Tsifran OD (Сifran OD)

Mofumahali Ciprofloxacin e sebetsa in vitro mefuta e mengata e fapaneng ea li-gram tse se nang gram le tse ntle tsa gram. Ketso ea bactericidal ea ciprofloxacin ke litholoana tsa thibelo ea enzymes topoisomerase II (DNA gyrase) le topoisomerase IV, tse hlokahalang bakeng sa ho pheta, ho ngola, ho lokisa le ho pheta-pheta DNA ea baktheria. Mochine oa ts'ebetso oa fluoroquinolones, ho kenyelletsa ciprofloxacin, o fapana le ts'ebetso ea ts'ebetso ea penicillin, cephalosporins, aminoglycosides, macrolides le tetracyclines. Ka hona, likokoana-hloko tse loantšang lihlopha tsena tsa lithethefatsi li ka ba le kutloelo-bohloko ea ciprofloxacin le li-quinolones tse ling. Ha ho na tšireletso e tsebahalang ea sefapano lipakeng tsa ciprofloxacin le lihlopha tse ling tsa litlhare tse thibelang likokoana-hloko. Ho hanela in vitro ho profrofloxacin e hlaha butle butle. Ciprofloxacin e sebetsa khahlano le mefuta e mengata ea likokoana-hloko tse latelang in vitrots'oaetso ea mafu,
Likokoana-hloko tsa aerobic gram e ntle: Enterococcus faecalis (likarolo tse ngata li na le kutloelo-bohloko haholo), Staphylococcus aureus (MSSA), Staphylococcus epidermidis (MSSA), Staphylococcus saprophyticus, Streptococcus pneumoniae (PSSP), Streptococcus pyogenes,
likokoana-hloko tse mpe tsa aerobic: Campylobacter jejuni, Citrobacter diversus, Citrobacter freundii, Enterobacter cloacae, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Straissergioerioerius geriomerio grioorioerio drioerio drioerio drioerio grioerio. , Serratia marcescens, Shigella sonnei, Shigella boydii, Shigella dysenteriae, Shigella flexneri.
Ciprofloxacin le eona e mafolofolo in vitro le ka ho sebelisa leseli le kopanyang le Bacillus anthracis. Ciprofloxacin o na in vitro bonyane ba inhibitory concentration (MIC) ≤1 μg / ml mabapi le boholo ba (90%) ba likokoana-hloko tse latelang:
Likokoana-hloko tsa aerobic gram e ntle: Staphylococcus haemolyticus, Staphylococcus hominis, Streptococcus pneumoniae (PRSP),
likokoana-hloko tse mpe tsa aerobic: Acinetobacter iwoffi, Pasteurella multocida, Aeromonas hydrophila, Salmonella enteritidis, Edwardsiella tarda, Vibrio Cholerae, Enterobacter aerogene, Vibrio parahaemolyticus, Klebsiella oxytoca, Vibrio vulnificus, Legionellainophocolila.
Mathata a mangata Burkholderia cepacia le likhathatso tse ling Stenotrophomonas maltophilia li khahlanong le ciprofloxacin, joalo ka libaktheria tse ngata tsa anaerobic, ho kenyeletsoa Bacteroides fragilis le Clostridium Hardile.
Mofumahali Matlapa a matlafalitsoeng a lokolloang ka lehare la ciprofloxacin a entsoe ka mokhoa oa hore lithethefatsi li tsamaee butle ho feta matlapa a tloaelehileng a lokolloang kapele. Matlapa a matlafalitsoeng a ciprofloxacin a tsitsitseng le matlapa a lokolloang kapele arofrofox ha a fetohe. Pale ea pharmacokinetic ea ciprofloxacin matlapa a ntlafalitsoeng a 500 le 1000 mg ha a nkuoa hang ka letsatsi a tšoana le a matlapa a 250 le 500 mg ka tokollo ea hang hang ha a nkuoa makhetlo a 2 ka letsatsi ho latela AUC bakeng sa nako ea lihora tse 24.
Bophahamo ba karolelano ea iv intravenous ciprofloxacin e ka ba boima ba mmele oa 2.1-2.7 l / kg. Liphetho tsa lithuto tse entsoeng ka molomo le / ts'ebelisong ea ciprofloxacin, li bonts'a hore, ho latela mokhoa oa ts'ebeliso, lithethefatsi li kenella liseleng tse fapaneng. Ho tlangoa ha profrofloxacin ka liprotheine tsa serum ke 2040%. Ho ile ha rekisoa li-metabolites tse 4 tsa moroto. Li-metabolites tsena li se li boletse mosebetsi oa antimicrobial ho feta ciprofloxacin e sa fetoheng. Excretion ea metabolites ena e etsahala hoo e batlang e le ka botlalo ka lihora tse 24 ka mor'a ts'ebeliso ea moriana. Li-kinetics tse matlafalitsoeng tsa koprofloxacin li ts'oana le tsa matlapa a nts'itsoeng kapele a profrofloxacin. Hoo e ka bang 35% ea lethal e tsoang ka molomo ha le hlalosoe ntle ho moroto. Mofuta oa morara o hlaha hoo e ka bang ka botlalo ka mor'a lihora tse 24 ka mor'a ho sebelisa moriana. Hoo e ka bang 20-31% ea tekanyetso ea molomo ea ciprofloxacin e lokolloang hang hang e fuoe mantle ka matsatsi a 5. Ho bakuli ba nang le ts'ebetso ea renal e fokotsitsoeng, halofo ea bophelo ba ciprofloxacin e nka nako e telele.

