Vasotens H (Vasotens® H)

Vazotens N: litaelo tsa tšebeliso le litlhahlobo

Lebitso la Latin: Vasotenz H

Khoutu ea ATX: C09DA01

Motsoako o sebetsang: losartan (Losartan) + hydrochlorothiazide (Hydrochlorothiazide)

Moetsi: Actavis hf. (Iceland), Actavis, Ltd. (Malta)

Tlhabollo ea litlhaloso le foto: 07/11/2019

Litheko makaleng a litlhare: ho tloha li-ruble tse 375.

Vazotens N ke setlhare se kopaneng sa antihypertensive.

Sokolla foromo le sebopeho

Foromo ea litekanyetso - matlapa a koahetsoeng ka filimi: pota, biconvex, le likotsi tsa morao le likotsi mahlakoreng ka bobeli a letlapa, ka lehlakoreng le leng la likotsi ho na le "LH", ka lehlakoreng le leng - "1" (litekanyetso tsa 50 mg + 12.5 mg) kapa "2" (litekanyetso tsa 100 mg + 25 mg) (ka har'a pakete e nang le lilakane tse 7, 10 kapa 14, ka har'a pakete ea lilakane tse 2 kapa tse 4 tsa matlapa a 7, kapa 1, 3, 9 kapa 10 blisters ea matlapa a 10, kapa 1 kapa. Mabili a mabeli a matlapa a 14 le litaelo tsa Vazotenza N).

Letlapa la 1

• likarolo tse sebetsang: potasiamo ea losartan - 50 kapa 100 mg, hydrochlorothiazide - 12,5 kapa 25 mg, ka ho latellana
• excipients: croscarmellose sodium, microcrystalline cellulose, mannitol, magnesium stearate, povidone, White Opadrai (hypromellose 50cP, hypromellose 3cP, titanium dioxide, macrogol, hydroxypropyl cellulose).

Mofumahali

Vazotens N ke setlhare se matlafatsang se kopaneng.

Lits'oants'o tsa lintho tse sebetsang:

• losartan ke angiotensin II receptor antagonist (subtype AT1). Fokotsa khatello ea mali (BP), khatello ea methapo ea pelo (OPSS), khatello ea potoloho ea methapo, mokokotlo oa adrenaline le aldosterone maling, e fokotsa boima ba morao, e nang le phello ea diuretic. Bakeng sa bakuli ba nang le ho nyekeloa ke pelo ho sa feleng, e thibela nts'etsopele ea myocardial hypertrophy mme e eketsa mamello ea boikoetliso. Ha e thibele kinase II - enzyme e senyang bradykinin,
• hydrochlorothiazide ke thiazide diuretic. Fokotsa ho ts'oaroa ha ion ea sodium, e ntlafatsa tlhahiso ea bicarbonate ea moroto, phosphates le ion ea potasiamo.

Ka hona, Vazotens N e fokotsa molumo oa mali a potoloha, e fetola ho phahama ha lebota la vascular, e ntlafatsa phello e sithabetsang ea ganglia, e fokotsa khatello ea khatello ea li-vasoconstrictors, ka tsela eo e theole khatello ea mali.

Mofumahali

Kamora ho tsamaisoa ka molomo, losartan e kenella ka potlako maling a gastrointestinal (GIT). E tšoauoa ka bioavailability e tlase, motsoako

33% E na le phello ea ho fetela ka har'a sebete. E tšelisoa ke carboxylation, e hlahisang ho theoa ha metabolites e sa sebetseng le metabolism ea mantlha ea pharmacologic e sebetsang (E-3174). Ekaba 99% ea lethal dose e manama le liprotheine tsa plasma. Kamora ho nka Vazotenza N ka hare, tekanyo e kholo ea losartan e fihlella ka hare ho hora e le 1, metabolite e sebetsang - lihora tse 3-4. halofo ea bophelo (T_½) losartan - lihora tse 1.5-2, E-3174 - lihora tse 3-4. E bonahala: ka mala - 60% ea lethal dose, liphio - 35%.

Kamora ho tsamaisoa ka molomo, hydrochlorothiazide e kenella ka potlako mochesong oa lijo. Ha e tšeloe ka har'a sebete. T_½ - lihora tse 5.8-14.8. Boholo (

61%) e pepesitsoe e sa fetoha moroto.

Contraindication

• hypotension e matla ea kahare,
• Qobello ea ho fokola ha reisal QC (tumello ea creatinine) ≤ 30 di ml / min,
• ho hloka matla ha sebete,
• hypovolemia (ho kenyelletsa le semelo sa litekanyetso tse phahameng tsa diuretics),
• anuria
• lilemo tse 18
• ho ima le ho nyekeloa
• hypersensitivity ho losartan, hydrochlorothiazide, tse ling tse tsoang sulfonamide kapa karolo efe kapa efe e thusang ea lithethefatsi.

