2003) Ntle le moo, e na le phello ea immunostimulating (A. Zhabko. ., 2003) ka ho eketsa tlhahiso ea li-antibodies tse felletseng le li-interferon, ho tsosa motsoako oa mefuta ea oksijene e sebetsang ka li-neutrophils le ho etsa hore maemo a li-immunoglobulins, T le B lymphocyte .Derinat e tloaelehileng metabolism ea lipid, e theole boemo ba cholesterol e felletseng, triglycerides, LDL cholesterol le e eketsa boemo ba cholesterol ea HDL ho serum ea mali (Mordanov R., 1999).Ntle le moo, sethethefatsi sena se na le tšusumetso e matla mesebetsing ea methapo, tsamaiso ea methapo ea mmele le tsamaiso ea 'mele ea ho itšireletsa mafung, ha e na thepa ea mutagenic, embryotoxic, teratogenic, allergenic.

Likahare tsa mokhethoa oa lingaka oa thuto ea bongaka Gogina, Elena Dmitrievna

KHAOLO I. PUSELETSO YA TLALA.

1.1 Lefu la tsoekere e le bothata ba kajeno ba bongaka le ba sechaba.

1.2 Lisosa tsa pele tsa lefu la tsoekere la mofuta oa 2.

1.3 Motheo oa lefutso la "mellitus" e sa itšetleheng ka insulin.

1.4 Motheo oa Autoimmune oa "mellitus" o sa ts'epahalang oa insulin.

1.5 Angiopathy ke e 'ngoe ea mathata a mantlha a lefu la tsoekere.

KHAOLO II. LITLHAKISO TSA MOTSO OA LITLHAKISO TSE BOTSOANG.

2.1 Litšobotsi tsa bakuli tse kenyellelitsoeng thutong. Moralo oa ho ithuta.

2.2 Mekhoa ea lipatlisiso tsa bongaka.

2.3 Mekhoa ea lipatlisiso tsa laboratori.

2.3.1 Boikemisetso ba tsoekere ea mali.

2.3.2 Boikemisetso ba hemoglobin ea glycosylated (HBA1).

2.3.3 Mekhoa ea ho fumana setšoantšo sa lipid.

2.3.4 Mokhoa oa ho etsa qeto ea li-immunoglobulins A (IgA), M (IgM), G (IgG).

2.3.5 Mokhoa oa ho khetha tlhahlobo ea HCT.

2.3.6 Mokhoa oa ho etsa qeto ea protheine ea C-reactive (hsCPB).

2.3.7 Boikemisetso ba matšoao a foromo ea leukocyte.

2.4 Mekhoa ea Ultrasonic ea ho hlahloba microcirculation.

2,5 Boleng ba tlhahlobo ea bophelo ho latela foromo e khutšoane ea (SF) -36.

2.6 Ts'ebetso ea lipalo.

KHAOLO EA III. TLHOKOMELISO EA “DERINATE” HO LITLHAKU TSA BOTSOALLE BA CarBOHYDRate LE LIPID METABOLISM HO BATSOALI BA NA LE DIABETES TSE 2.

3.1 Boithuto ba metabolism ea carbohydrate ho bakuli ba nang le mofuta oa 2 lefu la tsoekere khahlano le semelo sa khalemelo le Derinat.

3.2 Litlamorao tsa Derinat ho metabolism ea lipid ho bakuli ba nang le lefu la tsoekere la mofuta oa 2.

KHAOLO IV. TLHOKOMELISO EA sehlahisoa sa lihlahisoa tsa lihlahisoa tsa lihlahisoa tsa lefutso ho batho ba bang le DM

KHAOLO EA V. LITLHAKISO TSE KHUTLISITSOENG TSA BOTEGENIKI BATSOALI KA TYPE 2 DIABETES IN PUO YA TLHALOSO EA PUSO.

KHAOLO VI. TLHOKOMELISO EA sehlahisoa sa lihlahisoa tsa lihlahisoa tsa lihlahisoa tsa bophelo BOPHELO KE BATSOALI BA LEBITENG LA 2 DM.

Kenyelletso ea dissertation (karolo ea karolo e sa sebetseng) ka sehlooho se reng "Boithuto ba katleho ea motsoako oa lithethefatsi ho bakuli ba nang le lefu la tsoekere la mofuta oa 2"

Bohlokoa ba sehlooho. Hajoale, lefu la tsoekere le nka "lefu la seoa" mme le emela bothata bo ka sehloohong ba bongaka le ba sechaba bakeng sa linaha tse tsoetseng pele le linaha tsa boraro tsa lefatše (Dedov I.I., 2008). Ho latela WHO, linaheng tsohle tsa lefatše palo ea bakuli ba nang le lefu la tsoekere e feta limilione tse 175. Ho latela likhakanyo tsa kholo ea lefu lena, ka selemo sa 2010 palo ea bakuli ba joalo e tla fihla ho limilione tse 230, moo 80-90% e tla ba bakuli ba nang le mofuta oa 2 lefu la tsoekere Mellitus (DM) (International Diabetes Federation, 2007).

Palo ea batho ba tsofetseng, palo ea bakuli ba nang le lefu la tsoekere la mofuta oa 2 e ntse e eketseha ka sekhahla. Ho ata ha lefu la tsoekere Russia ke 5% (Dedov I.I., 2008). Bohlokoa ba sechaba ba ho ithuta lefu la tsoekere la mofuta oa 2 ke hore lefu lena le baka ho holofala kapele, le lefu le phahameng ka lebaka la mathata a mangata (nephropathy, neuropathy, retinopathy, jj.). Ho latela maikutlo a sejoale-joale, thupelo ea bongaka le tsoelo-pele ea motho ka mong ea tsoelo-pele ea lefu la tsoekere e itšetlehile ka tekanyo ea ho ata le ho teba ha mathata a methapo ea methapo (micro- le macroangiopathy) ho bakuli (Balabolkin M.I., Klebanova E.M., 2007). Ho 20-30% ea bakuli ba nang le lefu la tsoekere la mofuta oa 2, mathata a methapo e itseng ho lona a boetse a bonoa ka nako ea ho sibolla lefu la pelo. Bakuli ba fetang 90% ba nang le lefu la tsoekere la mofuta oa 2 ba na le metabolic syndrome (MS) nakong ea ho qala ha lefu lena (Klebanova EM, Balabolkin MI, 2006). Sena sohle se tiisa bohlokoa ba bongaka le bokuli ba lefu la tsoekere har'a mefuta e meng ea mafu a sa foleng, hobane ts'oaetso ea lefu la tsoekere la 2 le imena habeli ka nako e 'ngoe le e' ngoe lilemo tse 15-20 (Dedov II, 2006).