Foromo ea litekanyetso

Matlapa a lokollang lifilimi a koahetsoeng.

Letlapa le leng le le leng le ntlafalitsoeng la filimi le koahetsoeng le na le: Cyfran OD 500 mg
Ntho e sebetsang: ciprofloxacin - 500 mg. Tsifran OD 1000 mg
Ntho e sebetsang: ciprofloxacin - 1000 mg.
Baeti: sodium alginate (Keltone LVCR), hypromellose, sodium bicarbonate, crospovidone (CLM), magnesium stearate, colloidal silicon dioxide (200), talc.

Filimi sheath:
Opadry blanc 31B58910, talcum phofo, hypromellose, metsi a hloekisitsoeng, enke e ntšo bakeng sa mongolo (Opakod -S-1-17823 e ntso).
sebopeho sa opadra tšoeu 31B58910: hypromellose, lactose, titanium dioxide, macrogol 400, e fetoha mouoane nakong ea tlhahiso,
motsoako o kenyeletsa: shellac 45% (20% e hlalositsoeng) ho ethanol, isopropanol, n-butanol, propylene glycol, ammonia ea metsi ea 28%, dae e ntšo ea tšepe.

Fomu ea tokollo

Matlapa a nkileng nako e telele, filimi e koahetsoeng 500 mg, 1000 mg. Matlapa a 5 ka blister e 'ngoe, e nang le foil ea aluminium ka lehlakoreng le leng le foil ea aluminium e koahetsoeng ka filimi ea polyamide le filimi ea PVC ka lehlakoreng le leng, maleiri a le 1 kapa a mabeli ka lebokoseng la karete e nang le litaelo tsa ho sebelisoa.

Letlapa "Tsifran OD 500 mg"
Matlapa a nang le sebopeho sa oval, ho tloha ho o mosoeu ho isa ho o mosoeu, koaetsoeng ka filimi, ho e 'ngoe ea
mahlakore a enke ea lijo tse ngotsoeng "Cifran OD 500MG".

Mofuta oa tafole nakong ea khefu:
e hatelloa ka boima ho tloha bosoeu ho isa ho bosoeu.

Letlapa "Tsifran OD 1000 mg"
Matlapa a nang le sebopeho sa oval, ho tloha ho o mosoeu ho isa ho o mosoeu, o koahetsoeng ka filimi, "Cifran OD 1000MG" o ngotsoe ka lehlakoreng le leng la tafole ka enke ea lijo.
Mofuta oa Letlapa ka khefu: o hatelletse boima ho tloha ho o mosoeu ho isa ho o mosoeu.

Lebitso le sa Tšoaneleheng Kantle ho Naha

Lebitso la khoebo la sethethefatsi sena ke Cifran®. Lebitso le sa ameheng la machabeng ke Ciprofloxacin (Ciprofloxacin). Ka Selatine - Ciprofloxacinum.

Ciphran e sebetsa khahlano le libaktheria le likokoana-hloko tsa likokoana-hloko tse ngata tsa pathogenic.

J01MA02 Lithethefatsi tse sebetsang tsa antibacterial.

Ketso ea pharmacological

Ciphran e sebetsa khahlano le libaktheria tse ngata le likokoana-hloko tsa likokoana-hloko tse ling tsa tlhaho tse loantšang aminoglycosides. Ka hona, litsebi tsa bophelo bo botle li khothaletsa sethethefatsi sena ho loants'a tšoaetso e kopaneng e bakiloeng ke anaerobic, libaktheria tsa aerobic le tšoaetso ea mpa. Matla a bactericidal a ciprofloxacin a bakoa ke bokhoni ba ho sitisa motsoako oa li-enzyme tse hlokahalang bakeng sa bophelo ba microorganism.

Litsebi tsa bophelo bo botle li khothaletsa Cifran ho loantša tšoaetso ea motsoako.

Mofumahali

E kenngoa ka potlako likarolong tse kaholimo tsa mala. Palo e phahameng ea lithethefatsi 'meleng e fihlella kamora lihora tse 1-1,5 kamora ts'ebetso. Maemong ana, tšebeliso ea lijo ha e ame boemo ba ho amoheloa ha mmele.