Setsoalle (Vasotens N se lokela ho sebelisoa ka hloko):

• Tlolo ea tekano ea mali-electrolyte ea mali (ho omella, hypochloremic alkalosis, hyponatremia, hypokalemia, hypomagnesemia),
• bilteryal renal stenosis kapa artery stenosis ea a le mong,
• hypercalcemia, hyperuricemia le / kapa gout,
• lefu la tsoekere
• maloetse a methapo ea methapo (ho kenyeletsoa systemic lupus erythematosus),
• nalane e kulang,
• asthma ea lefu la bronchial,
• ts'ebeliso e le 'ngoe ea lithethefatsi tse seng khahlanong le ts'oaetso (NSAIDs), ho kenyelletsa le li-inhibitors tsa COX-2 (cycloo oxygenase-2).

Litlamorao

Ha o sebelisa Vazotenza H, litla-morao li ka hlaha ha o nka potasiamo losartan le / kapa hydrochlorothiazide.

Lintho tse ka re utloisang hampe:

• ho tsoa ho ts'ebetso ea pelo: ho fokotseha hoa khatello ea mali,
• ho tsoa ho tšilo ea lijo: ka seoelo (1%, ka lebaka la losartan e le karolo ea lithethefatsi) - lets'ollo, hepatitis,
• lehlakoreng la tsamaiso ea ho phefumoloha: ho khohlela (ka lebaka la ketso ea losartan),
• mokokotlo oa letlalo le ho kula: urticaria, angioedema (ho kenyelletsa ho ruruha ha molomo, pharynx, larynx le / kapa leleme), e ka lebisang ho sitisoeng ha mokhoa oa ho hema, ka seoelo haholo (ka lebaka la ketso ea losartan) - vasculitis, ho kenyelletsa Lefu la Shenlein-Genoch,
• paramethara ea laboratori: ka seoelo - hyperkalemia (serum potasiamo> 5.5 mmol / l), ts'ebetso e eketsehileng ea li-enzyme tsa sebete.

Ka khatello ea mali e hlokahalang, litlamorao tse atileng haholo ke ho tsekela.

Bongata

Haeba ho na le overdose, losartan e ka baka mathata a latelang: ho fokotseha ho hoholo hoa khatello ea mali, bradycardia, tachycardia.

Tekanyetso e feteletseng ea hydrochlorothiazide e ka bonahatsoa ke tahlehelo ea li-electrolyte (hyperchloremia, hypokalemia, hyponatremia), hammoho le ho omella hoa mmele, e leng litholoana tsa diuresis tse ngata.

Haeba ho se ho fetile nako esale a nka Vazotenza N, ho khothaletsoa tšilafalo ea ka mpeng. Phekolo ea ts'oaetso le ea tšehetso e laetsoe; ho lokisoa ha litšitiso tsa motlakase oa metsi hoa hlokahala. Haeba ho hlokahala, hemodialysis e etsoa ho tlosa losartan le metabolite ea eona e sebetsang 'meleng.

Hydrochlorothiazide

Nakong ea kalafo, ho hlokahala hore ho hlahlojoe boemo ba mokuli e le hore a tle a tsebe ho bonts'a matšoao a tlilohako a tlolo ea tekano ea methapo ea metsi, e ka hlahang khahlano le semelo sa ho hlatsuana kapa ho hlatsa. Ho bakuli ba joalo, ho boetse hoa hlokahala ho laola boemo ba li-electrolyte tse serum ea mali.

Liazine diuretics e ka kena-kenana le mamello ea glucose, e ka hlokang phetoho ea tekanyetso ea moemeli oa hypoglycemic kapa insulin.

Hydrochlorothiazide e ka fokotseha khalsiamo ea "calcium", hammoho le ho baka keketseho e nyane ea li-calcium serum. Haeba hypercalcemia e matla e fumanoe, hyperparathyroidism ea morao-rao e lokela ho nahanoa.

Li-Thiazides li ama metabolism ea calcium, ka hona, li ka khopamisa liphetho tsa thuto ea tšebetso ea litšoelesa tsa parathyroid. Ntlheng ena, mantsiboeeng a tlhahlobo, lithethefatsi li tlameha ho hlakoloa.

Hydrochlorothiazide e ka eketsa li-triglycerides tsa mali le cholesterol.

Nakong ea phekolo, ho eketsoa kapa ho eketseha ha systemic lupus erythematosus hoa khoneha.

Hydrochlorothiazide e ka baka nts'etsopele ea hyperuricemia le / kapa gout. Leha ho le joalo, losartan, e leng karolo ea bobeli e sebetsang ea Vazotenza N, e fokotsa litaba tsa uric, ka hona, e fokotsa ho teba ha hyperuricemia e bakoang ke diuretic.

