Insulin Humulin: litlhahlobo, litaelo tsa hore na lithethefatsi li etsa bokae

Ho 1 ml. Sehlahisoa Humulin Humulin e na le 100 IU ea "insulin" ea motho. Lithako tse sebetsang ke li-insulin tse qhibilihang ka 30% le insulin isofan.

Joalo ka ha ho sebelisoa likarolo tse thusang:

• metacresol e kolobisitsoeng,
• phenol
• sodium hydrogen phosphate heptahydrate,
• hydrochloric asiti,
• glycerol
• zinc oxide
• protamine sulfate,
• sodium hydroxide
• metsi.

Fomu ea tokollo

Ho hlophisoa ha insulin Humulin M3 insulin e fumaneha ka mokhoa oa ho emisoa bakeng sa tsamaiso ea subcutaneous ka libotlolong tsa 10 ml, hammoho le liketeketeng tsa 1.5 le 3 ml tse pakiloeng ka mabokoseng a likotoana tse 5. Li-Cartridge li etselitsoe hore li sebelisoe ho syringes ea Humapen le BD-Pen.

Lithethefatsi li na le phello ea hypoglycemic.

Humulin M3 e bua ka lithethefatsi tse khahlisang tsa DNA, insulin ke ho emisoa ka methapo ea mekhahlelo e 'meli ka nako e telele ea ketso.

Kamora ho tsamaisoa ha moriana, katleho ea litlhare li etsahala kamora metsotso e 30-60. Phello e phahameng e nka lihora tse peli ho isa ho tse 12, bolelele ba phello ke lihora tse 18-24.

Ts'ebetso ea "insulin" ea "insulin" e ka fapana ho latela sebaka sa taolo ea meriana, ho nepahala ha tekanyetso e khethiloeng, ts'ebetso ea 'mele ea mokuli, lijo le lintlha tse ling.

Phello e ka sehloohong ea Humulin M3 e amana le taolo ea mekhoa ea phetoho ea tsoekere. Insulin le eona e na le phello ea anabolic. Hoo e batlang e le liseleng tsohle (ntle le boko) le mesifa, insulin e kenya ts'ebetso ea "glucose" ea "intracellular" hare "glucose" le "amino acid", 'me e baka leqhubu la "anabolism" ea protheine.

Insulin e thusa ho fetola tsoekere hore e be glycogen, hape e thusa ho fetola tsoekere e ngata hore e be mafura le ho thibela gluconeogeneis.

Matšoao a ts'ebeliso le litla-morao

1. Diabetes mellitus, moo ho khothalletsoang kalafo ea insulin.
2. Lefu la tsoekere (lefu la tsoekere la basali ba bakhachane).

1. E thehiloe hypoglycemia.
2. Hypersensitivity.

Hangata nakong ea kalafo ka litokisetso tsa insulin, ho kenyelletsa Humulin M3, nts'etsopele ea hypoglycemia e bonoa. Haeba e na le sebopeho se matla, e ka tsosa moferefere (khatello ea maikutlo le tahlehelo ea kelello) ebile e ka lebisa lefung la mokuli.

Ho bakuli ba bang, ho kula ho ka hlaha, ho bontšoa ke ho hlohlona ha letlalo, ho ruruha le bofubelu sebakeng sa ente. Ka tloaelo, matšoao ana a nyamela a le mong ka matsatsi a 'maloa kapa libeke kamora ho qala kalafo.

Ka linako tse ling hona ha ho na kamano mabapi le ts'ebeliso ea mori ka boeona, empa ke litholoana tsa tšusumetso ea lintlha tsa kantle kapa ente e fosahetseng.

Ho na le lipontšo tse kulang tsa mofuta oa tlhaho. Li etsahala hangata haholo, empa li tebile le ho feta. Ka karabelo e joalo, ho latela tse latelang:

• ho hema ka thata
• ho hlohlona ka kakaretso
• sekhahla sa pelo
• theoha khatello ea mali
• ho hema hanyane
• ho ruruha ho feteletseng.