Boithuto ba metheo ea etiology le pathogenetic ea lefu la tsoekere la mofuta oa 2 kamehla bo tlisa tlhahisoleseling e ncha mabapi le mekhoa ea lefu la tsoekere le lisosa tse lebisang ho mathata a tloaelehileng a lefu lena. Kahoo, boithuto ba methapo ea boits'ireletso ea ts'ebelisano 'moho ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 e bonts'a likarolo tsa tšebelisano ea tsamaiso ea' mele ea ho itšireletsa mafung le endocrine nts'etsopele ea ts'ebetso ea methapo ea methapo (Metelitsa, V.I., 2005).Mesebetsi e rarahaneng e inehetse ho ithuteng karolo ea banyebi ba itšireletsang mafung a methati ea ho hola insulin ho loants'oa bakuli ba lefu la tsoekere la mofuta oa 2 le botenya. Ka lebaka la boithuto ba ts'ebetso ea endocrine ea lithane tsa adipose, e ile ea tsebahala ka litlamorao tse fapaneng tsa tumor necrosis factor gene (TNF-a), e khonang ho kenya ts'oaetso ea mmele, ho thibela ts'ebetso ea insulin, le ho kenya letsoho ho mathata a methapo ea methapo le methapo ea methapo (Dedov I.I. et al., 2004 Cheknev S.B., 1999, De Fronzo RA, 1992., Mercurio F., Manning AM, 1999). Phello ea pathological ea TNF-a ha e khethoe feela ke ts'ebetso ea tsela e se nang oxidative ea mahala ea mafura acid metabolism (FFA) le oxidation e se nang enzymatic ea tsoekere. Ntho ena e boetse e etsa hore ho be le polelo ea inhibitor ea activator ea fibrinogen-1, e fokotsa polelo ea adiponectin, e kenya ts'ebetsong protheine kinase C (Almazov V.A. et al., 1999, Butrova S.A., 2001, Shubina A.T. et al., 2001). Ka lebaka la ts'oaetso ea 'mele ea ho itšireletsa mafung, tlhahiso ea ntho ea ho phomola ea endothelial, nitric oxide (NO), ea fokotseha, mesebetsi ea boikhathollo ea lisele tsa mesifa e boreleli e ea senyeha, pherekano e akaretsang ea khatello ea methapo (OPSS) e ntse e eketseha, ho eketseha le ho fokotseha ha lisele tsa mesifa e boreleli ho ea eketseha - phello ea ho nchafatsoa ha mesifa, ho khomarela le ho fallisoa ha li-monocytes li qobelleha. - phello ea atherogenic le pro-inflammatory, ts'ebetso ea khokahanyo ea liplatelete le motsoako oa motlakase li ka khoneha - phello ea motsoako (Gracheva O.A., Smirnova O.I., 2003, Hotamisligil G., Shargill N., Spiegelman B. , 1993, Ruan H. et al., 2002).

Ka lebaka la ts'ebelisano-kholo ea maloetse a amanang le ts'oaetso ea methapo ea mali le a metabolic a bang teng ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 le mathata a amanang le lefu lena, bothata ba ho thibeloa ke kalafo kalafong e rarahaneng ea bakuli ba nang le lefu la tsoekere le fetoha haholo.

Sepheo: ho etsa lipatlisiso ka katleho ea tleliniki ea Derinat immunomodulator kalafong e rarahaneng ea bakuli ba nang le lefu la tsoekere la mofuta oa 2 le rarahaneng ke angiopathy ea maemo a tlase.

Lipheo tsa thuto. Ho latela sepheo nakong ea mosebetsi, mesebetsi e latelang e rarollotsoe:

1. Ho ithuta ka phello ea Derinat ho metabolism ea carbohydrate ho bakuli ba mofuta oa 2 lefu la tsoekere le rarahaneng ke angiopathy ea likarolo tse tlase.

2. Ho etsa lipatlisiso tsa liphetoho lipontšong tsa lipid tsa mali tsa bakuli ba nang le lefu la tsoekere la 2 le ho amohela "Derinat" ea litlhare e le karolo ea kalafo e rarahaneng.

3. Ho ithuta ka litlamorao tsa boitokisetso ba Derinat ho matšoao a ho itšireletsa mafung le ho se sebetse hantle ho bakuli ba nang le lefu la tsoekere la mofuta oa 2.

4. Ho lekola phello ea pheko e rarahaneng ea mofuta oa lefu la tsoekere la mofuta oa 2, ho kenyeletsoa le litokisetso tsa Derinat, setulong sa bethe ea microvascular.

5. Ho sekaseka matla a boleng ba matšoao a bophelo ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 le rarahaneng ke angiopathy ea lipheo tse tlase, phekolo e rarahaneng ea bona e kenyelletsang Derinat.

Sengoloa saense. Phuputso e entsoe ka phello ea litokisetso tsa Derinat kalafong e rarahaneng ea bakuli ba nang le lefu la tsoekere la mofuta oa 2, e rarahaneng ke angiopathy ea likarolo tse tlase, ho metabolism ea carbohydrate. Ho fumanoe hore ts'ebeliso ea Derinat e tsamaisana le ho potlakisa ha mantsoe bakeng sa puseletso ea ts'ebetso ea methapo ea methapo, e bonahatsang ho fokotseha ha boemo ba postprandial glycemia le glycated hemoglobin.

Ha re ithuta matšoao a itseng a ho itšireletsa mafung ho bakuli ba nang le lefu la tsoekere la mofuta oa 2, ho ile ha fumaneha hore phello ea mantlha ea boitokiso ba Derinat ke phetoho e kenyang matla ea ts'usumetso ho karolo ea pele ea "macrophage", immune immune. Ka nako e ts'oanang, Derinat e eketsa karabelo e matla ea karolo ea 'mele - ho latela protheine ea C-e sebetsang, empa ka tekanyo e tlase haholo ho feta kantle ho ts'ebeliso ea lithethefatsi. f

Ho fumanoe hore sepheo sa tlhophiso ea Derinata se na le mabaka 'me se nepahetse ka mokhoa o nepahetseng kalafong e rarahaneng ea bakuli ba nang le lefu la tsoekere la mofuta oa 2, kaha ho lebisa ho fokotseha hoa boemo ba tsoelo-pele ea atherosclerosis: ho fokotseha ho hoholo hoa cholesterol (cholesterol) le lipoproteins tse tlase (dDD).

Ho ile ha bontšoa hore ho bakuli ba phekoloang ka kalafo e rarahaneng, ho kenyelletsa le Derinat, ho na le ntlafatso ho lipontšo tsa Dopplerographic, tse bonts'ang ntlafatso ea microcirculation.Ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 ba amohetseng Derinat, nako ea phallo ea phallo ea mali kamora tlhahlobo ea ischemic e ne e le 4.0 ± 0,67 min. Ho bakuli ba sa kang ba fumana kalafo ea immunocorrection, letšoao lena e ne e le metsotso ea 3.0 ± 1,2. Leha ho le joalo, ho fokotseha butle ha nako ea phallo ea phallo ea mali ho tlatselitse ho hola ha litheko tse phahameng tsa dopplerographic ka ho boloka ha tsona nako.

Boithuto ba matšoao a mang a boleng ba bophelo ba bakuli ba nang le mekhoa e fapaneng ea phekolo bo bonts'itse hore ho kenyeletsoa ha Derinat kalafong ea mantlha ea lefu la tsoekere la 2 ho ntlafatsa ts'ebetso ea mmele, ho fokotsa matla a bohloko le ho eketsa bophelo ba kelello.