Khahlano le semelo sa kalafo ea diuretic, ho ba teng hoa karabelo ea hypersensitivity hoa khoneha, esita le ho bakuli ba nang le nalane ea asthma ea bronchial kapa allergies.

Tšusumetso ho bokhoni ba ho khanna makoloi le mekhoa e rarahaneng

Lithuto tse khethehileng tsa kliniki ho ithuta ka phello ea Vazotenza N mesebetsing ea kelello le ea psychomotor ha li so etsoa. Leha ho le joalo, nakong ea kalafo, ho tsekela le ho otsela li ka hlaha. Ka lebaka lena, tlhokomeliso e eletsoa ha u etsa mosebetsi o hlokang tlhokomelo e eketsehileng le lebelo la karabelo, haholo-holo mohato oa pele oa kalafo le nakong ea ho eketsa tekanyetso ea moriana.

Bokhachane le pelehi

Ha e sebelisoa ho trimesters ea bobeli le ea boraro ea bokhachane, losartan, joalo ka lithethefatsi tse ling tse amang renin-angiotensin-aldosterone system (RAAS), e ka baka sekoli sa ho hola esita le lefu la fetus.

Hydrochlorothiazide e tšela sethala sa placental, e ikemiselitsoe maling a thapo ea "umbilical". Ha e sebelisoa nakong ea kemaro, e eketsa kotsi ea jaundice ka popelong kapa leseeng, hammoho le thrombocytopenia le ho se leka-lekane ha 'mele oa mama.

Letlapa la Vasotens N le hanyetsoa nakong ea boimana. Haeba ho ima ho fumanoa nakong ea kalafo le moriana, o lokela ho o hlakola kapele kamoo ho ka khonehang.

Li-diuretics tsa Thiazide li fetela lebeseng la matsoele. Mosali o khothalletsoa hore a emise ho anyesa haeba kalafo ea lithethefatsi nakong ea ho nyekeloa e loketse.

Ho sebelisana le lithethefatsi

Losartan e ka sebelisoa hammoho le li-antihypertgency agents tse ling (diuretics, sympatholytics, beta-blockers). Ka nako e ts'oanang, ho khothaletsoa matla a phello.

Ha ho na litšebelisano tse kholo tsa lithethefatsi ka tšebeliso e tšoanang ea hydrochlorothiazide, erythromycin, cimetidine, ketoconazole, phenobarbital, warfarin, digoxin.

Ho bakuli ba nang le BCC e fokotsehileng ka lebaka la kalafo e fetileng e nang le litekanyetso tse kholo tsa diuretics, moriana o ka baka khatello e tlase ea khatello ea mali.

Ka tšebeliso e kopanetsoeng ea potasiamo-sparing diuretics (amiloride, triamteren, spironolactone), letsoai la potasiamo kapa litokisetso tsa potasiamo, keketseho ea boemo ba potasiamo ka serum ea mali e ka khonahala.

Fluconazole le rifampicin li fokotsa boemo ba plasma ba metabolite e sebetsang ea losartan. Bohlokoa ba bongaka ba litšebelisano tsena ha bo e-so fumanoe.

Losartan e khona ho eketsa litaba tsa lithium ho plasma ea mali. Tabeng ena, litokisetso tsa lithium li ka laeloa feela kamora tlhahlobo e hlokolosi ea melemo e lebelletsoeng le likotsi tse ka bang teng. Ha o sebelisa motsoako ona, karolo ea plasma ea lithium e lokela ho lekoloa ka hloko.

Matla a losartan a ka fokotsoa ke li-NSAIDs, ho kenyelletsa le li-inhibitors tse khethiloeng tsa COX-2. Bakeng sa bakuli ba nang le bothata ba ho sebetsa ha renal, maemong a mang, motsoako ona o ka tlatsetsa ho mpefala hoa ts'ebetso ea liphio, ho fihlela nts'etsopele ea ho hloleha ha renal ho hlobaetsang. Hangata phello ena e fetoha phetoho.

Sebopeho le mofuta oa tokollo

ka paketeng e nang le lithutsoana tse 7 tsa likhomphutha., ka paketeng ea lilakane tse 4, kapa ka har'a pakete ea blanc ea 14, ka har'a pakete ea likhabote tse 2.

ka paketeng e nang le lithutsoana tse 7 tsa likhomphutha., ka paketeng ea lilakane tse 4, kapa ka har'a pakete ea blanc ea 14, ka har'a pakete ea likhabote tse 2.