Maemong a boima haholo, ho kulisoa ke mmele ho ka baka ts'abo bophelong ba mokuli mme ho hloka tlhokomelo ea bongaka e potlakileng. Ka linako tse ling ho hlokahala hore ho be le insulin kapa ho e nyatsa.

Ha o sebelisa insulin ea liphoofolo, ho hanyetsa, hypersensitivity ho lithethefatsi, kapa lipodystrophy li ka hlaha. Ha u fana ka insulin Humulin M3, menyetla ea litlamorao tse joalo e batla e le zero.

Litaelo tsa ho sebelisoa

Insulin ea Humulin M3 ha e lumelloe ho tsamaisoa ka matla.

Ha u fana ka insulin, tekanyetso le mokhoa oa tsamaiso li ka khethoa feela ke ngaka. Sena se etsoa ka bonngoe ho mokuli ka mong, ho latela boemo ba glycemia 'meleng oa hae. Humulin M3 e etselitsoe tsamaiso e tsamaisang lintho ntle le tšitiso, empa hape e ka tsamaisoa ka mokhoa o kopaneng, insulin e lumella sena. Leha ho le joalo, motho ea nang le lefu la tsoekere o lokela ho tseba ho enta insulin.

Ka mokhoa o ikhethileng, lithethefatsi li kenngoa ka mpeng, thipa, lehetleng kapa mokokotlong. Sebakeng se le seng ente e ke ke ea hlola e fanoa hang ka khoeli. Nakong ea ts'ebetso, ho hlokahala hore ho sebelisoe lisebelisoa tsa entetso ka nepo, ho thibela nale hore e se ke ea kena methapong ea mali, eseng ho silila setsi sa ente ka mora ente.

Humulin M3 ke motsoako o entsoeng o hlophisitsoeng o nang le Humulin NPH le Humulin Regular. Sena se nolofalletsa ho se lokise tharollo pele ho tsamaiso ho mokuli ka boeena.

Ho itokisetsa insulin bakeng sa ente, vial kapa cartridge ea Humulin M3 NPH e lokela ho phuthoa makhetlo a 10 matsohong a hau mme, ha e fetoha likhato tse 180, e sisinyeha hanyane ka hanyane. Sena se tlameha ho etsoa ho fihlela ho emisoa ho tšoana le lebese kapa ho fetoha metsi a koahetsoeng ke maru.

Ho sisinya insulin NPH ka matla ha ho kgothaletswe, kaha sena se ka lebisa ponahalong ea foam mme sa kena-kenana le litekanyetso tse tobileng. Se ke ua sebelisa lithethefatsi ka mokokotlo kapa li-flakes tse qapiloeng kamora ho kopanya.

Tsamaiso ea insulin

Ho kenya sethethefatsi ka nepo, o lokela ho qala ka ho etsa mekhoa e meng ea pele. Taba ea pele, u hloka ho tseba sebaka sa ente, hlatsoa matsoho hantle mme u hlakole sebaka sena ka lesela le kolobisitsoeng ke joala.

Ebe ho hlokahala hore o tlose sekhahla se sirelletsang ka lesobeng la syringe, ho lokisa letlalo (ho le otlanya kapa ho le penya), ho kenya nale le ho etsa ente. Ebe nale e tlameha ho tlosoa mme metsotso e seng mekae ntle le ho itlotsa, tobetsa sebaka sa ente ka lesoba. Kamora moo, ka thuso ea cap e tsoang ka ntle e sirelletsang, o hloka ho otlolla nale, e e tlose ebe u e khutlisetsa cap, pente ea syringe.

U ke ke ua sebelisa nale e tšoanang le ea syringe habeli. Vial kapa cartridge e sebelisoa ho fihlela e se na letho ka ho feletseng, ebe e lahloa. Lipene tsa syringe li etselitsoe ts'ebeliso ea motho ka mong.