Biotransformed ka har'a sebete. E qala ho hloekisoa ho tsoa 'meleng ka mor'a lihora tse 3-5, haholo ka moroto le karolo e itseng ka mpeng. Ho batho ba nang le lefu la liphio, nako ea ho felisoa ha moriana e nka nako e telele.

Ho thusang

E laeloa mafu a sa rarahanang le a rarahaneng a bakoang ke ts'oaetso:

• tsamaiso ea broncho-pulmonary,
• Litho tsa ENT
• leihlo
• molomong oa molomo
• tsamaiso ea liphio le urogenital,
• mpa ea ka mpeng
• tsamaiso ea musculoskeletal.

Bakeng sa bana, setlhare sena se laetsoe kalafo ea tšenyo e amanang le pulmonic cystic fibrosis.

Contraindication

Digital ha e khethoe haeba mokuli a le:

• kutloisiso ea lithethefatsi tse tsoang sehlopheng sa quinolone,
• pseudomembranous colitis,
• mofuta ofe kapa ofe oa lefu la sethoathoa.

Digital ha e khothalletsoe hore e sebelisoe nakong ea kemaro le nakong ea kemaro.

Ntle le moo, ho latela litaelo tsa tšebeliso, sesebelisoa sena ha se khothaletsoe hore se sebelisoe nakong ea kemolo le nakong ea pelehi.

Bana le bacha ba laetsoe feela hore ba loane le ts'oaetso e bakoang ke cystic fibrosis kapa ts'okelo ea ts'oaetso ea koatsi.

Ciphran ha e sebelisoe hammoho le tizanidine.

Ka tlhokomelo

Ka hlokolosi, bakuli ba lilemo li beoa, hammoho le:

• le lefu la methapo ea methapo le khatello ea methapo,
• ka lefu la pelo
• ka liphoso tsa motlakase,
• ka renal le / kapa hepatic pathologies,
• ka bokuli ba kelello le lefu la sethoathoa.

Digital 500 e nkuoa pele ho lijo, ntle le ho hlafuna le ho se noe ka metsi.

E na le meeli haeba motho a fumanoa a e-na le mafu a litho tsa methapo ea methapo e qholotsoang ka ho nka fluoroquinolones.

Mokhoa oa ho nka Tsifran 500

E-ja pele ho lijo, ntle le ho hlafuna le metsi a nooang.

Batho ba baholo bakeng sa kalafo ea mafu a hlahang:

• ka mefuta e bobebe le e mahareng - 0,25-0,5 g habeli ka letsatsi,
• ka foromo e boima kapa e rarahaneng - 0,75 g habeli ka letsatsi.

Nako ea kalafo e khethoa ke foromo le boima ba nako ea lesion le tšoaetsanoang. Mekhoa ea kalafo e laetsoe ke ngaka ka bo eona.

Tekanyetso e le 'ngoe ea lithethefatsi ke 0,75 g, letsatsi le letsatsi - ha ho na ho feta 1.5 g.

Bakeng sa mafu a sebete kapa a liphio, litekanyetso tsa letsatsi le letsatsi tse phahameng ha lia lokela ho feta 0,8 g (0,2-0,4 g, lihora tse ling le tse ling tse 12).

Haeba mokuli a e-na le lefu la tsoekere, regimens ea kalafo ea lithibela-mafu e laeloa ke ngaka ka bo eona.

Le lefu la tsoekere

Ciprofloxacin ho lumeloa hore e ntlafatsa ts'ebetso ea lithethefatsi tsa hypoglycemic. Ka hona, ha ntho ena e kopantsoe, mohlala, le glibenclamide kapa glimepiride, hypoglycemic syndrome e ka hlaha.

Haeba mokuli a e-na le lefu la tsoekere, regimens ea kalafo ea lithibela-mafu e laeloa ke ngaka ka bo eona.

Ho tsoa ho tsamaiso ea methapo ea pelo

Sval of palpitations, arrhythmia, tachycardia, liphetoho khatello ea mali.

Tsifran e ka baka litla-morao ka mokhoa oa pelo ea pelo, arrhythmias, tachycardia, liphetoho khatello ea mali.

Tsamaiso ea methapo e bohareng

Bakuli ba bang ba bontša matšoao a asthenia, likhathatso tsa boroko, ho tšoenyeha, ho se utloe litsebeng, ho se sebetse hantle ha tatso ea Bud.

Bakuli ba bang ba na le mathata a ho robala.

Angioneurotic edema, lekhopho la letlalo, ho hlohlona le phello ea anaphylactic (e sa tloaelehang).