Litokisetso tse lokelang ho sireletsoa. 1. "Derinat" kalafong e rarahaneng ea mofuta oa tsoekere ea lefu la tsoekere e kenya letsoho ho potlakisa puseletso ea lefu la tsoekere, e tsamaeang le ho fokotseha ha glucose le hemoglobin ea glycosylated maling, empa le ka ho fokotseha ha cholesterol e felletseng, lipoprotein tse fokolang, ha ho se na phello e hlakileng ho triglycerides. le lipoprotein tse phahameng haholo.

2. Ts'ebeliso ea boitokiso ba Derinat kalafong e rarahaneng ea bakuli ba nang le lefu la tsoekere la mofuta oa 2 e tsamaisana le ho leka-lekana ha boits'ireletso ba mmele, bo hlahisitsoeng ka taolong ea boits'ireletso ba mmele le boharehi, hammoho le ntlafatso ea ts'ebetso ea methapo ea methapo.

3. Phekolo e kopaneng ea lefu la tsoekere la mofuta oa 2 ka ts'ebeliso ea Derinat immunomodulator e lebisa ntlafatsong ea boleng ba bophelo bo botle ba 'mele le ba kelello, sepheo le dintlha tse amanang le eona, nts'etsopele ea eona e kenyelletsang angiopathy, e tsoelang pele le pathology ena.

Bohlokoa bo sebetsang. Ho ipapisitsoe le lithuto, kalafo e akaretsang ea kalafo ea bakuli ba nang le lefu la tsoekere la mofuta oa 2 e rarahaneng ke angiopathy ea maemo a tlase, ho kenyelletsa kalafo e tloaelehileng ea hypoglycemic e sebelisang immunomodulator ea tlhaho.

Liphetho tse fumanoeng ts'ebelisong ea Derinat le litlamorao tsa ts'ebetso e senyehileng ea metabolic le bokhoni ba ho lekanyetsa ho se leka-lekane ha immunological ho re lumella ho e khothaletsa ka phekolo e rarahaneng ea mofuta oa lefu la tsoekere la mofuta oa 2.

Tšusumetso ea ho hlophisoa ha Derinat ka matšoao a microcirculation e na le phello e ntle tseleng ea angiopathy ho bakuli ba nang le lefu la tsoekere la mofuta oa 2, e liehisa tsoelo-pele ea bona, e ntlafatsang bophelo ba bakuli le ho lieha ho qala ha nako ea bokooa. Pheko ea ho kopanya le Derinat e thusa ho ntlafatsa kalafo le ntlafatso ea bakuli ba nang le lefu lena.

Ho etsa liteko tsa mosebetsi. Liphetho tsa mosebetsi li tlalehiloe ho III Congress of Russian Pharmacologists "Pharmacology - Practical Health Care" (St. Petersburg, 2007), kopano ea bongaka ea bongaka "likarolo tsa ts'ebeliso ea bongaka le tsa bongaka tsa bongaka" (Tver, 2007), le kopano ea naha ea "Allergology le Clinical Immunology - Interdisciplinary mathata ”(Moscow, 2008), XV National Congress National Congress" Monna le Phekolo "(Moscow, 2008), kopano ea selemo le selemo ea saense ea" Univesithi ea "" Ogarevsky "(Saransk, 2008).

Ts'ebetso ea liphetho tsa lipatlisiso. Liphetho tsa thuto li hlahisitsoe mosebetsing oa bongaka oa lefapha la bophelo bo botle ba 'mele la "Sepetlele sa Tleliniki ea Setereke", Tver, mme le sebelisoa ts'ebetsong ea thuto le lipatlisiso Lefapheng la Pharmacology ka thupelo ea thuto-kholo ea meriana le Lefapha la Bophelo bo Botle le Bophelo bo botle ba SEI HPE "Universityov State State e reheletsoeng ka mor'a N.P. Ogareva. "

Lingoliloeng Sehloohong sa dissertation, ho phatlalalitsoe libuka tse 8 tse kenyelletsoeng ho kenyelletsa le tse peli likhatisong tse khothalelitsoeng ke Khomishene ea Boemo bo Holimo ea Lefapha la Thuto le Saense ea Russia Federation.

Sebopeho le boholo ba dissertation.Dissertation e kenyelletsa kenyelletso, tlhahlobo ea lingoliloeng, lisebelisoa le mekhoa ea lipatlisiso, liphetho tsa lipatlisiso tsa rona, lipuisano tsa sephetho sa lipatlisiso, sephetho le lenane la lingoliloeng, tse nang le lintho tse 167, ho kenyelletsa le ba tsoang linaheng tse ling ba 60. Mosebetsi o thehiloe maqepheng a typcript a 145, o na le lipalo tse 24 le litafole tse 13.

Kenyelletso ea dissertion ka sehlooho "Pharmacology, Clinical Pharmacology", Gogina, Elena Dmitrievna, abstract

Boithuto ba metheo ea etiology le pathogenetic ea lefu la tsoekere la mofuta oa 2 kamehla bo tlisa tlhahisoleseling e ncha mabapi le mekhoa ea lefu la tsoekere le lisosa tse lebisang ho mathata a tloaelehileng a lefu lena. Kahoo, boithuto ba methapo ea boits'ireletso ea ts'ebelisano 'moho ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 e bonts'a likarolo tsa tšebelisano ea tsamaiso ea' mele ea ho itšireletsa mafung le endocrine nts'etsopele ea ts'ebetso ea methapo ea methapo (Metelitsa, V.I., 2005). Mesebetsi e rarahaneng e inehetse ho ithuteng karolo ea banyebi ba itšireletsang mafung a methati ea ho hola insulin ho loants'oa bakuli ba lefu la tsoekere la mofuta oa 2 le botenya. Ka lebaka la boithuto ba ts'ebetso ea endocrine ea lithane tsa adipose, e ile ea tsebahala ka litlamorao tse fapaneng tsa tumor necrosis factor gene (TNF-a), e khonang ho kenya ts'oaetso ea mmele, ho thibela ts'ebetso ea insulin, le ho kenya letsoho ho mathata a methapo ea methapo le methapo ea methapo (Dedov I.I. et al., 2004 Cheknev S.B., 1999, De Fronzo RA, 1992., Mercurio F., Manning AM, 1999). Phello ea pathological ea TNF-a ha e khethoe feela ke ts'ebetso ea tsela e se nang oxidative ea mahala ea mafura acid metabolism (FFA) le oxidation e se nang enzymatic ea tsoekere. Ntho ena e boetse e etsa hore ho be le polelo ea inhibitor ea activator ea fibrinogen-1, e fokotsa polelo ea adiponectin, e kenya ts'ebetsong protheine kinase C (Almazov V.A. et al., 1999, Butrova S.A., 2001, Shubina A.T. et al., 2001). Ka lebaka la ts'oaetso ea 'mele ea ho itšireletsa mafung, tlhahiso ea ntho ea ho phomola ea endothelial, nitric oxide (NO), ea fokotseha, mesebetsi ea boikhathollo ea lisele tsa mesifa e boreleli e ea senyeha, pherekano e akaretsang ea khatello ea methapo (OPSS) e ntse e eketseha, ho eketseha le ho fokotseha ha lisele tsa mesifa e boreleli ho ea eketseha - phello ea ho nchafatsoa ha mesifa, ho khomarela le ho fallisoa ha li-monocytes li qobelleha. - phello ea atherogenic le pro-inflammatory, ts'ebetso ea khokahanyo ea liplatelete le motsoako oa motlakase li ka khoneha - phello ea motsoako (Gracheva O.A., Smirnova O.I., 2003, Hotamisligil G., Shargill N., Spiegelman B. , 1993, Ruan H. et al., 2002).