Tšebelisano

Losartan e ntlafatsa phello ea lithethefatsi tse ling tsa antihypertensive. Ha ho na ts'ebelisano e kholo ea ts'ebelisano le hydrochlorothiazide, digoxin, anticoagulants e sa amaneng, cimetidine, phenobarbital, ketoconazole, erythromycin e hlokometsoe. Rifampicin le fluconazole ho tlalehiloe hore li theola boemo ba metabolite bo sebetsang. Bohlokoa ba bongaka ba litšebelisano tsena ha bo so ithutoe.

Joalo ka ts'ebetso ea lithethefatsi tse ling tse thibelang angiotensin II kapa ketso ea eona, tsamaiso e ts'oanang ea li-diuretics tsa potasiamo (mohlala, spironolactone, triamteren, amiloride), litokisetso tsa potasiamo, kapa tse ling tse nang le potasiamo li ka lebisa ho hyperkalemia.

Li-NSAID, ho kenyelletsa li-inhibitors tse khethiloeng tsa COX-2 li ka fokotsa phello ea li-diuretics le li-antihypertgency tse ling.

Ho bakuli ba bang ba nang le bothata ba ho sebetsa ba sa sebetse hantle ba phekoloang ke NSAIDs (ho kenyelletsa le li-inhibitors tsa COX-2), kalafo e mabapi le li-anteptonist tsa angiotensin II e ka baka tšenyo e eketsehileng ea ts'ebetso ea renal, ho kenyelletsa le ho hloleha ho hlobaetsang le makhopho.

Matla a antihypertensive a losartan, joalo ka lithethefatsi tse ling tsa antihypertgency, a ka fokola ha o nka indomethacin.

Lithethefatsi tse latelang li khona ho sebelisana le thiazide diuretics ka tsamaiso e ts'oanang ea tsona:

barbiturates, lithethefatsi tsa narcotic, ethanol - Orthostatic hypotension e ka 'na ea e-ba le monyetla,

hypoglycemic agents (li-insulin tsa molomo le insulin) - tokiso ea li-agents tsa hypoglycemic e ka hlokahala,

li-antihypertensives tse ling - tlatsetso e ka etsahala,

colestyramine le colestipol - fokotsa ho kenngoa ha hydrochlorothiazide,

corticosteroids, ACTH - tahlehelo e eketsehang ea li-electrolyte, haholo potasiamo,

mochine oa khatiso - mohlomong ho fokotseha ho fokolang hoa matla a khatello ea amine ea khatello, eseng ho kena-kenana le ts'ebeliso ea bona,

mesomo e sa nyenyefatseng ea mesifa (mohlala, tubocurarine) - hoa khoneha ho ntlafatsa ketso ea ba hlasimollang mesifa,

Litokisetso tsa lithium - diuretics e fokotsa ho hlaphoheloa hoa li-Li + mme e eketsa kotsi ea ho taoa ea lithium, ka hona, ho sebelisoa ka nako e tšoanang ha ho khothaletsoe,

Li-NSAID, ho kenyelletsa li-inhibitors tse khethiloeng tsa COX-2 - ho bakuli ba bang, tšebeliso ea li-NSAID, ho kenyelletsa Li-inhibitors tsa COX-2, li ka fokotsa diuretic, natriuretic le antihypertensive phello ea diuretics.

Tšusumetso ho litholoana tsa laboratori - Ka lebaka la phello ea khalsiamo ea calcium, li-thiazides li ka ama litholoana tsa tlhahlobo ea ts'ebetso ea parathyroid.

Tekanyetso le tsamaiso

Ka hare ho sa tsotelehe lijo.

Pilisi e le 'ngoe e tloaelehileng le ho e lokisa ke e' ngoe. ka letsatsi. Bakeng sa bakuli ba sa atleheng taolo ea khatello ea mali tekong ena, lethal dose le ka eketsoa matlapeng a mabeli. (50 mg / 12.5 mg) kapa Letlapa le le leng. (100 mg / 25 mg) nako e le 1 ka letsatsi. Sekhahla se phahameng ke matlapa a mabeli. (50 mg / 12.5 mg) kapa Letlapa le le leng. (100 mg / 25 mg) nako e le 1 ka letsatsi.

Ka kakaretso, phello e matla ea hypotensive e fihlella ka libeke tse 3 kamora ho qala kalafo.

Ha ho na tlhoko ea khetho e khethehileng ea tekanyetso ea pele bakeng sa bakuli ba tsofetseng.

Litaelo tse khethehileng

E ka sebelisoa hammoho le lithethefatsi tse ling tsa antihypertensive.

Ha ho na tlhoko ea khetho e khethehileng ea tekanyetso ea pele bakeng sa bakuli ba tsofetseng.

Lithethefatsi li ka eketsa khatello ea mali ea urea le ea creatinine plasma ea mali ho bakuli ba nang le methapo ea methapo ea methapo kapa renal artery stenosis ea a le mong.