Litaelo tse khethehileng

Bakuli bao nalane ea bona ea bongaka e nang le tlhaiso-leseling ka lefu la sethoathoa, ho tsitsipana, methapo ea methapo kapa lesapo la mokokotlo oa tlhaho li kotsing ea karabelo e sa lekaneng ho tsoa ho tsamaiso ea methapo e kholo ea methapo. Maemong a mang, ho ba le boemo ba psychosis bo tsamaeang le liteko tsa ho ipolaea. Ka hona, sethethefatsi sena se laetsoe feela matšoao a bohlokoa.

Ha o sebelisa moriana ona, ho pepesetsoa khanya ea letsatsi ho lokela ho qojoa, hobane ho kenya letsoho ponahalong ea khanya ea khanya.

Sebelisa botsofaling

Bakeng sa bakuli ba tsofetseng ba nang le ts'oaetso e sa sebetseng, e neng e kile ea phekoloa ka glucocorticosteroids, ho na le kotsi ea ho phatloha ha tendon ea Achilles. Ka hona, ha matšoao a tendonitis a hlaha, tsamaiso ea Cyfran e tlameha ho hlakoloa.

Bakeng sa bakuli ba tsofetseng ba nang le boits'oaro bo bobe ba ho itšireletsa mafung, ho na le kotsi ea ho phatloha ha tendon ea Achilles.

Bongata

Matšoao: ponahalo ea ho ba le letsoalo, hlooho e bohloko, maikutlo a bofokoli, ho nyekeloa le pelo le ho hlatsa. Maemong a overdose, ho hlokahala ho etsa lits'ebetso tse tloaelehileng tsa ho tlosa detox:

• seretse se chesang,
• tumellano ea emetics
• ho ja lihlahisoa tsa calcium le magnesium,
• tšebeliso ea likhase tse kholo tsa mokelikeli.

Ntle le moo, ho hlokahala hore ho shejoe ts'ebetso ea ts'ebetso ea urine, kaha ka ts'ebeliso e sa laoleheng ea lithethefatsi, ho na le litlamorao tse mpe tse mabapi le liphio.

Ho sebelisana le lithethefatsi tse ling

Ka tsamaiso e ts'oanang ea lithethefatsi tsa pelo, li-antidepressants le li-antipsychotic, e fanoa ka hloko.

Ha e kopantsoe le Theophylline, e ntlafatsa phello ea eona 'me e thusa ho liehisa' mele.

Ka tšebeliso e tšoanang le phenytoin, phetoho ea boteng ba eona maling e bonoa. Ho kenyelletsa ho ba teng ha maemo a kholisang, taolo ea kalafo ea phenytoin e hlokahala nakong eohle ea kalafo e kopaneng.

Li-NSAIDs (ntle le acetylsalicylic acid) hammoho le litekanyetso tse phahameng tsa quinolones li ka baka ts'abo.

Cyclosporin e kopaneng le Cyfran e thusa ho eketsa creatinine 'meleng.

Probenecid e liehisa ho tsoa ha ciprofloxacin ka har'a moroto.

Ha e kopantsoe le methotrexate, e fokotsa tsamaiso ea methapo ea methapo ea methapo ebile e eketsa khatello ea maikutlo.

Ts'ebeliso e rarahaneng ea Cyfran ka li-antagonists tsa Vitamin K e ntlafatsa thepa ea bona ea anticoagulant.

Hammoho le ropinirole kapa lidocaine, menyetla ea ho ba le litlamorao e ea eketseha.

Hammoho le warfarin, e eketsa monyetla oa ho tsoa mali.

Analog ea sebopeho sa Cifran bakeng sa ntho e sebetsang ke Ciprolet.

Litšoantšo tse amanang le sebopeho sa ntho e sebetsang ke:

• Alcipro
• Tsiprolet,
• Ciprolone
• Tsiprobay,
• Cypropane
• Tsiprosan
• Tsiprosin
• Cyprosol,
• Koprofloxabol,
• Koprofloxacin,
• Citral
• Tsifloksinal,
• Tsifran OD,
• Tsifran ST,
• Ecocifol le ba bang.

Nako ea kalafo e khethoa ke foromo le boima ba nako ea lesion le tšoaetsanoang.

Bopaki ba lingaka le bakuli ka Tsifran 500

Berezkin A.V., setsebi sa bophelo bo botle, Mezhdurechensk

Motsoako o mongata o thibelang likokoana-hloko o sebelisang bongaka, meno, bongaka, urology le lintho tse ling tse ikhethang. Ke fana ka litlhare tsena ka seoelo, hafeela ho na le bopaki kapa e le prophylaxis kamora ts'ebetso ea purulent le likotsi. Ke e nka e sebetsa ebile e loketse.

Kornienko L.F., ngaka ea mafu a basali, Irkutsk

Moriana o ka sebelisoa bakeng sa kalafo ea ka ntle ea mafu a ho ruruha. Ketsahalo e fapaneng e bonts'a katleho ea kalafo.