Sepheo: ho etsa lipatlisiso ka katleho ea tleliniki ea Derinat immunomodulator kalafong e rarahaneng ea bakuli ba nang le lefu la tsoekere la mofuta oa 2 le rarahaneng ke angiopathy ea maemo a tlase.

Lipheo tsa thuto. Ho latela sepheo nakong ea mosebetsi, mesebetsi e latelang e rarollotsoe:

1. Ho ithuta ka phello ea Derinat ho metabolism ea carbohydrate ho bakuli ba mofuta oa 2 lefu la tsoekere le rarahaneng ke angiopathy ea likarolo tse tlase.

2. Ho etsa lipatlisiso tsa liphetoho lipontšong tsa lipid tsa mali tsa bakuli ba nang le lefu la tsoekere la 2 le ho amohela "Derinat" ea litlhare e le karolo ea kalafo e rarahaneng.

3. Ho ithuta ka litlamorao tsa boitokisetso ba Derinat ho matšoao a ho itšireletsa mafung le ho se sebetse hantle ho bakuli ba nang le lefu la tsoekere la mofuta oa 2.

4. Ho lekola phello ea pheko e rarahaneng ea mofuta oa lefu la tsoekere la mofuta oa 2, ho kenyeletsoa le litokisetso tsa Derinat, setulong sa bethe ea microvascular.

Ho ile ha bontšoa hore ho bakuli ba phekoloang ka kalafo e rarahaneng, ho kenyelletsa le Derinat, ho na le ntlafatso ho lipontšo tsa Dopplerographic, tse bonts'ang ntlafatso ea microcirculation. Ho bakuli ba nang le lefu la tsoekere la mofuta oa 2 ba amohetseng Derinat, nako ea phallo ea phallo ea mali kamora tlhahlobo ea ischemic e ne e le 4.0 ± 0,67 min. Ho bakuli ba sa kang ba fumana kalafo ea immunocorrection, letšoao lena e ne e le metsotso ea 3.0 ± 1,2. Leha ho le joalo, ho fokotseha butle ha nako ea phallo ea phallo ea mali ho tlatselitse ho hola ha litheko tse phahameng tsa dopplerographic ka ho boloka ha tsona nako.

2.Ts'ebeliso ea boitokiso ba Derinat kalafong e rarahaneng ea bakuli ba nang le lefu la tsoekere la mofuta oa 2 e tsamaisana le ho ts'oaroa ha boits'ireletso ba mmele, ho bontšitsoeng taolong ea boits'ireletso ba mmele le tsamaiso ea methapo, hammoho le ntlafatso ea ts'ebetso ea methapo ea methapo.

Sebopeho le boholo ba dissertation. Dissertation e kenyelletsa kenyelletso, tlhahlobo ea lingoliloeng, lisebelisoa le mekhoa ea lipatlisiso, liphetho tsa lipatlisiso tsa rona, lipuisano tsa sephetho sa lipatlisiso, sephetho le lenane la lingoliloeng, tse nang le lintho tse 167, ho kenyelletsa le ba tsoang linaheng tse ling ba 60. Mosebetsi o thehiloe maqepheng a typcript a 145, o na le lipalo tse 24 le litafole tse 13.

Lokolla liforomo le sebopeho

Moriana o etselitsoe ho ts'oara methapo ea methapo, tsamaiso ea methapo, ts'ebeliso ea kantle le kalafo ea lehae ea mucosa ea molomo, e fumaneha ka mokhoa oa mokelikeli o nang le karolo ea mantlha ea 0.25 le 1.5%.

Karolo e ka sehloohong	Sodium Deoxyribonucleate	25 mg
Karolo e thusang	Sodium Chloride	10 mg
Metsi a litšila	10 ml

Mokelikeli oa entcutaneous le ente ea methapo e entsoe ka lijana tsa khalase tsa opaque tsa 5 le 10 ml.

Ho phekola mucosa ea nasal, sethethefatsi se rekisoa ka sejana sa khalase se nang le draper kapa sprayer ea 10 ml.

Mokhoa oa ketso

Phello ea pharmacological e ipapisitse le thepa ea sehlahisoa sa immunomodulating. Sethethefatsi se sebetsa ho li-antigen tse fumanehang metsing a 'mele oa motho, ho susumetsa ts'ebetso ea bona le ho kenya tšebetsong mesebetsi ea ts'ireletso.Ntle le moo, moriana o thusa ho potlakisa pholiso ea leqeba le ho lahloa ha lisele tsa necrotic sebakeng sa ts'oaetso ka lebaka la thepa e nchafatsang.

Ha ho etsoa radiotherapy ho bakuli ba mofets'e, ho fokotsehile hoa phello e mpe liseleng tsa ionizing radiation, e thusang ho tsamaisa lithuto tse pheta-phetoang tsa kalafo le ho ntlafatsa ts'ebetso ea eona.

Ha ho phekoloa lefu la pelo, ntho ena e eketsoa ka mokhoa o rarahaneng, ho ntlafatsa ts'ebetso ea myocardial, ho eketsa mamello ho mojaro.

Setlhare se thusa ho potlakisa le ho nolofatsa ts'ebetso ea ho hlaphoheloa ha mucous membrane ea mpeng le duodenum e nang le ulcen ulcers.

Mofumahali

Karolo e sebetsang e kenngoa habonolo ke meaho ea sele le ho tsamaisoa ka potlako ho eona ka lebaka la plasma le likarolo tse qapiloeng tsa mali, e kenngoa ka har'a micostructures mme e nka karolo phapusing ea matla a cellular.

Setlhare sena se tlosoa ka makhopho a 'mele,' me ka tekanyo e kholo le moroto.

Ho fokotseha ha maemo a mali ho bonoa kamora lihora tse 5. Ka tsamaiso ea letsatsi le letsatsi, moriana o khona ho bokellana liseleng: haholo mokokotlong oa masapo, mokokotlo, li-lymph node, tlase mpeng, sebete, bokong.

Matšoao a ho sebelisoa

Ts'ebeliso ea Derinat e ea hlokahala maemong a latelang:

Phekolo ea mathata a mafu a sefuba le a hlobaetsang a mafu a vaerase, a iponahatsang ka tsela ea bronchitis, pneumonia, asthma.
Ho ba teng ha maloetse a sa foleng a ho hema.
Ho fokolisa 'mele ka likokoana-hloko tse kotsi.
Haeba ho hlokahala, fokotsa mats'oao a ho kulisa: rhinitis, asthma, dermatitis.
Ha ho hlahlojoa peptic ulcer ea duodenum le mpeng.
Ho potlakisa pholiso ea maqeba, ho chesoa, boteng ba lisele tsa necrotic, ts'oaetso.
Ho gynecology le urology kalafong ea polycystic, chlamydia, mycoplasmosis, herpes, endometriosis, prostatitis, ureaplasmosis.
Ha ho etsoa opereishene ha ho etsoa opereishene le nakong ea tlhabollo.
Ha ho phekoloa lefu la pelo.
Ka stomatitis.
Ho felisa litlamorao tse bakang liso tsa trophic.
Molemong oa ho ruruha leqeba la mahlo.
Ka lebaka la ho pepesetsoa radiation.
Ka moralo oa ts'ebetso ea ho hlaphoheloa kamora lefu la radiation kapa kalafo ea lik'hemik'hale ho bakuli ba nang le mofetše.