Bongata

Humulin M3 NPH, joalo ka lithethefatsi tse ling sehlopheng sena sa lithethefatsi, ha e na litlhaloso tse nepahetseng tsa ts'ebeliso e feteletseng, hobane boemo ba glucose bo serumeng ea mali bo itšetlehile ka ts'ebelisano ea tsamaiso pakeng tsa boemo ba tsoekere, insulin le lits'ebetso tse ling tsa metabolic. Leha ho le joalo, overulin ea insulin e ka ba le litlamorao tse mpe haholo.

Hypoglycemia e hlaha ka lebaka la ho se sebe hantle pakeng tsa litaba tsa insulin kahara plasma le litšenyehelo tsa matla le tšebeliso ea lijo.

Matšoao a latelang ke a tšoaetso ea hypoglycemia e hlahang:

• lethargy
• tachycardia
• ho hlatsa
• mofufutso o feteletseng
• pallor ea letlalo
• ho thothomela
• hlooho e bohloko
• pherekano.

Maemong a mang, ho etsa mohlala, ka nalane e telele ea lefu la tsoekere kapa tlhahlobo ea lona e haufi, matšoao a ho qala ha hypoglycemia a ka fetoha. Hypoglycemia e bonolo e ka thibeloa ka ho nka tsoekere kapa tsoekere. Ka linako tse ling u ka hloka ho fetola tekanyetso ea insulin, ho hlahloba lijo kapa ho ikoetlisa.

Hypoglycemia e leka-lekaneng hangata e phekoloa ka tsamaiso ea glucagon e subcutaneous kapa intramuscular, ebe e lateloa ke ho kenella ha lik'habohaedreite. Maemong a tebileng, moo ho nang le mathata a methapo ea methapo, ho tsitsinyeha kapa mokokotlo, ntle le ente ea glucagon, ho tsitsisa ha tsoekere ho lokela ho tsamaisoa ka matla.

Nakong e tlang, bakeng sa ho thibela ho khutla ha hypoglycemia, mokuli o lokela ho ja lijo tse nang le lik'habohaedreite tse ngata. Maemo a matla haholo a hypoglycemic a hloka sepetlele sa tšohanyetso.

Ho sebelisana le lithethefatsi NPH

Ts'ebetso ea Humulin M3 e ntlafatsoa ke tsamaiso ea lithethefatsi tsa molomo tsa hypoglycemic, ethanol, acid e tsoang ho salicylic acid, li-inhibitors tsa monoamine oxidase, sulfonamides, li-inhibitors tsa ACE, angiotensin II receptor blockers.

Lithethefatsi tsa Glucocorticoid, lihormone tsa ho hola, lithibela-pelehi tsa molomo, danazole, lihormone tsa qoqotho, thiazide diuretics, beta2-sympathomimetics li lebisa ho fokotseha hoa phello ea hypoglycemic ea insulin.

Matlafatsa kapa, ka lehlakoreng le leng, fokolisa ho itšetleha ha insulin e khonang lancreotide le li-analogues tse ling tsa somatostatin.

Matšoao a hypoglycemia a lubricated ha a ntse a nka clonidine, reserpine le beta-blockers.

Lipehelo tsa thekiso, polokelo

Humulin M3 NPH e fumaneha pharmising feela ka lengolo la ngaka.

Setlhare se tlameha ho bolokoa ka mocheso oa likhato tse 2 ho isa ho tse 8, se ke ke sa hoamisoa le ho pepesetsoa khanya ea letsatsi le mocheso.

Vial ea NPH e buletsoeng e ka bolokoa ka mocheso oa likhato tse 15 ho isa ho 25 ka matsatsi a 28.

Ho latela maemo a hlokehang a mocheso, tokiso ea NPH e bolokiloe lilemo tse 3.

Litaelo tse khethehileng

Ho khaotsa ho sa phekoloe ha kalafo kapa ho khethoa ha litekanyetso tse fosahetseng (haholo-holo bakeng sa bakuli ba itšetlehileng ka insulin) ho ka lebisa nts'etsopele ea lefu la tsoekere la ketoacidosis kapa hyperglycemia, e ka behang bophelo ba mokuli kotsing.