Alla ea lilemo li 25, Ufa

O ile a tšoaroa ke 'metso,' me ngaka e ile ea fa 500 mg ea matlapa a Cyfran hang ka letsatsi. K'hemisteng e haufinyane ea litekanyetso li nepahetseng tsa antibiotic ena e ne e se. Ke rekile ka litekanyetso tsa 250 mg mme ka nka lipilisi tse 2 hang. Angina o ile a feta matsatsi a 3, empa ha a ka a sitisa thuto. E nkile matsatsi a 10. Litlamorao li tšosa: ho qala ka tšohanyetso tachycardia le dysbiosis ke motsoako o seng monate. Hona joale ke tšaba pheko ena 'me nke ke ka e sebelisa esita le ka khothalletso ea ngaka.

Matšoao a ts'ebeliso ea lithethefatsi Tsifran OD

Mafu a sa rarahanang le a rarahaneng a bakoang ke likokoana-hloko a amehang ka ciprofloxacin:

• tšoaetso ea phepelo ea phefumoloho: pneumonia e bakoang ke Klebsiella spp., Enterobacter spp., Proteus spp., Escherichia coli, Pseudomonas aeruginosa, Haemophilus spp., Moraxella catarrhalis, Legionella le staphylococci,
• tšoaetso ea tsebe e bohareng le lisosa tsa paranasal,
• tšoaetso ea bokhachane ba ka mpeng, tšoaetso ea baktheria ea tšilo ea lijo, lesapo la mokokotlo le lesapo la mokokotlo, hammoho le peritonitis,
• ts'oaetso ea liphio le tsamaiso ea moroto
• tšoaetso ea pelvic (gonorrhea, adnexitis, prostatitis),
• tšoaetso ea letlalo le lisele tse bonolo,
• tšoaetso ea masapo le manonyeletso.

Ts'ebeliso ea lithethefatsi Tsifran OD

Moriana o nooa ka mor'a lijo. Letlapa le meetse kaofela. Se ke oa khaola, ea silakanya, kapa ea hlafuna. Tekanyetso bakeng sa mokuli e mong le e mong e khethoa e nahanela boima ba 'mele, mofuta oa pathogen, kutloisiso ea pathogen, boemo ba tsamaiso ea' mele ea ho itšireletsa mafung, hammoho le ts'ebetso ea liphio le sebete. Nako ea kalafo e latela botebo ba ts'oaetso mme hangata ke matsatsi a 7-14.Leha ho le joalo, bakeng sa tšoaetso e matla kapa e rarahaneng, kalafo e telele e ka hlokahala.

Tekanyo e lekanang ea iv ciprofloxacin

500 mg (1 letlapa) Cyfran OD 1 nako ka letsatsi

200 mg makhetlo a mang le a mang a 12

1000 mg (1 letlapa) Cyfran OD 1 nako ka letsatsi

400 mg makhetlo a mang le a mang a 12

Bakeng sa bakuli ba nang le ts'ebetso ea renal e sa sebetseng hantle, haholoholo le ho hloleha haholo ha renal, ho hlokahala tokiso ea lethal dose.
Tafole e ka tlase e na le likhothaletso tsa litekanyetso bakeng sa ts'ebeliso ea bakuli ba nang le ts'oaetso ea renal.

Tlhahiso ea Creatinine, ml / min

Sekhahla se Khothallelitsoeng

Letlapa Tsifran OD 500-1000 mg 1 nako ka letsatsi

Matlapa a Cifran OD ha a khothalletsoe; matlapa a tloaelehileng a ciprofloxacin a ka sebelisoa ka tekanyo e latelang: 250-500 mg ea ciprofloxacin ka mor'a lihora tse ling le tse ling tse 18.

Bakuli ba hemo- kapa peritoneal dialysis

Matlapa a Cifran OD ha a khothalletsoe, matlapa a tloaelehileng a ka sebelisoa ka tekanyetso e latelang: 250-500 mg ea ciprofloxacin ka mor'a lihora tse ling le tse ling tse 24 (kamora ho daoa ka thipa)

* Ho bakuli ba nang le tumello ea creatinine ≤30 ml / min bakeng sa ts'oaetso e rarahaneng ea moroto le ho ruruha ho matla ha pyelonephritis, 500 mg ea cyfran OD hang ka letsatsi.

Haeba feela ho tsebahala ka tlhahiso ea "metabolinine" serumeng ea mali, mokhoa o latelang o ka sebelisoa ho lekola tumello ea tlhahiso eaine.

bakeng sa banna:


tumello ea creatinine (ml / min) =

Boima ba 'mele (kg) × (140 - lilemo)

72 (plasma creatinine (mg / dl)

Ha ho na tlhoko ea ho fetola tekanyetso ea ciprofloxacin ho bakuli ba nang le mokhoa o tsitsitseng oa cirrhosis ea sebete e sa foleng. Leha ho le joalo, pharmacokinetics ea ciprofloxacin ho bakuli ba nang le ho hloleha ha sebete ka bongata ha e e-so fumanoe ka botlalo.