U ka e nka joang?

Ka mokhoa o makatsang, lithethefatsi li fanoa butle butle ka nako ea metsotso e 1.5-2 ho litekanyetso tse 5 ml (1 ml e lekana le 15 mg ea moriana).

Tekanyetso ea batho ba baholo:

Boloetse	Palo ea liente
Ho ruruha ho matla	3-5 ka mehla
Ho ruruha ho sa feleng	Matsatsi a 5 a pele a 5 ka mor'a lihora tse 24, matsatsi a 5 a latelang - kamora lihora tse 72
Gynecological kapa urological	Metsotso e meng le e meng e 24- 248
Lefu la pelo	10 matsatsi a mang le a mang a mabeli
Alsa ea Peptic	5 kamora matsatsi a mabeli
Lefuba	10-15 letsatsi le letsatsi
Oncological	3-10 lihora tse ling le tse ling tse 24-48

Tekanyetso ea bana:

Mongoaha	Tekanyetso e le 'ngoe
Ho fihlela lilemo tse peli	0.5 di ml
Ho tloha ho lilemo tse peli ho isa ho tse 10	0.5 di ml ka selemo se seng le se seng sa bophelo
Kamora lilemo tse 10	5 di ml

Palo e lekaneng e lumelletsoeng ea bana bakeng sa thupelo e le 'ngoe ke 5.

Na hoa khoneha ho sebelisa moriana oa lefu la tsoekere?

Ho amoheloa ho ka etsahala ho latela tlhahlobo e hlokolosi ea likhahla tsa tsoekere ea mali.

Bakeng sa mekhoa ea ho inhalation u sebelisa nebulizer bakeng sa mathata a tšoaetsanoang le a tšoaetsanoang, sinusitis, adenoids mme kamora ho bata, ho sebelisoa tharollo ea 0,25%, tekanyo e phahameng ea lithethefatsi ka letsatsi ke 2 ml e hlapolotsoeng ka 2 ml ea Sodium chloride.

Molemong oa kalafo ea bronchitis e thibelang, mafu a ho hema, ho kgothaletswa ho sebelisa tharollo ea 1.5%.

Nako ea ts'ebetso ea 1 ha ea lokela ho feta metsotso e 5.

Le lefu la tsoekere

Ha u sebelisa meriana ena, batho ba nang le lefu la tsoekere ba lokela ho lekola maemo a tsoekere ea mali ka hloko le ho feta, hobane meriana e khona ho ba le phello ea hypoglycemic, i.e. tsoekere e tlase.

Sesebelisoa ha se etse hore ho kula ho se amehe ha motho ka mong bakeng sa likarolo tsa eona, ho fapana le moo, ho felise matšoao a ho kulisoa.

Sebelisa nakong ea bokhachane le pelehi

Ho nka Derinat nakong ea ho beleha ngoana ho lumelloa feela ka mor'a ho buisana le ngaka haeba phello e lebelletsoeng ho mokuli e feta kotsi e ka bang teng ho lesea. Nakong ea ho fepa ngoana ka lebese la matsoele, tšebeliso ea mori le eona e lumelloa ka thata ha e laetsoe ke ngaka.

Ho sebelisana le lithethefatsi tse ling

Ka tsamaiso e le 'ngoe ea Derinat le lithibela-mafu, ho eketsoa katleho ea katleho ea morao. Molemong oa ho phekola maloetse a tšoaetsanoang le a peptic ulcer, lithethefatsi, hammoho le lithethefatsi tsa bohlokoa, li ka fokotsa mokhoa oa kalafo, tsa fokotsa tekanyetso ea meriana le ho eketsa nako ea tšoarelo.

Ts'ebetsong ea ts'ebetso ea bongaka e sebelisang ts'ebetso ea ts'ebetso ea bongaka e thusa ho fokotsa ho tahoa, ho thibela tšoaetso hore e se ke ea kena leqebeng, ho matlafatsa ts'ireletso ea tlhaho ea mmele le ho tsitsisa ts'ebetso ea ho theha mali.

Setlhare ha se tsamaisane le litokisetso tse thehiloeng mafura a sebakeng seo (ka litlolo).

Ke bokae?

Litsenyehelo tsa moriana li amana ka kotloloho le sepheo le sebopeho sa vial:

Fokotsa foromo, bophahamo	Theko ka li-ruble
Sesebelisoa sa khalase se nang le fafatsa, 10 ml	370
Liquid bakeng sa ts'ebeliso ea kantle, 10 ml	280
Sesebelisoa sa khalase se nang le mokelikeli, 10 ml	318
Sekhahla sa liente ka lilampi tse 5 tsa ml	1900

Lipehelo le maemo a sebaka sa polokelo ea Derinat

Setlhare se lula se loketse ho sebelisoa lilemo tse 5 ho tloha ka letsatsi la tlhahiso. E tlameha ho bolokoa sebakeng se lefifi le moo bana ba ke keng ba e fumana, ka mocheso oa moea oa +4. + 18 ° C.

Litlhahlobo mabapi le Derinat

Vladimir, ea lilemo li 39, Arkhangelsk.

Ke ne ke hlokofatsoa ke nko khafetsa, haholo nakong ea selemo le ea hoetla, kamora ho khethoa ha Derinat, khatello ea maikutlo e potlaka haholo, 'me ho khutla ho sa khaotseng. Ha ke so leke ho hong ho mo feta ho mo feta.

Victoria, ea lilemo li 25, Zainsk.

Ngaka ea bana e laetse moriana ona oa lilemo tse peli hore o noe motsoako, o laetsoe hore o itlotse kahare mme o o tšele ka linkong. Selemong se fetileng, hangata ho fumanoe hore o na le bronchitis e thibelang, e tšoaroang ka sirapo, ha ea ka ea thusa. Sesebelisoa sena se ile sa sebetsana ka potlako.

U ka sebelisa viburnum ka lefu la tsoekere la mofuta oa 2?

Bakeng sa kalafo ea manonyeletso, babali ba rona ba sebelisitse DiabeNot ka katleho. Ha re bona sehlahisoa sena se tsebahala, re nkile qeto ea ho e ela hloko.

Viburnum e thusang ke mofuta oa lefu la tsoekere la 2? Litsebi tse ling tsa lefu la tsoekere li fa semela sena mefuta e meng e ikhethang e ka folisang tsoekere e kulang ka botlalo. Ho joalo, pheko e felletseng ke mohopolo bakeng sa batho ba bobebe, empa tšebeliso e tloaelehileng ea monokotsoai oa viburnum, li-decoctions tsa makhapetla le makhasi li tla ba le phello e ntle 'meleng oa mokuli. Empa phello ea pholiso ea semela sena ke efe ebile e ka lula e phekoloa?