Hydrochlorothiazide e ka eketsa bongata ba methapo ea methapo le methapo ea methapo ea methapo ea metsi (ho fokotseha ha BCC, hyponatremia, hypochloremic alkalosis, hypomagnesemia, hypokalemia). le triglycerides, ho qholotsa ho hlaha hoa hyperuricemia le / kapa gout.

Ho amoheloa ha lithethefatsi tse sebetsang ka kotloloho tsamaisong ea renin-angiotensin nakong ea likhahla tsa II le tsa boraro tsa bokhachane ho ka lebisa lefung la masea. Haeba ho ima ho hlaha, ho tlosoa hoa lithethefatsi ho bontšoa.

Ha ho na tlhahisoleseling mabapi le phello ea bokhoni ba ho khanna koloi le mekhoa e meng.

Matšoao a ho sebelisoa

Mori o ngolloa bakuli ba nang le mathata a fapaneng:

1. Phekolo ea methapo. Setlhare sena se bontšoa bakuli ba nang le khatello ea mali. Ha u ntse u sebelisa moriana oa "Vazotens" ho hlokahala hore ho hlahlojoe matšoao a khatello ea mali khafetsa.
2. Ho nyekeloa ke pelo ho sa feleng. Ka tsoelo-pele ea mofuta o joalo oa methapo ea pelo, boikemisetso ba pelo bo fokotseha ho bakuli. Maemong a mangata, lefu lena le fumanoa ke batho ba baholo.

Moriana "Vazotens" o laetsoe hammoho le lithethefatsi tse ling. Moriana o mamelloa hantle ha o ntse o noa le li-inhibitors tsa ACE. Ngaka e hlile e nahana ka katleho ea phekolo le litšobotsi tsa 'mele.

Moriana o laeloa ho hloleha ha pelo

U ka nka joang le ho hatelloa ke eng

"Vazotens" e laeloa bakuli ba nang le khatello e phahameng ea mali. Setlhare se nooa ka molomo, ho sa tsotelehe lijo. U hloka ho nwa matlapa a 1 hang ka letsatsi.

Haeba bakuli ba fumanoe ba na le khatello ea mali, kalafo e qala ka tekanyetso e fokolang. Mokuli o fuoa 50 mg ea losartan. Haeba ho hlokahala ebile ho latela bopaki ba ngaka, litekanyetso li ka eketsoa ho 100 mg. Ebe palo eo e aroloa ka tekanyetso e 'meli - hoseng le mantsiboea.

Batho ba nang le ho nyekeloa ke pelo ba lokela ho sebelisa litekanyetso tse fokolang tsa kalafo. Motsoako oa pele ke 12,5 mg hang ka letsatsi. Haeba mokuli a mamella kalafo hantle, kamora matsatsi a 7, 7 litekanyetso li eketseha.

Thutela-litso

Mori Vazotens o bua ka lithethefatsi tse antihypertensive - bahanyetsi ba itseng ba li-receptor tsa angiotensin 2. Ha e hatelle mofuta oa enzyme ea kinase, e senyang bradykinin. Lithethefatsi li na le diuretic effect, ha li ame litaba tsa adrenaline, aldosterone ho plasma.

Ka lebaka la ts'ebetso ea lithethefatsi, hypertrophy ea methapo ea methapo ea mokokotlo ha e hlahe, mamello ho ts'ebetso ea 'mele e eketseha ka ho se sebetse ha pelo. Kamora tekanyetso e le 'ngoe ea matlapa, khatello e ea fokotseha, phello e fihla pheletsong ea eona kamora lihora tse 6 ebe e lula ka letsatsi. Ho sebetsa ha moriana ho bonahala ho libeke tse 3-6 tsa kalafo. Ka cirrhosis ea sebete, khatello ea ntho e sebetsang ea eketseha, ka hona, ho hlokahala phetoho ea tekanyetso.

Losartan e kenella ka potlako ka mpeng, e na le bioavailability ea 33%. Ntho ena e fihla sehlohlolong ka mor'a hora, metabolite e sebetsang - kamora lihora tse 3-4. Bophelo ba halofo ea losartan ke lihora tse 1.5-2, metabolite ke lihora tse 6-9. Karolo ea boraro ea tekanyetso e tšeloa ka har'a moroto, 'me o mong o na le mantle.

Sebopeho sa Vazotenza N se kenyelletsa diuretic hydrochlorothiazide, e bolelang ntho ea mofuta oa thiazide. E fokotsa ho ts'oaroa ha ion ea sodium, e eketsa tlhahiso ea phosphates ea moroto, bicarbonate. Ka ho fokotsa bongata ba mali a potoloha, khatello ea fokotseha, ho busetsoa hoa liphetoho tsa leboteng la vascular, phello ea khatello ea li-vasoconstrictors ea fokotseha, 'me phello ea khatello ea maikutlo ho ganglia ea eketseha.