Litla-morao tsa lithethefatsi Tsifran OD

Khafetsa ≥1, ≤10%
Litho tsa ka mpeng: ho nyekeloa ke pelo, lets'ollo.
Letlalo: lekhopho la letlalo.
Khafetsa ≥0.1, ≤≤1%
'Mele ka kakaretso: bohloko ba ka mpeng, candidiasis, asthenia.
Litho tsa ka mpeng: keketseho ea li-transaminase tsa hepatic: AlAT, AsAT, phosphatase ea alkal, ho hlatsa, dyspepsia, anorexia, flatulence, bilirubinemia.
Sisteme ea Hematopoietic: eosinophilia, leukopenia.
Sistimi ea Urinary: eketseha creatinine, urea naetrojene.
Sistimi ea musculoskeletal: arthralgia.
CNS: ho tsekela, ho opeloa ke hlooho, ho khathatsoa ke boroko, ho ruruha, pherekano.
Letlalo: ho hlohlona, ​​lekhopho la letlalo la tlhaho ea maculopapular, urticaria.
Litho tsa maikutlo: tlolo ea molao.
Khafetsa ≥0.01, ≤≤0.1%
'Mele ka kakaretso: bohloko, bohloko maotong, bohloko mokokotlong, sefubeng.
Ts'ebetso ea pelo: tachycardia, migraine, syncope, vasodilation, hypotension.
Litho tsa ka mpeng: candidiasis (ka molomo), jaundice, jaundice ea cholestatic, lefu la pseudomembranous colitis.
Sisteme ea mali le tsamaiso ea methapo: anemia, leukopenia (granulocytopenia), leukocytosis, phetoho maemong a prothrombin, thrombocytopenia, thrombocythemia (thrombocytosis).
Hypersensitivity: karabelo, ke feberu ea lithethefatsi, likarabelo tsa anaphylactic.
Boloetse ba Metabolic: edema (peripheral, vascular, sefahleho), hyperglycemia.
Sistimi ea musculoskeletal: myalgia, ho ruruha ha manonyeletso.
CNS: migraine, hallucinations, mofufutso, paresthesia (peripheral paralgesia), ho tšoenyeha (ho tšoha, ho tšoenyeha), ho khathatseha boroko (lits'oantšo), ho tsitsipana, khatello ea maikutlo, khatello ea maikutlo, ho thothomela.
Sistimi ea boipelaetso: dyspnea, laryngeal edema.
Letlalo: photosensitivity reaction.
Litho tsa maikutlo: tinnitus, ho se utloe litsebeng ka nakoana (haholoholo ha molumo o mongata), ho sitisoa hoa pono (pono e sa bonahaleng), diplopia, chromatopsia, tahlehelo ea tatso (ho senyeha ha tatso).
Sistimi ea Genitourinary: ARF, ts'ebetso ea ho renal e sa sebetseng hantle, candidiasis ea vaginal, hematuria, crystalluria, nephritis ea mahareng.
Khafetsa ≤0.01%
Ts'ebetso ea pelo: vasculitis.
Litho tsa ka mpeng: candidiasis, sebete necrosis (ka seoelo - e ntse e tsoela pele ka nts'etsopele ea ho se atlehe hoa sebete), "pseudomembranous colitis ka sephetho se bolaeang, pancreatitis, hepatitis.
Sisteme ea mali le tsamaiso ea methapo: hemolytic anemia, petechiae, agranulocytosis, pancytopenia (e nang le ts'okelo ea bophelo), thibelo ea ts'ebetso ea mongobo (e nang le ts'okelo bophelong).
Hypersensitivity: ho thothomela (anaphylactic, ho sokela bophelo), lekhopho la letlalo, karabelo e ts'oanang le lefu la serum.
Boloetse ba Metabolic: ts'ebetso e eketsehileng ea amylase le / kapa lipase tsa mali.
Sistimi ea musculoskeletal: myasthenia gravis, tendonitis (haholo-holo Achilles tendon tendonitis), ho arohana ha karolo kapa ho phatloha ho felletseng ha tendon (haholo-holo Achilles tendon).
CNS: tsitsipano e matla ea mesifa e kholo, ho se tsitse ha gait, psychosis, methapo e matla ea kelello, ataxia, hypersthesia, tic.
Letlalo: petechiae, erythema multiforme, erythema nodosum, Stevens-Johnson syndrome, epidermal necrolysis (lefu la Lyell), lekhopho le phehellang la letlalo.
Litho tsa maikutlo: parosmia, tahlehelo ea monko (hangata e fetoha hape ha sethethefatsi se felisitsoe).