Bathong ba bang, ha u sebelisa insulin ea motho, matšoao a hypoglycemia a ka 'na a fapana le matšoao a insulin ea liphoofolo, kapa a ka ba le lipontšo tse bobebe.

Mokuli o lokela ho tseba hore haeba boemo ba tsoekere ea mali bo tloaelehile (mohlala, ka kalafo e matla ea insulin), matšoao a fanang ka maikutlo a hore hypoglycemia e ka nyamela.

Lipontšo tsena li ka fokola kapa tsa bonahala ka mokhoa o fapaneng haeba motho a nka beta-blockers kapa a e-na le nako e telele ea lefu la tsoekere, hammoho le boteng ba lefu la tsoekere.

Haeba hyperglycemia, joalo ka hypoglycemia, e sa lokisoe ka nako e nepahetseng, sena se ka lebisa ho lahleheloa ke letsoalo, ho akheha esita le lefu la mokuli.

Phetoho ea mokuli ho litokisetso tse ling tsa insulin tsa Nulin kapa mefuta ea tsona e lokela ho etsoa feela ka taolo ea ngaka. Ho fetola insulin ho sethethefatsi se nang le ts'ebetso e fapaneng, mokhoa oa tlhahiso (DNA recombinant, phoofolo), mefuta (pig, analog) e ka hloka ts'ohanyetso kapa, ho fapana le moo, khalemelo e boreleli ea litekanyetso tse behiloeng.

Ka mafu a a liphio kapa a sebete, ho se sebetse hantle ha boemo ba tšebetso, ho se sebetse hantle ha litšoelesa tsa adrenal le tšoelesa ea qoqotho, tlhoko ea mokuli ea insulin e ka fokotseha, 'me ka khatello e matla ea maikutlo le maemo a mang, ka lehlakoreng le leng, a eketseha.

Mokuli o lokela ho lula a hopola menyetla ea ho ba le hypoglycemia le ho lekola boemo ba 'mele oa hae hantle ha a khanna koloi kapa tlhokahalo ea mosebetsi o kotsi.

• Monodar (K15, K30, K50),
• Novomix 30 Flexspen,
• Ryzodeg Flextach,
• Remix ea Humalog (25, 50).
• Gensulin M (10, 20, 30, 40, 50),
• Gensulin N,
• Rinsulin NPH,
• Farmasulin H 30/70,
• Humodar B,
• Vosulin 30/70,
• Vosulin N,
• Mikstard 30 NM
• Protafan NM,
• Humulin.

Bokhachane le pelehi

Haeba mosali oa moimana a tšoeroe ke lefu la tsoekere, ho bohlokoa haholo ho eena hore a laole glycemia. Ka nako ena, tlhoko ea insulin hangata e fetoha ka linako tse fapaneng. Ka trimester ea pele, e oa, 'me keketseho ea bobeli le ea boraro, kahoo ho ka hlokahala hore ho fetoloe tekanyetso.

Hape, phetoho ea litekanyetso, lijo le ho ikoetlisa li ka hlokahala nakong ea ho beleha.

Haeba litokisetso tsena tsa insulin li loketse mokuli ea nang le lefu la tsoekere hangata, litlhahlobo mabapi le Humulin M3, joalo ka molao, li na le phetoho. Ho latela bakuli, lithethefatsi li sebetsa hantle haholo 'me ha li na litla-morao.

Ho bohlokoa ho hopola hore ho thibetsoe ka thata ho fana ka insulin, hammoho le ho e fetola e 'ngoe.

Botoro e le 'ngoe ea Humulin M3 e nang le litšenyehelo tsa 10 ml li bitsa chelete e tsoang ho li-ruble tse 500 ho isa ho tse 600, sephutheloana sa mabokose a mahlano a 3 ml a li-ruble tse 1000-1200.