Matla a viburnum 'meleng oa motho ea nang le lefu la tsoekere

Viburnum ea mofuta oa 2 lefu la tsoekere e tla thusa ho matlafatsa mmele oa mokuli, ho fana ka livithamine le ho thibela nts'etsopele ea mathata a lefu la tsoekere. Ho etsahalang 'meleng ka lefu la tsoekere? Ho joalo, pele, tlhahiso ea insulin e senyeha mme boemo ba tsoekere ea mali bo nyoloha. Empa tlolo ea metabolism ea tsoekere ke karolo feela ea lipontšo tsa lefu lena. Ka nts'etsopele ea lefu lena, matla a ho lekanya li-vithamine le li-microelement le lits'ebetso tse ling tsa metabolic lia senyeha, hangata e le mathata, marang-rang a likepe le pelo, sebete le liphio lia ntlafala.

Viburnum ea mofuta oa 2 lefu la tsoekere e thusa ho fokotsa menyetla ea ho ba le mathata a lefu la tsoekere.

Semela se na le litlamorao tse latelang ho 'mele:

Khahlano le ho ruruha le pholiso ea maqeba. Boleng bona bo bohlokoa haholo ho batho ba nang le lefu la tsoekere, hobane ka lefu lena, matla a mmele a ho hanela nts'etsopele ea tšoaetso ea vaerase a fokotseha, 'me maqeba a ho folisa hampe le ts'ebetso e meng ea' mele 'meleng e atisa ho tšoaetsoa.
Tsosoloso.Viburnum ka mofuta ofe kapa ofe e matlafatsa lits'ebetso tsohle le litho tsohle, e eketsa molumo oa lebota la vascular mme e matlafatsa mesifa ea pelo, hape e ntlafatsa ts'ebetso ea sebete le manyeme.
Sedative Phello e khutsitseng e tla thusa mokuli hore a phomole, a fokotse boroko ba bosiu. Ntle le moo, lefu la tsoekere le nkoa e le "bokuli ba khatello ea maikutlo" le litlamorao tsa khatello ea tlhahiso ea insulin le ts'ebetso ea enzyme ena e se e netefalitsoe.
Antispasmodic. Li-spasms tsa likepe tse nyane, haholo makaleng a tlase, li tšoaea lefu lena. Vasospasm ea nako e telele e nang le phallo ea mali e sa senyeheng e lebisa ho nts'etsopele ea hypoxia ea tishu le ho ba le bothata bo joalo khafetsa ho batho ba nang le lefu la tsoekere.
Ho hloekisa mali. K'holeseterole e feteletseng, lihlahisoa tse bolileng le lintho tse ling tse mpe li tlosoa maling, 'me lintlha tsa glucose le tsona lia tsitsa.

Mokhoa oa ho sebelisa

U ka ja monokotsoai, oa mofuta oa tsoekere joalo ka makhasi, makhasi kapa u etsa lihlahisoa tsa makhapetla:

Tee ea Viburnum. Monokotšoai o omisitsoeng kapa o mocha o tšeloa ka ketaneng. Palo e nkuoa khafetsa, ho latsoa, o ka eketsa makhasi a viburnum, phello ea kalafo e tla ba holimo haholo. Tšela metsi a belang 'me u koahele ketlele ka pane e futhumetseng e futhumatsang, u emetse ho pholile ka botlalo. O ka noella tee ea viburnum ntle le lithibelo, e thusa ho eketsa tsoekere, ho ntlafatsa boroko le ho fokotsa thabo.

Lero. E fafatsoa ho tloha ho monokotsoai o mocha o bokelloang kamora serame (lehloeo le phehella ho litholoana ho fihlela serame). Lero le na le phello e tšoanang 'meleng le tee, mokhoa o tloaelehileng oa letsatsi feela ha oa lokela ho feta 200 ml. Ho nosetsoa lero ho khothaletsoa motšehare, ho arola mokelikeli ho litekanyetso tse peli kapa tse tharo.
Motsoako oa mahe a linotsi le a berry Tharollo e ntle bakeng sa batho ba nang le lefu la tsoekere ba tsoelang pele ho ba le mathata a amanang le lefu la tsoekere. Kopanya metsoako ka karo-karolelano ea 1: 1 'me u je khaba ea makhetlo a 2 kapa a 3 ka letsatsi.
Bark. Ho kenella ho tsoa makhapetleng hangata ho khothalletsoa mothating oa pele oa lefu lena ho tsitsisa metabolism ea tsoekere, empa e tla ba le phello e ntle 'meleng oa ba nang le lefu la tsoekere nako e telele. Khaba ea khaba e nang le leralla le sithabetseng e tšeloa ka khalase ea metsi a belang ebe e belisoa halofo ea hora ka bateng ea metsi. Kamora moo, sejana se nang le moro se koaheloa ka lesela le futhumetseng ebe se tloha hore se pholile. Ho nooa ho khothalletsoa makhetlo a mararo ka letsatsi bakeng sa senoelo sa kotara.

Ha o sa khone ho ja viburnum

Mofuta oa 2 oa lefu la tsoekere o lula o tsamaisana le mathata, 'me ka a mang a ona, viburnum e ka mpefatsa lefu le ho feta.

Semela se ke ke sa jeoa ke mafu a latelang:

thrombophlebitis. Ho senyeha ha patency ea likepe tse nyane ho lebisa ho thrombosis. Mehatong ea morao ea lefu la lefu la tsoekere, methapo ea mali ka har'a lijana tse kholo kapa methapong ea varicose e ka ba teng. Ho ja viburnum ho tla eketsa ponahalo ea mali, ho qholotsa sebopeho sa metheo e mecha ea mali,
boimana. Matla a susumetsang a viburnum a ka ba le litlamorao tse mpe ha a beha litsamaiso le litho tsa mpa tsa mpa,
gout. Lefu lena le tšoauoa ka ho kenngoa ha letsoai la uric acid manonyeletsong, 'me liminerale tse ling tse etsang semela li ka eketsa letsoai le ho baka tlhaselo ea gouty.
hyperthyroidism. Iodine e fumanehang litholoana tsa viburnum e ama tšebetso ea tšoelesa ea qoqotho, 'me ho lona lefu lena mesebetsi ea lona e senyehile. Methapo e meng ea iodine e ka mpefatsa ho hoholo ha hypothyroidism.

Li-contraindication tse ling lia khoneha, boholo ba tsona bo amana le tlolo ea metabolism ea letsoai la liminerale.

Phekolo ea Soda

Lefu la tsoekere ke lefu le sa phekoleheng kajeno. Bongata bo boholo bo lula le eena. Empa haeba u latela litlhahiso tsa ngaka ka tieo, u se ke oa lebala ka litlhahlobo tse thibeloang, latela lijo le ho ikoetlisa, bophelo ba mokuli ea nang le lefu la tsoekere bo tla be bo tletse. Mekhoa e mengata e sa tloaelehang ea ho phekola lefu lena ea tsebahala.Kalafo e tsebahalang haholo ea lefu la tsoekere ka tšebeliso, ka mokhoa o makatsang oa soda le ho e. Mokhoa ona o 'nile oa sebelisoa ka nako e telele haholo. Nakong ea Ntoa ea I ea Lefatše, ha mokuli ea nang le lefu la tsoekere a oela, o ile a fuoa tharollo ea sopho e bonolo ea ho baka ka mothapong.