Litšebelisano tsa Lithethefatsi Cifran OD

Ts'ebeliso e tšoanang ea tizanidine le ciprofloxacin e kopantsoe. Joalo ka li-quinolones tse ling, tšebeliso e kopaneng ea ciprofloxacin e nang le theophylline e ka baka keketseho ea khatello ea theophylline le serum ea mali le ho lelefatsa nako ea bophelo ba halofo ea eona. Sena se ka eketsa kotsi ea karabelo e mpe e amanang le theophylline. Haeba tšebeliso ea meriana ena ka nako e tšoanang e ke ke ea qojoa, boemo ba serum theophylline bo lokela ho beoa leihlo le hore moralo oa litekanyetso o laetsoe ka nepo.
Li-quinolone tse ling, ho kopanyelletsa le ciprofloxacin, li ama metabolism ea caffeine. Sena se ka lebisa ho fokotseha ha ho pepesitsoe ha caffeine le ho lelefatsa nako ea bophelo ba eona bo halofo ho tloha serum.
Tšebeliso e le 'ngoe ea lithethefatsi leha e le life tsa sehlopha sa quinolone, ho kenyeletsa ciprofloxacin, e nang le lithethefatsi tse ngata tsa cationic, joalo ka li-antacids tse nang le magnesium kapa aluminium hydroxide, sucralfate, didanosine litafole tse ts'oaroang, kapa lihlahisoa tse nang le calcium, tšepe kapa zinki, li ka fokotsa ho amoheloa ha eona ka lebaka la tlisa khatello ea mali serum le moroto o tla ba tlase haholo ho feta kamoo ho hlokahalang.
Liphephetso tsa li-receptor tsa histamine H2, ho hlakile, ha li ame ka ho teba bioavailability ea ciprofloxacin. Ho kenngoa ha matlapa a ICfran OD ho ka fokotseha hanyane (20%) haeba a sebelisoa hammoho le omeprazole.
Phetoho ea boemo ba serum phenytoin (keketseho kapa ho fokotseha) e ile ea bonoa ho bakuli ba ileng ba nka ciprofloxacin ka nako e le 'ngoe.
Ts'ebeliso e kopaneng ea ciprofloxacin e nang le sulfonylurea ke ka seoelo e ileng ea lebisa ho hypoglycemia e matla.
Ho amoheloa ha li-quinolones tse ling, ho kenyelletsa le ciprofloxacin, ho ne ho amana le keketseho ea nakoana ea serum creatinine ho bakuli ba nkang cyclosporine ka nako e le 'ngoe.
Ho bile le litlaleho tsa hore li-quinolones, ho kenyelletsa ciprofloxacin, li ntlafatsa ts'ebetso ea "anticoagulant warfarin" kapa "derivatives" ea eona. Haeba ho hlokahala, tšebeliso e tšoanang ea meriana ena e lokela ho lekola nako ea prothrombin ka hloko le matšoao a mang a mali. Probenecid e ama secretion ea ciprofloxacin ke li-renal tubules, ka lebaka leo khatello ea aphrofloxacin e serum ea mali e eketsehang. Maemo ana a tlameha ho nahanoa haeba mokuli a sebelisa lithethefatsi ka bobeli ka nako e le 'ngoe.
Ho tsamaisoa ha Methotrexate ke lipompo tsa renal ho ka hatelloa ka tšebeliso ea nako e le 'ngoe ea ciprofloxacin, ho ka lebisang hoketseho ea maemo a plasma methotrexate. Sena se ka eketsa kotsi ea ho fetoha ha chefo ka lebaka la methotrexate. Bakuli ba fumanang kalafo ea methotrexate ba hloka ho hlahlojoa ha kalafo ea ciprofloxacin ka nako e le 'ngoe.
Metoclopramide e potlakisa ho amoheloa ha ciprofloxacin e nkiloeng ka molomo, ka tsela eo e eketsa nako ea ho fihlela mahloriso a eona a mangata plasma ea mali. Leha ho le joalo, ha ho na tšusumetso ho bioavailability ea ciprofloxacin e hlokometsoeng.

Lihlopheng tse khethehileng tsa bakuli

Ts'ebetsong e sa sebetseng ea renal: Ho bakuli ba nang le ts'ebetso ea renal e holofetseng, halofo ea bophelo ba ciprofloxacin e kanna ea eketseha hanyane. Maemong ana, ho hlokahala tokiso ea moriana oa litekanyetso.

Tabeng ea ts'ebetso ea ho senyeha ha sebete: Boithutong ba pele ho bakuli ba nang le mokhoa o tsitsitseng oa cirrhosis ea sebete, ha ho liphetoho tse kholo ho pharmacokinetics tsa ciprofloxacin li ile tsa hlokomeloa. Leha ho le joalo, lithuto tse mabapi le kinetics ea ciprofloxacin ho bakuli ba nang le bothata ba ho hloleha ka matla ba sebete ha lia etsoa.