Tekanyetso le tsamaiso

Matlapa a Vazotens a nooa hang ka letsatsi. Ka khatello ea mali e phahameng, tekanyetso ea letsatsi le letsatsi ke 50 mg, ka linako tse ling e eketsoa ho 100 mg ho litekanyetso tsa 1-2. Ka ho nyekeloa ke pelo, litekanyetso tsa pele ke 12,5 mg hang ka letsatsi. Tekanyetso e eketseha beke le beke ka 12,5 mg ho fihla 50 mg hang ka letsatsi. Ka tsamaiso e tšoanang ea diuretics, tekanyetso ea pele e fokotsoa ho 25 mg ka letsatsi.

Tabeng ea ho senyeha ha ts'ebetso ea sebete (ho fokotseha ha tumello ea creatinine), litekanyetso li ea fokotseha, botsofaling, le ho hloleha ha liphio, ho hlohlona ha ho etsoa. Phello e phahameng e hlaha kamora libeke tse 3 tsa kalafo. Ho bana, lithethefatsi ha li sebelisoe. Litaelo tse ikhethang bakeng sa tšebeliso ea eona ho tsoa ho litaelo:

1. Pele u fana ka moriana, ho lokisoa ha 'mele ho etsoa, ​​kapa u hloka ho sebelisa lithethefatsi ka tekanyetso e tlase.
2. Sesebelisoa se ka eketsa khatello ea urea maling le lefu la renal stenosis.
3. Nakong ea phekolo, ho hlokahala ho laola boemo ba potasiamo maling, haholo-holo ho batho ba tsofetseng, hobane bakuli ba joalo ba na le kotsi e eketsehileng ea ho ba le hyperkalemia (maemo a eketsehang a potasiamo ka plasma ea mali).
4. Tšebeliso ea moriana nakong ea kemolo e ka baka sekoli sa ho holofala kapa lefu la fetal. Nakong ea lebactation, tšebeliso ea li-vasotens e thibetsoe.

Lipehelo tsa thekiso le polokelo

Vazotens e bua ka lithethefatsi tse fanoang ke ngaka, tse bolokiloeng ka mocheso ho isa ho likhato tse 30 nako e sa feteng lilemo tse peli, li sa fihlelloa ke bana.

Li-antihypertgency agents tse nang le sebopeho se fapaneng li ka nkela lithethefatsi sebaka. Li-analog tsa Vazotens:

• Lorista - matlapa a thehiloeng ho losartan,
• Lozap ke sesebelisoa sa ho hlophisa letlapa le nang le losartan e le ntho e sebetsang.

Lebitso le sa Tšoaneleheng la Machabeng

INN ea lithethefatsi ke losartan.

Hangata kalafo ea Vasotens e fuoa batho ba nang le lefu la khatello ea mali.

Khethollong ea machaba ea ATX, moriana ona o na le khoutu ea C09CA01.

Lokolla liforomo le sebopeho

Motsoako o ka sehloohong oa Vazotens ke potasiamo losartan. Likarolo tse ling tsa meriana li kenyelletsa croscarmellose sodium, mannitol, hypromellose, magnesium stearate, talc, propylene glycol, jj. Sebopeho sa Vazotenza N, ho ekelletsa ho losartan, se kenyelletsa hydrochlorothiazide.

Vasotens e fumaneha ka mokhoa oa litafole tse nang le litekanyetso tsa 25, 50 le 100 mg. Matlapa a pota-potiloe ka sebopeho. Li koaetsoe ka khetla e tšoeu 'me li khethiloe "2L", "3L" kapa "4L" ho latela tekanyetso. Li kenngoa ka har'a marang-rang a li-pcs tse 7 kapa 10. Ka lebokoseng la karete ho na le mabokose a 1, 2, 3 kapa a 4 le leqephe la taeo le nang le tlhaiso-leseling ka lithethefatsi.

Vasotens e fumaneha ka mokhoa oa litafole tse nang le litekanyetso tsa 25, 50 le 100 mg.

Ketso ea pharmacological

Melemo ea pharmacological ea lithethefatsi e bakiloe ke ts'ebetso e boletsoeng ea Vazotenz, karolo ea mantlha e sebetsang eo e leng mofuta oa "angiotensin receptor antagonist". Ka kalafo ea vasotenz, ntho e sebetsang ea lithethefatsi e thusa ho fokotsa OPSS. Lithethefatsi li fokotsa khatello ea aldosterone le adrenaline maling a mali. Moriana ona o na le phello e kopaneng, o etsa hore khatello ea methapo e potolohe le ho potoloha ha pulmonary.