Matla a ho baka soda le ho feta 'meleng

Sodium bicarbonate ha e kotsi haholo, 'me maemong a mang e na le thuso ho batho. Soda ea baking e tsitsisa tekanyo ea acid-base. Ho motho ea phetseng hantle, tloaelo ea PH ke 7.35-7.45. Haeba u kheloha tloaelo ena, ho hlokahala hore u buisane le setsebi ho tseba lisosa tsa lefu lena.

Ho baka soda ho tsejoa ka eona:

antimicrobial
anti-allergic
anti-inflammatory.

E sebelisoa haholo kalafong ea rhinitis le bronchitis. Soda ea baking e phekola stomatitis le liso tsa ka. Ka thuso ea eona, ho chesoa ha likotsi tse nyane le likokonyana tsa limela, e boetse e thusa hantle ka ho kenella le ho ruruha letlalong. Soda ea baking e sebelisoa haholo bakeng sa ho soeufatsa meno.

Ho cosmetology, sodium bicarbonate e sebelisoa ho etsa mekhabiso e bonolo ea sefahleho. Tharollo ea sopo e hlatsoa lijana le ho hlatsuoa moriri hantle, e li etse li silila.

Ka melemo eohle le tšebeliso e pharalletseng ea sopho ea ho baka, ha rea lokela ho lebala hore ha se pheko ea mafu ohle. Ha acidity ea mpa e fokotsoe, tšebeliso ea tharollo ea sopho ea ho baka e thibetsoe ka mokhoa o hlakileng, hobane ho ka eketsoa maloetse. 'Me ka boemo bo eketsehileng ba acidity, phello e khahlanong le eona ea kalafo ea khoneha.

Lefu la tsoekere

Bafuputsi ba Univesithi ea California ba boletse hore lefu la tsoekere le bakoa ke keketseho ea acidity ea sebete. 'Mele oa motho o lula o koalehile kamehla, o hloka ho hloekisoa kamehla ho tsoa chebeng. Boemo bo eketsehileng ba acidity bo fokotsa mosebetsi oa ho itšireletsa oa sebete. Sena se ama manyeme, ao butle-butle a fokotsang tlhahiso ea insulin, e lebisang ho lefu la tsoekere la mofuta oa II.

Ntlheng ena, bo-rasaense ba entse tlhahiso ea hore ba fokotse acidity e ngata haholo ka sesepa e bonolo ea ho baka. Sena, ka maikutlo a bona, se tla fokotsa kotsi ea ho hlaha ha lefu lena le maemo a mang a pathological. Haeba u nka ntlha ena, joale tšebeliso ea tharollo ea sodium bicarbonate e ka nkoa e le e 'ngoe ea litsela tsa ho phekola lefu lena. Mofuta oa lefu la tsoekere la Mofuta oa Bobeli, soda le ho e baka e fokotsa acidity ea mala mme e e hloekisa, ha sebete se khaotsa ho etsa mesebetsi ea sona ka matla a felletseng.

Tharollo ea sopho ea ho baka e thusa ho fokotsa maemo a tsoekere ea mali. Empa mokuli o lokela ho hopola hore sena se na le phello e mpe ts'ebetsong ea manyeme.

Kajeno, meriana ea sejoale-joale e fana ka khetho e kholo ea lithethefatsi tse sebetsang ho tsitsisa maemo a bakuli ba nang le lefu la tsoekere, mekhoa e mecha ea kalafo e se e qapiloe le ho hlahisoa, empa haeba mokuli a batla ho sebelisa kalafo ka li-adjuvants, o lokela ho ela hloko ho baka ho baka ka lebaka la ho fumaneha ha eona.

Phekolo ea soda ho latela Neumyvakin

Ivan Pavlovich Neumyvakin, rasaense ea tsebahalang lefatšeng, o tsejoa e le setsebi ka mekhoa e meng ea kalafo. O hlokomela ka hloko tsela eo tlhaho e fileng motho ka eona.

Phekolo ea bokahohleng bakeng sa maloetse a 'maloa, ho ea ka Neumyvakin, ke sesebelisoa se tloaelehileng sa ho baka, mme moprofesa a mo fa sebaka se ikhethang mokhoa oa hae oa ho phekola lefu la tsoekere la mofuta oa II. Buka ea hae "Soda - Myth or Reality" e tumme haholo har'a babali.

Ho ea ka rasaense, bothata bo boholo boo batho ba nang le bona bo amana le phetoho ea acid-base state, eo boemo ba eona bo lokelang ho ba khafetsa.

Ka tekanyo ho tloha ho 0 ho isa ho 14, letšoao lena le lokela ho lekana le 7. Letšoao le ka tlase ho 0 ke tikoloho ea acidic, e kaholimo ho 7 - alkaline. Letšoao le fetelang ka bongata ho 7.35-7.45, e tlaleha ho ba teng ha lefu le hlokang tlhahlobo e potlakileng, kalafo e hlokahala tlasa tataiso ea setsebi.

Pele u qala kalafo ea lefu la tsoekere ho ea ka mokhoa oa Dr. Neumyvakin, o lokela ho ea hlahlojoa ka botlalo ke lingaka ho bona hore na ho na le li-contraindication le ho ba teng ha maloetse. Sena se ka lebisa liphellong tse sa rateheng. Tsena li kenyeletsa:

mohato oa boraro mofetše
eketseha kapa ho fokotseha acidity,
mafu a ka mpeng
allergy
mofuta oa lefu la tsoekere.

Ts'ebeliso ea soda le ho e kalafo ha e khothalletsoe hore e otlolle mpa ka mpeng, e leng se khathollang mpa.

Phekolo ea soda bakeng sa lefu la tsoekere la Mofuta oa II ho latela Neumyvakin e lokela ho qala ka lethal dose le lenyenyane, ka hloko ho latela regimen e reriloeng. Ka makhetlo a mararo ka letsatsi, ho hlokahala hore u noe soda e qhibilihang ka metsing a futhumetseng kapa lebese.

Tharollo e lokiselitsoe ka tekanyo ea ¼ ea khaba ea soda le ho e khalase ea metsi ka nako e le ngoe. Ts'ebeliso ea tharollo ea soda ho latela mokhoa oa Neumyvakin e fana ka maikutlo a keketseho ea litekanyetso ho tloha 1 / 4h. l ho fihlela 1 tsp - makhetlo a mabeli ka mor'a lihora tse peli ka mor'a ho ja. Ho latela morero ona, tharollo e lokela ho nkuoa ka matsatsi a mararo, ebe matsatsi a mararo a hlokahala, ebe o tsoela pele ho nka tekanyetso e eketsehileng. Tharollo e nooa metsotso e 15 pele ho lijo.

Ho lokisa tharollo, ho hlokahala hore o kopanye ½ senoelo sa metsi a chesang le sirapo e belang, ebe o e tlotsa ka metsi a belang. Sesebelisoa se hlahisoang se lokela ho futhumala. Phekolo ea soda e qala hoseng ka mpeng e se nang letho.