Sebelisa nakong ea bokhachane le nakong ea ho anyesa

Cifran OD ha e khothalletsoe hore e sebelisoe nakong ea kemolo.
Ciprofloxacin e pepesitsoe lebeseng la matsoele, ka hona nakong ea ho nyekeloa, haeba ho hlokahala hore u sebelise Cifran OD, ka lebaka la bohlokoa ba ts'ebeliso ea eona bakeng sa mme, o lokela ho nka qeto ea ho khaotsa ho sebelisa moriana kapa ho anyesa.

Tekanyetso le tsamaiso

Ka hare.
Se ke oa roba, ho hlafuna, kapa ho seng joalo, senya litafole. Matlapa a lokela ho nooa ka molomo ka mor'a ho ja kaofela, ka metsi a mangata.
Ts'ebeliso ea Tsifran OD e lokela ho tsoela pele bonyane matsatsi a mang a mabeli kamora ho nyamela ka botlalo ha matšoao a lefu lena.
Litekanyetso tse khothalelitsoeng tsa batho ba baholo:

Khalemelo ea litekanyetso tsa kalafo ka ho hloleha ha poo:
Maemong a ts'ebetso ea ho fokola ha ausi, ho khothaletsoa mokhoa o latelang oa litekanyetso bakeng sa batho ba baholo:

Haeba ho tsebahala feela plasma creatinine mahloriso, ho khothalletsoa mokhoa o latelang
Litlhaloso tsa tumello ea creatinine:
Banna:

Tlhahiso ea Creatinine (ml / min.) = Boima ba 'mele (kg) x (140 - lilemo) / 72 x serum creatinine mahloriso (mg%)
Basali:
Tlhaloso ea Creatinine (ml / min.) = Sesupo sa 0,85 x se baliloe banna.

Litla-morao

Ho tsoa ts'ebetsong ea tšilo ea lijo: ho nyekeloa ke pelo, ho hlatsa, lets'ollo, ho opeloa ke mpa, ho ruruha, ho ipolaisa tlala, lefu la cholestatic (haholo-holo ho bakuli ba nang le mafu a nakong ea sebete), hepatitis, hepatonecrosis.

Ho tsoa tsamaisong ea methapo: ho tsekela kamehla, ho ferekanya kelello, ho hloka boroko, ho opa pelo, ho teneha, hlooho e bohloko, mokhathala o eketsehileng, ho tšoenyeha, ho thothomela, litoro tsa "bosiu", paralgesia paralgesia (anomaly ka pono ea bohloko), khatello e matla ea kelello, pherekano, khatello ea maikutlo le lipono tse ling karabelo ea kelello (ka linako tse ling e ea maemong ao mokuli a ka intšang kotsi), migraine, ho akheha, mokokotlo oa mokokotlo oa mokokotlo.

Ho tsoa lithong tsa kutlo: ho ferekana ha tatso le monko, ho senyeha hoa pono (diplopia, discoloration), tinnitus, tahlehelo ea kutlo.

Ho tsoa ho tsamaiso ea pelo le pelo: tachycardia, pelo ea methapo, ea fokotseha khatello ea mali, ea fafatsa mali letlalong la sefahleho.

Ho tsoa ho hematopoietic system: eozoftft, leukopenia, granulocytopenia, anemia, thrombocytopenia, leukocytosis, thrombocytosis, hemolytic anemia.

Matšoao a laboratori: hypoprothrombinemia, tšebetso e eketsehang ea transpase ea hepatic, hypercreatininemia, hyperbilirubinemia, hyperglycemia, ts'ebetso e eketsehileng ea alphaline phosphatase le lactate dehydrogenase.

Ho tsoa ts'ebetsong ea moroto: hematuria, crystalluria (haholo-holo e nang le motsoako oa alkaline oa moroto le li-diureis tse tlase), lephritis ea methapo ea kutlo (ka nts'etsopele ea ho se sebetse hantle hoa letheba), glomerulonephritis, dysuria, polyuria, ho boloka urine, albinuria, ho tsoa mali, ho fokolisa tšebetso ea nitrogen.

Litla-morao: ho hlohlona ha letlalo, likhahla, ho etsoa ha marangrang a tsamaeang le ho tsoa mali, le ho hlaha ha marang-rang a manyane, makhopho a lithethefatsi, letheba ka letlalo (petechiae), ho ruruha hoa sefahleho kapa larynx, dyspnea, vasculitis, erythema nodosum, erythema multiforme exudative Stevens-Johnson syndrome), chefo e kotsi ea epidermal necrolysis (lefu la Lyell).

Ho tsoa ts'ebetsong ea musculoskeletal: arthralgia, ramatiki, tendovaginitis, ropo ea tendon, myalgia.

Tse ling: ho ruruha ho eketsehileng, ho hlaka ka mahlo, bofokoli bo akaretsang, bonohe (candidiasis, pseudomembranous colitis).