Ntle le moo, likarolo tse sebetsang tsa lithethefatsi li fokotsa moroalo tsamaisong ea pelo le pelo 'me li na le phello e boletsoeng. Ka lebaka la phello e rarahaneng, kalafo e nang le li-vasotens e fokotsa kotsi ea myocardial hypertrophy. Moriana ona o thusa ho eketsa mamello ho bakuli ba nang le matšoao a matla a ho hloleha ha pelo.

Moriana ha o thibele ho kopana ha mofuta oa 2. Enzyme ena e na le tšusumetso ho senya bradykinin. Ha u sebelisa meriana ena, ho fokotseha ha khatello ea mali ho bonoa kamora lihora tse 6. Nakong e tlang, ts'ebetso ea ntho e sebetsang ea lithethefatsi butle-butle e fokotseha ho feta lihora tse 24. Ka ts'ebeliso e hlophisehileng, phello e phahameng e bonoa kamora libeke tse 3-6. Kahoo, moriana o hloka tšebeliso e telele ea nako e telele.

Ka tlhokomelo

Haeba mokuli a e-na le matšoao a ho fokola ha sebete le tšebetso ea a liphio, kalafo le Vazotens e hloka tlhokomelo e khethehileng ea ngaka. Ntle le moo, tlhokomelo e khethehileng e hloka hore ho sebelisoe vazotens kalafong ea batho ba nang le lefu la Shenlein Genoch. Maemong ana, ho lokisoa khafetsa tekanyetso ea moriana ho fokotsa kotsi ea ho ba le mathata a maholo.

U ka nka li-vasotens joang?

Moriana ona o etselitsoe tsamaiso ea molomo. Ho fihlela phello ea kalafo, mokuli o lokela ho nka tekanyetso e boletsoeng ea 1 hoseng. Ho ja ha ho ame ho kenngoa ha moriana. Ho tsitsisa khatello ea mali le ho e boloka e le boemong bo tloaelehileng, bakuli ba bontšoa ba nka Vazotenza ka tekanyo ea 50 mg ka letsatsi. Haeba ho hlokahala, lethalinyana le ka eketsoa ho 100 mg ka letsatsi.

Haeba mokuli a e-na le matšoao a ho hloleha ha pelo, ho khothalletsoa keketseho ea butle-butle ea lethal dose ea vasotenz. Taba ea mantlha, mokuli o fuoa moriana ka tekanyetso ea 12,5 mg ka letsatsi. Kamora hoo e ka bang beke, tekanyetso e nyolohela ho 25 mg. Kamora matsatsi a mang a 7 a ho sebelisa moriana, lethal dose la lona le nyolohela ho 50 mg ka letsatsi.

Haeba mokuli a e-na le matšoao a ho se sebetse hantle ha sebete, kalafo le Vazotens e hloka tlhokomelo e khethehileng ea ngaka.

Tsamaiso ea methapo e bohareng

Hoo e ka bang 1% ea bakuli ba fumanang kalafo ea vasotens ba na le matšoao a asthenia, hlooho e bohloko le ho tsekela. Mathata a ho robala, ho otsela hoseng, ho ba le khatello ea maikutlo, matšoao a ataxia le peropheral neuropathy maemong a sa tloaelehang a ka hlaha nakong ea kalafo ka vasotenz. Ho fokotsa tatso le ho senyeha hoa pono. Ntle le moo, ho na le kotsi ea ho sithabela ha litho tsa maoto.

Ho tsoa ts'ebetsong ea genitourinary

Ho nka vasotenza ho ka baka maemo a nts'etsopele ea mafu a tšoaetsanoang a mofets'e. Maemong a sa tloaelehang, bakuli ba na le litletlebo tsa ho ntša khafetsa le ho fokolisa tšebetso ea renal. Ho banna, ka kalafo ea vasotenz, ho fokotseha ha libido le nts'etsopele ea ho hloka matla ho ka bonoa.

Mohlomong ponahalo ea letlalo le omileng.

Ho tsoa ho tsamaiso ea methapo ea pelo

Ka kalafo ea vasotenz ea nako e telele, mokuli a ka ba le hypotension ea orthostatic. Litlhaselo tsa Angina le tachycardia lia khonahala. Maemong a sa tloaelehang, ho sebelisa lithethefatsi ho baka khaello ea mali.

Hangata, ts'ebeliso ea vasotenz e baka ho ruruha ho fokolang, ho hlahisoang ke ho hlohlona, ​​urticaria, kapa lekhopho la letlalo. Khafetsa o hlokometse ntlafatso ea angioedema.