Phekolo e boletsoeng ke Dr. Neumyvakin e ne e sa sebetsa hantle hakae, o lokela ho hopola hore ngaka e lokela ho laola tšebeliso ea lithethefatsi leha e le life. Hangata litlamorao tsa ho itlhalosa ke litlamorao tse matla tse ke keng tsa fetoloa. Mokhoa o mong le o mong oo mokuli a o khethang (ka meriana, soda kapa litlama), ntho ea bohlokoa ha se ho utloisa 'mele bohloko.

Mildronate: ho qoba mathata a mofuta oa lefu la tsoekere la mofuta oa 2

Lefu la tsoekere le ama methapo ea mali hampe 'me le ka baka lefu la pelo. Mathata ana a sebakeng sa pele hara mafu a lebisang lefung. Ka hona, lingaka li ela hloko haholo thibelo ea mathata ana a lefu la tsoekere.

Kajeno, sethethefatsi se bitsoang "Mildronate" se ntse se tsebahala, se thusang ho loants'a ka katleho le mafu a methapo ea mali le pelo. E hlahisitsoe ho tloha ka 1984 'me liphetho tsa ts'ebeliso ea eona li feta likhakanyo tse ntle tsa bongaka tsohle.

A re ke re hlahlobeng ka botlalo haholoanyane hore na pheko ena e ka thusa joang ho thibela mathata a lefu la tsoekere.

Mildronate le lefu la tsoekere

Motsoako o na le (3- (2,2,2-trimethylhydrazinium) propionate dihydrate), meldonium le MET-88. Setlhare sena sa anti-ischemic se qapiloe ke Setsi sa Latvia sa Organic Synthesis. Phello ea pelo ea Mildronate e bakiloe ke thibelo ea γ-butyrobetaine hydroxylase le phokotso ea beta oxidation ea mafura acid.

Litlamorao tsa Mildronate a lefu la tsoekere li ithutoe ka litoeba. Liphetho tsa liteko li bontšitse hore ho liphoofolo tse nang le lefu lena, tse fuoeng Mildronate bakeng sa libeke tse fetang tse 4, litekanyo tsa tsoekere li ile tsa fokotseha mme nts'etsopele ea mathata a mangata e emisitse.

Litliliniking, moriana o ne o sebelisetsoa ho phekola bakuli ba nang le lefu la tsoekere la mofuta oa 2. Teko e bonts'itse hore ts'ebeliso ea lithethefatsi e tloaetse maemo a tsoekere ea mali le ho thibela nts'etsopele ea discirculatory encephalopathy, diabetic retinopathy, autonomic neuropathy le mafu a mang. Lintlha tsena li netefalitse bohlokoa ba ho sebelisa lithethefatsi ho lefu la tsoekere ho thibela mathata a lefu lena, ho bakuli ba banyenyane le ho batho ba baholo.

Hape, sethethefatsi sena se bohlokoa bakeng sa lefu la coronary. E potlakisa ts'ebetso ea lik'hemik'hale tsa 'mele, e fa motho matla a eketsehileng, hape e thusa ho tlatsa mesifa ea pelo ka oksijene, e e isa myocardium.

Moriana ona o thusa 'mele kaofela ho phela hantle, o tiisetsa ho ikoetlisa ho eketsehileng. Lithethefatsi li ntlafatsa ts'ebetso ea boko, e lebisang ts'ebetsong e eketsehileng. Hangata batho ba nang le lefu la tsoekere ba ikutloa ba khathetse 'me ba khathala kapele.Mildronate ho lefu lena o tla thusa ho sebetsana le maemo ana le ho fana ka matla. Ha o sebelisa sethethefatsi sena, matla a khutlisoa ka makhetlo a mangata ka potlako.

Melemo ea vasodilating ea moriana ona e thusa ho ntlafatsa phallo ea mali lithong tsohle. Mildronate e thusa 'mele hore o fole ka potlako ka mor'a lefu la pelo. E thibela ho theoa ha necrosis, kahoo motho o hlaphoheloa kapele. Ka ho hloleha ha pelo ho matla, sethethefatsi sena se thusa konteraka ea mesifa ea pelo, e etsa hore e be le khatello ea maikutlo le khatello ea maikutlo, kahoo palo ea litlhaselo tsa angina e fokotsehile haholo.

Bakeng sa kalafo ea manonyeletso, babali ba rona ba sebelisitse DiabeNot ka katleho. Ha re bona sehlahisoa sena se tsebahala, re nkile qeto ea ho e ela hloko.

Setlhare sena se khutlisetsa phepelo e nepahetseng ea mali ho fundus.

Ts'ebeliso ea Mildronate e phekola botaoa ba joala bo sa foleng, e thusa ho tlosa mathata a ts'ebetsong a methapo e meholo ea kelello, eo hangata e bang teng ka ts'ebeliso e mpe ea joala.

Setlhare se hlahisoa ka mokhoa oa matlapa le likhabapo. Ho na le litekanyetso tse fapaneng: 250 le 500 mg. Li-package tse tloaelehileng, hangata matlapa a 40-60.

O iponahalitse hantle kalafong e rarahaneng ea maloetse a fapaneng, ho kenyelletsa le lefu la tsoekere ho batho ba bacha le ba baholo.

Phekolo ea infraction ea myocardial.
Ho eketsa khatello ea 'mele meroalo e boima.
Ka ho sebetsa ka thata kelellong.
Phekolo ea methapo, angina pectoris le ho nyekeloa ke pelo.
Phekolo ea ho potoloha ha kokoana-hloko ea mofuta oa lefu la tsoekere la mofuta oa 2 mellitus, cervical osteochondrosis, khatello ea methapo ea mali le mafu a mang.
Cardiomyopathy e bakoang ke ho senyeha ha lihormone le ho khaotsa ho ilela khoeli ho basali ba baholo.
Mokhathala o sa foleng.
Phekolo ea lijana tse khutlang ka mofuta oa 2 lefu la tsoekere.
Ho khaotsa ho ba le bothata ba ho phekola bokhoba ba tahi.

Mokhoa oa ho nka Mildronate

Moriana o lokela ho nooa hoseng, hobane o natefisa tsamaiso ea methapo 'me o ka lebisa ho ts'oaraneng ho batho ba tsofetseng, haeba oe noella ka mor'a lijo tsa mantsiboea.

Keketseho ea khatello ea methapo.
Intracranial neoplasms.
Ho senya ho potoloha ha mali bokong.
Allergy ho likarolo tsa moriana.

lekhopho la letlalo
ho nyekeloa
Kholo ea Quincke,
tachycardia
khatello e eketsehileng ho batho ba tsofetseng.

Kameho ea lithethefatsi ho basali baimana le bana ha e so ka e lekoa. Mofuteng oa 2 oa lefu la tsoekere, Mildronate o laetsoe lithupelong tsa ho boloka pelo le methapo ea mali e phetseng hantle, ho khutlisa katleho. Setlhare sena se ka taoa feela ka tumello ea ngaka e eang. U ke ke ua fana ka moriana ona.