Sebelisa nakong ea bokhachane le pelehi

Ho sebetsa hantle le polokeho ea tšebeliso ea vasotenza nakong ea kemolo ha e e-so ithutoe ka botlalo. Maemong ana, ho na le bopaki ba phello e mpe ea ntho e sebetsang ea lithethefatsi ho lesea le ho emara ka nako ea bobeli le ea boraro ea kemaro. Sena se eketsa kotsi ea hore ngoana a holofala hampe le lefu la intrauterine. Haeba ho hlokahala kalafo, ho ka khothalletsoa ho hana ho fepa matsoele.

Ka kalafo ea vasotenz ea nako e telele, mokuli a ka ba le hypotension ea orthostatic.

Theko ea li-vasotens

Litsenyehelo tsa moriana ho litlama li tsoa ho li-ruble tse 115 ho isa ho tse 300, ho latela litekanyetso.

E 'ngoe ea lithethefatsi tse tummeng ka ho fetisisa tsa lithethefatsi ke Lozap.
Cozaar ke analogue ea lithethefatsi Vazotens.
Setlhare se tšoanang ke sa Presartan.
Analogue ea lithethefatsi Vazotens ke Lorista.Lozarel ke e 'ngoe ea lipapatso tse tsebahalang tsa lithethefatsi Vazotens.

Litsebi tsa kelello

Grigory ea lilemo li 38, Moscow

Ts'ebetsong ea ka ea bongaka, hangata ke fana ka taelo ea ts'ebeliso ea li-vazotens bakeng sa bakuli ba nang le khatello ea mali ea methapo. Ka lebaka la phello e kopaneng ea "hypotensive" le "diuretic"), lithethefatsi ha li tlatsetse ho tloaelehileng khatello ea mali, empa li eketsa mamello ea mokuli ho ikoetlisa le ho fokotsa boima ba edema. Setlhare sena se mamelloa hantle esita le ke bakuli ba tsofetseng. Ntle le moo, e loketse ho kenyelletsoa phekolong e rarahaneng e sebelisang lithethefatsi tse ling tsa antihypertensive.

Irina, ea lilemo li 42, Rostov-on-Don.

Ke qetile lilemo tse fetang 15 ke sebetsa ke le ngaka ea lefu la pelo, 'me bakuli ba fumanang litletlebo tsa khatello e phahameng ea mali hangata ba beha Vazotens. Tšusumetso ea meriana ena maemong a mangata e lekane ho boloka khatello e tloaelehileng ntle le tlhoko ea ho eketsa diuretics. Setlhare sena se mamelloa hantle ke bakuli mme ha se hangata se bakang litlamorao. Ka lebaka la sena, u ka e sebelisa ka katleho lithutong tse telele.

Igor, ea lilemo li 45, Orenburg

Hangata ke khothaletsa tšebeliso ea vasotenza bakeng sa bakuli ba nang le lefu la pelo. Setlhare se u lumella ho fihlela bonolo ba khatello ea mali ka bonolo le ho fokotsa boima ba edema ea lipheletso tse tlase. Sesebelisoa se tsamaea hantle le lithethefatsi tse ling tse sebelisitsoeng kalafo ea boemo bona ba methapo. Ka lilemo tse ngata tsa ho ikoetlisa, ha ke e-so ka ke kopana le ponahalo ea litla-morao ho bakuli ba sebelisang vazotens.

Ha u sebelisa meriana ena, tlhokomelo e lokela ho nkuoa ho sebetsana le mekhoa e rarahaneng.

Margarita, ea lilemo li 48, Kamensk-Shakhtinsky

Ke se ke tloaelane le bothata ba khatello ea mali e phahameng ka lilemo tse fetang 15. Qalong, lingaka li khothalelitse ho theola boima ba 'mele, ho tsamaea kamehla moeeng o mocha le ho ja hantle, empa bothata bona bo ile ba mpefala butle-butle. Ha khatello e qala ho lula e tsitsitse ka 170/110, lingaka li ile tsa qala ho fana ka meriana. Lilemong tse 3 tse fetileng ke ile ka tšoaroa ke Vazotens. Sesebelisoa se fana ka phello e ntle. Ke e nka hoseng. Khatello e tsitsitse. Ho ruruha ha maoto ho ile ha nyamela. O ile a qala ho ikutloa a thabile le ho feta. Le litepisi tse nyolohang li fanoa hona joale ntle le ho hema ka thata.

Andrey ea lilemo li 52, Chelyabinsk

O ile a sebelisa meriana e fapaneng bakeng sa khatello. Hoo e ka bang selemo, ngaka ea mafu a pelo e laetse ts'ebeliso ea vazotens. Sesebelisoa se fana ka phello e ntle. U hloka ho e nka nako e le 'ngoe feela ka letsatsi. Khatello e khutletse ho tloaelehileng nakong ea libeke tse peli feela tsa ho ja. Hona joale ke sebelisa lithethefatsi tsena letsatsi le leng le le leng. Ha ke a bona litla-morao.